ATE244225T1 - Verfahren zur herstellung von chinolinderivaten - Google Patents
Verfahren zur herstellung von chinolinderivatenInfo
- Publication number
- ATE244225T1 ATE244225T1 AT98914017T AT98914017T ATE244225T1 AT E244225 T1 ATE244225 T1 AT E244225T1 AT 98914017 T AT98914017 T AT 98914017T AT 98914017 T AT98914017 T AT 98914017T AT E244225 T1 ATE244225 T1 AT E244225T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- quinoline derivatives
- producing quinoline
- derivative
- quinolone
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- HETSDWRDICBRSQ-UHFFFAOYSA-N 3h-quinolin-4-one Chemical class C1=CC=C2C(=O)CC=NC2=C1 HETSDWRDICBRSQ-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- GTDQGKWDWVUKTI-UHFFFAOYSA-N o-aminoacetophenone Chemical class CC(=O)C1=CC=CC=C1N GTDQGKWDWVUKTI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10122097 | 1997-04-18 | ||
| PCT/JP1998/001708 WO1998047873A1 (en) | 1997-04-18 | 1998-04-15 | Process for producing quinolone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244225T1 true ATE244225T1 (de) | 2003-07-15 |
Family
ID=14294825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98914017T ATE244225T1 (de) | 1997-04-18 | 1998-04-15 | Verfahren zur herstellung von chinolinderivaten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6187926B1 (de) |
| EP (1) | EP0990647B1 (de) |
| JP (1) | JP4303792B2 (de) |
| AT (1) | ATE244225T1 (de) |
| DE (1) | DE69816080T2 (de) |
| TW (1) | TW518323B (de) |
| WO (1) | WO1998047873A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2454538A1 (en) | 2001-06-22 | 2003-01-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| US7274800B2 (en) * | 2001-07-18 | 2007-09-25 | Intel Corporation | Dynamic gesture recognition from stereo sequences |
| EP2210607B1 (de) | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamid zur Behandlung von Krebs |
| TW201920110A (zh) | 2009-01-16 | 2019-06-01 | 美商艾克塞里克斯公司 | 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途 |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| EP3270692A4 (de) * | 2015-03-18 | 2019-02-13 | The Regents of the University of California | Chemikalien zum schutz gegen gliederfüsser |
| CN104909993B (zh) * | 2015-06-15 | 2017-07-07 | 江苏蓝丰生物化工股份有限公司 | 一种麦草畏关键中间体2,5‑二氯苯酚的工业合成方法 |
| MX2021005189A (es) | 2018-11-05 | 2022-01-18 | Aveo Pharmaceuticals Inc | Uso de tivozanib para tratar sujetos con cancer refractario. |
| JP2020100598A (ja) | 2018-12-25 | 2020-07-02 | 公益財団法人応用生化学研究所 | レンバチニブ誘導体、並びにそれを用いた医薬研究用組成物及び腫瘍治療剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030423B1 (de) * | 1979-12-07 | 1985-02-13 | FISONS plc | Verfahren zur Herstellung von 1,4-Dihydro-4-oxo-chinolin-2-carbonsäuren oder Salzen, Estern oder Amiden davon und Zwischenverbindungen dafür |
| JP2831000B2 (ja) * | 1988-03-03 | 1998-12-02 | 大日本製薬株式会社 | （２−アミノベンゾイル）酢酸エステル誘導体 |
| US5081121A (en) * | 1988-05-24 | 1992-01-14 | Tatsushi Osawa | 4(1h)-quinolone derivatives |
| US5225418A (en) * | 1991-12-17 | 1993-07-06 | Du Pont Merck Pharmaceutical Company | 5H-(1,2)benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents |
| US5571822A (en) * | 1994-09-30 | 1996-11-05 | The University Of North Carolina At Chapel Hill | Antitumor compounds |
-
1998
- 1998-04-15 JP JP54544998A patent/JP4303792B2/ja not_active Expired - Lifetime
- 1998-04-15 WO PCT/JP1998/001708 patent/WO1998047873A1/ja not_active Ceased
- 1998-04-15 DE DE69816080T patent/DE69816080T2/de not_active Expired - Lifetime
- 1998-04-15 AT AT98914017T patent/ATE244225T1/de not_active IP Right Cessation
- 1998-04-15 EP EP98914017A patent/EP0990647B1/de not_active Expired - Lifetime
- 1998-04-16 TW TW087105775A patent/TW518323B/zh not_active IP Right Cessation
-
1999
- 1999-10-18 US US09/420,521 patent/US6187926B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6187926B1 (en) | 2001-02-13 |
| EP0990647A4 (de) | 2000-05-17 |
| DE69816080T2 (de) | 2004-04-15 |
| DE69816080D1 (de) | 2003-08-07 |
| EP0990647B1 (de) | 2003-07-02 |
| JP4303792B2 (ja) | 2009-07-29 |
| EP0990647A1 (de) | 2000-04-05 |
| TW518323B (en) | 2003-01-21 |
| WO1998047873A1 (en) | 1998-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |