ATE253568T1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number: ATE253568T1
Authority: AT; Austria
Prior art keywords: producing citalopram; citalopram; preparation; producing; phtalid
Prior art date: 1999-12-30

Application number

AT99962133T

Other languages

English (en)

Inventor

Hans Petersen

Michael Harold Rock

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-30

Filing date

1999-12-30

Publication date

2003-11-15

1999-12-30 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253568T1 publication Critical patent/ATE253568T1/de

Links

229960001653 citalopram Drugs 0.000 title abstract 2
WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/74—Iron group metals
- B01J23/755—Nickel

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cephalosporin Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99962133T 1999-12-30 1999-12-30 Verfahren zur herstellung von citalopram ATE253568T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK1999/000740 WO2001049672A1 (en)	1999-12-30	1999-12-30	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
ATE253568T1 true ATE253568T1 (de)	2003-11-15

Family

ID=8157174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99962133T ATE253568T1 (de)	1999-12-30	1999-12-30	Verfahren zur herstellung von citalopram

Country Status (28)

Country	Link
US (2)	US20020198391A1 (de)
EP (1)	EP1246813B1 (de)
JP (1)	JP2003519218A (de)
KR (1)	KR100653141B1 (de)
CN (1)	CN1211377C (de)
AT (1)	ATE253568T1 (de)
AU (1)	AU1858400A (de)
BR (1)	BR9917604A (de)
CA (1)	CA2395733C (de)
CZ (1)	CZ20022627A3 (de)
DE (1)	DE69912652T2 (de)
DK (1)	DK1246813T3 (de)
EA (1)	EA004055B1 (de)
ES (1)	ES2207312T3 (de)
HK (1)	HK1052512B (de)
HR (1)	HRP20020633A2 (de)
HU (1)	HUP0203840A3 (de)
IL (2)	IL150367A0 (de)
IS (1)	IS2167B (de)
MX (1)	MXPA02006504A (de)
NO (1)	NO328359B1 (de)
PL (1)	PL198803B1 (de)
PT (1)	PT1246813E (de)
SI (1)	SI1246813T1 (de)
SK (1)	SK11052002A3 (de)
TR (1)	TR200201688T2 (de)
UA (1)	UA73336C2 (de)
WO (1)	WO2001049672A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR200102957T2 (tr)	1999-04-14	2004-12-21	H. Lundbeck A/S	Sitalopram hazırlanması için metod.
EP1246812B1 (de)	1999-12-28	2004-03-17	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
PL197821B1 (pl)	2000-01-14	2008-04-30	Lundbeck & Co As H	Sposób wytwarzania 5-cyjanoftalidu
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
NL1017500C1 (nl)	2000-03-13	2001-04-26	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
PL360110A1 (en)	2000-03-13	2004-09-06	H.Lundbeck A/S	Method for the preparation of citalopram
BR0109364A (pt) *	2000-03-13	2002-12-24	Lundbeck & Co As H	Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
JP2003527386A (ja)	2000-03-14	2003-09-16	ハー・ルンドベック・アクチエゼルスカベット	シタロプラムの製造方法
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US6339182B1 (en) *	2000-06-20	2002-01-15	Chevron U.S.A. Inc.	Separation of olefins from paraffins using ionic liquid solutions
WO2004085416A1 (en) *	2003-03-24	2004-10-07	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
CN100457747C (zh) *	2006-11-21	2009-02-04	浙江大学	抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
CN103127815B (zh) *	2013-02-19	2015-10-28	浙江大学	一种利用卤硫作用提高二氧化硫捕集性能的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (de)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
US4665181A (en) *	1984-05-17	1987-05-12	Pennwalt Corporation	Anti-inflammatory phthalazinones
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
JPH0881456A (ja) *	1994-09-14	1996-03-26	Sumitomo Chem Co Ltd	１，１，３，３−テトラクロロ−１，３−ジヒドロイソベンゾフラン誘導体の製造法
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
CN1206207C (zh)	1997-07-08	2005-06-15	H.隆德贝克有限公司	氰酞氟苯胺的制备方法
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
HUP0002953A3 (en)	1997-11-11	2002-12-28	Lundbeck & Co As H	Method for preparation of citalopram and intermediates used for them
DE69904853T2 (de)	1998-10-20	2003-09-04	Lundbeck As Valby H	Verfahren zur herstellung von citalopram
SI1140886T1 (en)	1998-12-23	2003-08-31	H. Lundbeck A/S	Method for the preparation of 5-cyanophthalide
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr)	1999-04-14	2004-12-21	H. Lundbeck A/S	Sitalopram hazırlanması için metod.
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
EP1228056B1 (de)	1999-10-25	2004-09-22	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
EP1246812B1 (de)	1999-12-28	2004-03-17	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
PL197821B1 (pl)	2000-01-14	2008-04-30	Lundbeck & Co As H	Sposób wytwarzania 5-cyjanoftalidu
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
CA2354877C (en)	2000-08-18	2006-05-02	H. Lundbeck A/S	Method for the preparation of citalopram
EA003581B1 (ru)	2000-12-22	2003-06-26	Х.Лундбекк А/С	Способ получения чистого циталопрама
AU2001100399B4 (en)	2000-12-28	2002-03-21	H Lundbeck As	Process for the preparation of pure citalopram

1999
- 1999-12-30 SI SI9930473T patent/SI1246813T1/xx unknown
- 1999-12-30 AT AT99962133T patent/ATE253568T1/de not_active IP Right Cessation
- 1999-12-30 EA EA200200728A patent/EA004055B1/ru not_active IP Right Cessation
- 1999-12-30 CA CA002395733A patent/CA2395733C/en not_active Expired - Fee Related
- 1999-12-30 AU AU18584/00A patent/AU1858400A/en not_active Abandoned
- 1999-12-30 HK HK03104874.0A patent/HK1052512B/zh not_active IP Right Cessation
- 1999-12-30 DK DK99962133T patent/DK1246813T3/da active
- 1999-12-30 PL PL355531A patent/PL198803B1/pl not_active IP Right Cessation
- 1999-12-30 CN CNB998170674A patent/CN1211377C/zh not_active Expired - Fee Related
- 1999-12-30 TR TR2002/01688T patent/TR200201688T2/xx unknown
- 1999-12-30 WO PCT/DK1999/000740 patent/WO2001049672A1/en not_active Ceased
- 1999-12-30 CZ CZ20022627A patent/CZ20022627A3/cs unknown
- 1999-12-30 BR BR9917604-1A patent/BR9917604A/pt not_active Application Discontinuation
- 1999-12-30 MX MXPA02006504A patent/MXPA02006504A/es active IP Right Grant
- 1999-12-30 IL IL15036799A patent/IL150367A0/xx unknown
- 1999-12-30 ES ES99962133T patent/ES2207312T3/es not_active Expired - Lifetime
- 1999-12-30 HR HRP20020633 patent/HRP20020633A2/hr not_active Application Discontinuation
- 1999-12-30 HU HU0203840A patent/HUP0203840A3/hu unknown
- 1999-12-30 UA UA2002065265A patent/UA73336C2/uk unknown
- 1999-12-30 EP EP99962133A patent/EP1246813B1/de not_active Expired - Lifetime
- 1999-12-30 KR KR1020027008572A patent/KR100653141B1/ko not_active Expired - Fee Related
- 1999-12-30 DE DE69912652T patent/DE69912652T2/de not_active Expired - Lifetime
- 1999-12-30 SK SK1105-2002A patent/SK11052002A3/sk unknown
- 1999-12-30 PT PT99962133T patent/PT1246813E/pt unknown
- 1999-12-30 JP JP2001550212A patent/JP2003519218A/ja active Pending
2002
- 2002-06-19 IS IS6433A patent/IS2167B/is unknown
- 2002-06-23 IL IL150367A patent/IL150367A/en not_active IP Right Cessation
- 2002-06-27 US US10/186,337 patent/US20020198391A1/en not_active Abandoned
- 2002-06-28 NO NO20023150A patent/NO328359B1/no not_active IP Right Cessation
2005
- 2005-11-23 US US11/285,922 patent/US7271273B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7271273B2 (en)	2007-09-18
TR200201688T2 (tr)	2002-11-21
EP1246813B1 (de)	2003-11-05
US20020198391A1 (en)	2002-12-26
IS2167B (is)	2006-11-15
MXPA02006504A (es)	2002-12-09
HUP0203840A2 (en)	2003-05-28
PL198803B1 (pl)	2008-07-31
BR9917604A (pt)	2002-12-31
CN1391566A (zh)	2003-01-15
HK1052512B (zh)	2006-03-03
US20060079700A1 (en)	2006-04-13
EA004055B1 (ru)	2003-12-25
SI1246813T1 (en)	2004-08-31
IL150367A (en)	2010-06-16
IS6433A (is)	2002-06-19
PL355531A1 (en)	2004-05-04
NO20023150D0 (no)	2002-06-28
EP1246813A1 (de)	2002-10-09
CZ20022627A3 (cs)	2002-10-16
JP2003519218A (ja)	2003-06-17
KR20020073495A (ko)	2002-09-26
DK1246813T3 (da)	2004-03-01
WO2001049672A1 (en)	2001-07-12
NO20023150L (no)	2002-06-28
AU1858400A (en)	2001-07-16
ES2207312T3 (es)	2004-05-16
SK11052002A3 (sk)	2003-01-09
HUP0203840A3 (en)	2005-02-28
EA200200728A1 (ru)	2002-12-26
CN1211377C (zh)	2005-07-20
CA2395733C (en)	2007-03-20
PT1246813E (pt)	2004-02-27
IL150367A0 (en)	2002-12-01
KR100653141B1 (ko)	2006-12-01
CA2395733A1 (en)	2001-07-12
HK1052512A1 (en)	2003-09-19
DE69912652T2 (de)	2004-06-09
HRP20020633A2 (en)	2004-12-31
UA73336C2 (en)	2005-07-15
NO328359B1 (no)	2010-02-01
DE69912652D1 (de)	2003-12-11

Legal Events

Date

Code

Title

Description

2004-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1246813

Country of ref document: EP

2011-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69907037D1 (de)	2003-05-22	Verfahren zur herstellung von citalopram
DE60100016D1 (de)	2002-10-02	Verfahren zur herstellung von reinem citalopram
DE69900891D1 (de)	2002-03-21	Verfahren zur herstellung von citalopram
ATE235478T1 (de)	2003-04-15	Verfahren zur herstellung von citalopram
ATE230738T1 (de)	2003-01-15	Verfahren zur herstellung von citalopram
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