ATE241620T1 - 3-aza-piperidon- (tetrahydropyrimidin-2-on) und 3-oxa-piperidon (1,3-oxazin-2-on) derivate, deren herstellung und deren verwendung als tachykinin/neurokinin antagonisten - Google Patents

3-aza-piperidon- (tetrahydropyrimidin-2-on) und 3-oxa-piperidon (1,3-oxazin-2-on) derivate, deren herstellung und deren verwendung als tachykinin/neurokinin antagonisten

Info

Publication number: ATE241620T1
Authority: AT; Austria
Prior art keywords: alkyl; cycloalkyl; aryl; piperidone; optionally substituted
Prior art date: 1996-01-27

Application number

AT97200156T

Other languages

English (en)

Inventor

Alexander Roderick Mackenzie

Allan Patrick Marchington

Sandra Dora Meadows

Donald Stuart Middleton

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-27

Filing date

1997-01-20

Publication date

2003-06-15

1997-01-20 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241620T1 publication Critical patent/ATE241620T1/de

Links

WWPOWZJZUCGZAR-UHFFFAOYSA-N 1,3-diazinan-2-one Chemical compound O=C1NCCCN1.O=C1NCCCN1 WWPOWZJZUCGZAR-UHFFFAOYSA-N 0.000 title 1
WETKBHIGTMQSSY-UHFFFAOYSA-N O1C(N=CC=C1)=O.N1C(OCCC1)=O Chemical class O1C(N=CC=C1)=O.N1C(OCCC1)=O WETKBHIGTMQSSY-UHFFFAOYSA-N 0.000 title 1
102000003141 Tachykinin Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
108060008037 tachykinin Proteins 0.000 title 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 9
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
102000009493 Neurokinin receptors Human genes 0.000 abstract 1
108050000302 Neurokinin receptors Proteins 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT97200156T 1996-01-27 1997-01-20 3-aza-piperidon- (tetrahydropyrimidin-2-on) und 3-oxa-piperidon (1,3-oxazin-2-on) derivate, deren herstellung und deren verwendung als tachykinin/neurokinin antagonisten ATE241620T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9601680.3A GB9601680D0 (en)	1996-01-27	1996-01-27	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE241620T1 true ATE241620T1 (de)	2003-06-15

Family

ID=10787684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97200156T ATE241620T1 (de)	1996-01-27	1997-01-20	3-aza-piperidon- (tetrahydropyrimidin-2-on) und 3-oxa-piperidon (1,3-oxazin-2-on) derivate, deren herstellung und deren verwendung als tachykinin/neurokinin antagonisten

Country Status (11)

Country	Link
US (1)	US5846965A (de)
EP (1)	EP0790248B1 (de)
JP (1)	JP3026945B2 (de)
AT (1)	ATE241620T1 (de)
CA (1)	CA2195924C (de)
DE (1)	DE69722281T2 (de)
DK (1)	DK0790248T3 (de)
ES (1)	ES2197968T3 (de)
GB (1)	GB9601680D0 (de)
MX (1)	MXPA97000694A (de)
PT (1)	PT790248E (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3993899A (en) *	1998-05-18	1999-12-06	Merck & Co., Inc.	Method for treating or preventing chronic nonbacterial prostatitis and prostatodynia
GB9812037D0 (en) *	1998-06-04	1998-07-29	Pfizer Ltd	Piperidones
US6436928B1 (en)	1999-12-17	2002-08-20	Schering Corporation	Selective neurokinin antagonists
HK1045308A1 (zh) *	1999-12-17	2002-11-22	Schering Corporation	选择性神经激肽拮抗物
WO2001095904A1 (en) *	2000-06-12	2001-12-20	University Of Rochester	Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
WO2002013825A1 (en) *	2000-08-11	2002-02-21	Smithkline Beecham P.L.C.	Novel pharmaceutical use of quinnoline derivatives
PE20030762A1 (es)	2001-12-18	2003-09-05	Schering Corp	Compuestos heterociclicos como antagonistas nk1
WO2003068162A2 (en) *	2002-02-14	2003-08-21	Pharmasset Ltd.	Modified fluorinated nucleoside analogues
ITMI20030151A1 (it) *	2003-01-30	2004-07-31	Recordati Ind Chimica E Farma Ceutica S P A	Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
TW200508221A (en)	2003-06-13	2005-03-01	Astrazeneca Ab	New azetidine compounds
FR2873373B1 (fr) *	2004-07-23	2006-09-08	Sanofi Synthelabo	Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
AR057828A1 (es)	2005-09-29	2007-12-19	Astrazeneca Ab	Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US8106208B2 (en)	2006-05-18	2012-01-31	Albireo Ab	Benzamide compounds that act as NK receptor antagonists
AR066191A1 (es)	2007-03-22	2009-08-05	Schering Corp	Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
CN102573475B (zh)	2009-08-14	2016-01-20	欧科生医股份有限公司	神经激肽-1拮抗剂的静脉内制剂
EA201692301A1 (ru)	2014-07-01	2017-06-30	Ремпекс Фармасьютикалз, Инк.	Производные бороновой кислоты и их терапевтическое применение

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
CA2131154A1 (en)	1992-03-25	1993-09-30	Colin W. Greengrass	Antiviral peptides
TW432061B (en) *	1994-08-09	2001-05-01	Pfizer Res & Dev	Lactams
FR2729954B1 (fr) *	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant

1996
- 1996-01-27 GB GBGB9601680.3A patent/GB9601680D0/en active Pending
1997
- 1997-01-20 DK DK97200156T patent/DK0790248T3/da active
- 1997-01-20 ES ES97200156T patent/ES2197968T3/es not_active Expired - Lifetime
- 1997-01-20 DE DE69722281T patent/DE69722281T2/de not_active Expired - Fee Related
- 1997-01-20 AT AT97200156T patent/ATE241620T1/de not_active IP Right Cessation
- 1997-01-20 PT PT97200156T patent/PT790248E/pt unknown
- 1997-01-20 EP EP97200156A patent/EP0790248B1/de not_active Expired - Lifetime
- 1997-01-24 CA CA002195924A patent/CA2195924C/en not_active Expired - Fee Related
- 1997-01-24 US US08/788,001 patent/US5846965A/en not_active Expired - Fee Related
- 1997-01-24 JP JP9011450A patent/JP3026945B2/ja not_active Expired - Fee Related
- 1997-01-24 MX MXPA97000694A patent/MXPA97000694A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69722281D1 (de)	2003-07-03
CA2195924A1 (en)	1997-07-28
JPH09208582A (ja)	1997-08-12
CA2195924C (en)	1999-10-05
JP3026945B2 (ja)	2000-03-27
ES2197968T3 (es)	2004-01-16
MXPA97000694A (es)	2005-03-03
DE69722281T2 (de)	2003-11-27
EP0790248A1 (de)	1997-08-20
DK0790248T3 (da)	2003-08-04
US5846965A (en)	1998-12-08
EP0790248B1 (de)	2003-05-28
GB9601680D0 (en)	1996-03-27
PT790248E (pt)	2003-08-29

Legal Events

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2003-10-15

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Publication	Publication Date	Title
ATE241620T1 (de)	2003-06-15	3-aza-piperidon- (tetrahydropyrimidin-2-on) und 3-oxa-piperidon (1,3-oxazin-2-on) derivate, deren herstellung und deren verwendung als tachykinin/neurokinin antagonisten
CA2230936A1 (en)	1997-06-05	5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists
DE60222596D1 (de)	2007-10-31	Fettsäureverbindungen und deren herstellung und verwendungen
ATE449083T1 (de)	2009-12-15	Chinazolin-derivate und ihre verwendung als arzneimittel
KR100479182B1 (ko)	2005-03-25	폴리히드록시알카노에이트의 제조에 이용되는 미생물
ATE50987T1 (de)	1990-03-15	Dihydropyridinderivate, deren herstellung und verwendung.
GB2165542B (en)	1988-05-05	Dichloroaniline derivatives
KR900000351A (ko)	1990-01-30	1-아릴-나프토일아민 및 그의 제조방법
DE69722644D1 (de)	2003-07-10	Chroman derivate
EA200500521A1 (ru)	2005-12-29	3-фенилзамещенный пиридоиндолон, его получение и терапевтическое применение
EP1306369A4 (de)	2007-02-14	Neue schwefelverbindungen und intermolekulare verbindungen, die diese als komponente enthalten
ATE211137T1 (de)	2002-01-15	Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
DE60301725D1 (de)	2006-02-09	Dibenzodiazepin derivate, deren herstellung und verwendung
SE8604349L (sv)	1987-04-16	Dikloranilinderivat
ATE215080T1 (de)	2002-04-15	1,2-dithiolan derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
NO20064299L (no)	2006-11-06	Indanolderivat
ATE183742T1 (de)	1999-09-15	2-aminopyrazin-5-carbonsäureamid derivate, deren herstellung und deren verwendung als heilmittel
ATE231161T1 (de)	2003-02-15	6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln
MY103817A (en)	1993-09-30	Chloroaniline derivatives