DK1040191T3 - RANTES-mutanter og terapeutiske anvendelser heraf - Google Patents

RANTES-mutanter og terapeutiske anvendelser heraf

Info

Publication number: DK1040191T3
Authority: DK; Denmark
Prior art keywords: rantes; therapeutic uses; rantes mutants; mutants; wild
Prior art date: 1997-12-23

Application number

DK98966650T

Other languages

English (en)

Inventor

Paolo Lusso

Simona Polo

Original Assignee

San Raffaele Centro Fond

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-23

Filing date

1998-12-21

Publication date

2005-12-19

1997-12-23 Priority claimed from ITMI972865 external-priority patent/IT1297015B1/it

1998-08-07 Priority claimed from IT98MI001866 external-priority patent/IT1302012B1/it

1998-12-21 Application filed by San Raffaele Centro Fond filed Critical San Raffaele Centro Fond

2005-12-19 Application granted granted Critical

2005-12-19 Publication of DK1040191T3 publication Critical patent/DK1040191T3/da

Links

102000001327 Chemokine CCL5 Human genes 0.000 title abstract 4
108010055166 Chemokine CCL5 Proteins 0.000 title abstract 4
230000001225 therapeutic effect Effects 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000036436 anti-hiv Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK98966650T 1997-12-23 1998-12-21 RANTES-mutanter og terapeutiske anvendelser heraf DK1040191T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI972865 IT1297015B1 (it)	1997-12-23	1997-12-23	Mutanti di rantes e loro applicazioni terapeutiche
IT98MI001866 IT1302012B1 (it)	1998-08-07	1998-08-07	Derivati di rantes e loro applicazioni terapeutiche.
PCT/EP1998/008354 WO1999033989A2 (en)	1997-12-23	1998-12-21	Rantes mutants and therapeutic applications thereof

Publications (1)

Publication Number	Publication Date
DK1040191T3 true DK1040191T3 (da)	2005-12-19

Family

ID=26331556

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK98966650T DK1040191T3 (da)	1997-12-23	1998-12-21	RANTES-mutanter og terapeutiske anvendelser heraf
DK03027936T DK1431391T3 (da)	1997-12-23	1998-12-21	RANTES-mutanter og terapeutiske anvendelser heraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK03027936T DK1431391T3 (da)	1997-12-23	1998-12-21	RANTES-mutanter og terapeutiske anvendelser heraf

Country Status (10)

Country	Link
US (2)	US6608177B1 (da)
EP (2)	EP1431391B1 (da)
JP (1)	JP4323094B2 (da)
AT (2)	ATE308617T1 (da)
AU (1)	AU2415599A (da)
CA (1)	CA2316447C (da)
DE (2)	DE69832216T2 (da)
DK (2)	DK1040191T3 (da)
ES (2)	ES2247475T3 (da)
WO (1)	WO1999033989A2 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6025154A (en)	1995-06-06	2000-02-15	Human Genome Sciences, Inc.	Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en)	1995-06-06	2004-06-01	Human Genome Sciences, Inc.	Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
UA77950C2 (en) *	2000-10-04	2007-02-15	Applied Research Systems	Use of mutants of cc chemokines for treatment of multiple sclerosis
US7175988B2 (en)	2001-02-09	2007-02-13	Human Genome Sciences, Inc.	Human G-protein Chemokine Receptor (CCR5) HDGNR10
EP1458756B1 (en)	2001-12-17	2009-01-28	Laboratoires Serono SA	Chemokine mutants acting as chemokine antagonists
US7393934B2 (en)	2001-12-21	2008-07-01	Human Genome Sciences, Inc.	Human G-protein chemokine receptor (CCR5) HDGNR10
US7335350B2 (en) *	2002-04-04	2008-02-26	Laboratoires Serono Sa	Chemokines mutants having improved oral bioavailability
EP1723178A4 (en)	2004-03-12	2007-12-12	Human Genome Sciences Inc	HUMAN G-PROTEIN CHEMOKIN RECEPTOR (CCR5) HDGNR10
US7981410B2 (en) *	2006-11-13	2011-07-19	Functional Genetics, Inc.	Therapeutic targeting of escort proteins
ES2453592T3 (es)	2007-08-02	2014-04-08	Novimmune Sa	Anticuerpos anti-RANTES y métodos de uso de los mismos
WO2019229615A1 (en)	2018-05-28	2019-12-05	Université De Genève	Methods of inhibiting cerebral inflammation
WO2025172252A1 (en) *	2024-02-15	2025-08-21	Novo Nordisk A/S	Protracted ccr5 antagonists and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI972433A0 (fi) *	1994-12-08	1997-06-06	Glaxo Group Ltd	Rantes-peptidi ja fragmentteja sekä tätä sisältäviä tulehduksen hoitoon soveltuvia koostumuksia
FR2748938B1 (fr) *	1996-05-22	1998-07-31	Pasteur Institut	Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
AU4561497A (en) *	1996-09-25	1998-04-17	British Biotech Pharmaceuticals Limited	Human rantes mutants incapable of aggregate formation

1998
- 1998-12-21 AT AT03027936T patent/ATE308617T1/de active
- 1998-12-21 AU AU24155/99A patent/AU2415599A/en not_active Abandoned
- 1998-12-21 AT AT98966650T patent/ATE308616T1/de active
- 1998-12-21 JP JP2000526645A patent/JP4323094B2/ja not_active Expired - Fee Related
- 1998-12-21 EP EP03027936A patent/EP1431391B1/en not_active Expired - Lifetime
- 1998-12-21 ES ES03027936T patent/ES2247475T3/es not_active Expired - Lifetime
- 1998-12-21 DK DK98966650T patent/DK1040191T3/da active
- 1998-12-21 DE DE69832216T patent/DE69832216T2/de not_active Expired - Lifetime
- 1998-12-21 CA CA002316447A patent/CA2316447C/en not_active Expired - Fee Related
- 1998-12-21 ES ES98966650T patent/ES2247738T3/es not_active Expired - Lifetime
- 1998-12-21 WO PCT/EP1998/008354 patent/WO1999033989A2/en not_active Ceased
- 1998-12-21 DE DE69832197T patent/DE69832197T2/de not_active Expired - Lifetime
- 1998-12-21 DK DK03027936T patent/DK1431391T3/da active
- 1998-12-21 EP EP98966650A patent/EP1040191B1/en not_active Expired - Lifetime
1999
- 1999-07-08 US US09/581,070 patent/US6608177B1/en not_active Expired - Fee Related
2003
- 2003-03-28 US US10/400,487 patent/US7164000B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1040191B1 (en)	2005-11-02
EP1431391B1 (en)	2005-11-02
CA2316447C (en)	2009-07-28
ATE308617T1 (de)	2005-11-15
WO1999033989A3 (en)	1999-08-26
AU2415599A (en)	1999-07-19
JP2002507388A (ja)	2002-03-12
DE69832197D1 (de)	2005-12-08
DE69832197T2 (de)	2006-05-24
WO1999033989A2 (en)	1999-07-08
JP4323094B2 (ja)	2009-09-02
EP1431391A3 (en)	2004-10-06
US7164000B2 (en)	2007-01-16
US6608177B1 (en)	2003-08-19
ES2247475T3 (es)	2006-03-01
EP1431391A2 (en)	2004-06-23
EP1040191A2 (en)	2000-10-04
ES2247738T3 (es)	2006-03-01
CA2316447A1 (en)	1999-07-08
DK1431391T3 (da)	2005-12-19
DE69832216T2 (de)	2006-05-24
DE69832216D1 (de)	2005-12-08
US20030216549A1 (en)	2003-11-20
ATE308616T1 (de)	2005-11-15

Publication	Publication Date	Title
ATE185602T1 (de)	1999-10-15	Verändertes menschliches il-6
DE69731373D1 (de)	2004-12-02	Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
FI955315A0 (fi)	1995-11-06	HIV:n proteaasin inhibiittoreita, jotka ovat käyttökelpoisia AIDS'n hoitoon
DE69431060D1 (de)	2002-08-29	Klonierte glutaminsäure-decarboxylase
DE69730038D1 (de)	2004-09-02	Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen
DK0960127T3 (da)	2010-03-29	Isoleret dimert fibroblastaktiverende protein-alfa og anvendelser deraf
DK1040191T3 (da)	2005-12-19	RANTES-mutanter og terapeutiske anvendelser heraf
CA2120153A1 (en)	1993-04-15	Recombinant immunotoxins
ATE218616T1 (de)	2002-06-15	Humanes zirkulierendes cytokin cc-1
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ATE438658T1 (de)	2009-08-15	Neue polypeptide aus bienengift und dessen gebrauchsverfahren
DE69421665D1 (de)	1999-12-23	Anomere Fluorribosylamine
MX9205978A (es)	1993-04-01	Nuevas proteinas inhibidoras de trombina de garrapatas.
DE69534738D1 (de)	2006-04-06	Leukocyten-aktivierender Faktor
FR2710244B3 (fr)	1995-10-13	Composition diététique à base d'acides aminés essentiels.
SE8802323D0 (sv)	1988-06-21	8alfa-acylaminoergoline, its preparation and pharmaceutical compositions containing it
IT1225212B (it)	1990-11-02	Procedimento e mezzi per l'impressione in rilievo di tessuti, o pelli e simili
IT8722543V0 (it)	1987-10-14	Cerotto, in particolare per l'impiego in corrispondenza di zone articolari.
ATE106088T1 (de)	1994-06-15	Peptide und deren verwendung in der therapie.
IT1268425B1 (it)	1997-03-04	Sistema, per strumenti musicali e simili, in grado di interagire con l'utente segnalandogli, mediante illuminazioni, la corretta
IT1230707B (it)	1991-10-29	Pirimidine 2 4 disostituite loro preparazione ed impieghi terapeutici.
ITRM930343A0 (it)	1993-05-24	Proteine ricombinanti, vettori per l'espressione e loro usi.
IT8622694A0 (it)	1986-12-15	Dispositivo per l'applicazione manuale di contrassegni, bottoni esimili su tessuti in genere.