ATE240953T1 - Carbazolcarboxamide als 5-ht1f agonisten - Google Patents
Carbazolcarboxamide als 5-ht1f agonistenInfo
- Publication number
- ATE240953T1 ATE240953T1 AT98304343T AT98304343T ATE240953T1 AT E240953 T1 ATE240953 T1 AT E240953T1 AT 98304343 T AT98304343 T AT 98304343T AT 98304343 T AT98304343 T AT 98304343T AT E240953 T1 ATE240953 T1 AT E240953T1
- Authority
- AT
- Austria
- Prior art keywords
- carbazol
- carboxamide
- ht1f agonists
- ht1f
- agonists
- Prior art date
Links
- 102100036311 5-hydroxytryptamine receptor 1F Human genes 0.000 title 1
- 101710138086 5-hydroxytryptamine receptor 1F Proteins 0.000 title 1
- GFHHIWFKWFBNRU-UHFFFAOYSA-N 9h-carbazole-1-carboxamide Chemical compound C12=CC=CC=C2NC2=C1C=CC=C2C(=O)N GFHHIWFKWFBNRU-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- GZJDNSCLZKOHHP-UHFFFAOYSA-N 7-amino-6,7,8,9-tetrahydro-5h-carbazole-3-carboxamide Chemical class N1C2=CC=C(C(N)=O)C=C2C2=C1CC(N)CC2 GZJDNSCLZKOHHP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Organic Insulating Materials (AREA)
- Semiconductor Integrated Circuits (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
- Conductive Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4858497P | 1997-06-04 | 1997-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240953T1 true ATE240953T1 (de) | 2003-06-15 |
Family
ID=21955349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98304343T ATE240953T1 (de) | 1997-06-04 | 1998-06-02 | Carbazolcarboxamide als 5-ht1f agonisten |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0882726B1 (de) |
| JP (1) | JP2002502419A (de) |
| KR (1) | KR20010013409A (de) |
| CN (1) | CN1259049A (de) |
| AT (1) | ATE240953T1 (de) |
| AU (1) | AU729786B2 (de) |
| BR (1) | BR9810610A (de) |
| CA (1) | CA2291624A1 (de) |
| DE (1) | DE69814735T2 (de) |
| DK (1) | DK0882726T3 (de) |
| EA (1) | EA001718B1 (de) |
| ES (1) | ES2199410T3 (de) |
| HU (1) | HUP0004142A3 (de) |
| ID (1) | ID23053A (de) |
| IL (1) | IL133279A0 (de) |
| NO (1) | NO995963L (de) |
| NZ (1) | NZ501569A (de) |
| PL (1) | PL337221A1 (de) |
| PT (1) | PT882726E (de) |
| TR (1) | TR199903014T2 (de) |
| WO (1) | WO1998055115A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1937300A (en) * | 1998-12-11 | 2000-06-26 | Eli Lilly And Company | Indole derivatives and their use as 5-HT1F agonists |
| WO2000063171A1 (en) | 1999-04-20 | 2000-10-26 | Meiji Seika Kaisha, Ltd. | Tricyclic compounds |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| ATE380176T1 (de) | 1999-08-04 | 2007-12-15 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
| JP2003506388A (ja) * | 1999-08-04 | 2003-02-18 | アイカゲン インコーポレイテッド | 疼痛および不安症を処置または予防するための方法 |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| ES2388547T3 (es) | 2003-04-18 | 2012-10-16 | Eli Lilly And Company | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas de 5-HT 1F |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| US7312236B2 (en) | 2003-12-17 | 2007-12-25 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HT1F agonists |
| JP5092746B2 (ja) | 2005-08-08 | 2012-12-05 | アステラス製薬株式会社 | アシルグアニジン誘導体またはその塩 |
| KR20090114439A (ko) * | 2007-02-07 | 2009-11-03 | 아스텔라스세이야쿠 가부시키가이샤 | 아실구아니딘 유도체 |
| NZ596161A (en) | 2009-04-02 | 2013-11-29 | Colucid Pharmaceuticals Inc | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide |
| CN102791689B (zh) * | 2010-03-22 | 2014-10-29 | 埃科特莱茵药品有限公司 | 3-（杂芳基-氨基）-1,2,3,4-四氢-9h-咔唑衍生物及其作为前列腺素d2受体调节剂的用途 |
| US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
| HK1221166A1 (zh) * | 2013-04-09 | 2017-05-26 | Cresset Biomolecular Discovery Limited | 炎症性病症的治疗 |
| TWI826514B (zh) | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
| CN112125836A (zh) * | 2020-10-15 | 2020-12-25 | 濮阳惠成电子材料股份有限公司 | 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| CZ288897A3 (cs) * | 1995-03-20 | 1998-02-18 | Eli Lilly And Company | V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje |
| DE69610793T2 (de) * | 1995-06-23 | 2001-05-03 | Eli Lilly And Co., Indianapolis | 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole |
-
1998
- 1998-01-06 ID IDW991411A patent/ID23053A/id unknown
- 1998-06-01 EA EA199901113A patent/EA001718B1/ru not_active IP Right Cessation
- 1998-06-01 CN CN98805776A patent/CN1259049A/zh active Pending
- 1998-06-01 CA CA002291624A patent/CA2291624A1/en not_active Abandoned
- 1998-06-01 NZ NZ501569A patent/NZ501569A/en unknown
- 1998-06-01 PL PL98337221A patent/PL337221A1/xx unknown
- 1998-06-01 IL IL13327998A patent/IL133279A0/xx unknown
- 1998-06-01 KR KR19997011410A patent/KR20010013409A/ko not_active Withdrawn
- 1998-06-01 WO PCT/US1998/003340 patent/WO1998055115A1/en not_active Ceased
- 1998-06-01 BR BR9810610-4A patent/BR9810610A/pt not_active IP Right Cessation
- 1998-06-01 JP JP50237299A patent/JP2002502419A/ja not_active Ceased
- 1998-06-01 HU HU0004142A patent/HUP0004142A3/hu unknown
- 1998-06-01 AU AU77955/98A patent/AU729786B2/en not_active Ceased
- 1998-06-01 TR TR1999/03014T patent/TR199903014T2/xx unknown
- 1998-06-02 AT AT98304343T patent/ATE240953T1/de not_active IP Right Cessation
- 1998-06-02 EP EP98304343A patent/EP0882726B1/de not_active Expired - Lifetime
- 1998-06-02 DE DE69814735T patent/DE69814735T2/de not_active Expired - Fee Related
- 1998-06-02 DK DK98304343T patent/DK0882726T3/da active
- 1998-06-02 PT PT98304343T patent/PT882726E/pt unknown
- 1998-06-02 ES ES98304343T patent/ES2199410T3/es not_active Expired - Lifetime
-
1999
- 1999-12-03 NO NO995963A patent/NO995963L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010013409A (ko) | 2001-02-26 |
| AU729786B2 (en) | 2001-02-08 |
| NO995963D0 (no) | 1999-12-03 |
| IL133279A0 (en) | 2001-04-30 |
| NZ501569A (en) | 2001-11-30 |
| PL337221A1 (en) | 2000-08-14 |
| ES2199410T3 (es) | 2004-02-16 |
| BR9810610A (pt) | 2000-09-12 |
| TR199903014T2 (xx) | 2000-05-22 |
| WO1998055115A1 (en) | 1998-12-10 |
| EA199901113A1 (ru) | 2000-08-28 |
| AU7795598A (en) | 1998-12-21 |
| CA2291624A1 (en) | 1998-12-10 |
| DE69814735D1 (de) | 2003-06-26 |
| HUP0004142A3 (en) | 2002-10-28 |
| ID23053A (id) | 2000-01-20 |
| HUP0004142A2 (hu) | 2001-05-28 |
| DE69814735T2 (de) | 2004-03-25 |
| JP2002502419A (ja) | 2002-01-22 |
| EA001718B1 (ru) | 2001-08-27 |
| CN1259049A (zh) | 2000-07-05 |
| PT882726E (pt) | 2003-09-30 |
| NO995963L (no) | 1999-12-03 |
| DK0882726T3 (da) | 2003-09-22 |
| EP0882726B1 (de) | 2003-05-21 |
| EP0882726A1 (de) | 1998-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE240953T1 (de) | Carbazolcarboxamide als 5-ht1f agonisten | |
| ES2194960T3 (es) | N-(2-sustituido-3-(2-aminoetil)-1h-indol-5-il)-amidas como nuevos agonistas de 5-ht1f. | |
| DK0842934T3 (da) | 5-HT1F agonister | |
| DE69319976D1 (de) | 7-Substituierte-9-substituierte Glycylamido-6-Demethyl-6-Deoxytetracycline | |
| PT618190E (pt) | 9-¬glicil substituido)amido|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas | |
| FI925595A0 (fi) | Piperazinyl- och piperidinylcyklohexanolfoereningar | |
| DE69331774D1 (de) | 7-Substituierte-8-substituierte-9-substituierte Amino-7-Demethyl-6-Deoxy-Tetracycline als antibiotische Mittel | |
| PT1671949E (pt) | Piridinilaminas substituídas | |
| IL119698A0 (en) | Novel 9- ([haloacyl) amido]-6-demethyl-6-deoxytetracycline intermediates | |
| ATE126509T1 (de) | Disäuren von diarylstyrylchinolin. | |
| FI920023A0 (fi) | Heteroarylpiperazinfoereningar som antipsykotiska aemnen. | |
| NO20002408D0 (no) | 5-HT1F antagonister | |
| BR9902096A (pt) | Pitazóis. | |
| TR200001122T2 (tr) | Farmasötikler olarak bifenil türevleri. | |
| PT1140932E (pt) | Derivados de 1,8-benzonaftiridina | |
| SI0987268T1 (en) | Pharmaceutical agents containing epothilone A-N-oxide and/or epothilone B-N-oxide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0882726 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |