ATE242253T1 - Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sind - Google Patents
Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sindInfo
- Publication number
- ATE242253T1 ATE242253T1 AT94925701T AT94925701T ATE242253T1 AT E242253 T1 ATE242253 T1 AT E242253T1 AT 94925701 T AT94925701 T AT 94925701T AT 94925701 T AT94925701 T AT 94925701T AT E242253 T1 ATE242253 T1 AT E242253T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- inhibitors
- antiproliferants
- gaft
- compounds usable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101000606741 Homo sapiens Phosphoribosylglycinamide formyltransferase Proteins 0.000 abstract 2
- 102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003944 phosphoribosylglycinamide formyltransferase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
- C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
- C07D517/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG1996008313A SG44827A1 (en) | 1994-07-28 | 1994-07-28 | Compounds useful as antiproliferative agents and garft inhibitors |
| PCT/US1994/008522 WO1996003407A1 (en) | 1994-07-28 | 1994-07-28 | Compounds useful as antiproliferative agents and garft inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242253T1 true ATE242253T1 (de) | 2003-06-15 |
Family
ID=26665124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94925701T ATE242253T1 (de) | 1994-07-28 | 1994-07-28 | Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sind |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0783507B1 (de) |
| JP (1) | JP3473956B2 (de) |
| AT (1) | ATE242253T1 (de) |
| AU (1) | AU698868B2 (de) |
| DE (1) | DE69432801T2 (de) |
| DK (1) | DK0783507T3 (de) |
| ES (1) | ES2201079T3 (de) |
| FI (1) | FI112661B (de) |
| NO (1) | NO308997B1 (de) |
| NZ (1) | NZ271766A (de) |
| RU (1) | RU2136686C1 (de) |
| SG (1) | SG44827A1 (de) |
| WO (1) | WO1996003407A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
| NL1014751C2 (nl) * | 2000-03-24 | 2001-09-25 | Marijke Cristiaans | Middel ter bevordering van borstgroei. |
| US20040043959A1 (en) * | 2002-03-04 | 2004-03-04 | Bloom Laura A. | Combination therapies for treating methylthioadenosine phosphorylase deficient cells |
| WO2004113328A1 (en) * | 2003-06-25 | 2004-12-29 | Pfizer Inc. | Convergent asymmetric synthesis route to produce a key intermediate towards the synthesis of a garft inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123550A (en) | 1977-10-31 | 1978-10-31 | Syntex (U.S.A.) Inc. | Bicyclo[3.1.0]hexylethylaminocarbonyl-substituted heteroaryl cardiovascular agents |
| ZA861235B (en) * | 1985-03-08 | 1986-10-29 | Univ Princeton | Pyrido(2,3-d)pyrimidine derivatives |
| EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
| JPH08504765A (ja) * | 1992-12-16 | 1996-05-21 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | 抗増殖性の置換５−チアピリミジノンおよび５−セレノピリミジノン化合物 |
-
1994
- 1994-07-28 DE DE69432801T patent/DE69432801T2/de not_active Expired - Fee Related
- 1994-07-28 SG SG1996008313A patent/SG44827A1/en unknown
- 1994-07-28 EP EP94925701A patent/EP0783507B1/de not_active Expired - Lifetime
- 1994-07-28 ES ES94925701T patent/ES2201079T3/es not_active Expired - Lifetime
- 1994-07-28 DK DK94925701T patent/DK0783507T3/da active
- 1994-07-28 WO PCT/US1994/008522 patent/WO1996003407A1/en not_active Ceased
- 1994-07-28 AU AU75520/94A patent/AU698868B2/en not_active Ceased
- 1994-07-28 JP JP50570496A patent/JP3473956B2/ja not_active Expired - Fee Related
- 1994-07-28 NZ NZ271766A patent/NZ271766A/xx unknown
- 1994-07-28 AT AT94925701T patent/ATE242253T1/de not_active IP Right Cessation
- 1994-07-28 RU RU97103519/04A patent/RU2136686C1/ru not_active IP Right Cessation
-
1997
- 1997-01-24 FI FI970318A patent/FI112661B/fi not_active IP Right Cessation
- 1997-01-27 NO NO970350A patent/NO308997B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69432801T2 (de) | 2003-12-04 |
| FI970318L (fi) | 1997-03-05 |
| AU698868B2 (en) | 1998-11-12 |
| EP0783507B1 (de) | 2003-06-04 |
| FI112661B (fi) | 2003-12-31 |
| NO970350L (no) | 1997-03-12 |
| AU7552094A (en) | 1996-02-22 |
| WO1996003407A1 (en) | 1996-02-08 |
| DE69432801D1 (de) | 2003-07-10 |
| RU2136686C1 (ru) | 1999-09-10 |
| DK0783507T3 (da) | 2003-09-15 |
| ES2201079T3 (es) | 2004-03-16 |
| JPH10504541A (ja) | 1998-05-06 |
| JP3473956B2 (ja) | 2003-12-08 |
| NO970350D0 (no) | 1997-01-27 |
| EP0783507A1 (de) | 1997-07-16 |
| SG44827A1 (en) | 1997-12-19 |
| FI970318A0 (fi) | 1997-01-24 |
| NO308997B1 (no) | 2000-11-27 |
| NZ271766A (en) | 1999-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0783507 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |