ATE241011T1 - Serin-reiche peptidlinker - Google Patents

Serin-reiche peptidlinker

Info

Publication number
ATE241011T1
ATE241011T1 AT92907232T AT92907232T ATE241011T1 AT E241011 T1 ATE241011 T1 AT E241011T1 AT 92907232 T AT92907232 T AT 92907232T AT 92907232 T AT92907232 T AT 92907232T AT E241011 T1 ATE241011 T1 AT E241011T1
Authority
AT
Austria
Prior art keywords
serine
peptide linkers
ser
rich peptide
domains
Prior art date
Application number
AT92907232T
Other languages
English (en)
Inventor
James S Huston
Hermann Oppermann
Serge N Timasheff
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of ATE241011T1 publication Critical patent/ATE241011T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92907232T 1991-02-27 1992-02-27 Serin-reiche peptidlinker ATE241011T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66222691A 1991-02-27 1991-02-27
PCT/US1992/001478 WO1992015682A1 (en) 1991-02-27 1992-02-27 Serine-rich peptide linkers

Publications (1)

Publication Number Publication Date
ATE241011T1 true ATE241011T1 (de) 2003-06-15

Family

ID=24656899

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92907232T ATE241011T1 (de) 1991-02-27 1992-02-27 Serin-reiche peptidlinker

Country Status (9)

Country Link
EP (1) EP0573551B1 (de)
JP (1) JPH06508985A (de)
AT (1) ATE241011T1 (de)
AU (1) AU664030B2 (de)
CA (1) CA2100671C (de)
DE (1) DE69233068T2 (de)
DK (1) DK0573551T3 (de)
ES (1) ES2194838T3 (de)
WO (1) WO1992015682A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121424A (en) * 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
DK0393438T3 (da) 1989-04-21 2005-05-30 Amgen Inc TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor
CA2372813A1 (en) * 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
WO1994012520A1 (en) * 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
US5670347A (en) 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
DE69930938T2 (de) 1998-07-10 2007-01-11 Scios Inc., Fremont Verfahren zur herstellung eines peptids mit einem pi grösser als 8 oder kleiner als 5
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US10000574B2 (en) 2003-11-28 2018-06-19 Amgen Research (Munich) Gmbh Compositions comprising polypeptides
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
EP3539981A1 (de) 2006-09-10 2019-09-18 Glycotope GmbH Verwendung von menschlichen zellen myeloischen leukämieursprungs zur expression von antikörpern
PL1920781T3 (pl) 2006-11-10 2015-06-30 Glycotope Gmbh Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów
ATE548052T1 (de) 2008-01-17 2012-03-15 Philogen Spa Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler
EP2116555A1 (de) 2008-05-08 2009-11-11 Bayer Schering Pharma Aktiengesellschaft Verwendung eines spezifisch an ED-B Fibronectin bindenden radioaktiv markierten Moleküls bei einem Verfahren zur Behandlung von Hodgkin-Lymphom
WO2010059315A1 (en) 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
WO2011110490A1 (en) 2010-03-09 2011-09-15 Bayer Pharma Aktiengesellschaft Process for the production of radioactively labelled scfv antibody fragments, kits and compositions
WO2012085064A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
EP2659275B1 (de) * 2010-12-23 2017-11-22 Roche Diagnostics GmbH Erkennung eines polypeptiddimers durch ein bivalentes bindemittel
EP2655414B1 (de) 2010-12-23 2018-08-29 Roche Diagniostics GmbH Bispezifisches bindungsmolekül
ES2686313T3 (es) 2011-08-22 2018-10-17 Glycotope Gmbh Microorganismos que portan un antígeno tumoral
JP6126097B2 (ja) * 2011-09-06 2017-05-10 ノヴォ ノルディスク アー／エス Ｇｌｐ−１誘導体
US20130344565A1 (en) * 2012-06-21 2013-12-26 Rapid Pathogen Screening, Inc. Optimization of Expression and Purification of Recombinant Human MxA Protein in E. Coli
WO2014036520A1 (en) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
EP3262217A4 (de) 2015-02-24 2018-07-18 BioAtla LLC Bedingt aktive biologische proteine
WO2017078839A1 (en) 2015-11-02 2017-05-11 Bioatla, Llc Conditionally active polypeptides
SG11202010496WA (en) 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
WO2020144164A1 (en) 2019-01-07 2020-07-16 Bactolife Aps Pathogen binding proteins
PH12022550165A1 (en) 2019-07-26 2023-05-08 Visterra Inc Interleukin-2 agents and uses thereof
US12098178B2 (en) 2020-12-04 2024-09-24 Visterra, Inc. Methods of using interleukin-2 agents
EP4731681A1 (de) 2023-06-23 2026-04-29 Imcheck Therapeutics Bispezifische antikörper gegen btn3a und die pd-1/pd-l1-hemmende achse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US831967A (en) * 1905-08-29 1906-09-25 Eugenie Mearis Table.
DE69007975T2 (de) * 1989-08-22 1994-07-21 Immunex Corp Fusionsprotein bestehend aus gm-csf und il-3.
CA2372813A1 (en) * 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker

Also Published As

Publication number Publication date
CA2100671C (en) 1999-02-02
AU664030B2 (en) 1995-11-02
JPH06508985A (ja) 1994-10-13
DK0573551T3 (da) 2003-08-04
EP0573551A1 (de) 1993-12-15
ES2194838T3 (es) 2003-12-01
CA2100671A1 (en) 1992-08-28
AU1440392A (en) 1992-10-06
DE69233068T2 (de) 2004-01-22
WO1992015682A1 (en) 1992-09-17
EP0573551B1 (de) 2003-05-21
DE69233068D1 (de) 2003-06-26
EP0573551A4 (en) 1994-06-08

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