ATE243710T1 - Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g - Google Patents
Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin gInfo
- Publication number
- ATE243710T1 ATE243710T1 AT92908481T AT92908481T ATE243710T1 AT E243710 T1 ATE243710 T1 AT E243710T1 AT 92908481 T AT92908481 T AT 92908481T AT 92908481 T AT92908481 T AT 92908481T AT E243710 T1 ATE243710 T1 AT E243710T1
- Authority
- AT
- Austria
- Prior art keywords
- human
- proteins
- neutrophil elastase
- cathepsin inhibitors
- compositions
- Prior art date
Links
- 102000005600 Cathepsins Human genes 0.000 title 1
- 108010084457 Cathepsins Proteins 0.000 title 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 title 1
- 102000052502 human ELANE Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 2
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Insects & Arthropods (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/664,989 US5223409A (en) | 1988-09-02 | 1991-03-01 | Directed evolution of novel binding proteins |
| US71583491A | 1991-06-17 | 1991-06-17 | |
| PCT/US1992/001501 WO1992015605A2 (en) | 1991-03-01 | 1992-02-28 | Inhibitors of human neutrophil elastase and human cathepsin g |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE243710T1 true ATE243710T1 (de) | 2003-07-15 |
Family
ID=27099103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03000399T ATE431364T1 (de) | 1991-03-01 | 1992-02-28 | Inhibitoren der menschlichen elastase von neutrophilen |
| AT92908481T ATE243710T1 (de) | 1991-03-01 | 1992-02-28 | Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03000399T ATE431364T1 (de) | 1991-03-01 | 1992-02-28 | Inhibitoren der menschlichen elastase von neutrophilen |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1325931B1 (de) |
| JP (1) | JP3819931B2 (de) |
| AT (2) | ATE431364T1 (de) |
| AU (1) | AU1581692A (de) |
| CA (1) | CA2105304C (de) |
| DE (3) | DE573603T1 (de) |
| DK (1) | DK0573603T3 (de) |
| ES (1) | ES2124203T3 (de) |
| WO (1) | WO1992015605A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US7078383B2 (en) * | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
| DK1820858T3 (da) | 1991-03-01 | 2009-11-02 | Dyax Corp | Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf |
| US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
| US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
| JP2769083B2 (ja) * | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| JP4221059B2 (ja) * | 1994-06-02 | 2009-02-12 | アベンティス・インコーポレイテッド | エラスターゼインヒビターのプロドラッグとしてのアシル化エノール誘導体 |
| ES2137509T3 (es) * | 1994-06-02 | 1999-12-16 | Merrell Pharma Inc | Perfluoroalquilcetonas, inhibidoras de elastasa y procedimientos para su preparacion. |
| EP0699750A1 (de) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Eine Sammling an Phagemiden, eine Sammling von Escherichia coli Zellen die diese Phagemide tragen, eine Sammling an Phagemid-Partikeln die daraus hergestellt würden und Phagemid-Partikel die durch dieses Verfahren erhalten würden |
| JPH10506463A (ja) * | 1994-09-21 | 1998-06-23 | サイトーゲン コーポレーション | ペプチドライブラリー由来の抗原結合性ペプチド（アブチド） |
| US5885577A (en) * | 1994-09-21 | 1999-03-23 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
| ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
| US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
| HU226419B1 (en) | 1996-03-11 | 2008-12-29 | Aerovance | Human bikunin |
| AR030257A1 (es) * | 1998-12-22 | 2003-08-20 | Bayer Ag | Uso de un inhibidor de proteasa serina de tipo kunitz para la fabricacion de un medicamento para acelerar la velocidad de aclaramiento mucociliar |
| GB9908195D0 (en) | 1999-04-09 | 1999-06-02 | Microbiological Res Authority | Treatment of intracellular infection |
| EP1201249A1 (de) * | 2000-10-31 | 2002-05-02 | Debiopharm S.A. | Suspension von EPI-HNE-4, daraus hergestelltes Trockenpulveraerosol, Herstellungsverfahren und Arzneimittel enthaltend diese Suspension- oder Aerosolzubereitung und ihre Verwendung |
| CN100396329C (zh) * | 2000-10-31 | 2008-06-25 | 德比奥药物股份有限公司 | Epi-hne蛋白质悬浮液,其制备方法,其派生的干粉气溶胶,含有所述悬浮液或气溶胶的药物组合物及其应用 |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| JP2008506391A (ja) * | 2004-07-13 | 2008-03-06 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 改良されたアプロチニン変異体 |
| WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
| JP5985826B2 (ja) | 2008-12-16 | 2016-09-06 | ノバルティス アーゲー | 酵母ディスプレイ系 |
| CN110055221B (zh) * | 2019-04-16 | 2021-10-08 | 清华大学 | 一种基于细胞三维打印技术的类脑疾病治疗组织模型及其制备方法与应用 |
| EP4031138A1 (de) | 2019-09-17 | 2022-07-27 | Mereo Biopharma 4 Limited | Alvelestat zur verwendung bei der behandelung von transplantatabstossung, bronchiolitis-obliterans-syndrom und transplantat-gegen-wirtszelle |
| DK4106757T3 (da) | 2020-04-16 | 2023-10-23 | Mereo Biopharma 4 Ltd | Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel |
| JP2024540952A (ja) | 2021-10-20 | 2024-11-06 | メレオ バイオファーマ ４ リミテッド | 線維化の治療における使用のための好中球エラスターゼ阻害剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| CA1341029C (en) * | 1985-02-04 | 2000-06-20 | Michael Kolb | Peptidase inhibitors |
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| EP1997891A1 (de) * | 1988-09-02 | 2008-12-03 | Dyax Corporation | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
| EP0401508B1 (de) * | 1989-05-13 | 1994-11-23 | Bayer Ag | Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
-
1992
- 1992-02-28 ES ES92908481T patent/ES2124203T3/es not_active Expired - Lifetime
- 1992-02-28 DE DE0573603T patent/DE573603T1/de active Pending
- 1992-02-28 DE DE69233760T patent/DE69233760D1/de not_active Expired - Fee Related
- 1992-02-28 AU AU15816/92A patent/AU1581692A/en not_active Abandoned
- 1992-02-28 DE DE69233108T patent/DE69233108T2/de not_active Expired - Lifetime
- 1992-02-28 DK DK92908481T patent/DK0573603T3/da active
- 1992-02-28 JP JP50820492A patent/JP3819931B2/ja not_active Expired - Fee Related
- 1992-02-28 AT AT03000399T patent/ATE431364T1/de not_active IP Right Cessation
- 1992-02-28 WO PCT/US1992/001501 patent/WO1992015605A2/en not_active Ceased
- 1992-02-28 EP EP03000399A patent/EP1325931B1/de not_active Expired - Lifetime
- 1992-02-28 EP EP92908481A patent/EP0573603B1/de not_active Expired - Lifetime
- 1992-02-28 CA CA002105304A patent/CA2105304C/en not_active Expired - Lifetime
- 1992-02-28 AT AT92908481T patent/ATE243710T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992015605A3 (en) | 1992-12-23 |
| WO1992015605A2 (en) | 1992-09-17 |
| JPH06510522A (ja) | 1994-11-24 |
| EP1325931B1 (de) | 2009-05-13 |
| DE69233760D1 (de) | 2009-06-25 |
| EP0573603B1 (de) | 2003-06-25 |
| DE69233108T2 (de) | 2004-04-29 |
| ES2124203T3 (es) | 2004-04-16 |
| EP1325931A1 (de) | 2003-07-09 |
| AU1581692A (en) | 1992-10-06 |
| DE573603T1 (de) | 1999-05-06 |
| CA2105304A1 (en) | 1992-09-02 |
| EP0573603A1 (de) | 1993-12-15 |
| ATE431364T1 (de) | 2009-05-15 |
| JP3819931B2 (ja) | 2006-09-13 |
| DE69233108D1 (de) | 2003-07-31 |
| CA2105304C (en) | 2005-10-04 |
| DK0573603T3 (da) | 2003-10-20 |
| ES2124203T1 (es) | 1999-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0573603 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |