ATE241961T1 - Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatoren - Google Patents
Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatorenInfo
- Publication number
- ATE241961T1 ATE241961T1 AT00912534T AT00912534T ATE241961T1 AT E241961 T1 ATE241961 T1 AT E241961T1 AT 00912534 T AT00912534 T AT 00912534T AT 00912534 T AT00912534 T AT 00912534T AT E241961 T1 ATE241961 T1 AT E241961T1
- Authority
- AT
- Austria
- Prior art keywords
- dry powder
- carrier particles
- powder inhalers
- modified carrier
- aerodynamic diameter
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000000181 anti-adherent effect Effects 0.000 abstract 1
- 239000003911 antiadherent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000455A IT1309592B1 (it) | 1999-03-05 | 1999-03-05 | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| PCT/EP2000/001773 WO2000053158A1 (en) | 1999-03-05 | 2000-03-02 | Modified carrier particles for use in dry powder inhalers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241961T1 true ATE241961T1 (de) | 2003-06-15 |
Family
ID=11382167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00912534T ATE241961T1 (de) | 1999-03-05 | 2000-03-02 | Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatoren |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6641844B1 (de) |
| EP (2) | EP1312357A3 (de) |
| AT (1) | ATE241961T1 (de) |
| AU (1) | AU3426400A (de) |
| DE (1) | DE60003162T2 (de) |
| ES (1) | ES2199793T3 (de) |
| IT (1) | IT1309592B1 (de) |
| WO (1) | WO2000053158A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE363892T1 (de) * | 1999-03-05 | 2007-06-15 | Chiesi Farma Spa | Verbesserte pulverformulierungen zur inhalation |
| IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ITMI991582A1 (it) * | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| GB0009469D0 (en) | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| JP5698423B2 (ja) | 2000-06-27 | 2015-04-08 | ベクトゥラ・リミテッド | 医薬組成物で使用するための粒子の製造法 |
| FI20002215A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
| FI20002216A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit astman hoitoon |
| ES2474199T3 (es) * | 2000-11-30 | 2014-07-08 | Vectura Limited | Composiciones farmacéuticas para inhalaci�n |
| DE60140268D1 (de) | 2000-11-30 | 2009-12-03 | Vectura Ltd | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
| US8337816B2 (en) | 2001-09-17 | 2012-12-25 | Glaxo Group Limited | Dry powder medicament formulations |
| ITMI20012174A1 (it) * | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| GB0219511D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| NZ538965A (en) | 2002-08-21 | 2006-11-30 | Norton Healthcare Ltd | Dry powder inhalation compositions |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| GB0321607D0 (en) * | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| DE102004048389A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| DE102004048390A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pulverinhalativa auf Basis modifizierter Laktosemischungen als Hilfsstoff |
| MX2007009656A (es) | 2005-02-10 | 2007-11-07 | Glaxo Group Ltd | Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma. |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| IN2015DN00888A (de) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| EP2010153A2 (de) * | 2006-04-03 | 2009-01-07 | Teva Pharmaceutical Industries Limited | Wirkstoffmikropartikel |
| DE102006053375A1 (de) * | 2006-11-10 | 2008-05-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mischung von Pulvern |
| GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2400950T3 (da) | 2009-02-26 | 2019-07-29 | Glaxo Group Ltd | Farmaceutiske formuleringer omfattende 4-{(1 r)-2-[(6-{2-[(2,6-dichlorbenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| EP2470167A4 (de) | 2009-08-27 | 2013-08-14 | Stc Unm | Verfahren und system zur dosierung und beschichtung von inhalationspulvern auf trägerpartikel |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| CN104257610A (zh) | 2010-04-01 | 2015-01-07 | 奇斯药制品公司 | 用于制备可吸入干粉所用的载体颗粒的方法 |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| EA026267B1 (ru) * | 2012-01-25 | 2017-03-31 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Композиция в форме сухого порошка, содержащая кортикостероид и бета-адренергическое лекарственное средство, для введения ингаляцией |
| US9603907B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Dry powder formulations of dNase I |
| US20150272988A1 (en) | 2012-03-07 | 2015-10-01 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| CN104470503A (zh) | 2012-04-13 | 2015-03-25 | 葛兰素史克知识产权开发有限公司 | 聚集粒子 |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| GB201305825D0 (en) | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| WO2022094100A1 (en) | 2020-10-28 | 2022-05-05 | Insmed Incorporated | Dry powder compositions of treprostinil prodrugs and methods of use thereof |
| WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2107715B (en) | 1981-10-19 | 1985-11-13 | Glaxo Group Ltd | Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| PL200941B1 (pl) * | 1998-11-13 | 2009-02-27 | Jagotec Ag | Suchy proszkowy preparat inhalacyjny |
| IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| ATE363892T1 (de) | 1999-03-05 | 2007-06-15 | Chiesi Farma Spa | Verbesserte pulverformulierungen zur inhalation |
| GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
-
1999
- 1999-03-05 IT IT1999MI000455A patent/IT1309592B1/it active
-
2000
- 2000-03-02 AU AU34264/00A patent/AU3426400A/en not_active Abandoned
- 2000-03-02 EP EP03003987A patent/EP1312357A3/de not_active Withdrawn
- 2000-03-02 EP EP00912534A patent/EP1158960B1/de not_active Expired - Lifetime
- 2000-03-02 ES ES00912534T patent/ES2199793T3/es not_active Expired - Lifetime
- 2000-03-02 AT AT00912534T patent/ATE241961T1/de active
- 2000-03-02 DE DE60003162T patent/DE60003162T2/de not_active Expired - Lifetime
- 2000-03-02 WO PCT/EP2000/001773 patent/WO2000053158A1/en not_active Ceased
- 2000-03-02 US US09/926,105 patent/US6641844B1/en not_active Expired - Lifetime
-
2003
- 2003-04-28 US US10/423,912 patent/US20040009127A1/en not_active Abandoned
- 2003-07-29 US US10/628,453 patent/US7132115B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT1309592B1 (it) | 2002-01-24 |
| ITMI990455A1 (it) | 2000-09-05 |
| EP1158960A1 (de) | 2001-12-05 |
| DE60003162T2 (de) | 2004-02-12 |
| ES2199793T3 (es) | 2004-03-01 |
| EP1158960B1 (de) | 2003-06-04 |
| US20040009127A1 (en) | 2004-01-15 |
| AU3426400A (en) | 2000-09-28 |
| DE60003162D1 (de) | 2003-07-10 |
| US6641844B1 (en) | 2003-11-04 |
| WO2000053158A1 (en) | 2000-09-14 |
| EP1312357A2 (de) | 2003-05-21 |
| EP1312357A3 (de) | 2004-01-07 |
| US7132115B2 (en) | 2006-11-07 |
| US20040096516A1 (en) | 2004-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE241961T1 (de) | Modifizierte trägerpartikel zur verwendung in trockenpulverinhalatoren | |
| CY1107488T1 (el) | Σταθερα ξηραμενα δια ψεκασμου πρωτεϊνικα σκευασματα | |
| ATE363892T1 (de) | Verbesserte pulverformulierungen zur inhalation | |
| PT871430E (pt) | Melhoramentos em e relacionados com pos para utilizacao em inaladores de po seco | |
| MXPA05014158A (es) | Estructuras absorbentes que comprenden particulas polimericas superabsorbentes recubiertas. | |
| NO20004980D0 (no) | Partikulær virkestoffbærer for pulmonær anvendelse | |
| DE69915650D1 (de) | Granuläre zusammensetzungen | |
| ES2137327T3 (es) | Agentes de control de espuma, en forma de particulas. | |
| TR200100422T2 (tr) | Primetanil ihtiva etmekte olan süspansiyon konsantre formülasyon | |
| NZ334112A (en) | Aerosol formulation comprising 1,1,1,2,3,3,3-heptafluoropropane, mometasone furoate and ethanol | |
| CA2016968A1 (en) | Air freshener composition | |
| PT1453380E (pt) | Composicoes contendo sacarido e silica hidrofobica | |
| MY148403A (en) | Aerosol formulation for the inhalation of beta-agonists | |
| BR0006230A (pt) | Composição compreendendo ácido ascórbico epectina | |
| ES2018897A6 (es) | Coadyuvante distribuidor de aire en especial para la industria de la construccion. | |
| PL288880A1 (en) | Melamine composition and stable dispersion of melamine in polyetheroles | |
| ATE417619T1 (de) | Sporopollenin enthaltende lösliche zusammensetzung und verwendung | |
| ATE38236T1 (de) | Steroidderivate. | |
| KR950010752A (ko) | 개선된 살충성 수성 현탁 농축액 및 이의 제조방법 | |
| DK0553647T3 (da) | Vandige polymerisatsammensætninger | |
| EP0357414A3 (de) | Verwendung von Serotonin-Antagonisten bei der Behandlung von Depression | |
| Arnoldi | Polyoxymethylene Moulding Material of Improved Thermal Stability and Diminished Formaldehyde Emission |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1158960 Country of ref document: EP |