ATE236891T1 - Verfahren zur extraktion von paclitaxel in hoher ausbeute aus paclitaxel enthaltendem material - Google Patents

Verfahren zur extraktion von paclitaxel in hoher ausbeute aus paclitaxel enthaltendem material

Info

Publication number: ATE236891T1
Authority: AT; Austria
Prior art keywords: paclitaxel; high yield; material containing; extracting; acetone
Prior art date: 1998-12-30

Application number

AT99962016T

Other languages

English (en)

Inventor

Samuel Siang Kiang Foo

Yili Bai

Martin Ehlert

Original Assignee

Phytogen Life Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-30

Filing date

1999-12-30

Publication date

2003-04-15

1999-12-30 Application filed by Phytogen Life Sciences Inc filed Critical Phytogen Life Sciences Inc

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236891T1 publication Critical patent/ATE236891T1/de

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 8
229960001592 paclitaxel Drugs 0.000 title abstract 8
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 8
239000000463 material Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000002244 precipitate Substances 0.000 abstract 2
239000003125 aqueous solvent Substances 0.000 abstract 1
238000011210 chromatographic step Methods 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000002156 mixing Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000377 silicon dioxide Substances 0.000 abstract 1
239000006228 supernatant Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Botany (AREA)
Cell Biology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Epidemiology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)

AT99962016T 1998-12-30 1999-12-30 Verfahren zur extraktion von paclitaxel in hoher ausbeute aus paclitaxel enthaltendem material ATE236891T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/223,694 US6136989A (en)	1998-12-30	1998-12-30	Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
PCT/CA1999/001238 WO2000040573A1 (en)	1998-12-30	1999-12-30	Method for high yield extraction of paclitaxel from paclitaxel-containing material

Publications (1)

Publication Number	Publication Date
ATE236891T1 true ATE236891T1 (de)	2003-04-15

Family

ID=22837622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99962016T ATE236891T1 (de)	1998-12-30	1999-12-30	Verfahren zur extraktion von paclitaxel in hoher ausbeute aus paclitaxel enthaltendem material

Country Status (15)

Country	Link
US (1)	US6136989A (de)
EP (1)	EP1140885B1 (de)
JP (1)	JP2002534422A (de)
KR (1)	KR20010103730A (de)
CN (1)	CN1160345C (de)
AT (1)	ATE236891T1 (de)
AU (1)	AU760242B2 (de)
BR (1)	BR9916621A (de)
CA (1)	CA2356896C (de)
DE (1)	DE69906800T2 (de)
ES (1)	ES2191481T3 (de)
HK (1)	HK1042476B (de)
NO (1)	NO20013276L (de)
TW (1)	TW490463B (de)
WO (1)	WO2000040573A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100666652B1 (ko) *	2000-02-25	2007-01-09	한화석유화학 주식회사	식물 원료로부터 초임계 유체를 이용하여 탁솔을 제조하는방법
US6229027B1 (en) *	2000-03-10	2001-05-08	Jian Liu	Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin IV
AU2002223319A1 (en)	2000-11-08	2002-05-21	Actipharm Inc.	Process for mass production of gmp paclitaxel and related taxanes
US6333419B1 (en) *	2000-11-28	2001-12-25	Indena Spa	Chromatographic separation method of paclitaxel and cephalomannin
WO2003047508A2 (en) *	2001-11-30	2003-06-12	Bristol-Myers Squibb Company	Paclitaxel solvates
TW200304947A (en) *	2002-02-08	2003-10-16	Bristol Myers Squibb Co	Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
US7687086B1 (en)	2003-02-28	2010-03-30	University Of Portland	Method for obtaining taxanes
US7105187B1 (en)	2003-02-28	2006-09-12	University Of Portland	Method for obtaining taxanes
FR2859996B1 (fr) *	2003-09-19	2006-02-03	Aventis Pharma Sa	Solvat acetonique du dimethoxy docetaxel et son procede de preparation
US7259268B2 (en) *	2003-12-31	2007-08-21	Samyang Genex Corporation	Method for purification of paclitaxel from paclitaxel-containing materials
US7838694B2 (en) *	2004-04-23	2010-11-23	Chatham Biotec, Limited	Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US7893283B2 (en) *	2004-06-04	2011-02-22	Chatham Biotec, Limited	Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en)	2004-06-25	2005-12-29	Phytogen Life Sciences Inc.	One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) *	2004-06-29	2005-12-29	Phytogen Life Sciences Inc.	Semi-synthetic conversion of paclitaxel to docetaxel
DE602004008903T2 (de) *	2004-07-13	2008-06-19	Indena S.P.A.	Verfahren zur Gewinnung von Paclitaxel aus Taxuspflanzen
US20070190623A1 (en) *	2006-02-15	2007-08-16	Rijhwani Sushil K	Process for purification and recovery of paclitaxel compounds
CN103275039B (zh) *	2013-06-21	2015-03-25	江苏红豆杉药业有限公司	一种从紫杉醇浸膏分离纯化紫杉醇的方法
CN104402845B (zh) *	2014-11-21	2016-10-05	朱艳玲	一种利用超声波从红豆杉中提取紫杉醇的方法
CN109942515A (zh) *	2019-04-28	2019-06-28	云南汉德生物技术有限公司	一种提取10-去乙酰基紫杉醇的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5466455A (en) *	1990-10-18	1995-11-14	Huffstutler, Jr.; Miles C.	Polyphase fluid-extraction process, resulting products and methods of use
US5091994A (en) *	1990-10-31	1992-03-03	Delane Louis A	Three-way hat
US5380916A (en) *	1990-11-02	1995-01-10	University Of Florida	Method for the isolation and purification of taxane derivatives
US5475120A (en) *	1990-11-02	1995-12-12	University Of Florida	Method for the isolation and purification of taxol and its natural analogues
EP0580759B1 (de) *	1991-04-19	1999-05-26	The University Of Mississippi	Verfahren und zubereitungen zur isolierung von taxanen
CA2072400C (en) *	1991-07-05	2003-08-19	Jayaprakash B. Nair	Supercritical extraction of taxanes
IT1258838B (it) *	1992-01-31	1996-02-29	Indena Spa	Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus
US5451392A (en) *	1992-03-03	1995-09-19	The Research And Development Institute At Montana State University	Production of taxol
US5445809A (en) *	1992-03-03	1995-08-29	Research And Development Institute At Montana State University	Production of taxol from the yew tree
US5453521A (en) *	1992-10-05	1995-09-26	Rhone-Poulenc Rorer S.A.	Process for obtaining 10-deacetylbaccatin III
FR2696462B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé d'obtention de la désacétyl-10 baccatine III.
FR2696463B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé d'obtention de la désacétyl-10 baccatine III.
WO1994012268A1 (en) *	1992-11-27	1994-06-09	Napro Biotherapeutics, Inc.	Processing taxane solutes using membranes
US5281727A (en) *	1992-11-27	1994-01-25	Napro Biotherapeutics, Inc.	Method of using ion exchange media to increase taxane yields
CA2126698A1 (en) *	1992-12-07	1994-06-23	Muraleedharan G. Nair	Process for the isolation and purification of taxol and taxanes from taxus spp.
US5279949A (en) *	1992-12-07	1994-01-18	Board Of Trustees Operating Michigan State University	Process for the isolation and purification of taxol and taxanes from Taxus spp
US5440055A (en) *	1993-03-12	1995-08-08	Aphios Corporation	Method and apparatus for extracting taxol from source materials
FR2703049B1 (fr) *	1993-03-22	1995-04-21	Rhone Poulenc Rorer Sa	Procédé de purification des taxoïdes.
US5642587A (en) *	1993-05-17	1997-07-01	Grow International Corp.	Compressed dormancy process for increased plant growth
GB9406423D0 (en) *	1994-03-31	1994-05-25	Ici Plc	Solvent extraction process
CN1112433A (zh) *	1994-05-24	1995-11-29	郭明	红豆杉属植物提取物及其应用
EP0700910A1 (de) *	1994-09-06	1996-03-13	Shionogi & Co., Ltd.	Isolierung von Taxol aus Taxus sumatrana
CA2163837C (en) *	1994-12-13	1999-07-20	Robert K. Perrone	Crystalline paclitaxel hydrates
CN1124735A (zh) *	1994-12-17	1996-06-19	浙江省医学科学院	从美丽红豆杉茎叶中提取分离紫杉醇的方法
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives
US5620875A (en) *	1995-02-17	1997-04-15	University Of Portland	Transfer of taxol from yew tree cuttings into a culture medium over time
CN1166780C (zh) *	1995-04-29	2004-09-15	(株)三养吉尼克斯	从紫杉属植物大量生产紫杉醇的方法
US5561055A (en) *	1995-05-05	1996-10-01	Bcm Developpement Inc.	Bacterial mass production of taxanes with Erwinia
FR2736355B1 (fr) *	1995-07-07	1997-11-07	Pf Medicament	Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
WO1997009443A1 (en) *	1995-09-05	1997-03-13	Michigan State University	PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
US5654448A (en) *	1995-10-02	1997-08-05	Xechem International, Inc.	Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5965752A (en) *	1996-08-23	1999-10-12	Institut National De La Recherche Scientifique	Preparative scale isolation and purification of taxanes

1998
- 1998-12-30 US US09/223,694 patent/US6136989A/en not_active Expired - Lifetime
1999
- 1999-12-17 TW TW088122292A patent/TW490463B/zh not_active IP Right Cessation
- 1999-12-30 AU AU18525/00A patent/AU760242B2/en not_active Ceased
- 1999-12-30 DE DE69906800T patent/DE69906800T2/de not_active Expired - Lifetime
- 1999-12-30 HK HK02101389.5A patent/HK1042476B/en not_active IP Right Cessation
- 1999-12-30 ES ES99962016T patent/ES2191481T3/es not_active Expired - Lifetime
- 1999-12-30 KR KR1020017008372A patent/KR20010103730A/ko not_active Withdrawn
- 1999-12-30 EP EP99962016A patent/EP1140885B1/de not_active Expired - Lifetime
- 1999-12-30 CN CNB99815315XA patent/CN1160345C/zh not_active Expired - Fee Related
- 1999-12-30 CA CA002356896A patent/CA2356896C/en not_active Expired - Lifetime
- 1999-12-30 AT AT99962016T patent/ATE236891T1/de not_active IP Right Cessation
- 1999-12-30 WO PCT/CA1999/001238 patent/WO2000040573A1/en not_active Ceased
- 1999-12-30 JP JP2000592281A patent/JP2002534422A/ja not_active Withdrawn
- 1999-12-30 BR BR9916621-6A patent/BR9916621A/pt not_active Application Discontinuation
2001
- 2001-06-29 NO NO20013276A patent/NO20013276L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2000040573A1 (en)	2000-07-13
HK1042476A1 (en)	2002-08-16
AU760242B2 (en)	2003-05-08
BR9916621A (pt)	2001-10-30
CA2356896A1 (en)	2000-07-13
CA2356896C (en)	2009-11-03
KR20010103730A (ko)	2001-11-23
CN1160345C (zh)	2004-08-04
US6136989A (en)	2000-10-24
DE69906800T2 (de)	2003-10-23
NO20013276D0 (no)	2001-06-29
CN1342155A (zh)	2002-03-27
JP2002534422A (ja)	2002-10-15
EP1140885B1 (de)	2003-04-09
ES2191481T3 (es)	2003-09-01
DE69906800D1 (de)	2003-05-15
AU1852500A (en)	2000-07-24
HK1042476B (en)	2003-12-24
EP1140885A1 (de)	2001-10-10
TW490463B (en)	2002-06-11
NO20013276L (no)	2001-07-19

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69906800D1 (de)	2003-05-15	Verfahren zur extraktion von paclitaxel in hoher ausbeute aus paclitaxel enthaltendem material
ATE180477T1 (de)	1999-06-15	Verfahren und zubereitungen zur isolierung von taxanen
ATE541569T1 (de)	2012-02-15	Verfahren zur isolation von phenolischen verbindungen
DE60218332D1 (de)	2007-04-05	Halbleiter-flüssigkristallzusammensetzung und verfahren zu ihrer herstellung
Ochocka et al.	1995	Determination of coumarins from Chrysanthemum segetum L. by capillary electrophoresis
DK0663910T3 (da)	1997-03-10	Fremgangsmåde til fremstilling af 10-desacetylbaccatin III
ATE297213T1 (de)	2005-06-15	Sojaextrakt, verfahren zu dessen herstellung und pharmazeutische zusammensetzung
DE50209503D1 (de)	2007-03-29	Verfahren zur extraktion und analyse von inhaltsstoffen aus organischem material
NO950966D0 (no)	1995-03-14	Fremgangsmåte til fjerning av oljebaserte materialer, samt preparat til gjennomföring av fremgangsmåten
DE50004569D1 (de)	2004-01-08	Verfahren zur gewinnung von phytosterinen durch kristallisation aus verminderten mengen methanols
CN103211844B (zh)	2015-04-15	红豆杉活性提取物的提取方法
ATE305771T1 (de)	2005-10-15	Verfahren zur herstellung von vitaminpulvern
ZA986161B (en)	1999-01-22	Treatment of formaldehyde-containing mixtures
Duong et al.	2024	Potential antioxidant compounds from the spores of Dicranopteris linearis and the branches of Averrhoa bilimbi
ATE285826T1 (de)	2005-01-15	Lösungsmittelextraktionsverfahren
ATE181507T1 (de)	1999-07-15	Harpagosid-angereicherter extrakt aus harpagophytum procumbens und verfahren zu seiner herstellung
ATE429411T1 (de)	2009-05-15	Verfahren zur isolierung phenolischer substanzen bzw. juvabionen aus knöterich enthaltendem holz
DE60003057D1 (de)	2003-07-03	Verfahren zur extraktion mit einem überkritischen fluid
ATE291432T1 (de)	2005-04-15	Verfahren zur entfernung von unerwünschten toxischen alkaloiden aus pflanzen oder aus pflanzlichen zubereitungen
DE50111115D1 (de)	2006-11-09	Verfahren und vorrichtung zur auftrennung eines stoffgemisches in seine bestandteile durch extraktivdestillation in einer trennwandkolonne
Sarer et al.	1996	Composition of the essential oil from Nepeta nuda ssp. albiflora (Boiss.) Gams
Radulovi? et al.	2006	Chemotaxonomically significant 2-ethyl substituted fatty acids from Stachys milaniiPetrovi?(Lamiaceae)
DE50103561D1 (de)	2004-10-14	Verfahren zur herstellung von phyllanthusextrakten
KR840004361A (ko)	1984-10-15	암의 치료용 "하이폭시데시-"(Hypoxidaceae)과의 식물 추출물
CA2108265A1 (en)	1992-10-20	Methods and compositions for isolating taxanes