ATE243537T1 - Vernetzung von bioprothesematerial zur kalzifikationsverminderung nach implantation - Google Patents

Vernetzung von bioprothesematerial zur kalzifikationsverminderung nach implantation

Info

Publication number
ATE243537T1
ATE243537T1 AT99948339T AT99948339T ATE243537T1 AT E243537 T1 ATE243537 T1 AT E243537T1 AT 99948339 T AT99948339 T AT 99948339T AT 99948339 T AT99948339 T AT 99948339T AT E243537 T1 ATE243537 T1 AT E243537T1
Authority
AT
Austria
Prior art keywords
tissue
bioprosthesis
crosslinking
biological
immersing
Prior art date
Application number
AT99948339T
Other languages
English (en)
Inventor
Crystal M Cunanan
Lillian Quintero
Michael N Helmus
Christine Loshbaugh
Chris H Sarner
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Application granted granted Critical
Publication of ATE243537T1 publication Critical patent/ATE243537T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/916—Blood vessel
    • Y10S623/917—Collagen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
AT99948339T 1998-09-21 1999-09-20 Vernetzung von bioprothesematerial zur kalzifikationsverminderung nach implantation ATE243537T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/157,546 US6214054B1 (en) 1998-09-21 1998-09-21 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
PCT/US1999/021707 WO2000016820A1 (en) 1998-09-21 1999-09-20 Crosslinking of bioprosthetic material to mitigate post-implantation calcification

Publications (1)

Publication Number Publication Date
ATE243537T1 true ATE243537T1 (de) 2003-07-15

Family

ID=22564201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99948339T ATE243537T1 (de) 1998-09-21 1999-09-20 Vernetzung von bioprothesematerial zur kalzifikationsverminderung nach implantation

Country Status (9)

Country Link
US (4) US6214054B1 (de)
EP (1) EP1098670B1 (de)
JP (1) JP2002526206A (de)
AT (1) ATE243537T1 (de)
AU (1) AU767210B2 (de)
BR (1) BR9914008A (de)
CA (1) CA2344061C (de)
DE (1) DE69909096T2 (de)
WO (1) WO2000016820A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US20080077251A1 (en) * 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
WO2000064371A1 (en) * 1999-04-27 2000-11-02 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic devices
WO2001015628A2 (en) * 1999-09-01 2001-03-08 Edwards Lifesciences Corporation In vivo screening methods for predicting calcification of implantable prosthetic material
US6458155B1 (en) * 2000-09-01 2002-10-01 Edwards Lifesciences Corporation Fresh donor heart valve sizer and method of use
US20030050276A1 (en) * 2001-08-15 2003-03-13 Cunanan Crystal M. Treatment of tissue, instruments and work surfaces to remove infectious agents
US20030022146A1 (en) * 2001-07-26 2003-01-30 Cunanan Crystal M. Oxidized bioprosthetic materials
US7008591B2 (en) * 2001-10-17 2006-03-07 Edwards Lifesciences Corporation Supercritical fluid extraction process for tissue preparation
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8308797B2 (en) * 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
WO2004006974A1 (en) * 2002-07-16 2004-01-22 Edwards Lifesciences Corporation Enhanced phospholipid reduction and calcification mitigation of biological materials
US20040024452A1 (en) * 2002-08-02 2004-02-05 Kruse Steven D. Valved prostheses with preformed tissue leaflets
US7008763B2 (en) * 2002-09-23 2006-03-07 Cheung David T Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7989157B2 (en) * 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20060195183A1 (en) * 2005-02-18 2006-08-31 The Cleveland Clinic Foundation Apparatus and methods for replacing a cardiac valve
US7579381B2 (en) * 2005-03-25 2009-08-25 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US20060259135A1 (en) * 2005-04-20 2006-11-16 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
EP1895942B1 (de) 2005-05-27 2020-05-13 Medtronic, Inc. Dichtung mit kragen für künstliche herzklappen
CN100443064C (zh) * 2005-09-08 2008-12-17 吴忠仕 用于肺动脉血管修复或重建的生物带瓣管道及制备方法
CN1986001B (zh) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 生物护创膜
CN1986006A (zh) 2005-12-20 2007-06-27 广州知光生物科技有限公司 生物型神经导管
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US20080275550A1 (en) * 2006-02-24 2008-11-06 Arash Kheradvar Implantable small percutaneous valve and methods of delivery
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US9006510B2 (en) * 2006-06-29 2015-04-14 Mayo Foundation For Medical Education And Research Genetically modified heart valve xenografts
US8007992B2 (en) * 2006-10-27 2011-08-30 Edwards Lifesciences Corporation Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol
US8142805B1 (en) 2006-11-06 2012-03-27 Clemson University Research Foundation Implantable devices including fixed tissues
US8105375B2 (en) * 2007-01-19 2012-01-31 The Cleveland Clinic Foundation Method for implanting a cardiovascular valve
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US20080294248A1 (en) * 2007-05-25 2008-11-27 Medical Entrepreneurs Ii, Inc. Prosthetic Heart Valve
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US8211165B1 (en) 2008-01-08 2012-07-03 Cook Medical Technologies Llc Implantable device for placement in a vessel having a variable size
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
AU2009295960A1 (en) 2008-09-29 2010-04-01 Cardiaq Valve Technologies, Inc. Heart valve
EP2341871B1 (de) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Abgabesystem für ein gefässimplantat
CN102438553A (zh) * 2009-03-31 2012-05-02 天成医疗有限公司 瓣叶对齐固定装置及其使用方法
US20100261662A1 (en) * 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
EP4119098A1 (de) 2009-04-15 2023-01-18 Edwards Lifesciences CardiAQ LLC Gefässimplantat und freisetzungssystem
CA2760461C (en) 2009-04-29 2014-10-07 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
WO2011002996A2 (en) * 2009-07-02 2011-01-06 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
EP2550029A4 (de) * 2010-03-15 2014-06-18 Peridyne Medical Llc Dünnes kollagengewebe für medizinproduktanwendungen
US9211361B2 (en) * 2010-03-15 2015-12-15 Kemal Schankereli Thin collagen tissue for medical device applications
BR122014006876B1 (pt) 2010-03-23 2020-09-29 Edwards Lifesciences Corporation Método para preparar material de membrana de tecido bioprotético
FR2959134B1 (fr) * 2010-04-22 2012-07-13 Carmat Procede pour l'obtention d'un materiau hemocompatible composite et materiau obtenu
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
WO2011139488A2 (en) 2010-05-06 2011-11-10 Mayo Foundation For Medical Education And Research Methods and materials for reducing cardiac xenograft rejection
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
WO2011147849A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
CN102946916B (zh) 2010-06-17 2015-03-18 爱德华兹生命科学公司 通过化学修饰抗原性碳水化合物稳定生物假体组织的方法
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
CN103391756B (zh) 2010-12-14 2016-06-01 科利柏心脏瓣膜有限责任公司 包括具有整合瓣叶的折叠膜尖瓣的可经皮输送的心脏瓣膜
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
CN102499993B (zh) * 2011-11-01 2014-01-15 上海微创医疗器械（集团）有限公司 一种边缘刚性化人工生物瓣膜的制备方法
WO2013169366A1 (en) 2012-05-11 2013-11-14 Rti Biologics, Inc. Xenograft soft tissue implants and methods of making and using
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
EP2712633B1 (de) * 2012-10-02 2015-04-29 Biotronik AG Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
WO2014144247A1 (en) 2013-03-15 2014-09-18 Arash Kheradvar Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
WO2016022797A1 (en) 2014-08-06 2016-02-11 Edwards Lifesciences Corporation Multi-lumen cannulae
EP3270825B1 (de) 2015-03-20 2020-04-22 JenaValve Technology, Inc. Herzklappenprothesenzuführsystem
EP3288495B1 (de) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Vorrichtung mit reduzierter herzschrittmacherrate bei herzklappenersatz
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
WO2018148839A1 (en) 2017-02-17 2018-08-23 Cardiovascular Diagnostics Inc. Transcatheter heart valve apparatus for calcific mitral stenosis
CA3062547A1 (en) 2017-05-31 2018-12-06 Edwards Lifesciences Corporation Collagen fibers and articles formed therefrom
EP4122507B1 (de) 2017-06-29 2024-04-17 St. Jude Medical, Cardiology Division, Inc. Verfahren zum herstellen einer verkalkungsbeständigen bioprosthetischen herzklappe
EP3743124B1 (de) 2018-01-23 2024-05-08 Edwards Lifesciences Corporation Verfahren zum vordehnen von implantierbaren biokompatiblen materialien sowie daraus hergestellte materialien und vorrichtungen
EP3743016B1 (de) 2018-01-23 2024-10-02 Edwards Lifesciences Corporation Halter für prothetische klappen, systeme und verfahren
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
CA3116158A1 (en) 2018-11-01 2020-05-07 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve
US11648109B2 (en) 2019-02-04 2023-05-16 Medtronic, Inc. Balloon expandable frame for transcatheter implantation of a cardiac valve prosthesis
CN113646015B (zh) * 2019-04-10 2023-01-10 美利奴生命科学有限公司 防止生物假体中使用的组织降解和退化的方法
US11771554B2 (en) 2019-05-17 2023-10-03 Medtronic, Inc. Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis
EP3965841A1 (de) 2019-12-09 2022-03-16 Edwards Lifesciences Corporation Bioprothetische gewebepräparation
RU2741224C1 (ru) * 2019-12-18 2021-01-22 Общество с ограниченной ответственностью "Ангиолайн Ресерч" Способ обработки биологической ткани для имплантируемого биопротеза
US12011349B2 (en) 2020-03-04 2024-06-18 Medtronic, Inc. Balloon expandable stent with lengthened commissure posts for transcatheter implantation of a cardiac valve prosthesis
US12083009B2 (en) 2020-04-15 2024-09-10 Vitae LLC Method of processing collagen-based tissue for bioprosthetic devices
EP4188281A1 (de) 2020-08-03 2023-06-07 Medtronic, Inc. Ballonexpandierbarer stent mit symmetrischer crimpkonfiguration zur transkatheterimplantation einer herzklappenprothese
US12275947B2 (en) 2021-10-25 2025-04-15 Fios Therapeutics, Llc Viable genetically modified sheep with an inactivated alpha-1,3-galactosyltransferase (GGTA1) gene
EP4422392A1 (de) 2021-10-25 2024-09-04 Fios Therapeutics, LLC Knockout-how für lebensfähige galactosyltransferase und verwandte verfahren
US12171658B2 (en) 2022-11-09 2024-12-24 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant
US20240173443A1 (en) * 2022-11-25 2024-05-30 InnovMedics, LLC Sterilizing biological tissue with supercritical carbon dioxide
WO2025199058A1 (en) 2024-03-21 2025-09-25 Edwards Lifesciences Corporation Water-soluble lubricants and applications for transcatheter valve replacement therapies

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2567929A (en) 1951-09-18 Process for preserving plant tissues
US2393580A (en) * 1942-03-31 1946-01-22 Edwin C Weiskopf Method of preparing tissue
US2484813A (en) 1945-06-06 1949-10-18 John O Bower Spun suture
US3002895A (en) * 1957-02-11 1961-10-03 Freedman David Incubator-shaker apparatus
US3093439A (en) * 1961-07-05 1963-06-11 Johnson & Johnson Process for preparing tanned collagenous material with dialdehyde starch
US3961097A (en) * 1971-10-28 1976-06-01 Gravlee Jr Joseph F Method of preparing tissue for microscopic examination
US3870789A (en) * 1972-12-01 1975-03-11 Kurt W Mikat Enhancement of morphologic detail in tissue
US3927422A (en) * 1973-12-12 1975-12-23 Philip Nicholas Sawyer Prosthesis and method for making same
US3966401A (en) * 1974-07-01 1976-06-29 Hancock Laboratories Incorporated Preparing natural tissue for implantation so as to provide improved flexibility
US4050893A (en) * 1974-07-22 1977-09-27 Hancock Laboratories, Inc. Arrangement for preparing natural tissue for implantation
IL47062A (en) 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4082507A (en) * 1976-05-10 1978-04-04 Sawyer Philip Nicholas Prosthesis and method for making the same
US4067091A (en) 1976-11-15 1978-01-10 Backman Philip E Method of preparing human remains for storage
US4120991A (en) 1976-12-10 1978-10-17 Technicon Instruments Corporation Process for mounting tissue sections with an U.V. light curable mounting medium
US4205059A (en) 1977-03-09 1980-05-27 Hagens Gunther Von Animal and vegetal tissues permanently preserved by synthetic resin impregnation
CA1087101A (en) 1977-08-05 1980-10-07 Cesar Romero-Sierra Freeze dried biological specimens
US4197658A (en) 1978-05-12 1980-04-15 Fts Systems, Inc. Tissue freeze dryer
US4328256A (en) 1978-08-18 1982-05-04 Queen's University At Kingston Preservation of green plant tissues
DE2914181C2 (de) 1979-04-07 1982-06-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren und Vorrichtung zum Trocknen temperaturempfindlicher Güter der Pharma- und Nahrungsmittelindustrie
US4294753A (en) 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4378224A (en) 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US4323358A (en) * 1981-04-30 1982-04-06 Vascor, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4372743A (en) * 1981-06-22 1983-02-08 American Hospital Supply Corp. Low-pressure fixation of valvular tissue intended for implantation
US4350492A (en) * 1981-08-24 1982-09-21 Vascor, Inc. Method for preparing tissue heart valve
FR2523810B1 (fr) 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
US4481009A (en) 1982-05-13 1984-11-06 American Hospital Supply Corporation Polymer incorporation into implantable biological tissue to inhibit calcification
US4405327A (en) 1982-08-25 1983-09-20 Extracorporeal Medical Specialties, Inc. Method for inhibiting mineralization of natural tissue during implantation
US4402697A (en) * 1982-08-25 1983-09-06 Extracorporeal Medical Specialties, Inc. Method for inhibiting mineralization of natural tissue during implantation
EP0124596A4 (de) 1982-11-12 1985-06-26 American Hospital Supply Corp Chemische sterilisation einpflanzbarer biologischer gewebe.
WO1984001879A1 (en) 1982-11-12 1984-05-24 American Hospital Supply Corp Surfactant treatment of implantable biological tissue to inhibit calcification
US5215541A (en) * 1982-11-12 1993-06-01 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
US4885005A (en) 1982-11-12 1989-12-05 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
US4599084A (en) 1983-05-24 1986-07-08 American Hospital Supply Corp. Method of using biological tissue to promote even bone growth
IT1159433B (it) * 1983-07-25 1987-02-25 Sorin Biomedica Spa Procedimento ed apparecchiatura per la fabbricazione di lembi valvolari per protesi valvolari cardiache e protesi valvolare cardiaca provvista di tali lembi
US5024830A (en) 1983-08-23 1991-06-18 The Board Of Regents, The University Of Texas Method for cryopreparing biological tissue for ultrastructural analysis
US4676070A (en) 1984-11-30 1987-06-30 The Board Of Regents, The University Of Texas Apparatus and method for cryopreparing biological tissue
US4865871A (en) 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
US4562047A (en) * 1983-12-19 1985-12-31 American Sterilizer Company Indicator seal and sterilizer container
US4753652A (en) 1984-05-04 1988-06-28 Children's Medical Center Corporation Biomaterial implants which resist calcification
GB8413319D0 (en) 1984-05-24 1984-06-27 Oliver Roy Frederick Biological material
US4553974A (en) 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
IT1180531B (it) 1984-09-21 1987-09-23 Ge Sv In Srl Protesi valvolare cardiaca bicuspide
US5011913A (en) 1985-06-28 1991-04-30 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
JPH0779694B2 (ja) 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
US4770665A (en) * 1985-11-05 1988-09-13 American Hospital Supply Corporation Elastomeric polymer incorporation into implantable biological tissue to inhibit calcification
US4729139A (en) 1985-11-05 1988-03-08 Baxter Travenol Selective incorporation of a polymer into implantable biological tissue to inhibit calcification
DE3541478A1 (de) 1985-11-23 1987-05-27 Beiersdorf Ag Herzklappenprothese und verfahren zu deren herstellung
US4911713A (en) * 1986-03-26 1990-03-27 Sauvage Lester R Method of making vascular prosthesis by perfusion
US5904718A (en) 1986-03-27 1999-05-18 Biocoll Laboratories, Inc. Delayed drug delivery system
US5108923A (en) 1986-04-25 1992-04-28 Collaborative Research, Inc. Bioadhesives for cell and tissue adhesion
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US4786287A (en) * 1986-10-10 1988-11-22 Baxter Travenol Laboratories Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue
US5044165A (en) 1986-12-03 1991-09-03 Board Of Regents, The University Of Texas Cryo-slammer
US4800603A (en) * 1987-01-30 1989-01-31 Jaffe Norman R Tissue fixation with vapor
US4838888A (en) 1987-04-17 1989-06-13 Baxter Travenol Laboratories, Inc. Calcification mitigation of implantable bioprostheses
FR2617855B1 (fr) 1987-07-08 1992-02-21 Bioetica Sa Procede de reticulation du collagene par introduction de groupes azides ainsi que les tissus et biomateriaux obtenus par mise en oeuvre du procede
US5147514A (en) 1987-08-02 1992-09-15 University Of North Carolina Process for cross-linking collagenous material and resulting product
US5149621A (en) 1987-08-21 1992-09-22 Cryolife, Inc. & Medical Univ. Of South Carolina Kit for cryopreserving blood vessels
JP2529112B2 (ja) 1987-08-31 1996-08-28 株式会社 高研 生体弁
US5131908A (en) * 1987-09-01 1992-07-21 Herbert Dardik Tubular prosthesis for vascular reconstructive surgery and process for preparing same
US4990131A (en) * 1987-09-01 1991-02-05 Herbert Dardik Tubular prostheses for vascular reconstructive surgery and process for preparing same
US4994237A (en) 1987-10-02 1991-02-19 The Beth Israel Hospital Association Microwave preservation of bioprostheses
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US4976733A (en) 1988-02-03 1990-12-11 Biomedical Design, Inc. Prevention of prosthesis calcification
US4969912A (en) 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
US5746775A (en) 1988-04-01 1998-05-05 The Board Of Regent6S Of The University Of Michigan Method of making calcification-resistant bioprosthetic tissue
US5094661A (en) 1988-04-01 1992-03-10 The University Of Michigan Calcification-resistant materials and methods of making same through use of trivalent aluminum
US5368608A (en) 1988-04-01 1994-11-29 University Of Michigan, The Board Of Regents Calcification-resistant materials and methods of making same through use of multivalent cations
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US4994030A (en) 1988-06-28 1991-02-19 Osteotech, Inc. Reconstitution of human bone and tissue
DE3834545A1 (de) * 1988-10-11 1990-04-12 Rau Guenter Flexibles schliessorgan, insbesondere herzklappe, und verfahren zur herstellung desselben
US5002566A (en) 1989-02-17 1991-03-26 Baxter International Inc. Calcification mitigation of bioprosthetic implants
DE69019512T2 (de) * 1989-02-17 1996-02-15 Baxter Int Verhinderung von verkalkung in bioprosthetischen implantaten.
US5068100A (en) 1989-03-09 1991-11-26 The Procter & Gamble Company Anticalculus compositions
US5051401A (en) 1989-04-07 1991-09-24 University Of South Alabama Inhibition of mineral deposition by phosphorylated and related polyanionic peptides
AU626686B2 (en) * 1989-06-09 1992-08-06 Medtronic, Inc. Dynamic fixation of porcine aortic valves
US4981319A (en) * 1989-07-17 1991-01-01 Ruben Gerzeny Hydraulic lift camper top
EP0411925B1 (de) 1989-08-02 1997-09-24 University Of North Carolina At Chapel Hill Verfahren zur Vernetzung von Kollagen und dadurch erzeugtes Produkt
US5154007A (en) 1989-08-17 1992-10-13 Board Of Regents University Of Texas System Method and apparatus for cryopreparing biological tissue
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US5068086A (en) * 1990-06-12 1991-11-26 Raytheon Company Method and apparatus for batch fixating tissue specimens
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US8067149B2 (en) 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5200399A (en) 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US5104405A (en) * 1991-02-21 1992-04-14 The University Of Southern California Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced
US5275954A (en) * 1991-03-05 1994-01-04 Lifenet Process for demineralization of bone using column extraction
US5998483A (en) 1991-09-20 1999-12-07 Camiener; Gerald W. Glyoxal-containing preservative compositions
US5476516A (en) 1992-03-13 1995-12-19 Albert Einstein College Of Medicine Of Yeshiva University Anticalcification treatment for aldehyde-tanned biological tissue
US5296583A (en) 1992-07-09 1994-03-22 University Of Michigan Calcification-resistant synthetic biomaterials
US5436291A (en) 1992-07-09 1995-07-25 University Of Michigan, The Board Of . . . Calcification-resistant synthetic biomaterials
US5437287A (en) * 1992-08-17 1995-08-01 Carbomedics, Inc. Sterilization of tissue implants using iodine
US5509932A (en) 1993-04-08 1996-04-23 Keogh; James R. Fixed tissue medical devices comprising albumin-binding dyes
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
EP0663214B1 (de) 1994-01-18 1999-03-31 Sci-Can, A Division Of Lux And Zwingenberger Ltd. Anordnung zur Dampf-Sterilisation von ärztlichen Instrumenten, Implantaten und ähnlichem
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
US5447536A (en) 1994-02-17 1995-09-05 Biomedical Design, Inc. Method for fixation of biological tissue
US6203755B1 (en) 1994-03-04 2001-03-20 St. Jude Medical, Inc. Electron beam sterilization of biological tissues
WO1995024873A1 (en) 1994-03-14 1995-09-21 Cryolife, Inc. Treated tissue for implantation and preparation methods
US5595571A (en) 1994-04-18 1997-01-21 Hancock Jaffe Laboratories Biological material pre-fixation treatment
EP0757562A1 (de) 1994-04-29 1997-02-12 W.L. Gore & Associates, Inc. Blutkontaktoberfläche unter verwendung von endothel auf einer subendotelialen extrazellulären matrix
JPH09512463A (ja) 1994-04-29 1997-12-16 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 天然内皮下基質を利用した改善された血液接触表面並びにその製造及び利用方法
US5558875A (en) 1994-06-06 1996-09-24 Wang; Su Method of preparing collagenous tissue
EP0713400A1 (de) 1994-06-15 1996-05-29 St.Jude Medical, Inc Erhöhte quervernetzung von natürlichem geweben
KR0131046B1 (ko) 1994-07-13 1998-04-14 김은영 항석회화 생체 조직 인공 심장 판막
US5931969A (en) * 1994-07-29 1999-08-03 Baxter International Inc. Methods and apparatuses for treating biological tissue to mitigate calcification
JP3797673B2 (ja) 1994-07-29 2006-07-19 エドワーズ ライフサイエンシーズ コーポレイション 石灰化を軽減するための移植可能な生物学的組織の処理方法およびこのような方法で処理された生体補綴物
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US5556379A (en) 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5549666A (en) 1994-09-02 1996-08-27 Baxter International Inc. Natural tissue valve prostheses having variably complaint leaflets
US5674298A (en) * 1994-10-21 1997-10-07 The Board Of Regents Of The University Of Michigan Calcification-resistant bioprosthetic tissue and methods of making same
KR0129833B1 (ko) * 1994-11-09 1998-04-04 박성수 조직 배양 방법 및 장치
US6372228B1 (en) 1994-11-15 2002-04-16 Kenton W. Gregory Method of producing elastin, elastin-based biomaterials and tropoelastin materials
AU692330B2 (en) 1994-12-30 1998-06-04 National University Of Singapore, The Method for reducing calcification of biological tissue used in implantable bioprostheses
WO1996032905A1 (en) 1995-04-19 1996-10-24 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US5913900A (en) 1995-06-07 1999-06-22 Corsscart, Inc. Substantially native meniscal cartilage heterografts
US6231608B1 (en) 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
US5865849A (en) 1995-06-07 1999-02-02 Crosscart, Inc. Meniscal heterografts
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5902338A (en) 1995-09-15 1999-05-11 Crosscart, Inc. Anterior cruciate ligament heterograft
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US6193749B1 (en) 1996-02-05 2001-02-27 St. Jude Medical, Inc. Calcification-resistant biomaterials
US6302909B1 (en) 1996-07-31 2001-10-16 St. Jude Medical, Inc. Calcification-resistant biomaterials
IT1285308B1 (it) 1996-03-12 1998-06-03 Sorin Biomedica Cardio Spa Procedimento per la preparazione di materiale biologico per impianto
US5919472A (en) 1996-03-19 1999-07-06 Medtronic, Inc. Treatment of aldehyde-fixed tissue
US6024735A (en) 1996-03-20 2000-02-15 Lifenet Research Foundation Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby
US5925552A (en) 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
US5945319A (en) 1996-04-25 1999-08-31 Medtronic, Inc. Periodate oxidative method for attachment of biomolecules to medical device surfaces
US5928916A (en) 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
US5766520A (en) 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation
US5645587A (en) 1996-06-05 1997-07-08 Chanda; Jyotirmay Prevention of calcification and degeneration of biological tissue grafts for implantation in humans
US5782931A (en) * 1996-07-30 1998-07-21 Baxter International Inc. Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods
US6121041A (en) 1996-07-31 2000-09-19 St. Jude Medical, Inc. Use of microorganisms for decellularizing bioprosthetic tissue
US6764509B2 (en) 1996-09-06 2004-07-20 Carbomedics Inc. Prosthetic heart valve with surface modification
US5782914A (en) 1996-11-29 1998-07-21 Bio-Vascular, Inc. Method for preparing heterogeneous tissue grafts
US5856172A (en) 1997-01-03 1999-01-05 Quality Technologies, Llc Preservation of microorganisms in a vial with a cap comprising an immobilized desiccant
US6506339B1 (en) 1997-02-10 2003-01-14 Biomedical Design, Inc. Method of sterilization
DE69814070T2 (de) * 1997-02-10 2003-12-18 Biomedical Design, Inc. Sterilisationsverfahren
US5856102A (en) 1997-02-26 1999-01-05 Bierke-Nelson; Diane Lynn Home/self-storage to improve DNA banking
AU746318B2 (en) 1997-04-11 2002-04-18 Cryolife, Inc. Tissue decellularization
US5891196A (en) * 1997-04-16 1999-04-06 Baxter International Inc. Method for actively binding heparin to crosslinked biological tissues
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US5987720A (en) 1997-07-08 1999-11-23 Yamamoto; William Shigeru Portable tomb for resurrection from mummified tissue DNA
US6166184A (en) 1997-08-18 2000-12-26 Medtronic Inc. Process for making a bioprosthetic device
US6117979A (en) 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US5862806A (en) 1997-10-30 1999-01-26 Mitroflow International, Inc. Borohydride reduction of biological tissues
US6267782B1 (en) 1997-11-20 2001-07-31 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal
US6008292A (en) * 1997-12-02 1999-12-28 Baxter International Inc. Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
US6254635B1 (en) 1998-02-02 2001-07-03 St. Jude Medical, Inc. Calcification-resistant medical articles
US6093530A (en) 1998-02-06 2000-07-25 Sulzer Carbomedics Inc. Non-calcific biomaterial by glutaraldehyde followed by oxidative fixation
US6251579B1 (en) 1998-02-13 2001-06-26 Sulzer Carbomedics Inc. Oxidative stabilization of collagen containing materials
US6383732B1 (en) 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
US6258320B1 (en) 1998-04-09 2001-07-10 David H. Persing Method for preservation of nucleic acids
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US7063726B2 (en) 1998-06-30 2006-06-20 Lifenet Plasticized bone grafts and methods of making and using same
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US6527979B2 (en) 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
US6156531A (en) 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
ES2234311T3 (es) 1998-09-30 2005-06-16 Medtronic, Inc. Procedimiento que permite reducir la mineralizacion de un tejido utilizado para un transplante.
US6214055B1 (en) 1998-10-30 2001-04-10 Mures Cardiovascular Research, Inc. Method and kit for rapid preparation of autologous tissue medical devices
US6066160A (en) 1998-11-23 2000-05-23 Quickie Llc Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing
US6375680B1 (en) 1998-12-01 2002-04-23 St. Jude Medical, Inc. Substrates for forming synthetic tissues
US6106555A (en) 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
US6364905B1 (en) 1999-01-27 2002-04-02 Sulzer Carbomedics Inc. Tri-composite, full root, stentless valve
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
DK1820516T3 (da) 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
US6287338B1 (en) 1999-03-10 2001-09-11 Sulzer Carbomedics Inc. Pre-stressing devices incorporating materials subject to stress softening
US6322593B1 (en) 1999-04-09 2001-11-27 Sulzer Carbomedics Inc. Method for treating cross-linked biological tissues
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
US6132986A (en) 1999-04-23 2000-10-17 Sulzer Carbomedics Inc. Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids
US6328762B1 (en) 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6312474B1 (en) 1999-09-15 2001-11-06 Bio-Vascular, Inc. Resorbable implant materials
AU1099901A (en) 1999-10-20 2001-04-30 Grain Processing Corporation Compositions including reduced malto-oligosaccharide preserving agents, and methods for preserving a material
US6322994B1 (en) 1999-11-04 2001-11-27 Genetix Limited Method of freeze-drying organisms
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6471723B1 (en) 2000-01-10 2002-10-29 St. Jude Medical, Inc. Biocompatible prosthetic tissue
US6872226B2 (en) 2001-01-29 2005-03-29 3F Therapeutics, Inc. Method of cutting material for use in implantable medical device
US6391538B1 (en) 2000-02-09 2002-05-21 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic tissue
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
US6696074B2 (en) 2000-12-04 2004-02-24 Tei Biosciences, Inc. Processing fetal or neo-natal tissue to produce a scaffold for tissue engineering
US20020111532A1 (en) 2000-12-19 2002-08-15 Pathak Chandrashekhar P. Tris(hydroxymethyl)phosphino compounds as tissue crosslinking agents
US6468660B2 (en) 2000-12-29 2002-10-22 St. Jude Medical, Inc. Biocompatible adhesives
US7078163B2 (en) 2001-03-30 2006-07-18 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US7918899B2 (en) 2002-01-25 2011-04-05 Biomedical Design, Inc. Variably crosslinked tissue
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
US6908591B2 (en) 2002-07-18 2005-06-21 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
US7189259B2 (en) 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US20040193259A1 (en) 2003-03-25 2004-09-30 Shlomo Gabbay Sizing apparatus for cardiac prostheses and method of using same
EP1626752A2 (de) 2003-05-16 2006-02-22 Blue Membranes GmbH Biokompatibel beschichtete medizinische implantate
WO2005042043A2 (en) 2003-10-28 2005-05-12 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
US7955788B2 (en) 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
US20060177426A1 (en) 2005-02-09 2006-08-10 Cecil Gibson Method of preserving lyophilized microorganisms for transport, storage and recovery of viable microorganisms
US7579381B2 (en) 2005-03-25 2009-08-25 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US20060217804A1 (en) 2005-03-25 2006-09-28 Dove Jeffrey S Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8470022B2 (en) 2005-08-31 2013-06-25 Cook Biotech Incorporated Implantable valve

Also Published As

Publication number Publication date
BR9914008A (pt) 2001-07-03
WO2000016820A1 (en) 2000-03-30
CA2344061A1 (en) 2000-03-30
US20070255423A1 (en) 2007-11-01
US7214344B2 (en) 2007-05-08
US6214054B1 (en) 2001-04-10
US6547827B2 (en) 2003-04-15
JP2002526206A (ja) 2002-08-20
DE69909096D1 (de) 2003-07-31
EP1098670A1 (de) 2001-05-16
AU767210B2 (en) 2003-11-06
CA2344061C (en) 2010-07-06
EP1098670B1 (de) 2003-06-25
DE69909096T2 (de) 2004-05-19
US8236241B2 (en) 2012-08-07
US20030226208A1 (en) 2003-12-11
AU6154399A (en) 2000-04-10
US20010032024A1 (en) 2001-10-18

Similar Documents

Publication Publication Date Title
ATE243537T1 (de) Vernetzung von bioprothesematerial zur kalzifikationsverminderung nach implantation
CA2196165A1 (en) Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods
PT756498E (pt) Tratamento de pre-fixacao de material biologico
DE69901612T2 (de) Verfahren zur herstellung von elastischem dehydriertem implantatgewebe
JP4555570B2 (ja) 移植後の石灰化を軽減する生物補綴組織の処理
CA2312376C (en) Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
DK0987998T3 (da) Decellulering af væv
DK0603920T3 (da) Fremgangsmåde til behandling af knoglevæv og tilsvarende implanterbare biologiske materialer
US5882850A (en) Method for reducing calcification of biological tissue used implantable bioprostheses
JP2002506677A (ja) 骨異種移植片
SE8902565L (sv) Saett foer preparering av en foer implantering avsedd implantatkropp
DE58907855D1 (de) Verfahren zur herstellung von rinder-pericard-materialien und ihre verwendung.
EP1582224A4 (de) Verfahren zur behandlung von biologischem gewebe mittels mikrowellenbestrahlung
Sung et al. Effects of various chemical sterilization methods on the crosslinking and enzymatic degradation characteristics of an epoxy‐fixed biological tissue
EP1124593A1 (de) Verfahren zur präparation von knochenmaterial
Pasquino et al. Bovine pericardium for heart valve bioprostheses: in vitro and in vivo characterization of new chemical treatments
DE3850655T2 (de) Verfahren zur Behandlung von Implantatmaterial und Implantat.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties