ATE242009T1 - Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen - Google Patents
Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationenInfo
- Publication number
- ATE242009T1 ATE242009T1 AT99965900T AT99965900T ATE242009T1 AT E242009 T1 ATE242009 T1 AT E242009T1 AT 99965900 T AT99965900 T AT 99965900T AT 99965900 T AT99965900 T AT 99965900T AT E242009 T1 ATE242009 T1 AT E242009T1
- Authority
- AT
- Austria
- Prior art keywords
- combinations
- transfer protein
- cholesteryl ester
- fibronic
- ester transfer
- Prior art date
Links
- 230000002526 effect on cardiovascular system Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title 1
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 2
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11395598P | 1998-12-23 | 1998-12-23 | |
| US14261699P | 1999-07-07 | 1999-07-07 | |
| PCT/US1999/027945 WO2000038724A1 (en) | 1998-12-23 | 1999-12-17 | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242009T1 true ATE242009T1 (de) | 2003-06-15 |
Family
ID=26811677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99965900T ATE242009T1 (de) | 1998-12-23 | 1999-12-17 | Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6458850B1 (de) |
| EP (2) | EP1140186B1 (de) |
| JP (1) | JP2002533410A (de) |
| KR (1) | KR20010099937A (de) |
| CN (1) | CN1338944A (de) |
| AT (1) | ATE242009T1 (de) |
| AU (1) | AU776664B2 (de) |
| BR (1) | BR9916485A (de) |
| CA (1) | CA2356157C (de) |
| CZ (1) | CZ20012341A3 (de) |
| DE (1) | DE69908645T2 (de) |
| DK (1) | DK1140186T3 (de) |
| EA (2) | EA004231B1 (de) |
| ES (1) | ES2201827T3 (de) |
| HK (2) | HK1040925B (de) |
| HU (1) | HUP0400886A2 (de) |
| IL (1) | IL143949A0 (de) |
| MX (1) | MXPA01006469A (de) |
| NO (1) | NO20013158L (de) |
| NZ (1) | NZ512534A (de) |
| PL (1) | PL348503A1 (de) |
| PT (1) | PT1140186E (de) |
| WO (1) | WO2000038724A1 (de) |
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| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| WO2003039352A2 (en) * | 2001-11-09 | 2003-05-15 | Atherogenics, Inc. | Methods of reversing and preventing cardiovascular pathologies |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
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| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
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| RU2330682C2 (ru) | 2003-09-26 | 2008-08-10 | Джапан Тобакко Инк. | Способ ингибирования продуцирования остаточных липопротеинов |
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| CN1891823B (zh) * | 2005-07-05 | 2011-03-30 | 北京诺赛基因组研究中心有限公司 | 具有特定单核苷酸多态性的cetp基因及其检测方法和用途 |
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| MX353660B (es) * | 2011-11-30 | 2018-01-23 | Dae Woong Pharma | Composicion farmaceutica para evitar o tratar hiperlipidemia. |
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| TWI691331B (zh) * | 2014-09-26 | 2020-04-21 | 日商興和股份有限公司 | 脂質異常症治療劑 |
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| DE19610932A1 (de) | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
| EP0801060A1 (de) | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclische Beta-3 adrenergische Angonisten |
| HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| DE19627431A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
| DE19627430A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
| US6066653A (en) * | 1997-01-17 | 2000-05-23 | Bristol-Myers Squibb Co. | Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs |
| DK0864582T3 (da) | 1997-03-14 | 2003-09-29 | Aventis Pharma Gmbh | Hypolidemiske 1,4-benzothiazepin-1,1-dioxider |
| JPH10287662A (ja) | 1997-04-08 | 1998-10-27 | Kitasato Inst:The | Ｆｏ−５６３７ａ物質及びｂ物質並びにそれらの製造法 |
| US5929062A (en) | 1997-06-19 | 1999-07-27 | University Of Western Ontario | Oxysterol inhibition of dietary cholesterol uptake |
| AU9297798A (en) * | 1997-09-16 | 1999-04-05 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| GB2329334A (en) | 1997-09-18 | 1999-03-24 | Reckitt & Colmann Prod Ltd | Cholesterol-lowering agents |
| DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
-
1999
- 1999-12-17 EP EP19990965900 patent/EP1140186B1/de not_active Expired - Lifetime
- 1999-12-17 EA EA200100706A patent/EA004231B1/ru not_active IP Right Cessation
- 1999-12-17 CZ CZ20012341A patent/CZ20012341A3/cs unknown
- 1999-12-17 DK DK99965900T patent/DK1140186T3/da active
- 1999-12-17 MX MXPA01006469A patent/MXPA01006469A/es unknown
- 1999-12-17 AT AT99965900T patent/ATE242009T1/de not_active IP Right Cessation
- 1999-12-17 JP JP2000590675A patent/JP2002533410A/ja active Pending
- 1999-12-17 BR BR9916485-0A patent/BR9916485A/pt not_active Application Discontinuation
- 1999-12-17 HK HK02102720.1A patent/HK1040925B/en not_active IP Right Cessation
- 1999-12-17 PL PL99348503A patent/PL348503A1/xx not_active Application Discontinuation
- 1999-12-17 CN CN99816149A patent/CN1338944A/zh active Pending
- 1999-12-17 HK HK02106472.2A patent/HK1045108A1/zh unknown
- 1999-12-17 PT PT99965900T patent/PT1140186E/pt unknown
- 1999-12-17 AU AU21576/00A patent/AU776664B2/en not_active Expired - Fee Related
- 1999-12-17 HU HU0400886A patent/HUP0400886A2/hu unknown
- 1999-12-17 WO PCT/US1999/027945 patent/WO2000038724A1/en not_active Ceased
- 1999-12-17 US US09/466,413 patent/US6458850B1/en not_active Expired - Fee Related
- 1999-12-17 EP EP03012144A patent/EP1340509A1/de not_active Withdrawn
- 1999-12-17 IL IL14394999A patent/IL143949A0/xx unknown
- 1999-12-17 CA CA002356157A patent/CA2356157C/en not_active Expired - Fee Related
- 1999-12-17 NZ NZ512534A patent/NZ512534A/en unknown
- 1999-12-17 ES ES99965900T patent/ES2201827T3/es not_active Expired - Lifetime
- 1999-12-17 DE DE69908645T patent/DE69908645T2/de not_active Expired - Fee Related
- 1999-12-17 EA EA200300914A patent/EA009466B1/ru not_active Application Discontinuation
- 1999-12-17 KR KR1020017008091A patent/KR20010099937A/ko not_active Withdrawn
-
2001
- 2001-06-22 NO NO20013158A patent/NO20013158L/no not_active Application Discontinuation
-
2002
- 2002-07-23 US US10/200,600 patent/US20030166720A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2356157C (en) | 2008-04-01 |
| US6458850B1 (en) | 2002-10-01 |
| BR9916485A (pt) | 2002-01-15 |
| CZ20012341A3 (cs) | 2001-12-12 |
| ES2201827T3 (es) | 2004-03-16 |
| IL143949A0 (en) | 2002-04-21 |
| CA2356157A1 (en) | 2000-07-06 |
| EP1140186B1 (de) | 2003-06-04 |
| CN1338944A (zh) | 2002-03-06 |
| HK1040925B (en) | 2003-09-11 |
| EP1340509A1 (de) | 2003-09-03 |
| HUP0400886A2 (hu) | 2004-07-28 |
| DE69908645D1 (de) | 2003-07-10 |
| US20030166720A1 (en) | 2003-09-04 |
| HK1040925A1 (en) | 2002-06-28 |
| PL348503A1 (en) | 2002-05-20 |
| DE69908645T2 (de) | 2004-05-13 |
| HK1045108A1 (zh) | 2002-11-15 |
| EP1140186A1 (de) | 2001-10-10 |
| JP2002533410A (ja) | 2002-10-08 |
| DK1140186T3 (da) | 2003-09-29 |
| NO20013158L (no) | 2001-08-22 |
| EA200300914A1 (ru) | 2003-12-25 |
| MXPA01006469A (es) | 2004-03-10 |
| NZ512534A (en) | 2003-11-28 |
| AU776664B2 (en) | 2004-09-16 |
| PT1140186E (pt) | 2003-10-31 |
| AU2157600A (en) | 2000-07-31 |
| EA004231B1 (ru) | 2004-02-26 |
| EA200100706A1 (ru) | 2001-12-24 |
| EA009466B1 (ru) | 2007-12-28 |
| KR20010099937A (ko) | 2001-11-09 |
| WO2000038724A1 (en) | 2000-07-06 |
| NO20013158D0 (no) | 2001-06-22 |
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