ATE241646T1 - Verfahren und vorrichtung zur herstellung eines zellfreien ersatzes roter blutzellen - Google Patents

Verfahren und vorrichtung zur herstellung eines zellfreien ersatzes roter blutzellen

Info

Publication number: ATE241646T1
Authority: AT; Austria
Prior art keywords: cell; producing; blood cells; red blood; free replacement
Prior art date: 1996-03-28

Application number

AT97919943T

Other languages

English (en)

Inventor

Richard E Dewoskin

Marc D Doubleday

Original Assignee

Northfield Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-28

Filing date

1997-03-27

Publication date

2003-06-15

1997-03-27 Application filed by Northfield Lab filed Critical Northfield Lab

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241646T1 publication Critical patent/ATE241646T1/de

Links

210000003743 erythrocyte Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Hematology (AREA)
Polymers & Plastics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Surgery (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT97919943T 1996-03-28 1997-03-27 Verfahren und vorrichtung zur herstellung eines zellfreien ersatzes roter blutzellen ATE241646T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1438996P	1996-03-28	1996-03-28
PCT/US1997/005088 WO1997035883A1 (en)	1996-03-28	1997-03-27	Method and apparatus for preparing an acellular red blood cell substitute

Publications (1)

Publication Number	Publication Date
ATE241646T1 true ATE241646T1 (de)	2003-06-15

Family

ID=21765191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97919943T ATE241646T1 (de)	1996-03-28	1997-03-27	Verfahren und vorrichtung zur herstellung eines zellfreien ersatzes roter blutzellen

Country Status (26)

Country	Link
US (5)	US6498141B2 (de)
EP (1)	EP0928294B1 (de)
JP (1)	JP2000507947A (de)
CN (1)	CN1129608C (de)
AP (1)	AP1028A (de)
AT (1)	ATE241646T1 (de)
AU (1)	AU740210B2 (de)
BG (1)	BG63919B1 (de)
BR (1)	BR9708388A (de)
CA (1)	CA2250274C (de)
CZ (1)	CZ299357B6 (de)
DE (1)	DE69722422T2 (de)
DK (1)	DK0928294T3 (de)
ES (1)	ES2200177T3 (de)
IL (1)	IL126376A (de)
IS (1)	IS4854A (de)
NO (1)	NO324121B1 (de)
NZ (2)	NZ538045A (de)
OA (1)	OA10884A (de)
PL (1)	PL187923B1 (de)
PT (1)	PT928294E (de)
RO (1)	RO121089B1 (de)
RU (1)	RU2203087C2 (de)
SK (1)	SK134398A3 (de)
UA (1)	UA64710C2 (de)
WO (1)	WO1997035883A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK134398A3 (en) *	1996-03-28	2001-01-18	Northfield Lab	Aqueous solution of the pyridoxylated polymerized hemoglobin and method for preparing the same
CA2444590C (en)	2001-04-18	2009-12-01	Robert L. Mcginnis	Stabilized hemoglobin solutions
DE10220992A1 (de) *	2002-05-11	2003-12-04	Sanguibiotech Ag	Verwendung eines oder mehrerer Sauerstoffträger, ausgewählt aus Hämoglobin, Myoglobin und Derivaten hiervon zur Behandlung einer Organfunktionsstörung infolge eines akuten Versorgungsmangels und zur Behandlung/Vermeidung einer Gewebeschädigung infolge einer solchen Störung
AU2003272827B2 (en) *	2002-10-03	2009-03-19	Northfield Laboratories, Inc.	Method for treating patients with massive blood loss
WO2004066953A2 (en) *	2003-01-29	2004-08-12	Northfield Laboratories, Inc.	Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
RU2278677C2 (ru) *	2004-09-30	2006-06-27	Общество с ограниченной ответственностью "МБФ"	Средство для стимулирования эритропоэза и устранения дефицита железа
SE528214C2 (sv) *	2005-06-23	2006-09-26	Proliff Ab	Förfarande för framställning av blodplättslysat
EP1978802A2 (de) *	2006-01-24	2008-10-15	Northfield Laboratories, Inc.	Polymerisiertes hämoglobinmedium und verwendung davon bei der isolierung und transplantation von inselzellen
US20090004159A1 (en) *	2006-01-24	2009-01-01	The Board Of Trustees Of The University Of Illinoi	Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
RU2340354C1 (ru) *	2007-06-05	2008-12-10	Общество с ограниченной ответственностью "Геленпол"	Кровезаменитель с функцией переноса кислорода
RU2341286C1 (ru) *	2007-07-25	2008-12-20	Общество с ограниченной ответственностью "Геленпол"	Способ получения кровезаменителя и установка для осуществления способа
RU2361608C1 (ru) *	2008-03-18	2009-07-20	Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм"	Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
EP3655019A4 (de) *	2017-07-18	2021-04-21	Virtech Bio, Inc.	Hämoglobin enthaltende blutersatzstoffe und verfahren zu deren herstellung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU583272B2 (en) *	1984-04-27	1989-04-27	Synthetic Blood Corporation	Coacervate system synthetic whole blood substitute
US4826811A (en) *	1986-06-20	1989-05-02	Northfield Laboratories, Inc.	Acellular red blood cell substitute
US5464814A (en) *	1986-06-20	1995-11-07	Northfield Laboratories, Inc.	Acellular red blood cell substitute
US5194590A (en) *	1986-06-20	1993-03-16	Northfield Laboratories, Inc.	Acellular red blood cell substitute
IL87708A (en) *	1988-09-08	1994-04-12	Technion Inst For Research And	Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof
SE9001378D0 (sv) *	1990-04-18	1990-04-18	Kabivitrum Ab	A method for the preparation of pyridoxylated hemoglobin
TW381022B (en) *	1993-08-16	2000-02-01	Hsia Jen Chang	Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
SK134398A3 (en) *	1996-03-28	2001-01-18	Northfield Lab	Aqueous solution of the pyridoxylated polymerized hemoglobin and method for preparing the same
US5998361A (en) *	1996-10-18	1999-12-07	University Of Maryland At Baltimore	Polymerized hemoglobin

1997
- 1997-03-27 SK SK1343-98A patent/SK134398A3/sk unknown
- 1997-03-27 ES ES97919943T patent/ES2200177T3/es not_active Expired - Lifetime
- 1997-03-27 US US09/155,419 patent/US6498141B2/en not_active Expired - Fee Related
- 1997-03-27 CN CN97194998A patent/CN1129608C/zh not_active Expired - Fee Related
- 1997-03-27 DE DE69722422T patent/DE69722422T2/de not_active Expired - Fee Related
- 1997-03-27 AU AU24253/97A patent/AU740210B2/en not_active Ceased
- 1997-03-27 DK DK97919943T patent/DK0928294T3/da active
- 1997-03-27 EP EP97919943A patent/EP0928294B1/de not_active Expired - Lifetime
- 1997-03-27 CZ CZ0310098A patent/CZ299357B6/cs not_active IP Right Cessation
- 1997-03-27 PT PT97919943T patent/PT928294E/pt unknown
- 1997-03-27 RU RU98119535/14A patent/RU2203087C2/ru active
- 1997-03-27 NZ NZ538045A patent/NZ538045A/en unknown
- 1997-03-27 CA CA002250274A patent/CA2250274C/en not_active Expired - Fee Related
- 1997-03-27 BR BR9708388-7A patent/BR9708388A/pt not_active Application Discontinuation
- 1997-03-27 JP JP9534650A patent/JP2000507947A/ja active Pending
- 1997-03-27 NZ NZ332067A patent/NZ332067A/en unknown
- 1997-03-27 WO PCT/US1997/005088 patent/WO1997035883A1/en not_active Ceased
- 1997-03-27 AP APAP/P/1998/001353A patent/AP1028A/en active
- 1997-03-27 AT AT97919943T patent/ATE241646T1/de not_active IP Right Cessation
- 1997-03-27 PL PL32910897A patent/PL187923B1/pl not_active IP Right Cessation
- 1997-03-27 RO RO98-01433A patent/RO121089B1/ro unknown
- 1997-03-27 IL IL126376A patent/IL126376A/en not_active IP Right Cessation
- 1997-03-27 UA UA98095067A patent/UA64710C2/uk unknown
1998
- 1998-09-25 NO NO19984473A patent/NO324121B1/no not_active IP Right Cessation
- 1998-09-25 OA OA9800177A patent/OA10884A/en unknown
- 1998-09-28 IS IS4854A patent/IS4854A/is unknown
- 1998-10-01 BG BG102810A patent/BG63919B1/bg unknown
2002
- 2002-10-17 US US10/274,099 patent/US20030191050A1/en not_active Abandoned
2004
- 2004-11-19 US US10/993,228 patent/US20050065067A1/en not_active Abandoned
2008
- 2008-01-10 US US11/972,322 patent/US7521417B2/en not_active Expired - Fee Related
2009
- 2009-04-20 US US12/426,566 patent/US20100197566A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AP9801353A0 (en)	1998-09-30
NZ332067A (en)	2001-03-30
US20080108555A1 (en)	2008-05-08
CA2250274A1 (en)	1997-10-02
OA10884A (en)	2001-10-11
AU2425397A (en)	1997-10-17
EP0928294A1 (de)	1999-07-14
UA64710C2 (en)	2004-03-15
AP1028A (en)	2001-11-30
PL329108A1 (en)	1999-03-15
NO324121B1 (no)	2007-08-27
CN1219939A (zh)	1999-06-16
CN1129608C (zh)	2003-12-03
IL126376A0 (en)	1999-05-09
RU2203087C2 (ru)	2003-04-27
BR9708388A (pt)	2000-01-04
IS4854A (is)	1998-09-28
EP0928294B1 (de)	2003-05-28
IL126376A (en)	2009-09-22
US20100197566A1 (en)	2010-08-05
PT928294E (pt)	2003-10-31
US20030191050A1 (en)	2003-10-09
US6498141B2 (en)	2002-12-24
ES2200177T3 (es)	2004-03-01
CZ299357B6 (cs)	2008-07-02
NZ538045A (en)	2006-11-30
RO121089B1 (ro)	2006-12-29
DK0928294T3 (da)	2003-09-22
PL187923B1 (pl)	2004-11-30
CA2250274C (en)	2003-09-16
BG63919B1 (bg)	2003-06-30
SK134398A3 (en)	2001-01-18
US20020025343A1 (en)	2002-02-28
US20050065067A1 (en)	2005-03-24
DE69722422D1 (de)	2003-07-03
NO984473L (no)	1998-11-25
NO984473D0 (no)	1998-09-25
DE69722422T2 (de)	2004-05-06
US7521417B2 (en)	2009-04-21
AU740210B2 (en)	2001-11-01
CZ310098A3 (cs)	1999-09-15
WO1997035883A1 (en)	1997-10-02
BG102810A (en)	1999-09-30
JP2000507947A (ja)	2000-06-27

Legal Events

Date

Code

Title

Description

2004-01-15

UEP

Publication of translation of european patent specification

Ref document number: 0928294

Country of ref document: EP

2010-12-15

REN

Ceased due to non-payment of the annual fee

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