ATE241608T1 - Verfahren zur gewinnung von taxol aus taxus cuspidata - Google Patents
Verfahren zur gewinnung von taxol aus taxus cuspidataInfo
- Publication number
- ATE241608T1 ATE241608T1 AT98900137T AT98900137T ATE241608T1 AT E241608 T1 ATE241608 T1 AT E241608T1 AT 98900137 T AT98900137 T AT 98900137T AT 98900137 T AT98900137 T AT 98900137T AT E241608 T1 ATE241608 T1 AT E241608T1
- Authority
- AT
- Austria
- Prior art keywords
- taxus cuspidata
- chlorophyll
- silica gel
- packing material
- extracting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 244000162450 Taxus cuspidata Species 0.000 title abstract 2
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 235000009065 Taxus cuspidata Nutrition 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
- 239000000284 extract Substances 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229930002875 chlorophyll Natural products 0.000 abstract 2
- 235000019804 chlorophyll Nutrition 0.000 abstract 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000012856 packing Methods 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 230000009849 deactivation Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB1998/000079 WO1999037796A1 (en) | 1998-01-26 | 1998-01-26 | Process of extracting taxol from taxus cuspidata |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241608T1 true ATE241608T1 (de) | 2003-06-15 |
Family
ID=11004653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98900137T ATE241608T1 (de) | 1998-01-26 | 1998-01-26 | Verfahren zur gewinnung von taxol aus taxus cuspidata |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1051505B1 (de) |
| CN (1) | CN1191366C (de) |
| AT (1) | ATE241608T1 (de) |
| WO (1) | WO1999037796A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100448859C (zh) * | 2003-03-17 | 2009-01-07 | 天然医药品公司 | 使用键合有聚乙烯亚胺的树脂提纯紫杉醇和紫杉醇混合物的方法 |
| CN1328269C (zh) * | 2004-03-18 | 2007-07-25 | 中国科学院大连化学物理研究所 | 一种紫杉醇的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009443A1 (en) * | 1995-09-05 | 1997-03-13 | Michigan State University | PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp |
-
1998
- 1998-01-26 WO PCT/IB1998/000079 patent/WO1999037796A1/en not_active Ceased
- 1998-01-26 AT AT98900137T patent/ATE241608T1/de active
- 1998-01-26 EP EP98900137A patent/EP1051505B1/de not_active Expired - Lifetime
- 1998-01-26 CN CNB988129744A patent/CN1191366C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1191366C (zh) | 2005-03-02 |
| CN1290304A (zh) | 2001-04-04 |
| WO1999037796A1 (en) | 1999-07-29 |
| EP1051505B1 (de) | 2003-05-28 |
| EP1051505A1 (de) | 2000-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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