ATE276998T1 - Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten - Google Patents

Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten

Info

Publication number: ATE276998T1
Authority: AT; Austria
Prior art keywords: salicylic acid; nitroxymethyl; acid derivatives; phenyl esters; producing
Prior art date: 1999-07-09

Application number

AT00942111T

Other languages

English (en)

Inventor

Graziano Castaldi

Erminio Oldani

Gabriele Razzetti

Francesca Benedini

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-09

Filing date

2000-06-21

Publication date

2004-10-15

2000-06-21 Application filed by Nicox Sa filed Critical Nicox Sa

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE276998T1 publication Critical patent/ATE276998T1/de

Links

150000003872 salicylic acid derivatives Chemical class 0.000 title abstract 3
-1 (NITROXYMETHYL)PHENYL Chemical class 0.000 title abstract 2
229940058287 salicylic acid derivative anticestodals Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000007524 organic acids Chemical class 0.000 abstract 2
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910017604 nitric acid Inorganic materials 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00942111T 1999-07-09 2000-06-21 Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten ATE276998T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI001517A ITMI991517A1 (it)	1999-07-09	1999-07-09	Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
PCT/EP2000/005722 WO2001004082A1 (en)	1999-07-09	2000-06-21	A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE276998T1 true ATE276998T1 (de)	2004-10-15

Family

ID=11383309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00942111T ATE276998T1 (de)	1999-07-09	2000-06-21	Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten

Country Status (25)

Country	Link
US (1)	US6696591B1 (de)
EP (1)	EP1194397B1 (de)
JP (1)	JP2003504352A (de)
KR (1)	KR100671996B1 (de)
CN (1)	CN1165511C (de)
AT (1)	ATE276998T1 (de)
AU (1)	AU775482B2 (de)
BR (1)	BR0012168A (de)
CA (1)	CA2377222A1 (de)
DE (1)	DE60014088T2 (de)
DK (1)	DK1194397T3 (de)
ES (1)	ES2228551T3 (de)
HU (1)	HUP0201766A3 (de)
IL (1)	IL147054A0 (de)
IT (1)	ITMI991517A1 (de)
MX (1)	MXPA02000245A (de)
NO (1)	NO20020052D0 (de)
NZ (1)	NZ516125A (de)
PL (1)	PL193252B1 (de)
PT (1)	PT1194397E (de)
RU (1)	RU2235717C2 (de)
SI (1)	SI1194397T1 (de)
TR (1)	TR200200010T2 (de)
WO (1)	WO2001004082A1 (de)
ZA (1)	ZA200110276B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP2002002582A0 (en)	1999-12-23	2002-09-30	Nitromed Inc	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de)	2000-12-21	2007-01-11	Nitromed, Inc., Bedford	Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
CA2487414A1 (en)	2002-06-11	2003-12-18	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en)	2002-07-03	2009-09-24	Nicox S.A.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en)	2002-07-29	2007-07-17	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
KR20070053214A (ko)	2004-08-26	2007-05-23	니콜라스 피라말 인디아 리미티드	신규 생분해성 링커를 함유하는 프로드럭
TW200616604A (en)	2004-08-26	2006-06-01	Nicholas Piramal India Ltd	Nitric oxide releasing prodrugs containing bio-cleavable linker
NZ569396A (en)	2006-02-03	2011-06-30	Nicox Sa	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
EP2048129A1 (de) *	2007-10-12	2009-04-15	Lonza Ag	Verfahren zur Herstellung organischer Nitrate
CN101973879B (zh) *	2010-09-27	2013-03-13	广安凯特医药化工有限公司	一种吉法酯的制备方法
RU2720180C2 (ru)	2013-09-24	2020-04-27	Универзитет Цу Кельн	Соединения, применяемые в лечении неопластических заболеваний
WO2015127372A1 (en) *	2014-02-24	2015-08-27	Nature Works Llc	Process for making esters of 2-acetoxyalkanoic acids using an alpha-hydroxyalkanoic acid ester and an acetate ester as starting materials
EP3333148B1 (de) *	2014-02-24	2020-10-14	NatureWorks LLC	Ververfahren zur herstellung eines 2-acetoxyalkansäureesters
CN107074716A (zh) *	2014-07-18	2017-08-18	比奥考金特有限责任公司	包含水杨酸酯和聚水杨酸酯的组合物及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
JP3646223B2 (ja) *	1992-06-16	2005-05-11	日本農薬株式会社	求電子反応による芳香族化合物の製造方法及び芳香族化合物
EP0722434B1 (de) *	1993-10-06	1998-07-29	Nicox S.A.	Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
FR2724378B1 (fr) *	1994-09-09	1996-12-20	Rhone Poulenc Chimie	Procede de preparation de l'acide picrique
DE19515970A1 (de) *	1995-05-02	1996-11-07	Bayer Ag	Acetylsalicylsäurenitrate
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
IT1307928B1 (it) *	1999-01-26	2001-11-29	Nicox Sa	Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

1999
- 1999-07-09 IT IT1999MI001517A patent/ITMI991517A1/it unknown
2000
- 2000-06-21 NZ NZ516125A patent/NZ516125A/en unknown
- 2000-06-21 PT PT00942111T patent/PT1194397E/pt unknown
- 2000-06-21 JP JP2001509694A patent/JP2003504352A/ja active Pending
- 2000-06-21 IL IL14705400A patent/IL147054A0/xx not_active IP Right Cessation
- 2000-06-21 AU AU56845/00A patent/AU775482B2/en not_active Ceased
- 2000-06-21 US US10/019,316 patent/US6696591B1/en not_active Expired - Fee Related
- 2000-06-21 DE DE60014088T patent/DE60014088T2/de not_active Expired - Fee Related
- 2000-06-21 ES ES00942111T patent/ES2228551T3/es not_active Expired - Lifetime
- 2000-06-21 EP EP00942111A patent/EP1194397B1/de not_active Expired - Lifetime
- 2000-06-21 SI SI200030541T patent/SI1194397T1/xx unknown
- 2000-06-21 CN CNB008100225A patent/CN1165511C/zh not_active Expired - Fee Related
- 2000-06-21 PL PL352359A patent/PL193252B1/pl unknown
- 2000-06-21 BR BR0012168-1A patent/BR0012168A/pt not_active Application Discontinuation
- 2000-06-21 HU HU0201766A patent/HUP0201766A3/hu unknown
- 2000-06-21 RU RU2002100083/04A patent/RU2235717C2/ru not_active IP Right Cessation
- 2000-06-21 DK DK00942111T patent/DK1194397T3/da active
- 2000-06-21 AT AT00942111T patent/ATE276998T1/de not_active IP Right Cessation
- 2000-06-21 WO PCT/EP2000/005722 patent/WO2001004082A1/en not_active Ceased
- 2000-06-21 TR TR2002/00010T patent/TR200200010T2/xx unknown
- 2000-06-21 KR KR1020027000057A patent/KR100671996B1/ko not_active Expired - Fee Related
- 2000-06-21 CA CA002377222A patent/CA2377222A1/en not_active Abandoned
- 2000-06-21 MX MXPA02000245A patent/MXPA02000245A/es active IP Right Grant
2001
- 2001-12-13 ZA ZA200110276A patent/ZA200110276B/xx unknown
2002
- 2002-01-07 NO NO20020052A patent/NO20020052D0/no unknown

Also Published As

Publication number	Publication date
EP1194397A1 (de)	2002-04-10
NZ516125A (en)	2004-06-25
US6696591B1 (en)	2004-02-24
AU5684500A (en)	2001-01-30
JP2003504352A (ja)	2003-02-04
HUP0201766A2 (en)	2002-10-28
DE60014088D1 (de)	2004-10-28
NO20020052L (no)	2002-01-07
RU2235717C2 (ru)	2004-09-10
WO2001004082A1 (en)	2001-01-18
IL147054A0 (en)	2002-08-14
EP1194397B1 (de)	2004-09-22
DE60014088T2 (de)	2005-10-06
AU775482B2 (en)	2004-08-05
ITMI991517A0 (it)	1999-07-09
ES2228551T3 (es)	2005-04-16
SI1194397T1 (en)	2005-02-28
KR20020024298A (ko)	2002-03-29
CA2377222A1 (en)	2001-01-18
KR100671996B1 (ko)	2007-01-19
CN1360566A (zh)	2002-07-24
DK1194397T3 (da)	2005-01-31
MXPA02000245A (es)	2004-09-10
TR200200010T2 (tr)	2002-09-23
CN1165511C (zh)	2004-09-08
PL193252B1 (pl)	2007-01-31
PL352359A1 (en)	2003-08-11
HUP0201766A3 (en)	2003-08-28
PT1194397E (pt)	2005-02-28
ZA200110276B (en)	2003-05-28
NO20020052D0 (no)	2002-01-07
BR0012168A (pt)	2002-03-19
ITMI991517A1 (it)	2001-01-09

Legal Events

Date

Code

Title

Description

2005-04-15

UEP

Publication of translation of european patent specification

Ref document number: 1194397

Country of ref document: EP

2010-03-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE276998T1 (de)	2004-10-15	Verfahren zur herstellung von (nitroxymethyl)phenylestern von salicylsäurederivaten
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