ATE243217T1 - Verfahren zur herstellung von gm3 - Google Patents

Verfahren zur herstellung von gm3

Info

Publication number: ATE243217T1
Authority: AT; Austria
Prior art keywords: lactone; alpha; isomer; basic catalyst; beta
Prior art date: 1998-02-17

Application number

AT99932498T

Other languages

English (en)

Inventor

Richard Schmidt

Julio C Castro-Palomino

Gerd Ritter

Lloyd J Old

Original Assignee

Ludwig Inst Cancer Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-17

Filing date

1999-02-17

Publication date

2003-07-15

1999-02-17 Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE243217T1 publication Critical patent/ATE243217T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
PFJKOHUKELZMLE-VEUXDRLPSA-N ganglioside GM3 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 PFJKOHUKELZMLE-VEUXDRLPSA-N 0.000 abstract 4
239000003054 catalyst Substances 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
150000002596 lactones Chemical class 0.000 abstract 2
CERZMXAJYMMUDR-QBTAGHCHSA-N 5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid Chemical compound N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-QBTAGHCHSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Control Of Motors That Do Not Use Commutators (AREA)
Insulating Bodies (AREA)

AT99932498T 1998-02-17 1999-02-17 Verfahren zur herstellung von gm3 ATE243217T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/024,528 US5977329A (en)	1996-02-16	1998-02-17	Methods of synthesizing GM3
PCT/US1999/003407 WO1999041264A1 (en)	1998-02-17	1999-02-17	Methods of synthesizing gm3

Publications (1)

Publication Number	Publication Date
ATE243217T1 true ATE243217T1 (de)	2003-07-15

Family

ID=21821063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99932498T ATE243217T1 (de)	1998-02-17	1999-02-17	Verfahren zur herstellung von gm3

Country Status (7)

Country	Link
US (1)	US5977329A (de)
EP (1)	EP1064291B1 (de)
JP (1)	JP2002503668A (de)
AT (1)	ATE243217T1 (de)
AU (1)	AU745735B2 (de)
DE (1)	DE69908919T2 (de)
WO (1)	WO1999041264A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1302530B1 (it) *	1998-12-16	2000-09-05	Fidia Spa In Amministrazione S	Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1.
JP4854843B2 (ja) *	1999-11-22	2012-01-18	森永乳業株式会社	３’−シアリルラクトースラクトンの製造方法
WO2004080960A2 (en)	2003-03-06	2004-09-23	Neose Technologies Inc.	Methods and compositions for the enzymatic synthesis of gangliosides
WO2012113404A1 (en) *	2011-02-21	2012-08-30	Glycom A/S	Novel glycosyl phosphites

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4593091A (en) *	1981-08-04	1986-06-03	Fidia, S.P.A.	Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
JPH0278694A (ja) *	1988-09-12	1990-03-19	Rikagaku Kenkyusho	新規なシアル酸供与体及びその製造法並びに該シアル酸供与体を用いた立体選択的なグリコシドの製造法
US5756695A (en) *	1996-02-16	1998-05-26	Ludwig Institute For Cancer Research	Methods of synthesizing GM2

1998
- 1998-02-17 US US09/024,528 patent/US5977329A/en not_active Expired - Fee Related
1999
- 1999-02-17 EP EP99932498A patent/EP1064291B1/de not_active Expired - Lifetime
- 1999-02-17 JP JP2000531456A patent/JP2002503668A/ja active Pending
- 1999-02-17 AU AU32975/99A patent/AU745735B2/en not_active Ceased
- 1999-02-17 DE DE69908919T patent/DE69908919T2/de not_active Expired - Fee Related
- 1999-02-17 AT AT99932498T patent/ATE243217T1/de not_active IP Right Cessation
- 1999-02-17 WO PCT/US1999/003407 patent/WO1999041264A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1999041264A1 (en)	1999-08-19
US5977329A (en)	1999-11-02
EP1064291A1 (de)	2001-01-03
AU745735B2 (en)	2002-03-28
DE69908919D1 (de)	2003-07-24
EP1064291B1 (de)	2003-06-18
EP1064291A4 (de)	2001-10-17
JP2002503668A (ja)	2002-02-05
AU3297599A (en)	1999-08-30
DE69908919T2 (de)	2004-05-19

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Legal Events

Date	Code	Title	Description
2003-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties