ATE243518T1 - 5-androsten 3-beta, 17-alpha diol als tumorwachstumshemmer - Google Patents

5-androsten 3-beta, 17-alpha diol als tumorwachstumshemmer

Info

Publication number: ATE243518T1
Authority: AT; Austria
Prior art keywords: beta; androsten; tumor growth; alpha; growth inhibitor
Prior art date: 1996-04-11

Application number

AT97920244T

Other languages

English (en)

Inventor

Roger M Loria

Original Assignee

Roger M Loria

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-11

Filing date

1997-04-10

Publication date

2003-07-15

1997-04-10 Application filed by Roger M Loria filed Critical Roger M Loria

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE243518T1 publication Critical patent/ATE243518T1/de

Links

QADHLRWLCPCEKT-SLMGBJJTSA-N (3s,8r,9s,10r,13s,14s,17r)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CC=C21 QADHLRWLCPCEKT-SLMGBJJTSA-N 0.000 title 1
239000003966 growth inhibitor Substances 0.000 title 1
230000004614 tumor growth Effects 0.000 title 1
QADHLRWLCPCEKT-UHFFFAOYSA-N Androstenediol Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)O)C4C3CC=C21 QADHLRWLCPCEKT-UHFFFAOYSA-N 0.000 abstract 1
QADHLRWLCPCEKT-LOVVWNRFSA-N androst-5-ene-3beta,17beta-diol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC=C21 QADHLRWLCPCEKT-LOVVWNRFSA-N 0.000 abstract 1
229950009148 androstenediol Drugs 0.000 abstract 1
238000003782 apoptosis assay Methods 0.000 abstract 1
230000032677 cell aging Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
230000005522 programmed cell death Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT97920244T 1996-04-11 1997-04-10 5-androsten 3-beta, 17-alpha diol als tumorwachstumshemmer ATE243518T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1504296P	1996-04-11	1996-04-11
US1898596P	1996-06-04	1996-06-04
PCT/US1997/005849 WO1997037662A1 (en)	1996-04-11	1997-04-10	5-ANDROSTENE 3β,17α DIOL AS AN INHIBITOR OF TUMOR GROWTH

Publications (1)

Publication Number	Publication Date
ATE243518T1 true ATE243518T1 (de)	2003-07-15

Family

ID=26686886

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT97920244T ATE243518T1 (de)	1996-04-11	1997-04-10	5-androsten 3-beta, 17-alpha diol als tumorwachstumshemmer
AT03014193T ATE311886T1 (de)	1996-04-11	1997-04-10	Verwendung einer zusammensetzung enthaltend 5- androsten-3beta,17alpha-diol

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT03014193T ATE311886T1 (de)	1996-04-11	1997-04-10	Verwendung einer zusammensetzung enthaltend 5- androsten-3beta,17alpha-diol

Country Status (8)

Country	Link
EP (1)	EP0925064B1 (de)
JP (1)	JP2000508643A (de)
AT (2)	ATE243518T1 (de)
DE (2)	DE60308917T2 (de)
DK (1)	DK0925064T3 (de)
ES (2)	ES2254828T3 (de)
PT (1)	PT925064E (de)
WO (1)	WO1997037662A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1362591B1 (de) *	1996-04-11	2005-12-07	LORIA, Roger M.	Verwendung einer Zusammensetzung enthaltend 5-Androsten-3beta,17alpha-diol
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en)	1998-06-11	2006-02-28	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
PT1955700E (pt)	1999-09-30	2011-05-04	Harbor Biosciences Inc	Tratamento terap?utico de doen?as associadas ao receptor de androg?nios
AU2001241779A1 (en) *	2000-02-25	2001-09-03	Hollis-Eden Pharmaceuticals, Inc.	Method of treatment of prostate cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4898694A (en) *	1987-11-25	1990-02-06	Schwartz Arthur G	17-Hydroxy-steroids
US5461042A (en) *	1988-12-30	1995-10-24	Loria; Roger M.	Regulation of the immune system
US5206008A (en) *	1991-04-15	1993-04-27	Virginia Commonwealth University	Enhancement of immune response
US5478566A (en) *	1993-09-29	1995-12-26	Loria; Roger M.	Stimulation of cytokine production

1997
- 1997-04-10 EP EP97920244A patent/EP0925064B1/de not_active Expired - Lifetime
- 1997-04-10 DK DK97920244T patent/DK0925064T3/da active
- 1997-04-10 ES ES03014193T patent/ES2254828T3/es not_active Expired - Lifetime
- 1997-04-10 PT PT97920244T patent/PT925064E/pt unknown
- 1997-04-10 DE DE60308917T patent/DE60308917T2/de not_active Expired - Fee Related
- 1997-04-10 AT AT97920244T patent/ATE243518T1/de not_active IP Right Cessation
- 1997-04-10 JP JP9536454A patent/JP2000508643A/ja not_active Ceased
- 1997-04-10 ES ES97920244T patent/ES2202606T3/es not_active Expired - Lifetime
- 1997-04-10 AT AT03014193T patent/ATE311886T1/de not_active IP Right Cessation
- 1997-04-10 WO PCT/US1997/005849 patent/WO1997037662A1/en not_active Ceased
- 1997-04-10 DE DE69723087T patent/DE69723087T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60308917T2 (de)	2006-12-28
EP0925064A1 (de)	1999-06-30
EP0925064A4 (de)	2001-11-07
ATE311886T1 (de)	2005-12-15
EP0925064B1 (de)	2003-06-25
DE69723087D1 (de)	2003-07-31
DE60308917D1 (de)	2006-11-16
DK0925064T3 (da)	2003-10-20
ES2254828T3 (es)	2006-06-16
WO1997037662A1 (en)	1997-10-16
ES2202606T3 (es)	2004-04-01
DE69723087T2 (de)	2004-05-06
JP2000508643A (ja)	2000-07-11
PT925064E (pt)	2003-11-28

Legal Events

Date

Code

Title

Description

2004-01-15

UEP

Publication of translation of european patent specification

Ref document number: 0925064

Country of ref document: EP

2009-01-15

REN

Ceased due to non-payment of the annual fee

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DE3161494D1 (en)	1983-12-29	Cosmetic preparations
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ATE243518T1 (de)	2003-07-15	5-androsten 3-beta, 17-alpha diol als tumorwachstumshemmer
EP0858262A4 (de)	1998-12-02	Thrombininhibitoren
CA2252110A1 (en)	1997-10-16	5-androstene 3.beta.,17.alpha. diol as an inhibitor of tumor growth
WO1999031136A3 (en)	1999-08-26	Methods for maintaining or restoring tissue-appropriate phenotype of soft tissue cells
IL110585A0 (en)	1994-11-11	Tripeptides, their preparation and pharmaceutical compositions containing them
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ATE225793T1 (de)	2002-10-15	Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten
EP0598269A3 (en)	1995-12-13	Apparatus for the culture of living cells and tissues.