ATE225793T1 - Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten - Google Patents

Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten

Info

Publication number
ATE225793T1
ATE225793T1 AT96911556T AT96911556T ATE225793T1 AT E225793 T1 ATE225793 T1 AT E225793T1 AT 96911556 T AT96911556 T AT 96911556T AT 96911556 T AT96911556 T AT 96911556T AT E225793 T1 ATE225793 T1 AT E225793T1
Authority
AT
Austria
Prior art keywords
indolecarbazoles
contain hydroxyl
soluble esters
esters
selected soluble
Prior art date
Application number
AT96911556T
Other languages
English (en)
Inventor
John P Mallamo
Robert L Hudkins
Original Assignee
Cephalon Inc
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/417,611 external-priority patent/US5650407A/en
Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE225793T1 publication Critical patent/ATE225793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
AT96911556T 1995-04-05 1996-04-03 Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten ATE225793T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/417,611 US5650407A (en) 1995-04-05 1995-04-05 Selected soluble esters of hydroxyl-containing indolocarbazoles
US08/624,707 US5686444A (en) 1995-04-05 1996-03-26 Selected soluble esters of hydroxyl-containing indolocarbazoles
PCT/US1996/004568 WO1996031515A1 (en) 1995-04-05 1996-04-03 Selected soluble esters of hydroxyl-containing indolocarbazoles

Publications (1)

Publication Number Publication Date
ATE225793T1 true ATE225793T1 (de) 2002-10-15

Family

ID=27023791

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911556T ATE225793T1 (de) 1995-04-05 1996-04-03 Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten

Country Status (15)

Country Link
US (2) US5686444A (de)
EP (1) EP0827505B1 (de)
JP (1) JPH11504623A (de)
KR (1) KR100429117B1 (de)
AT (1) ATE225793T1 (de)
AU (1) AU700658B2 (de)
BR (1) BR9608044A (de)
CA (1) CA2215111A1 (de)
DE (1) DE69624236T2 (de)
DK (1) DK0827505T3 (de)
ES (1) ES2183941T3 (de)
NO (1) NO311575B1 (de)
NZ (1) NZ306205A (de)
PT (1) PT827505E (de)
WO (1) WO1996031515A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686444A (en) 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
WO1999033795A1 (en) * 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6200968B1 (en) * 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
CN1329034C (zh) * 1998-09-25 2007-08-01 赛福伦公司 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1500989A (fr) * 1966-08-30 1967-11-10 Produits cosmétiques pour les soins de la peau
GB1317185A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Acyloxy-3alpha-hydroxy-pregnones
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4894226A (en) * 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
JPH0826036B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
US4923986A (en) * 1987-03-09 1990-05-08 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance K-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
WO1993008809A1 (en) * 1991-11-08 1993-05-13 The University Of Southern California Compositions containing k-252 compounds for potentiation of neurotrophin activity
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
EP0630898B1 (de) * 1992-09-21 2001-11-28 Kyowa Hakko Kogyo Co., Ltd. Heilmittel für thrombozytopenia
WO1994020106A1 (fr) * 1993-03-03 1994-09-15 Kyowa Hakko Kogyo Co., Ltd. Renforceur de sensibilite pour agent antineoplasique
EP0699204B1 (de) * 1993-05-28 1998-04-15 Cephalon, Inc. Anwendung von indolocarbazol-derivaten zur behandlung von prostataerkrankungen
US5686444A (en) 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US5650407A (en) 1995-04-05 1997-07-22 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles

Also Published As

Publication number Publication date
AU700658B2 (en) 1999-01-14
EP0827505A1 (de) 1998-03-11
NO974580D0 (no) 1997-10-03
DE69624236D1 (de) 2002-11-14
KR100429117B1 (ko) 2004-07-19
BR9608044A (pt) 1999-01-26
NO974580L (no) 1997-11-27
NZ306205A (en) 2000-01-28
ES2183941T3 (es) 2003-04-01
MX9707632A (es) 1998-06-30
CA2215111A1 (en) 1996-10-10
NO311575B1 (no) 2001-12-10
JPH11504623A (ja) 1999-04-27
AU5440896A (en) 1996-10-23
EP0827505B1 (de) 2002-10-09
US5686444A (en) 1997-11-11
WO1996031515A1 (en) 1996-10-10
EP0827505A4 (de) 1998-08-12
USRE38332E1 (en) 2003-11-25
DK0827505T3 (da) 2003-02-17
DE69624236T2 (de) 2003-09-11
KR19980703588A (ko) 1998-11-05
PT827505E (pt) 2003-01-31
HK1009370A1 (en) 1999-06-04

Similar Documents

Publication Publication Date Title
AU693747B2 (en) Imidazo(4,5-c)pyridin-4-amines
EP0386757A3 (en) Biodegradable poly (phosphate esters)
EP0450771A3 (en) Method and apparatus for writing by the emission of atoms
AU8050791A (en) Compositions and methods for the controlled release of soluble active substances
EP0712384A4 (de) Wasserfreie gaserzeugende tetrazolzusammensetzung und verfahren zur herstellung
ES2186783T3 (es) Derivados de la dolastatina, su preparacion y uso.
AU6272896A (en) Methods for the generation of sequence signatures from nucle ic acids
DE69302634D1 (de) Pfropfcopolymer, Verfahren zur Herstellung davon und dieses Copolymer als aktive Komponente enthaltende Weichmacher
DE69007625D1 (de) Absorbierende mittelzusammenstellung und verfahren zur herstellung derselben.
DE69735583D1 (de) Semisynthetisches verfahren zur herstellung von didemninanalogen
AU2821295A (en) Compositions and methods for the treatment of tumors
IL122942A0 (en) Esters of 1-beta-d-arabinofuranosylcytosine and pharmaceutical compositions containing them
DE69624236D1 (de) Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten
JO1677B1 (en) 3,3 'compounds - dithiobase (prepernic acid) and its organic salts
MX9305998A (es) 6-heterociclic-4-amino-1, 3, 4, 5,-tetrahidrobenz[cd] indoles yprocedimiento para su preparacion.
ES483661A1 (es) Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos
NZ223293A (en) Beta-alkyl melatonins and pharmaceutical compositions
AU6786898A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric di sorders
DE69011990D1 (de) Verfahren zur Herstellung eines Esters.
DE69220176D1 (de) Verfahren zur Herstellung eines Emulsionspfropfcopolymers
AU7770991A (en) Method and composition for the treatment of cancer
GEP20084346B (en) Protein kinase c inhibitors
EP0925064A4 (de) 5-ANDROSTEN 3-beta, 17-alpha DIOL ALS TUMORWACHSTUMSHEMMER
AU6786798A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric di sorders
ATE113291T1 (de) Polyaromatische ester von makroliden antibiotika und linkosamiden antibiotika, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutischen und kosmetischen zusammensetzungen.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee