ATE239801T1 - Mikropartikel mit multiplen fluoreszenz-signalen - Google Patents

Mikropartikel mit multiplen fluoreszenz-signalen

Info

Publication number
ATE239801T1
ATE239801T1 AT99904191T AT99904191T ATE239801T1 AT E239801 T1 ATE239801 T1 AT E239801T1 AT 99904191 T AT99904191 T AT 99904191T AT 99904191 T AT99904191 T AT 99904191T AT E239801 T1 ATE239801 T1 AT E239801T1
Authority
AT
Austria
Prior art keywords
fluorescent
microparticles
methods
nanoparticles
particles
Prior art date
Application number
AT99904191T
Other languages
English (en)
Inventor
Mark B Chandler
Don Chandler
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corp filed Critical Luminex Corp
Application granted granted Critical
Publication of ATE239801T1 publication Critical patent/ATE239801T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G01N2015/1014—Constitution of reference particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99904191T 1998-01-22 1999-01-22 Mikropartikel mit multiplen fluoreszenz-signalen ATE239801T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7216098P 1998-01-22 1998-01-22
PCT/US1999/001315 WO1999037814A1 (en) 1998-01-22 1999-01-22 Microparticles with multiple fluorescent signals

Publications (1)

Publication Number Publication Date
ATE239801T1 true ATE239801T1 (de) 2003-05-15

Family

ID=22105965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904191T ATE239801T1 (de) 1998-01-22 1999-01-22 Mikropartikel mit multiplen fluoreszenz-signalen

Country Status (9)

Country Link
US (1) US6268222B1 (de)
EP (1) EP1049807B1 (de)
JP (1) JP3468750B2 (de)
KR (1) KR100593712B1 (de)
AT (1) ATE239801T1 (de)
AU (1) AU2464299A (de)
CA (1) CA2318779C (de)
DE (1) DE69907630T2 (de)
WO (1) WO1999037814A1 (de)

Families Citing this family (371)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951716B2 (en) * 1995-03-13 2005-10-04 Mark Hechinger Anti-platelet immunoglobulin bead positive control
US6933106B2 (en) * 1995-03-13 2005-08-23 Mark Hechinger Platelet immunoglobulin bead suspension and flow cytometry
KR19990008052A (ko) * 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6933331B2 (en) 1998-05-22 2005-08-23 Nanoproducts Corporation Nanotechnology for drug delivery, contrast agents and biomedical implants
JP4357112B2 (ja) * 1997-10-14 2009-11-04 ルミネックス コーポレイション 精密蛍光染色された粒子及びその製造及び使用方法
AU3555599A (en) * 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
US6423410B1 (en) * 1998-09-04 2002-07-23 Mds Proteomics, Inc. Ultrasonically generated paramagnetic polymer particles
US7116407B2 (en) * 1998-12-15 2006-10-03 Union Biometrica, Inc. System for axial pattern analysis of multicellular organisms
JP3978961B2 (ja) * 1998-12-25 2007-09-19 特種製紙株式会社 偽造防止用紙に使用する蛍光発色粒子、その製造方法、及び蛍光発色粒子を使用した偽造防止用紙
US6696304B1 (en) 1999-02-24 2004-02-24 Luminex Corporation Particulate solid phase immobilized protein quantitation
US6261782B1 (en) 1999-04-06 2001-07-17 Yale University Fixed address analysis of sequence tags
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
WO2000063695A1 (en) 1999-04-16 2000-10-26 Tibotec N.V. Encoding of microcarriers
US6423818B1 (en) * 1999-07-30 2002-07-23 Takehisa Matsuda Coumarin endcapped absorbable polymers
JP2003527087A (ja) 1999-08-13 2003-09-16 イェール・ユニバーシティ バイナリーコード化配列タグ
DE60040603D1 (de) 1999-08-17 2008-12-04 Luminex Corp Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
DE60027576T2 (de) 1999-08-17 2007-05-03 Luminex Corp., Austin Verkapselung von fluoreszierenden partikeln
CA2401782A1 (en) * 2000-01-31 2001-08-02 John T. Mcdevitt Portable sensor array system
CA2309575A1 (en) * 2000-05-26 2001-11-26 James E. Guillet Internally cross-linked macromolecules
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) * 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20020019004A1 (en) * 2000-08-03 2002-02-14 Albert Orfao Method for isolating molecules, cells and other particles which are specifically bound to a large particle
AU2001286771A1 (en) * 2000-08-24 2002-03-04 Sendx Medical, Inc. The use of a multiple dye system to enhance the spectral properties of dyed microparticles in an immunoassay
US7241399B2 (en) 2000-09-08 2007-07-10 Centrum Fuer Angewandte Nanotechnologie (Can) Gmbh Synthesis of nanoparticles
WO2002020695A1 (de) 2000-09-08 2002-03-14 Nanosolutions Gmbh Dotierte nanopartikel
US7465540B2 (en) 2000-09-21 2008-12-16 Luminex Corporation Multiple reporter read-out for bioassays
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
EP1346224B1 (de) 2000-10-19 2017-03-01 Mycartis N.V. Verfahren zur manipulation von mikroträgern zu identifizierungszwecken
US20020081617A1 (en) * 2000-11-08 2002-06-27 Tione Buranda Fluorescence and FRET based assays for biomolecules on beads
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1354206A2 (de) * 2000-12-13 2003-10-22 Bio-Rad Laboratories, Inc. Standard-verdünnungsmittel für multiplex-bestimmungen
EP1379284A4 (de) * 2001-01-05 2007-07-25 Gen Hospital Aktivierbare bildgebende sonden
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20030165865A1 (en) * 2001-01-29 2003-09-04 Hinkel Christopher A. Methods of analysis of nucleic acids
US20020127586A1 (en) * 2001-01-31 2002-09-12 Novozymes A/S Method of analyzing granular composition by fluorescene analysis
US20020115116A1 (en) * 2001-02-22 2002-08-22 Yong Song Multiplex protein interaction determinations using glutathione-GST binding
AU2002255771B2 (en) 2001-03-16 2007-10-18 Qtl Biosystems, Llc Fluorescent polymer superquenching-based bioassays
US7189767B2 (en) * 2001-03-30 2007-03-13 Rohm And Haas Company Colorants, dispersants, dispersions, and inks
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20030170695A1 (en) * 2001-06-29 2003-09-11 Liang Shi Enzymatic ligation-based identification of nucleotide sequences
US20030082584A1 (en) * 2001-06-29 2003-05-01 Liang Shi Enzymatic ligation-based identification of transcript expression
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US6855426B2 (en) * 2001-08-08 2005-02-15 Nanoproducts Corporation Methods for producing composite nanoparticles
CA2459320C (en) * 2001-09-06 2016-07-05 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
US7064309B2 (en) 2001-09-17 2006-06-20 The Boeing Company Method for detecting foreign object debris
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
EP1476753B1 (de) * 2001-11-14 2013-08-14 Luminex Corporation Funktionalisierte komponenten für verbesserte immobilisierung
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
FR2832507B1 (fr) * 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
US20030166509A1 (en) * 2001-11-20 2003-09-04 Advanced Inhalation Research, Inc. Compositions for sustained action product delivery and methods of use thereof
AU2002362013B2 (en) * 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
US7241629B2 (en) * 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
US20030166303A1 (en) * 2001-12-21 2003-09-04 David Peritt Novel screening method for molecular antagonist using flow-cytometry
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US6792019B2 (en) * 2002-02-28 2004-09-14 Texas Instruments Incorporated Driver with tail currents in discrete subranges
AU2003219275B2 (en) * 2002-03-07 2008-01-24 Cambridge Enterprise Ltd SCD fingerprints
AU2002330390A1 (en) * 2002-03-20 2003-09-29 Hosokawa Micron Corporation Method of manufacturing chemical-containing composite particles
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US20030215791A1 (en) * 2002-05-20 2003-11-20 Applied Spectral Imaging Ltd. Method of and system for multiplexed analysis by spectral imaging
WO2003102216A2 (en) 2002-05-31 2003-12-11 Diversa Corporation Multiplexed systems for nucleic acid sequencing
DE60324225D1 (de) 2002-06-14 2008-12-04 Rohm & Haas Farbmittel, Dispergiermittel und Dispersionen enthaltend polymere Nanopartikel
US7091275B1 (en) 2002-06-14 2006-08-15 Rohm And Haas Company Aqueous polymeric composition containing polymeric nanoparticles and treatments prepared therefrom
AU2003204606A1 (en) * 2002-06-14 2004-01-15 Rohm And Haas Company Water-based adhesives
EP1371679B1 (de) * 2002-06-14 2008-04-09 Rohm And Haas Company Wässrige Zusammensetzung enthaltend Polymernanopartikel
TW200404820A (en) * 2002-06-14 2004-04-01 Rohm & Haas Aqueous nanoparticle dispersions
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
EP2107120A1 (de) * 2002-07-24 2009-10-07 Board of Regents, The University of Texas System Erfassung und Detektion von Mikroben mittels Membranverfahren
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
JP4087200B2 (ja) * 2002-09-17 2008-05-21 ユニバーサル・バイオ・リサーチ株式会社 粒子複合体及び該粒子複合体の作製方法
US8394944B2 (en) * 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
US7009003B2 (en) * 2002-09-30 2006-03-07 Rohm And Haas Company Plastic composition
CN1283739C (zh) * 2002-09-30 2006-11-08 罗姆和哈斯公司 喷墨油墨用聚合物粘合剂
US7138438B2 (en) * 2002-09-30 2006-11-21 Rohm And Haas Company Polymeric nanoparticle formulations and their use for improving the dirt pick up resistance of a coating
US7244775B2 (en) * 2002-09-30 2007-07-17 Rohm And Haas Company Damage resistant coatings, films and articles of manufacture containing crosslinked nanoparticles
US20040086867A1 (en) * 2002-10-30 2004-05-06 Jian Han Method for detecting nucleic acid
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
MXPA05005071A (es) 2002-11-12 2005-07-22 Becton Dickinson Co Diagnostico de la sepsis o sirs usando perfiles de biomarcadores.
EP1573054A4 (de) * 2002-11-12 2005-12-28 Becton Dickinson Co Sepsis- oder sirs-diagnose mittels biomarkerprofilen
BR0316232A (pt) * 2002-11-12 2005-10-04 Becton Dickinson Co Métodos para determinar o estado de sepsia, para prognosticar o começo de sepsia e para diagnosticar a sìndrome de resposta inflamatória sistêmica em um indivìduo
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7708974B2 (en) 2002-12-10 2010-05-04 Ppg Industries Ohio, Inc. Tungsten comprising nanomaterials and related nanotechnology
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
CA2516116A1 (en) * 2003-01-16 2004-08-05 St. John's University Nanoparticle based stabilization of ir fluorescent dyes
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
EP2161343B1 (de) * 2003-02-13 2013-10-23 The Regents Of the University of California Verfahren und Zusammensetzungen zum Erkennen und Analysieren von polynucleotid-bindenden Protein-Wechselwirkungen mit lichtnutzenden Multichromophoren
WO2004074452A2 (en) * 2003-02-19 2004-09-02 The Regents Of The University Of California Multiplex mapping of protein interactions
ITMI20030339A1 (it) * 2003-02-26 2004-08-27 Pranha 50 Ltda Metodo, apparato e dispositivi per il risanamento di condotte mediante introduzione di tubi in materiale plastico.
WO2004081571A1 (fr) * 2003-03-13 2004-09-23 Chengdu Kuachang Medical Industrial Limited Procede et dispositif de detection de polypeptides, et compose ligand comprenant des nanoparticules
WO2004090548A1 (en) * 2003-03-13 2004-10-21 Chengdu Kuachang Medical Industrial Limited Device for analysis or separation containing an active nanostructured carrier, its preparation method and applications
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
WO2004102196A1 (fr) * 2003-04-30 2004-11-25 Chengdu Kuachang Medical Industrial Limited Dispositif comprenant des nanostructures destine a une separation ou une analyse, et preparation et mise en oeuvre de ce dispositif
US7432298B2 (en) * 2003-05-09 2008-10-07 Applied Biosystems Inc. Fluorescent polymeric materials containing lipid soluble rhodamine dyes
US7491830B2 (en) * 2003-05-09 2009-02-17 Applied Biosystems Inc. Phenyl xanthene dyes
US7260485B2 (en) * 2003-07-18 2007-08-21 Luminex Corporation Method and systems for distinguishing between materials having similar spectra
US8012768B2 (en) * 2003-07-18 2011-09-06 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
WO2005008219A2 (en) 2003-07-18 2005-01-27 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
CN1860242B (zh) * 2003-08-01 2013-11-06 戴诺生物技术有限公司 自杂交多重靶核酸探针及其使用方法
US7692773B2 (en) * 2003-08-05 2010-04-06 Luminex Corporation Light emitting diode based measurement systems
US7069191B1 (en) 2003-08-06 2006-06-27 Luminex Corporation Methods for reducing the susceptibility of a peak search to signal noise
KR101149880B1 (ko) * 2003-08-13 2012-05-24 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US7348399B2 (en) 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules
US7550557B2 (en) * 2003-08-29 2009-06-23 Louisiana Tech University Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7544770B2 (en) * 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US9149440B2 (en) * 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
US20050084513A1 (en) * 2003-10-21 2005-04-21 Board Of Regents Nanocoating for improving biocompatibility of medical implants
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
AU2004286253A1 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
WO2005059551A2 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7869011B2 (en) 2003-12-22 2011-01-11 Novo Norkisk A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
WO2005064338A1 (en) * 2003-12-23 2005-07-14 University Of Florida Research Foundation, Inc. Microparticles for use in diagnostic methods
WO2005071412A2 (en) 2004-01-09 2005-08-04 Applera Corporation Phosphor particle coded beads
JP2007518106A (ja) * 2004-01-14 2007-07-05 ルミネックス・コーポレーション 測定システムの１つ以上のパラメータを変更するための方法
CN1910440A (zh) * 2004-01-14 2007-02-07 卢米尼克斯股份有限公司 用于动态范围扩展的方法和系统
US20050277205A1 (en) * 2004-02-20 2005-12-15 Ki-Bum Lee Multicomponent magnetic nanorods for biomolecular separations
US7422696B2 (en) * 2004-02-20 2008-09-09 Northwestern University Multicomponent nanorods
US7229778B2 (en) * 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
JP2005265654A (ja) 2004-03-19 2005-09-29 Hitachi Maxell Ltd 複合化粒子
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
EP1580559B1 (de) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methoden zur Verringerung der Varianz der Analytkonzentrationen von komplexen Probenmischungen
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
EP1735619A4 (de) * 2004-04-01 2007-09-26 Rules Based Medicine Inc Universelle flintenprüfung
WO2005106462A2 (en) * 2004-04-26 2005-11-10 Drexel University Methods for use of fluorescent nanoparticles to determine free volume and to detect and deliver materials to repair cracks in polymers and polymer composites
US7465543B1 (en) 2004-05-21 2008-12-16 The United States Of America, As Represented By The Secretary Of Agriculture Multiplex DNA identification of clinical yeasts using flow cytometry
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
DE502004007951D1 (de) * 2004-08-18 2008-10-09 Roche Diagnostics Gmbh Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
CN103951595B (zh) 2004-10-12 2015-10-14 卢米尼克斯股份有限公司 形成染色的微球体和染色的微球体群的方法
JP4988578B2 (ja) * 2004-10-12 2012-08-01 ルミネックス コーポレーション ミクロスフェアの表面特性を変化させるための方法
US20060084184A1 (en) * 2004-10-19 2006-04-20 Renovar Incorporated Reagents for urine-based immunological assays
GB2420850A (en) 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
EP1828748A1 (de) * 2004-12-17 2007-09-05 Luminex Corporation Systeme, beleuchtungsuntersysteme und verfahren zur erhöhung der durch ein fluorophor emittierten fluoreszenz
CA2594458C (en) 2005-01-10 2016-08-23 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006074482A2 (en) * 2005-01-10 2006-07-13 The Regents Of The University Of California Methods and kits for strand-specific polynucleotide detection with cationic multichromophores
JP4452188B2 (ja) * 2005-01-17 2010-04-21 凸版印刷株式会社 カラービーズ製造装置、カラービーズ製造方法及びバイオ分析装置
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
CN101650998B (zh) 2005-01-20 2013-02-06 卢米尼克斯股份有限公司 微球、包含其的微球群、以及分析试验样品的方法
CA2775655C (en) * 2005-01-20 2014-03-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Multiplexed analysis for determining a serodiagnosis of viral infection
US7666594B2 (en) 2005-01-31 2010-02-23 The Regents Of The University Of California Methods for assaying a sample for an aggregant
DE102005007374A1 (de) * 2005-02-17 2006-08-24 Universität Ulm Nanopartikel und deren Verwendung
US20070053950A1 (en) * 2005-02-28 2007-03-08 Gajanan Shukla P Composition of polymer microcapsules of biocide for coating material
KR20080006617A (ko) 2005-04-15 2008-01-16 백톤 디킨슨 앤드 컴퍼니 패혈증의 진단
US7897257B2 (en) * 2005-04-18 2011-03-01 Ge Healthcare Bio-Sciences Ab Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof
WO2006115870A2 (en) * 2005-04-20 2006-11-02 Becton Dickinson And Company Multiplex microparticle system
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20090325258A1 (en) * 2005-06-03 2009-12-31 Tokyo University Of Agriculture And Technology Magnetic particle holding carrier and method for preparing the same
JP4652902B2 (ja) * 2005-06-23 2011-03-16 株式会社日立ソリューションズ 安定保存された担体微小粒子
EP1904846A4 (de) * 2005-06-29 2009-03-18 Rules Based Medicine Inc Verfahren und kits zur diagnose von akutem koronarsyndrom
NO20053373D0 (no) * 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
CA2984772C (en) 2005-09-21 2018-04-03 Luminex Corporation Methods and systems for image data processing
CA2623408C (en) * 2005-09-26 2014-04-01 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US20090117560A1 (en) * 2005-09-27 2009-05-07 Toshihiko Fujikawa Method of Forming Self Assembly Substance on Microsphere and Method of Detecting Target Analyte
US20070072309A1 (en) * 2005-09-29 2007-03-29 General Electric Company Analytical compositions including nanometer-sized transducers, methods to make thereof, and devices therefrom
DE102005047609A1 (de) * 2005-10-05 2007-04-12 Giesecke & Devrient Gmbh Echtheitssicherung von Wertdokumenten mittels Merkmalsstoffen
KR100795100B1 (ko) 2005-10-31 2008-01-17 한국과학기술연구원 단백질 키나아제에 의한 단백질 인산화의 영상화를 위한고분자 나노 입자 및 그의 용도
US7572643B2 (en) * 2005-11-21 2009-08-11 E. I. Du Pont De Nemours And Company Nanoparticle composite-coated glass microspheres for use in bioassays
US7926730B2 (en) * 2005-11-30 2011-04-19 Pitney Bowes Inc. Combined multi-spectral document markings
US20070119950A1 (en) * 2005-11-30 2007-05-31 Auslander Judith D Document edge encoding using multi-spectral encoding tags
JP4902183B2 (ja) * 2005-12-06 2012-03-21 日立マクセル株式会社 機能性赤外蛍光粒子
ATE525482T1 (de) 2005-12-23 2011-10-15 Nanostring Technologies Inc Nanoreporter und verfahren zu deren herstellung und verwendung
US20070239483A1 (en) * 2006-01-09 2007-10-11 Biophysical Corporation Methods for individualized health assessment service
EP2363205A3 (de) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen Und Verfahren Zur Verwendung Bei Der Bildung Und Kontrolle Von Nanoreaktoren
US8309025B1 (en) 2006-01-26 2012-11-13 Luminex Corporation Methods and systems for determining composition and completion of an experiment
EP1987360B1 (de) 2006-01-27 2012-03-07 Tripath Imaging, Inc. Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür
US20070190536A1 (en) * 2006-02-16 2007-08-16 Academia Sinica Method for using biomaterials as reagent for nano-patterning
WO2007097377A1 (ja) * 2006-02-24 2007-08-30 The Furukawa Electric Co., Ltd. フローサイトメトリーによる生体分子の定量システム、その定量方法、細胞の検出・分取システム、その検出・分取方法、それらに用いる蛍光シリカ粒子、及び複数個の蛍光シリカ粒子を組み合わせたキット
WO2007103859A2 (en) * 2006-03-03 2007-09-13 Luminex Corporation Methods, products, and kits for identifying an analyte in a sample
CA2643169A1 (en) * 2006-03-17 2007-09-27 Vivacta Ltd A chemical sensing device
US9182398B2 (en) * 2006-04-01 2015-11-10 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
US8124943B1 (en) 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
WO2007120762A2 (en) * 2006-04-14 2007-10-25 Cambrios Technologies Corporation Fluorescent particles bound to multifunctional scaffolds and their uses
WO2007121436A2 (en) * 2006-04-17 2007-10-25 Luminex Corporation Methods, particles, and kits for determining activity of a kinase
US20080020475A1 (en) * 2006-05-05 2008-01-24 Rules-Based Medicine, Inc Methods and kits for the diagnosis of hypothyroidism
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9810707B2 (en) * 2006-05-17 2017-11-07 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US20080277626A1 (en) * 2006-05-23 2008-11-13 Evident Technologies, Inc. Quantum dot fluorescent inks
WO2007143615A2 (en) 2006-06-02 2007-12-13 Luminex Corporation Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
EP2073940A2 (de) * 2006-08-17 2009-07-01 The Regents of the University of California Benutzerspezifische lithographische partikel
US7501290B2 (en) * 2006-09-13 2009-03-10 Hanley Brian P Intraplexing method for improving precision of suspended microarray assays
US8124598B2 (en) * 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US8062609B2 (en) * 2006-11-10 2011-11-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
WO2008064336A2 (en) 2006-11-22 2008-05-29 Inivitrogen Corporation Autoimmune disease biomarkers
US9456983B1 (en) * 2006-12-08 2016-10-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition with enhanced vessel targeting
CN102851369B (zh) 2006-12-13 2015-01-21 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
US20080261253A1 (en) * 2007-01-12 2008-10-23 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of galactosemia
WO2008094709A2 (en) * 2007-02-01 2008-08-07 Trustees Of Columbia University In The City Of New York Methods and compositions for treating t-cell leukemia
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008100791A1 (en) * 2007-02-16 2008-08-21 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
EP1961825A1 (de) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Verfahren zur Vorhersage des Auftretens von Metastasen bei Brustkrebspatienten
CA2679586A1 (en) * 2007-02-27 2008-10-23 Northwestern University Molecule attachment to nanoparticles
DE102007010860B4 (de) * 2007-03-01 2014-05-15 PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Verfahren zur Identifikation eines Partikels mit zwei oder mehr monodispers eingebetteten Fluorophoren
WO2008109797A1 (en) * 2007-03-08 2008-09-12 Rules-Based Medicine, Inc. Methods for rapid disease screening
WO2008121349A1 (en) * 2007-03-29 2008-10-09 University Of Delaware Tag and target delivery system
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
DE102007031137A1 (de) 2007-06-13 2008-12-18 Attomol Gmbh Molekulare Diagnostika Verfahren und Sonden/Primärsystem zum "real time" Nachweis eines Nukleinsäuretargets
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
AU2008289383A1 (en) * 2007-07-24 2009-02-26 Northwestern University Coated colloidal materials
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US8171777B2 (en) * 2007-09-17 2012-05-08 Adam Richard Schilffarth Systems, storage mediums, and methods for identifying particles in flow
US8871687B2 (en) * 2007-09-28 2014-10-28 Quest Diagnostics Investments Incorporated Nucleic acid sequencing by single-base primer extension
WO2009064489A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Process for directing assemblies of particulate dispersions using surface roughness
US20090170214A1 (en) * 2007-12-27 2009-07-02 Luminex Corporation Luminescent Reporter Modality for Analyzing an Assay
WO2009091643A1 (en) 2008-01-07 2009-07-23 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
JP2011509405A (ja) * 2008-01-07 2011-03-24 ルミネックス コーポレーション 生物学的標的の免疫磁気捕捉および撮像の方法
EP2732826B1 (de) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluoreszierende Bildgebungsmittel
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
JP4582224B2 (ja) 2008-05-02 2010-11-17 ソニー株式会社 マイクロビーズ作製方法及びマイクロビーズ
JP4561869B2 (ja) 2008-05-08 2010-10-13 ソニー株式会社 マイクロビーズ自動識別方法及びマイクロビーズ
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
US20100075322A1 (en) * 2008-08-22 2010-03-25 Hooper Dennis G Methods and Compositions for Identifying Mycotoxins and Fungal Species
US20100068729A1 (en) * 2008-09-12 2010-03-18 Rules-Based Medicine, Inc. Method and kits for the diagnosis of diabetes
AU2009296526B2 (en) 2008-09-24 2015-11-19 First Light Diagnostics, Inc. Method for detecting analytes
JP5375005B2 (ja) 2008-09-30 2013-12-25 ソニー株式会社 マイクロビーズ作製方法
US8586141B2 (en) * 2008-10-06 2013-11-19 Xerox Corporation Fluorescent solid ink made with fluorescent nanoparticles
US8236198B2 (en) * 2008-10-06 2012-08-07 Xerox Corporation Fluorescent nanoscale particles
US8222313B2 (en) * 2008-10-06 2012-07-17 Xerox Corporation Radiation curable ink containing fluorescent nanoparticles
US8541154B2 (en) * 2008-10-06 2013-09-24 Xerox Corporation Toner containing fluorescent nanoparticles
US8147714B2 (en) * 2008-10-06 2012-04-03 Xerox Corporation Fluorescent organic nanoparticles and a process for producing fluorescent organic nanoparticles
US9732324B2 (en) 2008-10-23 2017-08-15 Cornell University Anti-viral method
CN102265155B (zh) 2008-11-10 2014-08-13 卢米耐克斯公司 用于制备和使用多重检测中的大孔珠粒的方法和体系
JP5529505B2 (ja) * 2008-11-13 2014-06-25 ベクトン・ディキンソン・アンド・カンパニー 蛍光分析装置のための機器セットアップシステム
US8415161B2 (en) 2008-11-13 2013-04-09 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US8343775B2 (en) * 2009-05-06 2013-01-01 Hanley Brian P Method and device for affinity differential intraplexing
EP2258865A1 (de) * 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Lysinspezifische Demethylase 1 (LSD1) ist ein Biomarker für Brustkrebs
DK3223013T3 (en) 2009-07-02 2019-04-15 Sloan Kettering Inst Cancer Res FLUORESCING SILICA-BASED NANOPARTICLES
US12161734B2 (en) 2009-07-02 2024-12-10 Sloan-Kettering Institute For Cancer Research Multimodal silica-based nanoparticles
JP5589616B2 (ja) 2009-09-15 2014-09-17 ソニー株式会社 マイクロビーズ解析方法及びマイクロビーズ解析装置
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
JP2011085587A (ja) * 2009-10-15 2011-04-28 Becton Dickinson & Co 蛍光分析装置のための機器セットアップシステム
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
WO2011079064A1 (en) * 2009-12-23 2011-06-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods and kits for identyfing human adenovirus serotypes
US8927271B1 (en) 2010-01-21 2015-01-06 Jack T. Johansen Compositions and methods for detecting target analytes
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8747677B2 (en) 2010-04-09 2014-06-10 Luminex Corporation Magnetic separation device
US8767069B2 (en) 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US8274656B2 (en) 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
EP2613610A4 (de) * 2010-09-03 2015-05-20 Adeka Corp Farbkonversionsfilter
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US9525092B2 (en) 2010-11-05 2016-12-20 Pacific Light Technologies Corp. Solar module employing quantum luminescent lateral transfer concentrator
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
JP5900489B2 (ja) * 2011-03-25 2016-04-06 コニカミノルタ株式会社 免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20140220598A1 (en) * 2011-09-09 2014-08-07 Tohoku University Biological substance detection method
CN108192952A (zh) 2011-09-29 2018-06-22 露美内克丝公司 水解探针
CA2852915C (en) 2011-10-18 2018-05-15 Luminex Corporation Methods and systems for image data processing
DK3327110T3 (en) 2011-11-07 2020-04-27 Rapid Micro Biosystems Inc Kassette til sterilitetstest
US20130112942A1 (en) 2011-11-09 2013-05-09 Juanita Kurtin Composite having semiconductor structures embedded in a matrix
US20130112941A1 (en) 2011-11-09 2013-05-09 Juanita Kurtin Semiconductor structure having nanocrystalline core and nanocrystalline shell with insulator coating
JP6215223B2 (ja) 2011-12-09 2017-10-18 アンスティテュ・パストゥール マルチプレックス免疫スクリーニングアッセイ
EP2788765B1 (de) * 2011-12-09 2017-02-15 Sietze Sietzema Verfahren zum nachweis von bakterien in milch
US9804156B2 (en) 2012-03-06 2017-10-31 Life Technologies Corporation Biomarkers for systemic lupus erythematosus
EP2839021B1 (de) 2012-04-16 2022-02-23 Rapid Micro Biosystems, Inc. Zellkultivierungsvorrichtung
WO2013188857A2 (en) 2012-06-15 2013-12-19 Luminex Corporation Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria
EP2872619B1 (de) 2012-07-11 2018-02-14 Imstem Biotechnology Inc. Mesenchymale stammzellen aus menschlichen embryonalen stammzellen, verfahren dafür und verwendungen davon
US10519434B2 (en) 2012-07-13 2019-12-31 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US8759075B2 (en) * 2012-07-13 2014-06-24 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US9425365B2 (en) 2012-08-20 2016-08-23 Pacific Light Technologies Corp. Lighting device having highly luminescent quantum dots
US8889457B2 (en) 2012-12-13 2014-11-18 Pacific Light Technologies Corp. Composition having dispersion of nano-particles therein and methods of fabricating same
US8956821B2 (en) 2013-02-06 2015-02-17 Medical Service Consultation International, Llc Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins
US20140243231A1 (en) 2013-02-28 2014-08-28 The Terasaki Family Foundation Methods and compositions for the efficient reuse of multiply dyed particles
WO2014136885A1 (ja) 2013-03-08 2014-09-12 コニカミノルタ株式会社 組織染色用染色剤、組織染色用染色剤の製造方法および組織染色用染色剤を含む組織染色用キット
EP3608022A1 (de) 2013-03-15 2020-02-12 The Trustees of Princeton University Verfahren und vorrichtungen für reinigung mit hohem durchsatz
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN105307687A (zh) 2013-03-15 2016-02-03 索隆-基特林癌症研究协会 多模态的基于二氧化硅的纳米粒子
EP2971287B1 (de) 2013-03-15 2019-08-14 GPB Scientific, LLC Mikrofluidische on-chip-verarbeitung von partikeln
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
CA2910034C (en) 2013-04-26 2022-08-30 Med-Logics, Inc. Tissue removal device, systems, and methods using vacuum pulses and ultrasonic vibrations
US20140378327A1 (en) 2013-06-19 2014-12-25 Luminex Corporation Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
EP3715470B1 (de) 2013-08-09 2023-10-11 Luminex Corporation Sonden für verbesserte schmelzunterscheidung und multiplexierung in nukleinsäuretests
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
CN106459126B (zh) * 2014-04-08 2019-10-01 国立大学法人弘前大学 新型葡萄糖衍生物、及使用该衍生物的细胞成像方法及显像剂
US9662096B2 (en) 2014-05-01 2017-05-30 Diomics Corporation Devices and kits for collection, storage and analysis of samples and methods of production and use thereof
US10111963B2 (en) 2014-05-29 2018-10-30 Memorial Sloan Kettering Cancer Center Nanoparticle drug conjugates
CN105219373B (zh) * 2014-06-05 2019-06-25 中翰盛泰生物技术股份有限公司 一种载体颗粒及其制备方法
US20160025603A1 (en) 2014-07-22 2016-01-28 Diomics Corporation Airborne agent collectors, methods, systems and devices for monitoring airborne agents
EP4613872A3 (de) 2014-08-11 2025-11-12 Luminex Corporation Sonden zur verbesserten schmelzunterscheidung und multiplexierung in nukleinsäuretests
EP3179912B1 (de) 2014-08-15 2020-10-14 Diomics Corporation Filme zur entnahme und analyse biologischer analyten sowie verfahren zur herstellung
CA2976005A1 (en) 2015-02-06 2016-08-11 Cell Idx, Inc. Antigen-coupled immunoreagents
US11971354B2 (en) 2015-04-08 2024-04-30 Molecular Devices, Llc Methods and systems for fluorescence detection using infrared dyes
US10571396B2 (en) * 2015-04-08 2020-02-25 Molecular Devices, Llc Methods and systems for fluorescence detection
WO2016166295A1 (de) 2015-04-15 2016-10-20 Attomol Gmbh Molekulare Diagnostika Verfahren zum reaktionsraumbegrenzten nachweis von einem oder mehreren analyten in einer probe
JP6974178B2 (ja) 2015-05-29 2021-12-01 メモリアル スローン ケタリング キャンサー センター フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法
CA2996529A1 (en) 2015-08-24 2017-03-02 Gpb Scientific, Llc Methods and devices for multi-step cell purification and concentration
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10845305B1 (en) * 2015-11-20 2020-11-24 Verily Life Sciences Llc Method for increasing sensor resolution by spectrally stacking responsive dyes
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
DE102015225457B4 (de) * 2015-12-16 2017-07-20 BSH Hausgeräte GmbH Sensorvorrichtung zum Bestimmen zumindest einer Eigenschaft einer Flüssigkeit, wasserführendes Haushaltsgerät mit der Sensorvorrichtung sowie Verfahren zum Bestimmen zumindest einer Eigenschaft einer Flüssigkeit
PL3436823T3 (pl) * 2016-03-30 2021-08-09 Macroarray Diagnostics Gmbh Macierz antygenów
EP3634500B1 (de) 2017-05-25 2023-10-25 Memorial Sloan-Kettering Cancer Center Mit zirkonium -89 markierte ultrakleine nanopartikel und verfahren dafür
EP3675876A4 (de) 2017-09-01 2021-06-02 GPB Scientific, Inc. Verfahren zur herstellung therapeutisch aktiver zellen unter verwendung von mikrofluidik
CN108531550A (zh) * 2018-02-01 2018-09-14 武汉尚码生物科技有限公司 一种微粒载体的标记和鉴别方法及其应用
CN119804399A (zh) 2018-04-19 2025-04-11 曙光诊断学公司 靶标检测
CA3100851A1 (en) 2018-05-24 2019-11-28 The University Of Melbourne Circulatory biomarkers for placental or fetal health
EP3591406A1 (de) * 2018-07-06 2020-01-08 Euroimmun Medizinische Labordiagnostika AG Vorrichtung und verfahren zur antikörperdetektion
AU2019353145B2 (en) 2018-10-04 2025-12-04 First Light Diagnostics, Inc. Microbial analysis without cell purification
KR102205473B1 (ko) * 2018-12-21 2021-01-21 칸트사이언스 주식회사 세포 내 pH 측정방법
WO2020172496A1 (en) * 2019-02-21 2020-08-27 Ding Qinxue Method of removing non-specific binding signals using microparticles
US12042281B2 (en) 2019-07-17 2024-07-23 Terumo Cardiovascular Systems Corporation Fluorescent nanomaterial sensors and related methods
WO2021016133A1 (en) * 2019-07-19 2021-01-28 Washington University Particle-based method for defining a gut microbiota in humans or other animal species
WO2022165167A1 (en) * 2021-01-29 2022-08-04 Flowmetric Life Sciences, Inc. Detecting sars-cov-2 and other infective agents
WO2022221693A1 (en) * 2021-04-15 2022-10-20 Cornell University Aluminosilicate nanoparticle sensors and uses thereof
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
WO2024192141A1 (en) 2023-03-13 2024-09-19 Dana-Farber Cancer Institute, Inc. Treatment of cancers having a drug-resistant mesenchymal cell state
CN117607286A (zh) * 2023-11-09 2024-02-27 国家毒品实验室浙江分中心(浙江省毒品技术中心) 一种精神活性物质检测方法、荧光探针及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045431B (en) * 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4717655A (en) * 1982-08-30 1988-01-05 Becton, Dickinson And Company Method and apparatus for distinguishing multiple subpopulations of cells
US5093234A (en) 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US4987539A (en) 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
JP4357112B2 (ja) * 1997-10-14 2009-11-04 ルミネックス コーポレイション 精密蛍光染色された粒子及びその製造及び使用方法

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US6268222B1 (en) 2001-07-31
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