ES2155136T3 - Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. - Google Patents

Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.

Info

Publication number
ES2155136T3
ES2155136T3 ES95930289T ES95930289T ES2155136T3 ES 2155136 T3 ES2155136 T3 ES 2155136T3 ES 95930289 T ES95930289 T ES 95930289T ES 95930289 T ES95930289 T ES 95930289T ES 2155136 T3 ES2155136 T3 ES 2155136T3
Authority
ES
Spain
Prior art keywords
illaco
benzotiepines
taurocolate
capturing
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930289T
Other languages
English (en)
Inventor
Len Fang Lee
Raymond Eugene Miller
Samuel Joseph Tremont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2155136T3 publication Critical patent/ES2155136T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS BENZOTIEPINAS, DERIVADOS Y ANALOGOS DE LAS MISMAS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU USO EN MEDICINA, EN PARTICULAR EN LA PROFILAXIS Y TRATAMIENTO DE CONDICIONES HIPERLIPIDEMICAS, COMO LAS ASOCIADAS CON ATEROSCLEROSIS, O HIPERCOLESTEROLEMIA, EN MAMIFEROS.
ES95930289T 1994-09-13 1995-08-28 Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. Expired - Lifetime ES2155136T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30552694A 1994-09-13 1994-09-13

Publications (1)

Publication Number Publication Date
ES2155136T3 true ES2155136T3 (es) 2001-05-01

Family

ID=23181154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930289T Expired - Lifetime ES2155136T3 (es) 1994-09-13 1995-08-28 Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.

Country Status (13)

Country Link
EP (1) EP0781278B1 (es)
JP (1) JP3304093B2 (es)
CN (1) CN1084741C (es)
AT (1) ATE199718T1 (es)
AU (1) AU700557B2 (es)
BR (1) BR9508916A (es)
CA (1) CA2199944A1 (es)
DE (1) DE69520364T2 (es)
DK (1) DK0781278T3 (es)
ES (1) ES2155136T3 (es)
GR (1) GR3035583T3 (es)
PT (1) PT781278E (es)
WO (1) WO1996008484A1 (es)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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ZA956647B (en) * 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
EP1440972A1 (en) * 1996-03-11 2004-07-28 G.D. Searle & Co. Novel benzothiepines having pharmaceutical activity.
KR19990087721A (ko) * 1996-03-11 1999-12-27 지.디. 썰 앤드 컴파니 회장 담즙산 운반 및 타우로콜레이트 흡수 저해제로서의 활성을 갖는 신규한 벤조티에핀
DE04010088T1 (de) * 1996-03-11 2005-07-14 G.D. Searle Llc Neue Benzothiepine mit pharmazeutischer Wirkung.
GB9704208D0 (en) * 1997-02-28 1997-04-16 Glaxo Group Ltd Chemical compounds
EP1331225A1 (en) * 1997-12-19 2003-07-30 G.D. Searle & Co. Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
BR9814300A (pt) * 1997-12-19 2002-02-05 Searle & Co Método de preparação de óxidos de tetraidrobenzotiepina enanciomericamente enriquecidos
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19825804C2 (de) * 1998-06-10 2000-08-24 Aventis Pharma Gmbh 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
AU2157500A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
DK1140189T3 (da) 1998-12-23 2003-09-15 Searle Llc Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer
BR9916486A (pt) * 1998-12-23 2002-02-05 Searle Llc Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares
DE69911058T2 (de) * 1998-12-23 2004-06-03 G.D. Searle Llc, Chicago Kombinationen einem ibat inhibitor und einem mtp inhibitor für kardiovaskuläre indikationen
EA004877B1 (ru) 1998-12-23 2004-08-26 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
US6458850B1 (en) 1998-12-23 2002-10-01 G.D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
WO2000069845A1 (en) * 1999-05-18 2000-11-23 Takeda Chemical Industries, Ltd. Processes for the preparation of 2,3-dihydrothiepine derivatives
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
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EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
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EA038594B1 (ru) 2011-10-28 2021-09-21 Шайр Хьюман Дженетик Терапис, Инк. Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени
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US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
DE1593760A1 (de) * 1967-02-01 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Benz-epinderivate
AU626881B2 (en) * 1988-07-14 1992-08-13 F. Hoffmann-La Roche Ag Benzofused heterocyclics used as pharmaceuticals
FR2661676A1 (fr) * 1990-05-02 1991-11-08 Lipha Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
JPH0825973B2 (ja) * 1991-04-12 1996-03-13 シェリング・コーポレーション アシル補酵素ａ：コレステロールアシルトランスフェラーゼの阻害剤としての二環式アミド
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
FR2698873B1 (fr) * 1992-12-07 1995-02-24 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
DE102018100125A1 (de) * 2018-01-04 2019-07-04 Miele & Cie. Kg Wasserzulaufsteuerung und Waschautomat

Also Published As

Publication number Publication date
DE69520364D1 (de) 2001-04-19
DE69520364T2 (de) 2001-09-13
PT781278E (pt) 2001-08-30
DK0781278T3 (da) 2001-04-17
EP0781278A1 (en) 1997-07-02
WO1996008484A1 (en) 1996-03-21
CN1084741C (zh) 2002-05-15
EP0781278B1 (en) 2001-03-14
GR3035583T3 (en) 2001-06-29
AU3373695A (en) 1996-03-29
JP3304093B2 (ja) 2002-07-22
JPH10505830A (ja) 1998-06-09
ATE199718T1 (de) 2001-03-15
AU700557B2 (en) 1999-01-07
CN1162311A (zh) 1997-10-15
BR9508916A (pt) 1997-12-30
CA2199944A1 (en) 1996-03-21

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