ATE241976T1 - N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind - Google Patents

N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind

Info

Publication number: ATE241976T1
Authority: AT; Austria
Prior art keywords: substituted; carbon atoms; sulfonyl; bis; alkyl groups
Prior art date: 1997-11-03

Application number

AT98953830T

Other languages

English (en)

Inventor

Alan C Sartorelli

Krishnamruthy Shyam

Philip G Penketh

Shu-Hui Chen

Original Assignee

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-03

Filing date

1998-10-21

Publication date

2003-06-15

1998-10-21 Application filed by Univ Yale filed Critical Univ Yale

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241976T1 publication Critical patent/ATE241976T1/de

Links

RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 title 1
229940034982 antineoplastic agent Drugs 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
150000002429 hydrazines Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000004417 unsaturated alkyl group Chemical group 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/61—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups further bound to another hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98953830T 1997-11-03 1998-10-21 N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind ATE241976T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/963,182 US6040338A (en)	1997-11-03	1997-11-03	N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
PCT/US1998/022266 WO1999022726A1 (en)	1997-11-03	1998-10-21	N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents

Publications (1)

Publication Number	Publication Date
ATE241976T1 true ATE241976T1 (de)	2003-06-15

Family

ID=25506863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98953830T ATE241976T1 (de)	1997-11-03	1998-10-21	N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind

Country Status (12)

Country	Link
US (1)	US6040338A (de)
EP (1)	EP1028721B1 (de)
JP (1)	JP4331889B2 (de)
KR (1)	KR100566688B1 (de)
CN (1)	CN1124846C (de)
AT (1)	ATE241976T1 (de)
AU (1)	AU735349B2 (de)
BR (1)	BR9813923A (de)
CA (1)	CA2308315C (de)
DE (1)	DE69815380T2 (de)
ES (1)	ES2200383T3 (de)
WO (1)	WO1999022726A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6715188B1 (en) *	2002-09-24	2004-04-06	3M Innovative Properties Company	Hinged tab for slot and tab closure systems
WO2004098504A2 (en) *	2003-04-30	2004-11-18	Yale University	Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and methods of treating tumors
US6855695B2 (en) *	2003-06-13	2005-02-15	Vion Pharmaceuticals, Inc.	Water-soluble SHPs as novel alkylating agents
WO2005094282A2 (en) *	2004-03-26	2005-10-13	Vion Pharmaceuticals, Inc.	Combination therapy comprising cloretazinetm
JP4814245B2 (ja) *	2004-09-21	2011-11-16	ヴァイオンファーマシューティカルズ、インコーポレーテッド	低酸素選択性抗腫瘍剤としてのスルホニルヒドラジンのリン酸含有プロドラッグ
EP2542696B1 (de)	2010-03-01	2016-09-28	Caris Life Sciences Switzerland Holdings GmbH	Theranostik-biomarker
JP2013526852A (ja)	2010-04-06	2013-06-27	カリスライフサイエンシズルクセンブルクホールディングス	疾患に対する循環バイオマーカー

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4684747A (en) *	1984-12-20	1987-08-04	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4892887A (en) *	1984-12-20	1990-01-09	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4962114A (en) *	1986-01-21	1990-10-09	Yale University	1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
US4806531A (en) *	1986-02-20	1989-02-21	Yale University	2,3-bis(aziridinyl)-1,4-naphthoquinone sulfonate derivatives having antineoplastic activity
JP2563176B2 (ja) *	1986-08-05	1996-12-11	富士写真フイルム株式会社	ハロゲン化銀カラ−写真感光材料
US5101072A (en) *	1989-09-06	1992-03-31	Yale University	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents
US5214068A (en) *	1989-09-06	1993-05-25	Yale University	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents
US5256820A (en) *	1991-11-08	1993-10-26	Yale University	1-alkyl-2-acyl-1,2-disulfonylhydrazines
US5281715A (en) *	1992-05-13	1994-01-25	Yale University	2-formylpyridine thiosemicarbazone compounds
US5637619A (en) *	1995-07-05	1997-06-10	Yale University	Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines

1997
- 1997-11-03 US US08/963,182 patent/US6040338A/en not_active Expired - Fee Related
1998
- 1998-10-21 EP EP98953830A patent/EP1028721B1/de not_active Expired - Lifetime
- 1998-10-21 JP JP2000518660A patent/JP4331889B2/ja not_active Expired - Fee Related
- 1998-10-21 BR BR9813923-1A patent/BR9813923A/pt not_active Application Discontinuation
- 1998-10-21 WO PCT/US1998/022266 patent/WO1999022726A1/en not_active Ceased
- 1998-10-21 AT AT98953830T patent/ATE241976T1/de not_active IP Right Cessation
- 1998-10-21 CA CA002308315A patent/CA2308315C/en not_active Expired - Fee Related
- 1998-10-21 CN CN98810755A patent/CN1124846C/zh not_active Expired - Fee Related
- 1998-10-21 DE DE69815380T patent/DE69815380T2/de not_active Expired - Lifetime
- 1998-10-21 KR KR1020007004771A patent/KR100566688B1/ko not_active Expired - Fee Related
- 1998-10-21 ES ES98953830T patent/ES2200383T3/es not_active Expired - Lifetime
- 1998-10-21 AU AU11103/99A patent/AU735349B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2308315A1 (en)	1999-05-14
DE69815380T2 (de)	2004-05-13
CN1124846C (zh)	2003-10-22
BR9813923A (pt)	2000-09-26
US6040338A (en)	2000-03-21
EP1028721B1 (de)	2003-06-04
AU1110399A (en)	1999-05-24
EP1028721A1 (de)	2000-08-23
KR100566688B1 (ko)	2006-04-03
JP2001521893A (ja)	2001-11-13
WO1999022726A1 (en)	1999-05-14
AU735349B2 (en)	2001-07-05
CA2308315C (en)	2009-01-06
CN1278169A (zh)	2000-12-27
JP4331889B2 (ja)	2009-09-16
DE69815380D1 (de)	2003-07-10
EP1028721A4 (de)	2001-01-31
ES2200383T3 (es)	2004-03-01
KR20010031708A (ko)	2001-04-16
HK1032916A1 (en)	2001-08-10

Legal Events

Date	Code	Title	Description
2003-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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BG92804A (bg)	1993-12-24	4-бензоилизоксазолови производни
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CA2323150A1 (en)	1999-10-07	New porphyrins and their use
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ATE241976T1 (de)	2003-06-15	N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
KR920701120A (ko)	1992-08-11	치환된 비시클로헵탄디온 유도체
ATE227296T1 (de)	2002-11-15	Phosphoepoxide, verfahren zu deren herstellung und ihre verwendungen
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
CA2144344A1 (en)	1994-03-31	Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents
KR960702463A (ko)	1996-04-27	Dc-89 유도체[dc-89 derivative]
MY104777A (en)	1994-05-31	Benzoxazine dyes
ES8505994A1 (es)	1985-06-16	Un metodo para preparar 2(1h)-piridinonas
MA24197A1 (fr)	1997-12-31	Nouvelles fungarrestines
BR9508979A (pt)	1997-10-28	Carboxamidas bicíclicas como antagonistas de 5-ht1a
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
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TR199901474T2 (xx)	1999-09-21	�misazol t�revleri i�in proses.
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YU49004B (sh)	2003-04-30	LANOSTA-7,9-DIEN-3Гџ, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE
KR940014390A (ko)	1994-07-18	3'-o-프로파르길-트리플루오로티미딘의 티오에스테르 유도체, 이의 제조방법 및 이를 유효 성분으로 하는 제암제