DK0882726T3 - Carbazolcarboxamider som 5-HT1F-agonister - Google Patents
Carbazolcarboxamider som 5-HT1F-agonisterInfo
- Publication number
- DK0882726T3 DK0882726T3 DK98304343T DK98304343T DK0882726T3 DK 0882726 T3 DK0882726 T3 DK 0882726T3 DK 98304343 T DK98304343 T DK 98304343T DK 98304343 T DK98304343 T DK 98304343T DK 0882726 T3 DK0882726 T3 DK 0882726T3
- Authority
- DK
- Denmark
- Prior art keywords
- carboxamides
- carbazole
- ht1f agonists
- ht1f
- agonists
- Prior art date
Links
- 102100036311 5-hydroxytryptamine receptor 1F Human genes 0.000 title 1
- 101710138086 5-hydroxytryptamine receptor 1F Proteins 0.000 title 1
- GFHHIWFKWFBNRU-UHFFFAOYSA-N 9h-carbazole-1-carboxamide Chemical class C12=CC=CC=C2NC2=C1C=CC=C2C(=O)N GFHHIWFKWFBNRU-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- GZJDNSCLZKOHHP-UHFFFAOYSA-N 7-amino-6,7,8,9-tetrahydro-5h-carbazole-3-carboxamide Chemical class N1C2=CC=C(C(N)=O)C=C2C2=C1CC(N)CC2 GZJDNSCLZKOHHP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Organic Insulating Materials (AREA)
- Conductive Materials (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
- Semiconductor Integrated Circuits (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4858497P | 1997-06-04 | 1997-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0882726T3 true DK0882726T3 (da) | 2003-09-22 |
Family
ID=21955349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98304343T DK0882726T3 (da) | 1997-06-04 | 1998-06-02 | Carbazolcarboxamider som 5-HT1F-agonister |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0882726B1 (da) |
| JP (1) | JP2002502419A (da) |
| KR (1) | KR20010013409A (da) |
| CN (1) | CN1259049A (da) |
| AT (1) | ATE240953T1 (da) |
| AU (1) | AU729786B2 (da) |
| BR (1) | BR9810610A (da) |
| CA (1) | CA2291624A1 (da) |
| DE (1) | DE69814735T2 (da) |
| DK (1) | DK0882726T3 (da) |
| EA (1) | EA001718B1 (da) |
| ES (1) | ES2199410T3 (da) |
| HU (1) | HUP0004142A3 (da) |
| ID (1) | ID23053A (da) |
| IL (1) | IL133279A0 (da) |
| NO (1) | NO995963L (da) |
| NZ (1) | NZ501569A (da) |
| PL (1) | PL337221A1 (da) |
| PT (1) | PT882726E (da) |
| TR (1) | TR199903014T2 (da) |
| WO (1) | WO1998055115A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034266A1 (en) * | 1998-12-11 | 2000-06-15 | Eli Lilly And Company | Indole derivatives and their use as 5-ht1f agonists |
| US6713473B1 (en) | 1999-04-20 | 2004-03-30 | Meiji Seika Kaisha, Ltd. | Tricyclic compounds |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| EP1200086A4 (en) * | 1999-08-04 | 2009-05-27 | Icagen Inc | THERAPEUTIC OR PROPHYLACTIC METHODS OF PAIN AND ANXIETY |
| EP1208085B1 (en) | 1999-08-04 | 2007-12-05 | Icagen, Inc. | Benzanilides as potassium channel openers |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| JP2006523692A (ja) | 2003-04-18 | 2006-10-19 | イーライ リリー アンド カンパニー | ５−ｈｔ１ｆ作用薬としての（ピペリジニルオキシ）フェニル、（ピペリジニルオキシ）ピリジニル、（ピペリジニルスルファニル）フェニル、および（ピペリジニルスルファニル）ピリジニル化合物 |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| EP1697305B1 (en) | 2003-12-17 | 2007-08-15 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists |
| EP1923387B1 (en) | 2005-08-08 | 2011-10-19 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
| WO2008096791A1 (ja) * | 2007-02-07 | 2008-08-14 | Astellas Pharma Inc. | アシルグアニジン誘導体 |
| JP5727457B2 (ja) | 2009-04-02 | 2015-06-03 | コルーシッド ファーマシューティカルズ， インコーポレイテッド | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| MX2012010820A (es) * | 2010-03-22 | 2012-10-10 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroaril-amino)-1, 2, 3, 4-tetrahidro-9h-carbazo l y sus uso como moduladores del receptor de prostaglandina d2. |
| US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
| US20160051526A1 (en) * | 2013-04-09 | 2016-02-25 | Cresset Biomolecular Discovery Ltd | The Local Treatment of Inflammatory Ophthalmic Disorders |
| TWI826514B (zh) | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| AR119319A1 (es) | 2019-07-09 | 2021-12-09 | Lilly Co Eli | Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida |
| CN112125836A (zh) * | 2020-10-15 | 2020-12-25 | 濮阳惠成电子材料股份有限公司 | 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| KR19980703048A (ko) * | 1995-03-20 | 1998-09-05 | 피터쥐.스트링거 | 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트 |
| EP0749962B1 (en) * | 1995-06-23 | 2000-11-02 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles |
-
1998
- 1998-01-06 ID IDW991411A patent/ID23053A/id unknown
- 1998-06-01 CN CN98805776A patent/CN1259049A/zh active Pending
- 1998-06-01 AU AU77955/98A patent/AU729786B2/en not_active Ceased
- 1998-06-01 NZ NZ501569A patent/NZ501569A/en unknown
- 1998-06-01 IL IL13327998A patent/IL133279A0/xx unknown
- 1998-06-01 BR BR9810610-4A patent/BR9810610A/pt not_active IP Right Cessation
- 1998-06-01 JP JP50237299A patent/JP2002502419A/ja not_active Ceased
- 1998-06-01 TR TR1999/03014T patent/TR199903014T2/xx unknown
- 1998-06-01 EA EA199901113A patent/EA001718B1/ru not_active IP Right Cessation
- 1998-06-01 HU HU0004142A patent/HUP0004142A3/hu unknown
- 1998-06-01 WO PCT/US1998/003340 patent/WO1998055115A1/en not_active Ceased
- 1998-06-01 CA CA002291624A patent/CA2291624A1/en not_active Abandoned
- 1998-06-01 PL PL98337221A patent/PL337221A1/xx unknown
- 1998-06-01 KR KR19997011410A patent/KR20010013409A/ko not_active Withdrawn
- 1998-06-02 ES ES98304343T patent/ES2199410T3/es not_active Expired - Lifetime
- 1998-06-02 DE DE69814735T patent/DE69814735T2/de not_active Expired - Fee Related
- 1998-06-02 AT AT98304343T patent/ATE240953T1/de not_active IP Right Cessation
- 1998-06-02 PT PT98304343T patent/PT882726E/pt unknown
- 1998-06-02 DK DK98304343T patent/DK0882726T3/da active
- 1998-06-02 EP EP98304343A patent/EP0882726B1/en not_active Expired - Lifetime
-
1999
- 1999-12-03 NO NO995963A patent/NO995963L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995963D0 (no) | 1999-12-03 |
| KR20010013409A (ko) | 2001-02-26 |
| PL337221A1 (en) | 2000-08-14 |
| ES2199410T3 (es) | 2004-02-16 |
| EA199901113A1 (ru) | 2000-08-28 |
| DE69814735T2 (de) | 2004-03-25 |
| NO995963L (no) | 1999-12-03 |
| AU7795598A (en) | 1998-12-21 |
| EA001718B1 (ru) | 2001-08-27 |
| EP0882726A1 (en) | 1998-12-09 |
| EP0882726B1 (en) | 2003-05-21 |
| ID23053A (id) | 2000-01-20 |
| PT882726E (pt) | 2003-09-30 |
| ATE240953T1 (de) | 2003-06-15 |
| DE69814735D1 (de) | 2003-06-26 |
| NZ501569A (en) | 2001-11-30 |
| JP2002502419A (ja) | 2002-01-22 |
| BR9810610A (pt) | 2000-09-12 |
| WO1998055115A1 (en) | 1998-12-10 |
| AU729786B2 (en) | 2001-02-08 |
| TR199903014T2 (xx) | 2000-05-22 |
| IL133279A0 (en) | 2001-04-30 |
| HUP0004142A3 (en) | 2002-10-28 |
| CA2291624A1 (en) | 1998-12-10 |
| CN1259049A (zh) | 2000-07-05 |
| HUP0004142A2 (hu) | 2001-05-28 |
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