ATE244015T1 - Formulierungen fuer faktor ix - Google Patents
Formulierungen fuer faktor ixInfo
- Publication number
- ATE244015T1 ATE244015T1 AT95915040T AT95915040T ATE244015T1 AT E244015 T1 ATE244015 T1 AT E244015T1 AT 95915040 T AT95915040 T AT 95915040T AT 95915040 T AT95915040 T AT 95915040T AT E244015 T1 ATE244015 T1 AT E244015T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- formulations
- administration
- methods
- storage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/233,663 US6372716B1 (en) | 1994-04-26 | 1994-04-26 | Formulations for factor IX |
| PCT/US1995/004263 WO1995028954A1 (en) | 1994-04-26 | 1995-04-06 | Formulations for factor ix |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244015T1 true ATE244015T1 (de) | 2003-07-15 |
Family
ID=22878181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95915040T ATE244015T1 (de) | 1994-04-26 | 1995-04-06 | Formulierungen fuer faktor ix |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6372716B1 (de) |
| EP (1) | EP0758248B1 (de) |
| JP (4) | JPH09512267A (de) |
| AT (1) | ATE244015T1 (de) |
| AU (1) | AU695084B2 (de) |
| CA (1) | CA2182200C (de) |
| DE (1) | DE69531204T2 (de) |
| DK (1) | DK0758248T3 (de) |
| ES (1) | ES2202356T3 (de) |
| PT (1) | PT758248E (de) |
| WO (1) | WO1995028954A1 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| US7786070B2 (en) | 1997-09-10 | 2010-08-31 | Novo Nordisk Healthcare A/G | Subcutaneous administration of coagulation factor VII |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| EP1280548B1 (de) | 2000-05-03 | 2013-12-11 | Novo Nordisk Health Care AG | Subkutane Verabreichung des Koagulationsfaktor VII |
| RU2163140C1 (ru) * | 2000-07-05 | 2001-02-20 | Гематологический научный центр РАМН | Концентрат фактора ix системы свертывания крови и способ его получения |
| AU2002225681A1 (en) * | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| RU2357751C2 (ru) | 2001-12-21 | 2009-06-10 | Ново Нордиск Хелт Кэр Аг | Жидкая композиция полипептидов фактора vii |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| BRPI0311959B8 (pt) | 2002-06-21 | 2021-05-25 | Novo Nordisk Healthcare Ag | composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii |
| MXPA05008156A (es) * | 2003-02-01 | 2005-09-30 | Neuralab Ltd | Inmunizacion activa para generar anticuerpos para beta-a soluble. |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| RU2364609C2 (ru) | 2003-05-23 | 2009-08-20 | Ново Нордиск Хелт Кэр Аг | Стабилизация белка в растворе |
| PE20050627A1 (es) * | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| WO2004112828A1 (en) | 2003-06-25 | 2004-12-29 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
| AU2004264282B2 (en) | 2003-08-14 | 2010-10-14 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of Factor VII polypeptides |
| KR20150138427A (ko) | 2003-12-19 | 2015-12-09 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 안정화된 조성물 |
| CA2571292C (en) | 2004-06-30 | 2013-05-21 | Nektar Therapeutics Al, Corporation | Polymer-factor ix moiety conjugates |
| US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
| US20060257396A1 (en) * | 2004-12-15 | 2006-11-16 | Jacobsen Jack S | Abeta antibodies for use in improving cognition |
| PE20061329A1 (es) * | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
| ES2396555T3 (es) * | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| KR20070107079A (ko) * | 2005-01-28 | 2007-11-06 | 와이어쓰 | 안정화된 액체 폴리펩타이드 제형 |
| ES2569917T3 (es) | 2005-06-21 | 2016-05-13 | Xoma (Us) Llc | Anticuerpos y fragmentos de los mismos que se unen a IL-1beta |
| US20070135343A1 (en) | 2005-11-01 | 2007-06-14 | Wyeth | Sodium chloride solution for drug reconstitution or dilution |
| KR20080071192A (ko) * | 2005-11-22 | 2008-08-01 | 와이어쓰 | 면역글로불린 융합 단백질 제형 |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| EP3124045A3 (de) | 2006-12-20 | 2017-05-03 | Xoma (Us) Llc | Behandlung von il-1-beta-bedingten erkrankungen |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| EP2146746A4 (de) * | 2007-04-18 | 2011-03-23 | Janssen Alzheimer Immunotherap | Vorbeugung und behandlung von zerebraler amyloid-angiopathy |
| EP2150537A4 (de) * | 2007-06-01 | 2010-09-22 | Acologix Inc | Hochtemperaturstabile peptidformulierung |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| DK2391650T3 (en) | 2007-12-20 | 2015-01-12 | Xoma Us Llc | Methods of treating gout |
| AU2008340304B2 (en) * | 2007-12-21 | 2016-03-03 | Aptevo Biotherapeutics Llc | Stabilized factor IX formulations containing trehalose |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| PL2889043T3 (pl) * | 2008-12-16 | 2019-09-30 | Genzyme Corporation | Syntetyczne związki pośrednie do wytwarzania koniugatów oligosacharyd-białko |
| WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
| DK2663580T3 (en) | 2011-01-10 | 2017-03-13 | Ct Atlantic Ltd | COMBINATION THERAPY INCLUDING TUMOR ASSOCIATED ANTI-BINDING ANTIBODIES |
| US20140093514A1 (en) | 2011-06-03 | 2014-04-03 | University Of Zurich | Magea3 binding antibodies |
| EP2714743A1 (de) | 2011-06-03 | 2014-04-09 | CT Atlantic Ltd. | Magea3-bindende antikörper |
| JP6320300B2 (ja) | 2011-12-19 | 2018-05-09 | ゾーマ (ユーエス) リミテッド ライアビリティ カンパニー | 座瘡を治療するための方法 |
| US10774132B2 (en) | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
| WO2013106489A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
| TWI810729B (zh) * | 2012-09-25 | 2023-08-01 | 美商百歐維拉提夫治療公司 | Fix多肽的應用 |
| US10441531B2 (en) * | 2012-11-09 | 2019-10-15 | Bloodworks | Protein stabilizing factors |
| CN105358678A (zh) | 2013-03-08 | 2016-02-24 | 密苏里大学董事会 | 治疗和/或预防1型糖尿病的方法和组合物 |
| TWI828269B (zh) | 2013-03-15 | 2024-01-01 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
| EP3019533B1 (de) | 2013-07-11 | 2020-01-08 | The Scripps Research Institute | Doppelwendel-immunglobulinfusionsproteine und zusammensetzungen daraus |
| WO2015017146A2 (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
| US10640574B2 (en) | 2013-07-18 | 2020-05-05 | Taurus Biosciences, Llc | Humanized antibodies with ultralong complementary determining regions |
| AU2014318579A1 (en) | 2013-09-13 | 2016-04-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| WO2015052086A1 (en) | 2013-10-09 | 2015-04-16 | Nestec S.A. | Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome |
| CN105829349B (zh) | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| AU2014337385B2 (en) | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Chimeric antigen receptor T cell switches and uses thereof |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| SG11201607642RA (en) | 2014-03-24 | 2016-10-28 | Biogen Ma Inc | Lyophilized factor ix formulations |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| EP3283113A4 (de) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimierte pne-basierte chimäre t-zell-rezeptor-schalter und verwendungen davon |
| NZ737400A (en) | 2015-06-01 | 2019-09-27 | Medigene Immunotherapies Gmbh | T cell receptor library |
| WO2016193300A1 (en) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | Method for generating antibodies against t cell receptor |
| US20180256716A1 (en) | 2015-06-01 | 2018-09-13 | Medigene Immunotherapies Gmbh | T-cell receptor specific antibodies |
| WO2016205488A1 (en) | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| EA037092B1 (ru) | 2015-07-06 | 2021-02-04 | Юсб Биофарма Срл | Тау-связывающие антитела |
| JP6951825B2 (ja) | 2015-09-04 | 2021-10-20 | ザ スクリプス リサーチ インスティテュート | インスリン免疫グロブリン融合タンパク質 |
| PT3387019T (pt) | 2015-12-09 | 2022-01-14 | Scripps Research Inst | Proteínas de fusão de imunoglobulina de relaxina e métodos de uso |
| BR112018012694A2 (pt) | 2015-12-23 | 2018-12-04 | Medigene Immunotherapies Gmbh | composição de célula dendrítica, vacina de célula dendrítica, composição e kit |
| KR102613430B1 (ko) | 2016-10-19 | 2023-12-18 | 더 스크립스 리서치 인스티튜트 | 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도 |
| US20200199207A1 (en) | 2017-06-23 | 2020-06-25 | Mabylon Ag | Anti-allergen antibodies |
| US12458705B2 (en) | 2018-06-12 | 2025-11-04 | Angiex, Inc. | Antibody-oligonucleotide conjugates |
| JP7765379B2 (ja) | 2019-08-12 | 2025-11-06 | ピュリノミア バイオテック, インコーポレイテッド | Cd39発現細胞のadcc標的化を介してt細胞媒介性免疫応答を促進及び増強するための方法及び組成物 |
| CA3158893A1 (en) | 2019-10-24 | 2021-04-29 | Minotaur Therapeutics, Inc. | Chimeric cytokine modified antibodies and methods of use thereof |
| CA3163507A1 (en) | 2019-12-04 | 2021-06-10 | The Scripps Research Institute | Peptide conjugates and methods of use |
| CN118251420A (zh) | 2021-04-28 | 2024-06-25 | 米诺陶治疗公司 | 人源化嵌合牛抗体和使用方法 |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| CA3239280A1 (en) | 2021-12-01 | 2023-06-08 | UCB Biopharma SRL | Formulations comprising fab-peg |
| CN118829726A (zh) * | 2022-03-08 | 2024-10-22 | 科纳斯特股份有限公司 | 包含胶原酶、钙、组氨酸及甘氨酸的组合物及胶原酶的稳定化方法 |
| WO2023212483A1 (en) | 2022-04-29 | 2023-11-02 | Purinomia Biotech, Inc. | Methods and compositions for treating eosinophil driven diseases and disorders |
| EP4635980A1 (de) | 2024-04-19 | 2025-10-22 | Medigene Immunotherapies GmbH | Uni-tags-spezifischer antikörper |
| TW202547865A (zh) | 2024-05-17 | 2025-12-16 | 比利時商Ucb生物製藥公司 | 具有il-11結合特異性的抗體 |
| WO2025238133A1 (en) | 2024-05-17 | 2025-11-20 | UCB Biopharma SRL | Multispecific antibody with binding specificity for il-11 and il-17 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5480406A (en) * | 1977-12-09 | 1979-06-27 | Tanabe Seiyaku Co Ltd | Preparation of urokinase for injection |
| DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
| US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| US4470968A (en) * | 1983-01-13 | 1984-09-11 | Miles Laboratories, Inc. | Pasteurized therapeutically active blood coagulation factor concentrates |
| AT376881B (de) * | 1983-05-02 | 1985-01-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern |
| US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US4597966A (en) * | 1985-01-09 | 1986-07-01 | Ortho Diagnostic Systems, Inc. | Histidine stabilized immunoglobulin and method of preparation |
| US4952675A (en) * | 1985-02-01 | 1990-08-28 | New York University | Method for purifying antihemophilic factor |
| JP2584443B2 (ja) | 1985-04-22 | 1997-02-26 | ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド | 活性化▲i▼▲x▼因子の高収率産生 |
| DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
| JP2708749B2 (ja) * | 1987-08-10 | 1998-02-04 | エーザイ株式会社 | 修飾型tPA含有注射用組成物 |
| EP0317376B2 (de) | 1987-10-23 | 1996-04-03 | Centre Regional De Transfusion Sanguine De Lille | Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat |
| US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| DE4001451A1 (de) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| JPH05331071A (ja) * | 1992-01-17 | 1993-12-14 | Asahi Chem Ind Co Ltd | カルシトニン遺伝子関連ペプチド類の凍結乾燥組成物および安定化法 |
| US5288853A (en) * | 1992-04-30 | 1994-02-22 | Alpha Therapeutic Corporation | Factor viii purification process |
| WO1994007510A1 (en) * | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| ES2079994B1 (es) * | 1992-10-07 | 1996-08-01 | Cusi Lab | Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica. |
| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
-
1994
- 1994-04-26 US US08/233,663 patent/US6372716B1/en not_active Expired - Lifetime
-
1995
- 1995-04-06 CA CA002182200A patent/CA2182200C/en not_active Expired - Lifetime
- 1995-04-06 PT PT95915040T patent/PT758248E/pt unknown
- 1995-04-06 AT AT95915040T patent/ATE244015T1/de active
- 1995-04-06 WO PCT/US1995/004263 patent/WO1995028954A1/en not_active Ceased
- 1995-04-06 AU AU22075/95A patent/AU695084B2/en not_active Expired
- 1995-04-06 ES ES95915040T patent/ES2202356T3/es not_active Expired - Lifetime
- 1995-04-06 DK DK95915040T patent/DK0758248T3/da active
- 1995-04-06 JP JP7527660A patent/JPH09512267A/ja not_active Withdrawn
- 1995-04-06 EP EP95915040A patent/EP0758248B1/de not_active Expired - Lifetime
- 1995-04-06 DE DE69531204T patent/DE69531204T2/de not_active Expired - Lifetime
-
2006
- 2006-05-22 JP JP2006141780A patent/JP4789698B2/ja not_active Expired - Lifetime
-
2007
- 2007-06-13 JP JP2007156252A patent/JP2007224052A/ja not_active Withdrawn
-
2009
- 2009-11-25 JP JP2009267797A patent/JP2010077148A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09512267A (ja) | 1997-12-09 |
| EP0758248A1 (de) | 1997-02-19 |
| CA2182200C (en) | 1999-02-02 |
| DE69531204D1 (de) | 2003-08-07 |
| US6372716B1 (en) | 2002-04-16 |
| JP2010077148A (ja) | 2010-04-08 |
| AU2207595A (en) | 1995-11-16 |
| DE69531204T2 (de) | 2004-04-22 |
| ES2202356T3 (es) | 2004-04-01 |
| CA2182200A1 (en) | 1995-11-02 |
| AU695084B2 (en) | 1998-08-06 |
| DK0758248T3 (da) | 2003-10-27 |
| EP0758248B1 (de) | 2003-07-02 |
| WO1995028954A1 (en) | 1995-11-02 |
| JP2007224052A (ja) | 2007-09-06 |
| JP4789698B2 (ja) | 2011-10-12 |
| JP2006219500A (ja) | 2006-08-24 |
| PT758248E (pt) | 2003-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69531204D1 (de) | Formulierungen fuer faktor ix | |
| DE69729786D1 (de) | Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen | |
| DE69620877D1 (de) | Arzneimittelformulierungen für il-12 | |
| NO971889D0 (no) | Forbindelser og sammensetninger for levering av aktive midler | |
| DK1093819T3 (da) | Forbindelse og præparat til tilförsel af aktive midler | |
| WO2001005355A3 (en) | Formulations for il-11 | |
| IL140710A0 (en) | Pulmonary delivery of active agents | |
| DE69524742D1 (de) | Interleukin-11 präparat | |
| ES2170102T3 (es) | Aminociclohexilesteres y utilizacion de los mismos. | |
| CY1108532T1 (el) | Ενωσεις και συνθεσεις για την παροχη δραστικων παραγοντων | |
| NZ240230A (en) | Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof | |
| SE9201628D0 (sv) | Pharmaceutical composition | |
| YU19499A (sh) | Benzonaftiridini kao bronhijalni terapeutici | |
| DE69636285D1 (de) | ISOLIERTES FrpB NUKLEINSÄUREMOLEKÜL UND ENTSPRECHENDE IMPFSTOFF | |
| ATE213937T1 (de) | Spezielle halofantrinhaltige zusammensetzungen | |
| AU8332791A (en) | Oral pharmaceutical compositions containing melatonin | |
| DE69330601D1 (de) | Serotoninergische ergolin derivate | |
| BG100248A (bg) | Инхибитори на скваленсинтетаза | |
| ATE305517T1 (de) | Neurotrypsin | |
| PT1017681E (pt) | Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios | |
| ATE227122T1 (de) | Stabilisierte tablettenformulierung | |
| BG104452A (en) | New derivatives of the methylenebisphosphonic acid | |
| ATE204286T1 (de) | Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge | |
| AP9801399A0 (en) | Zona pellucida proteins for contraception. | |
| IT1254452B (it) | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0758248 Country of ref document: EP |