ATE242270T1 - Stabilisierte proteine mit protease- inhibitorfunktion und varianten davon - Google Patents

Stabilisierte proteine mit protease- inhibitorfunktion und varianten davon

Info

Publication number
ATE242270T1
ATE242270T1 AT97941633T AT97941633T ATE242270T1 AT E242270 T1 ATE242270 T1 AT E242270T1 AT 97941633 T AT97941633 T AT 97941633T AT 97941633 T AT97941633 T AT 97941633T AT E242270 T1 ATE242270 T1 AT E242270T1
Authority
AT
Austria
Prior art keywords
variants
protease inhibitor
inhibitor function
stabilized proteins
stabilized
Prior art date
Application number
AT97941633T
Other languages
English (en)
Inventor
Paul Elliott Correa
Charles Winston Saunders
Michael Laskowski Jr
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE242270T1 publication Critical patent/ATE242270T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT97941633T 1996-09-24 1997-09-23 Stabilisierte proteine mit protease- inhibitorfunktion und varianten davon ATE242270T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2694496P 1996-09-24 1996-09-24
PCT/US1997/016355 WO1998013387A1 (en) 1996-09-24 1997-09-23 Stabilized proteinaceous protease inhibitors and variants thereof

Publications (1)

Publication Number Publication Date
ATE242270T1 true ATE242270T1 (de) 2003-06-15

Family

ID=21834705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97941633T ATE242270T1 (de) 1996-09-24 1997-09-23 Stabilisierte proteine mit protease- inhibitorfunktion und varianten davon

Country Status (10)

Country Link
US (1) US6579698B1 (de)
EP (1) EP0929577B1 (de)
JP (1) JP2000506394A (de)
AR (1) AR009819A1 (de)
AT (1) ATE242270T1 (de)
BR (1) BR9711540A (de)
CA (1) CA2266323A1 (de)
DE (1) DE69722639T2 (de)
DK (1) DK0929577T3 (de)
WO (1) WO1998013387A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9912519A (pt) * 1998-06-26 2001-05-02 Procter & Gamble Variantes estabilizadas de inibidor de subtilisina de streptomyces
AR020105A1 (es) * 1998-07-07 2002-04-10 Procter & Gamble Porteasas fusionadas con variante del inhibidor subtilisina de streptomyces, adn que codifica a dicha proteina fusionada, composicion que comprende lamisma y un sistema de expresion que comprende dicho adn
US20040038845A1 (en) * 2000-08-21 2004-02-26 Pedersen Poul Erik Method for production of a protease-inhibitor complex
CN101027034B (zh) * 2004-09-29 2013-01-23 花王株式会社 口腔用组合物
US7759299B2 (en) * 2006-07-24 2010-07-20 Ecolab Inc. Warewashing composition for use in automatic dishwashing machines
US20080090745A1 (en) * 2006-10-13 2008-04-17 Fox Bryan P Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
EP2412792A1 (de) * 2010-07-29 2012-02-01 The Procter & Gamble Company Flüssige Reinigungsmittelzusammensetzung
JP2012180514A (ja) * 2011-02-10 2012-09-20 Sanyo Chem Ind Ltd 液体洗剤組成物
CN103842378B (zh) * 2011-10-12 2018-01-02 三洋化成工业株式会社 蛋白质性蛋白酶抑制剂以及含有其的蛋白质溶液和洗涤剂组合物
JP6214382B2 (ja) * 2013-12-19 2017-10-18 花王株式会社 衣料用洗浄剤組成物
DE102022205593A1 (de) 2022-06-01 2023-12-07 Henkel Ag & Co. Kgaa Wasch- und reinigungsmittel mit verbesserter enzymstabilität

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324534A1 (de) 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4801537A (en) 1984-06-08 1989-01-31 Genex Corporation Vector for expression of polypeptides in bacilli
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
ATE103930T1 (de) 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5039446A (en) 1988-07-01 1991-08-13 Genencor International, Inc. Liquid detergent with stabilized enzyme
JPH0648988B2 (ja) 1988-07-26 1994-06-29 工業技術院長 トロンビン阻害物質の製造法
WO1990002175A1 (en) 1988-08-16 1990-03-08 Novo Nordisk A/S A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
US5550042A (en) 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
JPH0399099A (ja) * 1989-09-12 1991-04-24 Tsumura & Co ポリペプチドおよび該ポリペプチドを有効成分とするプロテアーゼ阻害剤
DK204290D0 (da) 1990-08-24 1990-08-24 Novo Nordisk As Enzymatisk detergentkomposition og fremgangsmaade til enzymstabilisering
US5674833A (en) 1990-09-18 1997-10-07 Novo Nordisk A/S Detergent compositions containing protease and novel inhibitors for use therein
DK223790D0 (da) 1990-09-18 1990-09-18 Novo Nordisk As Proteaseholdig detergentkomposition
US5178789A (en) 1991-06-27 1993-01-12 Genencor International, Inc. Liquid detergent with stabilized enzyme
US5527487A (en) 1991-11-27 1996-06-18 Novo Nordisk A/S Enzymatic detergent composition and method for enzyme stabilization
US5371198A (en) 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
DK23692D0 (da) 1992-02-25 1992-02-25 Novo Nordisk As Detergentkomposition
US5623059A (en) 1992-03-09 1997-04-22 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
DK43192D0 (da) 1992-03-31 1992-03-31 Novo Nordisk As Detergentkomposition
AU7257994A (en) * 1993-07-09 1995-02-06 Michael Laskowski Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
US5616485A (en) 1993-12-23 1997-04-01 Cangene Corporation Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides
JPH0838191A (ja) 1994-05-27 1996-02-13 Japan Energy Corp プロテア−ゼインヒビタ−ｓｓｉと異種蛋白質との融合蛋白質の製造方法
WO1997015670A1 (en) 1995-10-25 1997-05-01 Arris Pharmaceutical Corporation Novel subtilisin inhibitors

Also Published As

Publication number Publication date
JP2000506394A (ja) 2000-05-30
DK0929577T3 (da) 2003-10-06
DE69722639D1 (de) 2003-07-10
AR009819A1 (es) 2000-05-03
WO1998013387A1 (en) 1998-04-02
EP0929577B1 (de) 2003-06-04
CA2266323A1 (en) 1998-04-02
BR9711540A (pt) 2001-06-19
EP0929577A1 (de) 1999-07-21
DE69722639T2 (de) 2004-04-29
US6579698B1 (en) 2003-06-17

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