ATE240958T1 - Crf rezeptor-antagonisten und darauf bezogene methoden - Google Patents
Crf rezeptor-antagonisten und darauf bezogene methodenInfo
- Publication number
- ATE240958T1 ATE240958T1 AT99961675T AT99961675T ATE240958T1 AT E240958 T1 ATE240958 T1 AT E240958T1 AT 99961675 T AT99961675 T AT 99961675T AT 99961675 T AT99961675 T AT 99961675T AT E240958 T1 ATE240958 T1 AT E240958T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- related methods
- crf receptor
- compounds
- treatment
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19095898A | 1998-11-12 | 1998-11-12 | |
| US40074499A | 1999-09-21 | 1999-09-21 | |
| PCT/US1999/026984 WO2000027850A2 (en) | 1998-11-12 | 1999-11-12 | Crf receptor antagonists and methods relating thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240958T1 true ATE240958T1 (de) | 2003-06-15 |
Family
ID=26886600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99961675T ATE240958T1 (de) | 1998-11-12 | 1999-11-12 | Crf rezeptor-antagonisten und darauf bezogene methoden |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6348466B1 (de) |
| EP (1) | EP1129096B1 (de) |
| JP (1) | JP2002529469A (de) |
| KR (1) | KR20010080402A (de) |
| CN (1) | CN1178941C (de) |
| AT (1) | ATE240958T1 (de) |
| AU (1) | AU755997B2 (de) |
| BR (1) | BR9915129A (de) |
| CA (1) | CA2349904A1 (de) |
| DE (1) | DE69908173T2 (de) |
| DK (1) | DK1129096T3 (de) |
| ES (1) | ES2196898T3 (de) |
| HK (1) | HK1038925B (de) |
| IL (1) | IL143105A0 (de) |
| NO (1) | NO20012228D0 (de) |
| NZ (1) | NZ511267A (de) |
| PT (1) | PT1129096E (de) |
| TR (1) | TR200102178T2 (de) |
| WO (1) | WO2000027850A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030016222A (ko) * | 2000-02-14 | 2003-02-26 | 니뽄 다바코 산교 가부시키가이샤 | 수술후 스트레스 예방ㆍ치료제 |
| EP1278751A1 (de) * | 2000-05-01 | 2003-01-29 | Bristol-Myers Squibb Pharma Company | Tricyclische kondensierte pyridin- und pyrimidin-derivate als crf rezeptor antagonisten |
| ES2207614T3 (es) * | 2000-05-18 | 2004-06-01 | Neurocrine Biosciences, Inc. | Antagonistas del receptor de crf y metodos relacionados con estos. |
| US6541469B2 (en) | 2000-05-18 | 2003-04-01 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| CA2427656A1 (en) * | 2000-11-03 | 2002-05-23 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
| AU2002226674B2 (en) | 2000-12-28 | 2007-03-22 | Ono Pharmaceutical Co., Ltd. | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient |
| WO2002064592A1 (en) * | 2000-12-28 | 2002-08-22 | Neurocrine Biosciences, Inc. | Tricyclic crf receptor antagonists |
| HUP0304035A2 (hu) | 2001-04-30 | 2004-04-28 | Glaxo Group Limited | Kortikotropin-releasing faktor (CRF) receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| US7273871B2 (en) | 2001-07-17 | 2007-09-25 | Sb Pharmco Puerto Rico Inc. | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists |
| GB0117395D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| AU2004249629B2 (en) | 2003-06-25 | 2009-07-30 | Ono Pharmaceutical Co., Ltd. | Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same |
| US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
| WO2005063749A1 (en) * | 2003-12-22 | 2005-07-14 | Sb Pharmco Puerto Rico Inc | Crf receptor antagonists and methods relating thereto |
| EP1766014A4 (de) | 2004-06-03 | 2008-12-10 | Athlomics Pty Ltd | Mittel und verfahren zur diagnose von stress |
| WO2006031322A2 (en) * | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| ME01512B (me) | 2004-08-25 | 2014-04-20 | Ardea Biosciences Inc | S-triazolil alfa-merkaptoacetanilida kao inhibitori HIV reversne transkriptaze |
| ATE541848T1 (de) | 2005-05-05 | 2012-02-15 | Ardea Biosciences Inc | Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv |
| EP2132211A4 (de) | 2006-11-09 | 2011-12-07 | Ardea Biosciences Inc | 4-cyanphenylamino-substituierte bizyklische und heterozyklische verbindungen als hiv-hemmer |
| BRPI0819847B1 (pt) | 2007-11-27 | 2022-01-11 | Ardea Biosciences, Inc | Compostos e composições |
| EP2220091B1 (de) | 2007-12-14 | 2012-07-25 | Ardea Biosciences, Inc. | Reverse-transkriptase-hemmer |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
| US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| DK0674624T3 (da) | 1992-12-17 | 1999-09-13 | Pfizer | Pyrazoler med CRF-antagonistisk aktivitet |
| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| KR100190730B1 (ko) | 1992-12-17 | 1999-06-01 | 디. 제이. 우드, 스피겔 알렌 제이 | 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| BR9307646A (pt) | 1992-12-17 | 1999-05-25 | Pfizer | Pirrolopirimidinas como antagonistas de crf |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| TW574214B (en) | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| ES2135062T3 (es) | 1994-06-16 | 1999-10-16 | Pfizer | Pirazolo y pirrolopiridinas. |
| JPH10506126A (ja) | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス |
| FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| CA2249598A1 (en) | 1996-03-26 | 1997-10-02 | Paul Joseph Gilligan | Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| US6326368B1 (en) | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| AU747708B2 (en) | 1996-07-24 | 2002-05-23 | Du Pont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| DK0920429T3 (da) | 1996-08-06 | 2003-05-12 | Pfizer | Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| PL332040A1 (en) * | 1996-08-28 | 1999-08-16 | Pfizer | Substitution 6,5-heterobicyclic derivatives |
| AU4270297A (en) | 1996-09-16 | 1998-04-02 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
| US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
-
1999
- 1999-11-12 CA CA002349904A patent/CA2349904A1/en not_active Abandoned
- 1999-11-12 CN CNB998131725A patent/CN1178941C/zh not_active Expired - Fee Related
- 1999-11-12 PT PT99961675T patent/PT1129096E/pt unknown
- 1999-11-12 AU AU18199/00A patent/AU755997B2/en not_active Ceased
- 1999-11-12 US US09/439,841 patent/US6348466B1/en not_active Expired - Fee Related
- 1999-11-12 KR KR1020017005818A patent/KR20010080402A/ko not_active Ceased
- 1999-11-12 HK HK02100689.4A patent/HK1038925B/en not_active IP Right Cessation
- 1999-11-12 TR TR2001/02178T patent/TR200102178T2/xx unknown
- 1999-11-12 IL IL14310599A patent/IL143105A0/xx unknown
- 1999-11-12 AT AT99961675T patent/ATE240958T1/de not_active IP Right Cessation
- 1999-11-12 ES ES99961675T patent/ES2196898T3/es not_active Expired - Lifetime
- 1999-11-12 NZ NZ511267A patent/NZ511267A/xx unknown
- 1999-11-12 EP EP99961675A patent/EP1129096B1/de not_active Expired - Lifetime
- 1999-11-12 DE DE69908173T patent/DE69908173T2/de not_active Expired - Lifetime
- 1999-11-12 JP JP2000581028A patent/JP2002529469A/ja active Pending
- 1999-11-12 DK DK99961675T patent/DK1129096T3/da active
- 1999-11-12 BR BR9915129-4A patent/BR9915129A/pt not_active IP Right Cessation
- 1999-11-12 WO PCT/US1999/026984 patent/WO2000027850A2/en not_active Ceased
-
2001
- 2001-05-04 NO NO20012228A patent/NO20012228D0/no not_active Application Discontinuation
- 2001-12-20 US US10/027,789 patent/US6723721B2/en not_active Expired - Lifetime
-
2004
- 2004-02-23 US US10/785,386 patent/US20040229879A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ511267A (en) | 2002-12-20 |
| ES2196898T3 (es) | 2003-12-16 |
| WO2000027850A2 (en) | 2000-05-18 |
| AU755997B2 (en) | 2003-01-02 |
| US6348466B1 (en) | 2002-02-19 |
| HK1038925A1 (en) | 2002-04-04 |
| US20020143008A1 (en) | 2002-10-03 |
| US20040229879A1 (en) | 2004-11-18 |
| EP1129096A2 (de) | 2001-09-05 |
| CA2349904A1 (en) | 2000-05-18 |
| US6723721B2 (en) | 2004-04-20 |
| NO20012228L (no) | 2001-05-04 |
| CN1326458A (zh) | 2001-12-12 |
| PT1129096E (pt) | 2003-09-30 |
| NO20012228D0 (no) | 2001-05-04 |
| IL143105A0 (en) | 2002-04-21 |
| DK1129096T3 (da) | 2003-09-15 |
| DE69908173D1 (de) | 2003-06-26 |
| BR9915129A (pt) | 2001-08-07 |
| DE69908173T2 (de) | 2004-08-19 |
| HK1038925B (en) | 2003-12-05 |
| EP1129096B1 (de) | 2003-05-21 |
| WO2000027850A3 (en) | 2000-08-03 |
| JP2002529469A (ja) | 2002-09-10 |
| AU1819900A (en) | 2000-05-29 |
| CN1178941C (zh) | 2004-12-08 |
| TR200102178T2 (tr) | 2002-01-21 |
| KR20010080402A (ko) | 2001-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1129096 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |