ATE244698T1 - Neuroprotective verbindungen - Google Patents

Neuroprotective verbindungen

Info

Publication number
ATE244698T1
ATE244698T1 AT98960031T AT98960031T ATE244698T1 AT E244698 T1 ATE244698 T1 AT E244698T1 AT 98960031 T AT98960031 T AT 98960031T AT 98960031 T AT98960031 T AT 98960031T AT E244698 T1 ATE244698 T1 AT E244698T1
Authority
AT
Austria
Prior art keywords
sup
group
aryl
alkyl
formula
Prior art date
Application number
AT98960031T
Other languages
English (en)
Inventor
Ashley Ker Pringle
Mark Bradley
Lars Eric Sundstrom
Fausto Iannotti
Original Assignee
Univ Southampton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southampton filed Critical Univ Southampton
Application granted granted Critical
Publication of ATE244698T1 publication Critical patent/ATE244698T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrotherapy Devices (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
AT98960031T 1997-12-16 1998-12-16 Neuroprotective verbindungen ATE244698T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9726569.8A GB9726569D0 (en) 1997-12-16 1997-12-16 Neuroprotective agents
PCT/GB1998/003775 WO1999031049A1 (en) 1997-12-16 1998-12-16 Neuroprotective agents

Publications (1)

Publication Number Publication Date
ATE244698T1 true ATE244698T1 (de) 2003-07-15

Family

ID=10823695

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98960031T ATE244698T1 (de) 1997-12-16 1998-12-16 Neuroprotective verbindungen

Country Status (19)

Country Link
US (2) US6797699B1 (de)
EP (1) EP1040096B1 (de)
JP (1) JP2002508349A (de)
KR (1) KR20010033249A (de)
CN (1) CN1284058A (de)
AT (1) ATE244698T1 (de)
AU (1) AU739296B2 (de)
CA (1) CA2315258C (de)
DE (1) DE69816337T2 (de)
DK (1) DK1040096T3 (de)
ES (1) ES2201563T3 (de)
GB (1) GB9726569D0 (de)
HU (1) HUP0004486A3 (de)
IL (1) IL136800A (de)
NO (1) NO20003075L (de)
NZ (1) NZ505110A (de)
PT (1) PT1040096E (de)
RU (1) RU2205177C2 (de)
WO (1) WO1999031049A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
GB2363983A (en) 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone
HRP20040784A2 (en) 2002-01-29 2005-04-30 Wyeth Compositions and methods for modulating connexin hemichannels
GB0202645D0 (en) * 2002-02-05 2002-03-20 Univ Southampton Treatment of chronic neurodegenerative diseases
WO2008105441A1 (ja) * 2007-02-27 2008-09-04 Ajinomoto Co., Inc. リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465303A (en) * 1939-04-03 1949-03-22 Research Corp Lactones
EP0241797B1 (de) * 1986-04-04 1991-06-12 Microbial Chemistry Research Foundation Spergualinähnliche Verbindungen und ihr Herstellungsverfahren
US6262125B1 (en) * 1986-12-02 2001-07-17 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5242947A (en) 1988-02-10 1993-09-07 New York University Use of polyamines as ionic-channel regulating agents
SK279476B6 (sk) * 1989-05-17 1998-11-04 Pfizer Deriváty 2-piperidino a 2-pyrolidino-1-alkanolov a
EP0597830A1 (de) * 1989-07-03 1994-05-25 New York University Nyu Medical Center Verwendung von Polyaminen als die Ionenkanäle regulierenden Wirkstoffe
RU2119496C1 (ru) * 1992-04-14 1998-09-27 Научно-исследовательский институт фармакологии Российской академии медицинских наук Производные n-ацилпролилдипептидов
SE9302334D0 (sv) * 1993-07-06 1993-07-06 Ab Astra New compounds
SE9302332D0 (sv) * 1993-07-06 1993-07-06 Ab Astra New compounds
SE9302333D0 (sv) * 1993-07-06 1993-07-06 Ab Astra New compounds
FR2773798B1 (fr) 1998-01-16 2001-02-02 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP1040096B1 (de) 2003-07-09
CA2315258C (en) 2008-07-15
DK1040096T3 (da) 2003-10-20
DE69816337T2 (de) 2004-04-15
CN1284058A (zh) 2001-02-14
DE69816337D1 (de) 2003-08-14
NZ505110A (en) 2003-01-31
PT1040096E (pt) 2003-09-30
IL136800A0 (en) 2001-06-14
IL136800A (en) 2005-07-25
HUP0004486A3 (en) 2002-11-28
AU739296B2 (en) 2001-10-11
KR20010033249A (ko) 2001-04-25
HUP0004486A2 (hu) 2001-05-28
EP1040096A1 (de) 2000-10-04
ES2201563T3 (es) 2004-03-16
CA2315258A1 (en) 1999-06-24
US7026297B2 (en) 2006-04-11
JP2002508349A (ja) 2002-03-19
WO1999031049A1 (en) 1999-06-24
US20040106560A1 (en) 2004-06-03
AU1571799A (en) 1999-07-05
US6797699B1 (en) 2004-09-28
RU2205177C2 (ru) 2003-05-27
NO20003075L (no) 2000-08-15
GB9726569D0 (en) 1998-02-11
HK1029331A1 (en) 2001-03-30
NO20003075D0 (no) 2000-06-15

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