ATE244241T1 - Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung - Google Patents
Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindungInfo
- Publication number
- ATE244241T1 ATE244241T1 AT99904571T AT99904571T ATE244241T1 AT E244241 T1 ATE244241 T1 AT E244241T1 AT 99904571 T AT99904571 T AT 99904571T AT 99904571 T AT99904571 T AT 99904571T AT E244241 T1 ATE244241 T1 AT E244241T1
- Authority
- AT
- Austria
- Prior art keywords
- telomerase
- inhibition
- quadruplex
- human telomerase
- human
- Prior art date
Links
- 108010017842 Telomerase Proteins 0.000 title abstract 5
- 108091081406 G-quadruplex Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000003993 interaction Effects 0.000 title abstract 2
- -1 nucleoside compounds Chemical class 0.000 abstract 2
- 238000005160 1H NMR spectroscopy Methods 0.000 abstract 1
- 239000000298 carbocyanine Substances 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- FVDOBFPYBSDRKH-UHFFFAOYSA-N perylene-3,4,9,10-tetracarboxylic acid Chemical compound C=12C3=CC=C(C(O)=O)C2=C(C(O)=O)C=CC=1C1=CC=C(C(O)=O)C2=C1C3=CC=C2C(=O)O FVDOBFPYBSDRKH-UHFFFAOYSA-N 0.000 abstract 1
- QWYZFXLSWMXLDM-UHFFFAOYSA-M pinacyanol iodide Chemical compound [I-].C1=CC2=CC=CC=C2N(CC)C1=CC=CC1=CC=C(C=CC=C2)C2=[N+]1CC QWYZFXLSWMXLDM-UHFFFAOYSA-M 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 102000055501 telomere Human genes 0.000 abstract 1
- 108091035539 telomere Proteins 0.000 abstract 1
- 210000003411 telomere Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7362998P | 1998-02-04 | 1998-02-04 | |
| PCT/US1999/002353 WO1999040087A2 (en) | 1998-02-04 | 1999-02-04 | Inhibition of human telomerase by a g-quadruplex-interaction compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244241T1 true ATE244241T1 (de) | 2003-07-15 |
Family
ID=22114844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99904571T ATE244241T1 (de) | 1998-02-04 | 1999-02-04 | Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US6156763A (de) |
| EP (1) | EP1053237B1 (de) |
| AT (1) | ATE244241T1 (de) |
| AU (1) | AU2494799A (de) |
| DE (1) | DE69909246D1 (de) |
| WO (1) | WO1999040087A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999040087A2 (en) * | 1998-02-04 | 1999-08-12 | The Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
| CA2392507A1 (fr) * | 1999-11-29 | 2001-06-07 | Aventis Pharma S.A. | Derives arylamines et leur application comme agent antitelomerase |
| FR2801588B1 (fr) * | 1999-11-29 | 2002-03-01 | Aventis Pharma Sa | Derives chimiques et leur application comme agent antitelomerase |
| AU2001282268A1 (en) * | 2000-08-08 | 2002-02-18 | Aventis Pharma S.A. | Phenantridine derivatives and their use as anti-telomerase agent |
| FR2821355A1 (fr) * | 2001-02-23 | 2002-08-30 | Aventis Pharma Sa | Derives chimiques et leur application comme agent antitelomerase |
| US6887873B2 (en) | 2001-03-23 | 2005-05-03 | Aventis Pharma S.A. | Triazine derivatives and their application as antitelomerase agents |
| US6753411B2 (en) | 2001-03-26 | 2004-06-22 | The Regents Of The University Of Colorado | Protection-of-telomere-1 (POT-1) proteins |
| WO2002096903A2 (fr) * | 2001-05-28 | 2002-12-05 | Aventis Pharma S.A. | Derives chimiques et leur application comme agent antitelomerase |
| AU2003226304A1 (en) * | 2002-04-05 | 2003-10-27 | Cylene Pharmaceuticals, Inc. | Methods for targeting quadruplex dna |
| AU2003262778A1 (en) * | 2002-08-20 | 2004-03-11 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for regulating transcription by targeting quadruplex dna |
| ATE405840T1 (de) | 2002-12-19 | 2008-09-15 | Scripps Research Inst | Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung |
| US7781163B2 (en) * | 2003-01-08 | 2010-08-24 | Lesley Davenport | G-quadruplex binding assays and compounds therefor |
| US20050113324A1 (en) * | 2003-01-15 | 2005-05-26 | Bondarev Igor E. | Modulation of line-1 reverse transcriptase |
| US20040180345A1 (en) * | 2003-03-14 | 2004-09-16 | Ingeneus Corporation | Pre-incubation method to improve signal/noise ratio of nucleic acid assays |
| US20080032286A1 (en) * | 2003-10-14 | 2008-02-07 | Cylene Pharaceuticals, Inc. | Competition Assay for Identifying Modulators of Quadruplex Nucleic Acids |
| US7691624B2 (en) * | 2003-10-22 | 2010-04-06 | Academia Sinica | Cancer cell detecting devices |
| US6979738B2 (en) * | 2003-10-22 | 2005-12-27 | Academia Sinica | Quadruplex stabilizer |
| US20050249669A1 (en) * | 2003-10-22 | 2005-11-10 | Academia Sinica | Quadruplex stabilizer |
| WO2005049867A1 (en) * | 2003-11-17 | 2005-06-02 | Cylene Pharmaceuticals, Inc. | Methods for identifying modulators of quadruplex nucleic acids |
| WO2005089094A2 (en) * | 2003-11-21 | 2005-09-29 | The Board Of Regents Of The University And Community College System Of Nevada | Materials and methods for the preparation of anisotropically-ordered solids |
| JP2007538103A (ja) | 2004-05-20 | 2007-12-27 | ザ スクリップス リサーチ インスティテュート | トランスサイレチン安定化 |
| US20080119492A1 (en) * | 2005-07-29 | 2008-05-22 | Jean-Marie Lehn | Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation |
| US20100249175A1 (en) * | 2005-12-02 | 2010-09-30 | Wilson W David | Dicationic compounds which selectively recognize G-quadruplex DNA |
| KR100833492B1 (ko) * | 2005-12-08 | 2008-05-29 | 한국전자통신연구원 | 핵산 나노구조체 및 그의 제조 방법 |
| US8481529B2 (en) * | 2006-05-16 | 2013-07-09 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Combination cancer chemotherapy |
| WO2008034016A2 (en) * | 2006-09-15 | 2008-03-20 | Foldrx Pharmaceuticals, Inc. | Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins |
| ITRM20070209A1 (it) * | 2007-04-12 | 2008-10-13 | Univ Roma | Derivati coronenici idrosolubili attivi come inibitori della telomerasi umana mediante induzione di strutture g-quadruplex e loro uso come agenti antitumorali. |
| US20100331368A1 (en) * | 2007-10-17 | 2010-12-30 | Tidwell Richard R | 2,5-diaryl selenophene compounds, aza 2,5-diaryl thiophene compounds, and their prodrugs as antiprotozoal agents |
| AU2008317002A1 (en) * | 2007-10-22 | 2009-04-30 | The Wistar Institute | Method for identifying a compound that modulates telomerase activity |
| US8377992B2 (en) * | 2007-10-22 | 2013-02-19 | The Wistar Institute | TRBD-binding effectors and methods for using the same to modulate telomerase activity |
| PT3330383T (pt) * | 2008-10-17 | 2020-05-06 | Geron Corp | Grn163l para utiliização como inibidor de telomerase no tratamento de cancro |
| RU2586330C2 (ru) | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
| CN103910727B (zh) * | 2012-12-31 | 2016-06-15 | 北京大学 | STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用 |
| CN103497154A (zh) * | 2013-08-12 | 2014-01-08 | 北京化工大学 | 一种水溶性苝酰亚胺类化合物及其作为dna嵌插剂和在抑制癌细胞生长中的应用 |
| EP3383876B1 (de) * | 2015-12-02 | 2025-04-23 | University of Utah Research Foundation | Chemische selbstdotierung eindimensionaler organischer nanomaterialien für anwendung mit hoher leitfähigkeit in der chemiresistiven gas- oder dampfmessung |
| CN105842287B (zh) * | 2016-03-16 | 2019-01-01 | 济南市农业科学研究院 | 用于检测二氧化氮的纳米材料及气敏传感器元件 |
| CN110237076A (zh) * | 2019-07-29 | 2019-09-17 | 河南大学 | PDINCl在制备抗肿瘤药物中的应用 |
| US20210333284A1 (en) * | 2020-04-28 | 2021-10-28 | Purdue Research Foundation | Methods and materials for large-scale assessment of ligand binding selectivity of g-quadruplex recognition using custom g4 microarrays |
| CN112521388B (zh) * | 2020-12-30 | 2021-11-09 | 河南大学 | 一种苝酰亚胺衍生物及应用 |
| CN112724137B (zh) * | 2021-01-19 | 2021-10-26 | 河南大学 | 一种苝酰亚胺衍生物及其制备方法和应用 |
| CN116925074B (zh) * | 2023-07-28 | 2025-08-15 | 河南大学 | 一种苝酰亚胺衍生物pdic-dpc及应用 |
| CN118108720B (zh) * | 2023-12-28 | 2026-03-10 | 河南大学 | 一种苝酰亚胺衍生物pdic-ns及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD299733A7 (de) * | 1980-12-23 | 1992-05-07 | Bitterfeld Chemie | Verfahren zur herstellung von schwarzen tarnpigmenten |
| JP3362865B2 (ja) * | 1991-03-21 | 2003-01-07 | クラリアント・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング | ペリレン化合物の分子内塩、その製造方法およびその用途 |
| DE4225357A1 (de) * | 1992-07-31 | 1994-02-03 | Basf Ag | Glanzpigmente auf Basis mit extern basischen, organischen Farbmitteln beschichteter, plättchenförmiger Substrate |
| US5416089A (en) * | 1993-06-24 | 1995-05-16 | The Du Pont Merck Pharmaceutical Company | Polycyclic and heterocyclic chromophores for bis-imide tumoricidals |
| US5920429A (en) * | 1995-09-29 | 1999-07-06 | Minnesota Mining And Manufacturing Company | Fluorescent dye blends |
| US5672643A (en) * | 1995-09-29 | 1997-09-30 | Minnesota Mining And Manufacturing Company | Fluorescent dye blends |
| CA2283057A1 (en) * | 1997-02-05 | 1998-08-06 | Board Of Regents, The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
| US6166210A (en) * | 1997-12-15 | 2000-12-26 | Ciba Specialty Chemicals Corporation | Perylene imide monocarboxylic acids |
| US6528517B1 (en) * | 1998-02-04 | 2003-03-04 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents |
| WO1999040087A2 (en) * | 1998-02-04 | 1999-08-12 | The Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
| US6492117B1 (en) * | 2000-07-12 | 2002-12-10 | Gendaq Limited | Zinc finger polypeptides capable of binding DNA quadruplexes |
-
1999
- 1999-02-04 WO PCT/US1999/002353 patent/WO1999040087A2/en not_active Ceased
- 1999-02-04 US US09/244,675 patent/US6156763A/en not_active Expired - Fee Related
- 1999-02-04 AT AT99904571T patent/ATE244241T1/de not_active IP Right Cessation
- 1999-02-04 AU AU24947/99A patent/AU2494799A/en not_active Abandoned
- 1999-02-04 EP EP99904571A patent/EP1053237B1/de not_active Expired - Lifetime
- 1999-02-04 DE DE69909246T patent/DE69909246D1/de not_active Expired - Lifetime
-
2000
- 2000-12-05 US US09/730,893 patent/US6689887B2/en not_active Expired - Fee Related
-
2001
- 2001-08-27 US US09/940,173 patent/US6623930B2/en not_active Expired - Fee Related
-
2004
- 2004-02-10 US US10/775,818 patent/US20040229894A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020107258A1 (en) | 2002-08-08 |
| WO1999040087A2 (en) | 1999-08-12 |
| EP1053237A2 (de) | 2000-11-22 |
| US6689887B2 (en) | 2004-02-10 |
| DE69909246D1 (de) | 2003-08-07 |
| AU2494799A (en) | 1999-08-23 |
| US20040229894A1 (en) | 2004-11-18 |
| US20030040525A1 (en) | 2003-02-27 |
| US6623930B2 (en) | 2003-09-23 |
| EP1053237B1 (de) | 2003-07-02 |
| US6156763A (en) | 2000-12-05 |
| WO1999040087A3 (en) | 1999-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |