ATE241628T1 - Imidazo(5,1-f)(1,2,4)triazinderivate - Google Patents
Imidazo(5,1-f)(1,2,4)triazinderivateInfo
- Publication number
- ATE241628T1 ATE241628T1 AT00308914T AT00308914T ATE241628T1 AT E241628 T1 ATE241628 T1 AT E241628T1 AT 00308914 T AT00308914 T AT 00308914T AT 00308914 T AT00308914 T AT 00308914T AT E241628 T1 ATE241628 T1 AT E241628T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazo
- triazine derivatives
- het
- curative
- chem
- Prior art date
Links
- AZTMMFCJOROKMO-UHFFFAOYSA-N imidazo[5,1-f][1,2,4]triazine Chemical class N1=CN=CC2=CN=CN21 AZTMMFCJOROKMO-UHFFFAOYSA-N 0.000 title 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 abstract 1
- 101150098694 PDE5A gene Proteins 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9924028.5A GB9924028D0 (en) | 1999-10-11 | 1999-10-11 | Pharmaceutically active compounds |
| GB0007345A GB0007345D0 (en) | 2000-03-28 | 2000-03-28 | Pharmaceutically active compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241628T1 true ATE241628T1 (de) | 2003-06-15 |
Family
ID=26243966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00308914T ATE241628T1 (de) | 1999-10-11 | 2000-10-10 | Imidazo(5,1-f)(1,2,4)triazinderivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6503908B1 (de) |
| EP (1) | EP1092719B1 (de) |
| JP (1) | JP3549826B2 (de) |
| AT (1) | ATE241628T1 (de) |
| BR (1) | BR0004779A (de) |
| CA (1) | CA2323008C (de) |
| DE (1) | DE60002969T2 (de) |
| DK (1) | DK1092719T3 (de) |
| ES (1) | ES2199122T3 (de) |
| MX (1) | MXPA00009937A (de) |
| PT (1) | PT1092719E (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2395558C (en) * | 1997-11-12 | 2007-07-17 | Bayer Aktiengesellschaft | Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| HU230030B1 (hu) | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
| AU2001276607A1 (en) * | 2000-08-11 | 2002-02-25 | Pfizer Inc. | Treatment of the insulin resistance syndrome with selective CGMP PDE5 inhibitors |
| US6548508B2 (en) | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
| GB0107751D0 (en) * | 2001-03-28 | 2001-05-16 | Pfizer Ltd | Pharmaceutically active compounds |
| US6794387B2 (en) | 2001-03-28 | 2004-09-21 | Pfizer Inc. | Pharmaceutically active compounds |
| EP1560584B1 (de) * | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab-i-inhibitoren |
| WO2002089808A1 (de) * | 2001-05-09 | 2002-11-14 | Bayer Healthcare Ag | Neue verwendung von 2-phenyl-substituierten imidazotriazinonen |
| GB0113344D0 (en) | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel heterocycles 3 |
| GB0113343D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 2 |
| DE10135815A1 (de) | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
| GB0209988D0 (en) * | 2002-05-01 | 2002-06-12 | Bayer Ag | Novel Heterocycles |
| DE10230605A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Substituierte Imidazotriazine |
| DE10232113A1 (de) * | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
| US8133903B2 (en) | 2003-10-21 | 2012-03-13 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases |
| EP1575951B1 (de) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel |
| US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
| AU2003303041B2 (en) | 2002-12-13 | 2008-07-24 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するイミダゾトリアジノン誘導体 |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| US7291640B2 (en) | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
| BRPI0506994A (pt) | 2004-01-22 | 2007-07-03 | Pfizer | derivados de triazol que inibem a atividade antagonista da vasopressina |
| US20050186275A1 (en) * | 2004-02-23 | 2005-08-25 | Standard Chem. & Pharm. Co. Ltd. | Sustained release tamsulosin formulations |
| DE102004023069A1 (de) * | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| DE102004038328A1 (de) * | 2004-08-06 | 2006-03-16 | Bayer Healthcare Ag | Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| US8268785B2 (en) | 2004-08-19 | 2012-09-18 | Switch Biotech Ag | Use of a Pde 5 inhibitor for treating and preventing hypopigmentary disorders |
| EP1759700B1 (de) * | 2004-08-19 | 2009-08-05 | Switch Biotech, LLC | Verwendung eines PDE5-Hemmers zur Behandlung und Vorbeugung von Hypopigmentierungsstörungen |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| CN102351862A (zh) * | 2005-02-18 | 2012-02-15 | 表面线段公司 | 药动学改善的化合物 |
| EA200701752A1 (ru) * | 2005-02-18 | 2008-04-28 | Сурфейс Логикс Инк. | Способ получения усовершенствованных фармакокинетических соединений, включающих функциональные остатки или группы, и фармацевтические композиции, содержащие эти соединения |
| DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| EP1863795B1 (de) | 2005-03-21 | 2008-10-29 | Pfizer Limited | Substituierte triazolderivate als oxytocinantagonisten |
| US20070004745A1 (en) * | 2005-03-25 | 2007-01-04 | Schering-Plough Corporation | Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors |
| US20070010525A1 (en) * | 2005-06-27 | 2007-01-11 | Meyer Jackson | Method and compositions for modulating neuropeptide hormone secretion |
| JP2009509984A (ja) * | 2005-09-29 | 2009-03-12 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 泌尿器系障害の処置用のpde阻害剤およびそれらの組合せ |
| KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Fabi 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ, インク. | Fabiインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (de) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | Salze, prodrugs und polymorphe von fab-i-inhibitoren |
| WO2008151734A1 (en) * | 2007-06-13 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | Pde inhibitors for the treatment of hearing impairment |
| PT3590928T (pt) | 2011-04-08 | 2021-08-19 | Janssen Sciences Ireland Unlimited Co | Derivados de pirimidina para o tratamento de infeções virais |
| JP6349256B2 (ja) | 2011-11-09 | 2018-06-27 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染の治療のためのプリン誘導体 |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| EA035790B1 (ru) | 2012-07-13 | 2020-08-11 | Янссен Сайенсиз Айрлэнд Юси | Макроциклические пурины для лечения вирусных инфекций |
| DK2906563T3 (en) | 2012-10-10 | 2018-06-06 | Janssen Sciences Ireland Uc | PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES |
| EA035431B1 (ru) | 2012-11-16 | 2020-06-15 | Янссен Сайенсиз Айрлэнд Юси | Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций |
| SG11201506639XA (en) | 2013-02-21 | 2015-09-29 | Janssen Sciences Ireland Uc | 2-aminopyrimidine derivatives for the treatment of viral infections |
| CN110590809B (zh) | 2013-03-29 | 2022-04-19 | 爱尔兰詹森科学公司 | 用于治疗病毒感染的大环脱氮-嘌呤酮 |
| SG11201509520QA (en) | 2013-05-24 | 2015-12-30 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
| PT3030563T (pt) | 2013-06-27 | 2017-11-15 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina para o tratamento de infeções virais e outras doenças |
| DK3027624T3 (en) | 2013-07-30 | 2019-01-07 | Janssen Sciences Ireland Uc | THIENO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| MA45539A (fr) | 2016-07-01 | 2019-05-08 | Janssen Sciences Ireland Unlimited Co | Dihydropyranopyrimidines pour le traitement d'infections virales |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| ES2912945T3 (es) | 2016-09-29 | 2022-05-30 | Janssen Sciences Ireland Unlimited Co | Profármacos de pirimidina para el tratamiento de infecciones virales y otras enfermedades |
| TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 2,4-二胺基喹唑啉衍生物及其醫學用途 |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2395558C (en) | 1997-11-12 | 2007-07-17 | Bayer Aktiengesellschaft | Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| DE19827640A1 (de) | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| BR9915532A (pt) | 1998-10-23 | 2001-08-14 | Pfizer | Inibidores de cgmp pde5 de pirazolopirimidinona para tratamento da disfunção sexual |
-
2000
- 2000-10-06 US US09/685,160 patent/US6503908B1/en not_active Expired - Fee Related
- 2000-10-06 CA CA002323008A patent/CA2323008C/en not_active Expired - Fee Related
- 2000-10-10 PT PT00308914T patent/PT1092719E/pt unknown
- 2000-10-10 AT AT00308914T patent/ATE241628T1/de not_active IP Right Cessation
- 2000-10-10 DE DE60002969T patent/DE60002969T2/de not_active Expired - Fee Related
- 2000-10-10 MX MXPA00009937A patent/MXPA00009937A/es active IP Right Grant
- 2000-10-10 EP EP00308914A patent/EP1092719B1/de not_active Expired - Lifetime
- 2000-10-10 DK DK00308914T patent/DK1092719T3/da active
- 2000-10-10 ES ES00308914T patent/ES2199122T3/es not_active Expired - Lifetime
- 2000-10-11 BR BR0004779-1A patent/BR0004779A/pt not_active IP Right Cessation
- 2000-10-11 JP JP2000310580A patent/JP3549826B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1092719B1 (de) | 2003-05-28 |
| EP1092719A2 (de) | 2001-04-18 |
| CA2323008A1 (en) | 2001-04-11 |
| CA2323008C (en) | 2005-07-12 |
| DE60002969T2 (de) | 2004-01-22 |
| JP2001151778A (ja) | 2001-06-05 |
| DK1092719T3 (da) | 2003-08-25 |
| JP3549826B2 (ja) | 2004-08-04 |
| MXPA00009937A (es) | 2002-10-23 |
| PT1092719E (pt) | 2003-08-29 |
| BR0004779A (pt) | 2001-05-29 |
| US6503908B1 (en) | 2003-01-07 |
| EP1092719A3 (de) | 2001-09-26 |
| DE60002969D1 (de) | 2003-07-03 |
| ES2199122T3 (es) | 2004-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE241628T1 (de) | Imidazo(5,1-f)(1,2,4)triazinderivate | |
| GB9823103D0 (en) | Pharmaceutically active compounds | |
| TR200200954T2 (tr) | Fosfodiesteraz inhibitörleri olarak 5-(2-ikame edilmiş-5-heterosiklilsülfonilpirid-3-il)- dihidropirazolo[4,3- D]pirimidin-7-onlar. | |
| DE60202134D1 (en) | Zyklische guanosine 3',5'-monophosphate phosphodiesterase inhibitoren | |
| ATE298238T1 (de) | Pyrazolo(4,3-d)pyrimidinon-verbindungen als cgmp pde-inhibitoren | |
| DK1123296T3 (da) | Pyrazolopyrimidinon cGMP PDE5-inhibitorer til behandling af seksuel forstyrrelse | |
| CA2287552A1 (en) | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction | |
| CA2322900A1 (en) | 2-(hetero)aryl-substituted purin-6-ones as phosphodiesterase inhibitors | |
| NO995211L (no) | Pyrazolpyrimidinoner som hemmer cyklisk guanosin-3',5'-monofosfatfosfodiesterase type 5 (cGMP PDE5), for behandling av seksuell dysfunksjon | |
| MXPA03011906A (es) | Derivados de imidazo' 1,2-a-piridina para la profilaxis y el tratamiento de infecciones virales por herpes. | |
| ATE79380T1 (de) | 2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung. | |
| NO933069L (no) | 1-substituert,2-substituert 1H-imidazo (4,5-c)-kinolin-4-aminer | |
| CA2413510A1 (en) | Condensed pyrazindione derivatives | |
| WO2002079203A8 (en) | Imidazo-triazine derivatives as pde 5 inhibitors | |
| AP2002002462A0 (en) | Pharmaceutically active compounds. | |
| ECSP003706A (es) | Compuestos farmaceuticamente activos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1092719 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |