ATE244303T1 - IN SICH GESCHLOSSENDE ßSENS-ß UND ßANTISENSEß- OLIGONUKLEOTIDE UND DEREN VERWENDUNGEN - Google Patents
IN SICH GESCHLOSSENDE ßSENS-ß UND ßANTISENSEß- OLIGONUKLEOTIDE UND DEREN VERWENDUNGENInfo
- Publication number
- ATE244303T1 ATE244303T1 AT92910423T AT92910423T ATE244303T1 AT E244303 T1 ATE244303 T1 AT E244303T1 AT 92910423 T AT92910423 T AT 92910423T AT 92910423 T AT92910423 T AT 92910423T AT E244303 T1 ATE244303 T1 AT E244303T1
- Authority
- AT
- Austria
- Prior art keywords
- oligonucleotides
- ßsens
- ßantisensß
- self
- contained
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 102000040945 Transcription factor Human genes 0.000 abstract 2
- 108091023040 Transcription factor Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101710095342 Apolipoprotein B Proteins 0.000 abstract 1
- 102100040202 Apolipoprotein B-100 Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 102000006754 Hepatocyte Nuclear Factor 1 Human genes 0.000 abstract 1
- 108010086512 Hepatocyte Nuclear Factor 1 Proteins 0.000 abstract 1
- 108010071690 Prealbumin Proteins 0.000 abstract 1
- 101150027674 S1 gene Proteins 0.000 abstract 1
- 102000009190 Transthyretin Human genes 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9105114A FR2675803B1 (fr) | 1991-04-25 | 1991-04-25 | Oligonucleotides fermes, antisens et sens et leurs applications. |
| PCT/FR1992/000370 WO1992019732A1 (fr) | 1991-04-25 | 1992-04-24 | Oligonucleotides fermes, antisens et sens, et leurs applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244303T1 true ATE244303T1 (de) | 2003-07-15 |
Family
ID=9412249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92910423T ATE244303T1 (de) | 1991-04-25 | 1992-04-24 | IN SICH GESCHLOSSENDE ßSENS-ß UND ßANTISENSEß- OLIGONUKLEOTIDE UND DEREN VERWENDUNGEN |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6369038B1 (de) |
| EP (2) | EP0581848B1 (de) |
| JP (1) | JPH06506834A (de) |
| AT (1) | ATE244303T1 (de) |
| AU (1) | AU660679B2 (de) |
| CA (1) | CA2102229A1 (de) |
| DE (1) | DE69233117T2 (de) |
| DK (1) | DK0581848T3 (de) |
| ES (1) | ES2199936T3 (de) |
| FR (1) | FR2675803B1 (de) |
| WO (1) | WO1992019732A1 (de) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5683874A (en) * | 1991-03-27 | 1997-11-04 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence |
| CA2106386A1 (en) * | 1991-04-18 | 1992-10-19 | Barbara C. F. Chu | Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences |
| FR2675803B1 (fr) * | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| US5698391A (en) * | 1991-08-23 | 1997-12-16 | Isis Pharmaceuticals, Inc. | Methods for synthetic unrandomization of oligomer fragments |
| JPH07502898A (ja) * | 1992-01-13 | 1995-03-30 | デューク・ユニバーシティー | 酵素rna分子 |
| US6521601B1 (en) * | 1992-04-14 | 2003-02-18 | Signal Pharmaceuticals, Inc. | Method and composition for inhibition of viral replication |
| GB2273932A (en) * | 1992-11-24 | 1994-07-06 | Stiefel Laboratories | Stable oligonucleotides |
| FR2703053B1 (fr) * | 1993-03-26 | 1995-06-16 | Genset Sa | Oligonucleotides agrafes et semi-agrafes, procede de preparation et applications . |
| FR2707880B1 (fr) * | 1993-06-30 | 1995-10-06 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques et leur utilisation, notamment pour le traitement des maladies neurodégénératives. |
| FR2708270B1 (fr) * | 1993-07-28 | 1995-10-20 | Genset Sa | Oligonucléotides antisens dirigés contre les virus Herpès Simplex de types 1 & 2. |
| EP0771320A4 (de) | 1993-07-29 | 1998-11-25 | Univ California | Lock-polynukleotid das die mhc-ii-expression unterdrückt und verwendung desselben |
| US5859226A (en) * | 1993-07-29 | 1999-01-12 | Regents Of The University Of California, The | Polynucleotide decoys that inhibit MHC-II expression and uses thereof |
| FR2710846B1 (fr) | 1993-10-04 | 1995-12-22 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques et leur utilisation, notamment dans le traitement des maladies neurogénératives. |
| US8431119B2 (en) | 1993-10-04 | 2013-04-30 | Aventis Pharma S.A. | Pharmaceutical compositions and utilization thereof particularly for the treatment of neurodegenerative diseases |
| US6399376B1 (en) * | 1993-11-05 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Modulation of vascular cell adhesive molecule expression through oligonucleotide interactions |
| ATE234919T1 (de) | 1993-12-23 | 2003-04-15 | Biognostik Ges | Antisense nukleinsäuren zur vorbeugung und behandlung von beschwerden in welchen die exprimierung von c-erbb-2 eine rolle spielt |
| FR2714383B1 (fr) * | 1993-12-29 | 1996-02-09 | Centre Nat Rech Scient | Contrôle de l'expression de gènes. |
| AU2116995A (en) * | 1994-03-07 | 1995-09-25 | University Of Medicine And Dentistry Of New Jersey | Cyclic polycationic polymer-oligonucleotide conjugates and methods for preparing same |
| US5674683A (en) * | 1995-03-21 | 1997-10-07 | Research Corporation Technologies, Inc. | Stem-loop and circular oligonucleotides and method of using |
| FR2732344B1 (fr) * | 1995-04-03 | 1997-06-20 | Genset Sa | Oligonucleotides a liaison covalente transversale, procede de preparation et synthon utile dans le procede |
| FR2732971B1 (fr) * | 1995-04-13 | 1997-07-04 | Genset Sa | Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere |
| US6509149B2 (en) * | 1995-06-06 | 2003-01-21 | Hybridon, Inc. | HPV-specific oligonucleotides |
| ES2109177B1 (es) * | 1995-10-11 | 1998-07-16 | Univ Barcelona | Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo. |
| US20030119724A1 (en) * | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
| EP0855403A1 (de) * | 1996-06-10 | 1998-07-29 | Laboratory of Molecular Biophotonics | Photosplatbare zyklische oligonukleotide |
| DE19631919C2 (de) * | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| EP0860167A1 (de) * | 1997-01-30 | 1998-08-26 | Robert Gurny | DNA und RNA Wirkstoffderivate in Nanopartikeln |
| US6586661B1 (en) | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| ATE440951T1 (de) | 1997-12-17 | 2009-09-15 | Serono Genetics Inst Sa | Verlängerte cdns, die für sekretierte proteine kodieren |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| JP2002526072A (ja) * | 1998-09-21 | 2002-08-20 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | 遺伝子発現の調節のためのヘアピンハイブリダイザー分子 |
| CA2361201A1 (en) * | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| AU2008202208C1 (en) * | 1999-01-30 | 2014-04-24 | Alnylam Pharmaceuticals, Inc. | Method and medicament for inhibiting the expression of a defined gene |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US20040138168A1 (en) * | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| KR20070118315A (ko) * | 1999-04-21 | 2007-12-14 | 와이어쓰 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물 |
| DE19935756A1 (de) * | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| ES2336887T5 (es) | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| EP1724355A3 (de) | 2000-08-30 | 2007-05-23 | North Carolina State University | Transgene Pflanzen, die molekulare Decoys enthalten, die den Proteininhalt ändern |
| EP1191097A1 (de) * | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induktion von "exon-skipping" in eukaryotischen Zellen |
| JP2004533807A (ja) | 2000-11-07 | 2004-11-11 | ノース・キャロライナ・ステイト・ユニヴァーシティ | プトレッシン−n−メチルトランスフェラーゼプロモーター |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| CA2369944A1 (en) * | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
| US7358066B2 (en) | 2001-07-24 | 2008-04-15 | Serono Genetics Institute S.A. | Variants and exons of the GlyT1 transporter |
| US6867189B2 (en) | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
| JP2005502383A (ja) * | 2001-09-27 | 2005-01-27 | ティモシー アルバート ホルトン | 核酸ライブラリーを作製する方法 |
| CN1240439C (zh) * | 2002-03-28 | 2006-02-08 | 南京凯基生物科技发展有限公司 | 肿瘤基因开关药物 |
| DE60310944T3 (de) | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Weitere neue formen von interferierende rns moleküle |
| AU2003225410A1 (en) | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| JP2007524395A (ja) * | 2003-06-25 | 2007-08-30 | ソーマジェニックス インコーポレイテッド | 標的依存性の環状化及びトポロジー的結合が可能なポリヌクレオチド |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| WO2005016348A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| CN1860228B (zh) * | 2003-09-30 | 2010-04-28 | 安琪士摩奇株式会社 | 订书钉型寡核苷酸及包含该订书钉型寡核苷酸的药物 |
| KR100698056B1 (ko) * | 2003-12-26 | 2007-03-23 | 엘지.필립스 엘시디 주식회사 | 레이저 빔 패턴 마스크 및 이를 이용한 결정화 방법 |
| WO2005113556A1 (en) | 2004-05-13 | 2005-12-01 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| WO2005117889A1 (en) * | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic |
| US20090004703A1 (en) * | 2004-05-28 | 2009-01-01 | Mologen Ag | Method for the Production of Suitable Dna Constructs for Specific Inhibition of Gene Expression by Rna Interference |
| NZ582988A (en) | 2004-10-21 | 2011-07-29 | Venganza Inc | Methods and materials for conferring resistance to pests and pathogens of plants |
| WO2006089106A2 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| DE202005004135U1 (de) * | 2005-03-11 | 2005-05-19 | Klocke Verpackungs-Service Gmbh | Mehrkomponentenverpackung mit Applikator |
| WO2006112705A2 (en) * | 2005-04-22 | 2006-10-26 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secondary rna structure. |
| WO2007095387A2 (en) * | 2006-02-17 | 2007-08-23 | Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
| WO2007123391A1 (en) * | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| EP1857548A1 (de) * | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Mittel und Verfahren zur Induktion von Exon-skipping |
| SI2049664T1 (sl) | 2006-08-11 | 2012-04-30 | Prosensa Technologies Bv | Enojna veriga oligonukleotidov, komplementarna repetitivnim elementom, za zdravljenje genetskih bolezni, povezanih z nestabilnostjo dnk ponovitev |
| US7943591B2 (en) | 2007-05-11 | 2011-05-17 | Adynxx, Inc. | Gene expression and pain |
| WO2009008727A2 (en) * | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
| CA2693742A1 (en) * | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| ES2639852T3 (es) | 2007-10-26 | 2017-10-30 | Academisch Ziekenhuis Leiden | Medios y métodos para contrarrestar los trastornos musculares |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| WO2009099326A1 (en) * | 2008-02-08 | 2009-08-13 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| EP4230747A3 (de) * | 2008-03-28 | 2023-11-15 | Pacific Biosciences Of California, Inc. | Zusammensetzungen und verfahren zur nukleinsäuresequenzierung |
| WO2009120374A2 (en) | 2008-03-28 | 2009-10-01 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
| US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| EP2119783A1 (de) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Verfahren für effizientes Exon (44)-Skipping bei Duchenne-Muskeldystrophie und entsprechende Mittel |
| WO2010036287A1 (en) | 2008-09-24 | 2010-04-01 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| US8383369B2 (en) * | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| KR20160091440A (ko) | 2008-11-13 | 2016-08-02 | 길리아드 칼리스토가 엘엘씨 | 혈액 종양에 대한 요법 |
| GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| BRPI1012333A2 (pt) | 2009-03-24 | 2016-03-29 | Gilead Calistoga Llc | atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso |
| US20100257634A1 (en) * | 2009-04-03 | 2010-10-07 | Venganza Inc. | Bioassay for gene silencing constructs |
| AP2011005956A0 (en) * | 2009-04-20 | 2011-10-31 | Gilead Calistoga Llc | Methods of treatment for solid tumors. |
| EP2421971B1 (de) | 2009-04-24 | 2016-07-06 | BioMarin Technologies B.V. | Oligonukleotid mit einem inosin zur behandlung von dmd |
| CA2768843A1 (en) | 2009-07-21 | 2011-01-27 | Gilead Calistoga Llc | Treatment of liver disorders with pi3k inhibitors |
| WO2011078672A1 (en) | 2009-12-24 | 2011-06-30 | Prosensa Technologies B.V. | Molecule for treating an inflammatory disorder |
| GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| NZ627896A (en) | 2012-01-27 | 2016-11-25 | Biomarin Technologies B V | Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy |
| WO2013130868A1 (en) * | 2012-02-29 | 2013-09-06 | Isis Pharmaceuticals, Inc. | Methods for modulating fibrinogen expression |
| NZ629684A (en) | 2012-03-05 | 2016-10-28 | Gilead Calistoga Llc | Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
| PT2846839T (pt) | 2012-05-10 | 2019-05-29 | Adynxx Inc | Formulações para a administração de ingredientes ativos |
| NZ736970A (en) | 2013-12-20 | 2018-11-30 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| WO2015095605A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
| MA40059A (fr) | 2014-06-13 | 2015-12-17 | Gilead Sciences Inc | Inhibiteurs de la phosphatidylinositol 3-kinase |
| RU2017108238A (ru) | 2014-08-15 | 2018-09-17 | Эйдинкс, Инк. | Олигонуклеотиды-приманки для лечения боли |
| EP3810782A2 (de) | 2018-06-22 | 2021-04-28 | Asklepios Biopharmaceutical, Inc. | Vektoren zur genfreisetzung, die in zellen persistieren |
| WO2023069948A1 (en) | 2021-10-18 | 2023-04-27 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| KR20260030126A (ko) * | 2023-06-23 | 2026-03-05 | 아르네이 사이언시스 엘엘씨 | 고리형 핵산을 이용한 rna 치료제의 전달 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC2115A1 (fr) * | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| US5436141A (en) * | 1989-02-24 | 1995-07-25 | University Of Medicine And Dentistry Of New Jersey | Method for synthesizing stable single-stranded CDNA in eukaryotes by means of a bacterial retron and products |
| US5405775A (en) * | 1989-02-24 | 1995-04-11 | The University Of Medicine And Dentistry Of New Jersey | Retrons coding for hybrid DNA/RNA molecules |
| US5434070A (en) * | 1989-02-24 | 1995-07-18 | The University Of Medicine And Dentistry Of New Jersey | Reverse transcriptases from Escherichia coli and Myxococcus xanthus |
| DE3928900A1 (de) * | 1989-08-31 | 1991-03-07 | Europ Lab Molekularbiolog | Neue nucleotidderivate, ihre herstellung und ihre verwendung |
| WO1992017484A1 (en) * | 1991-03-27 | 1992-10-15 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides |
| US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
| CA2106386A1 (en) | 1991-04-18 | 1992-10-19 | Barbara C. F. Chu | Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences |
| FR2675803B1 (fr) * | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
-
1991
- 1991-04-25 FR FR9105114A patent/FR2675803B1/fr not_active Expired - Fee Related
-
1992
- 1992-04-24 JP JP4510454A patent/JPH06506834A/ja active Pending
- 1992-04-24 AU AU17596/92A patent/AU660679B2/en not_active Ceased
- 1992-04-24 DE DE69233117T patent/DE69233117T2/de not_active Expired - Fee Related
- 1992-04-24 ES ES92910423T patent/ES2199936T3/es not_active Expired - Lifetime
- 1992-04-24 CA CA002102229A patent/CA2102229A1/fr not_active Abandoned
- 1992-04-24 US US08/137,134 patent/US6369038B1/en not_active Expired - Fee Related
- 1992-04-24 DK DK92910423T patent/DK0581848T3/da active
- 1992-04-24 AT AT92910423T patent/ATE244303T1/de not_active IP Right Cessation
- 1992-04-24 WO PCT/FR1992/000370 patent/WO1992019732A1/fr not_active Ceased
- 1992-04-24 EP EP92910423A patent/EP0581848B1/de not_active Expired - Lifetime
-
1993
- 1993-01-22 EP EP19930400154 patent/EP0572287A3/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FR2675803B1 (fr) | 1996-09-06 |
| JPH06506834A (ja) | 1994-08-04 |
| DE69233117D1 (de) | 2003-08-07 |
| EP0581848A1 (de) | 1994-02-09 |
| EP0572287A3 (de) | 1994-01-12 |
| US6369038B1 (en) | 2002-04-09 |
| DE69233117T2 (de) | 2004-04-15 |
| FR2675803A1 (fr) | 1992-10-30 |
| CA2102229A1 (fr) | 1992-10-26 |
| DK0581848T3 (da) | 2003-10-27 |
| EP0572287A2 (de) | 1993-12-01 |
| ES2199936T3 (es) | 2004-03-01 |
| AU660679B2 (en) | 1995-07-06 |
| AU1759692A (en) | 1992-12-21 |
| WO1992019732A1 (fr) | 1992-11-12 |
| EP0581848B1 (de) | 2003-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE244303T1 (de) | IN SICH GESCHLOSSENDE ßSENS-ß UND ßANTISENSEß- OLIGONUKLEOTIDE UND DEREN VERWENDUNGEN | |
| DK0464638T3 (da) | Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger. | |
| DE69121618D1 (de) | Mutierte Luciferase vom Leuchtkäfer, mutiertes Luciferasegen, rekombinante DNS diese Gene enthaltend, und Verfahren zur Herstellung von mutierter Luciferase | |
| DE69627698D1 (de) | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren | |
| AR242987A1 (es) | Secuencias de adn no codificada y genes quimicamente regulables. | |
| DE69432586D1 (de) | Methode zum generieren von einzelsträngigen dna molekülen | |
| ATE184882T1 (de) | Materialien und methoden zur schädlingsbekämpfung | |
| ATE202487T1 (de) | Mono- oder polyfunktionelle konjugate von polylysine | |
| NO20000578D0 (no) | Et universalt anvendelig blodplasma | |
| DE69300806D1 (de) | Lackhilfsmittel und wasserverdünnbare Farbzusammensetzung. | |
| EP0645622A3 (de) | DNA-Basen-Analysegerät. | |
| EP0558944A3 (en) | Rna and dna molecules for producing virus resistance | |
| DK0642798T3 (da) | Kemisk definerede, ikke polymere valensplatformmolekyler og konjugater deraf | |
| DE69121975D1 (de) | Spezifischer Nachweis von Mycobacterium Tuberculosis | |
| DE69231143D1 (de) | Spezifische Nukleotidsequenz enthaltender Masernvirusvakzinstamm und Verfahren zu seiner absoluten Identifizierung | |
| DE69434315D1 (de) | Dap-2 tumorsupressorgen, durch sie kodierte protein und verwendung besagter gen und protein | |
| DE69113910D1 (de) | Härtbare Siloxanzusammensetzung und gehärteter Gegenstand. | |
| DE69104956D1 (de) | Eine exotherm reagierende Zusammensetzung und diese Zusammensetzung enthaltende Dose. | |
| FR2771753B1 (fr) | Gene de chitine-desacetylase, sequence d'adn hybridable, vecteur plasmidique qui le contient et organisme transforme par ce vecteur plasmidique | |
| DE69205752D1 (de) | Katalytische Zusammensetzung zum Deodorieren von Gasen und Verfahren zur Herstellung derselben. | |
| SE9502259L (sv) | Oligonukleotider för att inhibera expression av isoprenylproteintransferas | |
| DE69311488D1 (de) | Verfahren zur Kompatibilisierung von Harzen und diese kompatibilisierte Harze enthaltende Zusammensetzung | |
| DE68910036D1 (de) | Luciferase-Gen und neue rekombinante DNA sowie Verfahren zur Herstellung von Luciferase. | |
| DE69132828D1 (de) | Resistenzgene gegen Fusarsäure | |
| DE69534058D1 (de) | Genetische sequenzen welche pflanzenkrankheitsresistenz verursachen und verwendungen davon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0581848 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |