ATE244727T1 - Tetrapeptid, das die funktionelle aktivität von neuronen stimuliert, dieses enthaltendes pharmakologisches mittel und seine verwendung - Google Patents

Tetrapeptid, das die funktionelle aktivität von neuronen stimuliert, dieses enthaltendes pharmakologisches mittel und seine verwendung

Info

Publication number: ATE244727T1
Authority: AT; Austria
Prior art keywords: functional activity; tetrapeptide; salts; proposed; neurones
Prior art date: 1999-10-20

Application number

AT00937408T

Other languages

English (en)

Inventor

Vladimir Khatskelevi Khavinson

Vyacheslav Grigorievic Morozov

Vladimir Viktorovich Malinin

Evgeny Iosifovich Grigoriev

Original Assignee

Sankt Peterburgskaya Obschestv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-05-25

Publication date

2003-07-15

2000-05-25 Application filed by Sankt Peterburgskaya Obschestv filed Critical Sankt Peterburgskaya Obschestv

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE244727T1 publication Critical patent/ATE244727T1/de

Links

230000005714 functional activity Effects 0.000 title abstract 4
210000002569 neuron Anatomy 0.000 title abstract 4
239000002831 pharmacologic agent Substances 0.000 title abstract 3
150000003839 salts Chemical class 0.000 abstract 4
230000004936 stimulating effect Effects 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 2
230000001225 therapeutic effect Effects 0.000 abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical class [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
230000037396 body weight Effects 0.000 abstract 1
239000011575 calcium Chemical class 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
239000011777 magnesium Chemical class 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011591 potassium Chemical class 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
229960002429 proline Drugs 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 abstract 1
239000011701 zinc Chemical class 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT00937408T 1999-10-20 2000-05-25 Tetrapeptid, das die funktionelle aktivität von neuronen stimuliert, dieses enthaltendes pharmakologisches mittel und seine verwendung ATE244727T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
RU99121778/14A RU2155063C1 (ru)	1999-10-20	1999-10-20	Тетрапептид, стимулирующий функциональную активность нейронов, фармакологическое средство на его основе и способ его применения
PCT/RU2000/000218 WO2001029067A1 (en)	1999-10-20	2000-05-25	Tetrapeptide stimulating functional activity of neurones, pharmacological agent based thereon and method of use thereof

Publications (1)

Publication Number	Publication Date
ATE244727T1 true ATE244727T1 (de)	2003-07-15

Family

ID=20225904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00937408T ATE244727T1 (de)	1999-10-20	2000-05-25	Tetrapeptid, das die funktionelle aktivität von neuronen stimuliert, dieses enthaltendes pharmakologisches mittel und seine verwendung

Country Status (10)

Country	Link
US (1)	US7189701B1 (de)
EP (1)	EP1224212B1 (de)
JP (1)	JP4668497B2 (de)
AT (1)	ATE244727T1 (de)
AU (1)	AU784578B2 (de)
CA (1)	CA2388357A1 (de)
DE (1)	DE60003837T2 (de)
IL (1)	IL149243A0 (de)
RU (1)	RU2155063C1 (de)
WO (1)	WO2001029067A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7175679B2 (en)	2001-03-29	2007-02-13	Biotempt B.V.	Oligopeptide treatment of NF-κB mediated inflammation
US6844315B2 (en)	1998-05-20	2005-01-18	Erasmus Universiteit Rotterdam	Immunoregulator
US20030220258A1 (en)	2001-12-21	2003-11-27	Robbert Benner	Treatment of ischemic events
EP1138692A1 (de)	2000-03-29	2001-10-04	Erasmus Universiteit Rotterdam	Fragmente des menschlichen Choriongonadotropins als Immunoregulatoren
US8680059B2 (en)	1998-05-20	2014-03-25	Biotempt B.V.	Oligopeptide acetate and formulations thereof
US6921751B1 (en)	1998-05-20	2005-07-26	Erasmus Universiteit Rotterdam	Immunoregulator
USRE43279E1 (en)	2000-03-29	2012-03-27	Biotemp B.V.	Compositions capable of reducing elevated blood urea concentration
EP1300418A1 (de)	2001-10-04	2003-04-09	Erasmus Universiteit Rotterdam	Genregulation durch Oligopeptide
US7358330B2 (en)	2001-03-29	2008-04-15	Biotempt B.V.	Immunoregulatory compositions
US7576174B2 (en)	2000-03-29	2009-08-18	Biotempt B.V.	Compositions capable of reducing elevated blood urea concentration
RU2161501C1 (ru) *	2000-06-29	2001-01-10	Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн"	Способ получения пептидов, обладающих тканеспецифической активностью, и фармацевтические композиции на их основе
RU2238938C2 (ru) *	2001-05-24	2004-10-27	Пятигорская государственная фармацевтическая академия	Производное имидазо-[1,2-а]-бензимидазола - средство, оказывающее церебропротекторное действие при радиационных поражениях
RU2224528C2 (ru) *	2001-07-24	2004-02-27	Брянский государственный университет им. акад. И.Г. Петровского	Способ получения биологически активных пептидов каудальной нейросекреторной системы (кнсс) позвоночных
US7351686B2 (en) *	2001-12-06	2008-04-01	Yeda Research And Development Co. Ltd.	Method for neuronal protection in amyotrophic lateral sclerosis by a vaccine comprising Copolymer-1 or Copolymer-1 related peptides
US7786084B2 (en)	2001-12-21	2010-08-31	Biotempt B.V.	Treatment of burns
US7560433B2 (en)	2001-12-21	2009-07-14	Biotempt B.V.	Treatment of multiple sclerosis (MS)
US7501391B2 (en)	2001-12-21	2009-03-10	Biotempt B.V.	Treatment of transplant survival
RU2236857C2 (ru) *	2002-10-11	2004-09-27	Яско Анатолий Константинович	Способ лечения атрофии мозга, гидроцефалии мозга препаратом ветом-7048
RU2244928C2 (ru) *	2003-02-19	2005-01-20	Пинигина Нина Максимовна	Эндогенная фармацевтическая композиция, полученная на основе целенаправленной активации гуморальных медиаторов нервных окончаний коры головного мозга
JP4846799B2 (ja)	2005-07-05	2011-12-28	バイオテンプトベー．フェー．	腫瘍の治療
EP1864692A1 (de)	2006-06-07	2007-12-12	Biotempt B.V.	Verwendung von peptiden zum Schutz von Strahlenschäden
EP1857463A1 (de)	2006-05-03	2007-11-21	Ebewe Pharma Ges.m.b.H. Nfg. KG	Neuroprotektive Wirkungen von Peptide
RU2301678C1 (ru) *	2006-05-30	2007-06-27	Общество С Ограниченной Ответственностью "Сиа Пептайдс"	Пептид, стимулирующий регенерацию нейронов центральной нервной системы, фармацевтическая композиция на его основе и способ ее применения
EP2000134A1 (de) *	2007-06-06	2008-12-10	Neuraxo Biopharmaceuticals GmbH	Verwendung einer Substanz zur Behandlung von Verletzungen des peripheren Nervensystems
RU2362580C1 (ru) *	2007-11-07	2009-07-27	Федеральное государственное учреждение "Новокузнецкий научно-практический центр медико-социальной экспертизы и реабилитации инвалидов Федерального агентства по здравоохранению и социальному развитию" (ФГУ ННПЦ МСЭ и РИ Росздрава)	Способ лечения спастического и болевого синдромов у пациентов с последствиями позвоночно-спинномозговой травмы
US9265458B2 (en)	2012-12-04	2016-02-23	Sync-Think, Inc.	Application of smooth pursuit cognitive testing paradigms to clinical drug development
EA020866B1 (ru)	2013-02-28	2015-02-27	Замертон Холдингс Лимитед	Пептиды с цитопротекторной активностью и фармацевтическая композиция
US9380976B2 (en)	2013-03-11	2016-07-05	Sync-Think, Inc.	Optical neuroinformatics
EP3914280B1 (de) *	2019-01-25	2024-03-27	The Board of Regents of The University of Texas System	Neuartiges analgetisches nicht-opioid-arzneimittel
RU2768475C1 (ru) *	2021-07-08	2022-03-24	Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ"	Пептид, обладающий нейростимулирующей активностью и восстанавливающий способность к обучению и формированию памяти, фармацевтическая композиция на его основе и способ ее применения

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SU1623166A1 (ru) *	1989-04-03	1994-02-15	Институт биоорганической химии АН БССР	Нейтропептиды, обладающие поведенческой активностью
WO1991009051A1 (en) *	1989-12-15	1991-06-27	G.D. Searle & Co.	Substituted cyclic penicillanic acid tetrapeptides
US5652334A (en) *	1993-09-08	1997-07-29	City Of Hope	Method for design of substances that enhance memory and improve the quality of life

1999
- 1999-10-20 RU RU99121778/14A patent/RU2155063C1/ru active
2000
- 2000-05-25 AT AT00937408T patent/ATE244727T1/de active
- 2000-05-25 AU AU52585/00A patent/AU784578B2/en not_active Ceased
- 2000-05-25 US US10/110,981 patent/US7189701B1/en not_active Expired - Fee Related
- 2000-05-25 IL IL14924300A patent/IL149243A0/xx unknown
- 2000-05-25 CA CA002388357A patent/CA2388357A1/en not_active Abandoned
- 2000-05-25 DE DE60003837T patent/DE60003837T2/de not_active Expired - Lifetime
- 2000-05-25 JP JP2001531865A patent/JP4668497B2/ja not_active Expired - Fee Related
- 2000-05-25 WO PCT/RU2000/000218 patent/WO2001029067A1/en not_active Ceased
- 2000-05-25 EP EP00937408A patent/EP1224212B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60003837T2 (de)	2004-06-03
US7189701B1 (en)	2007-03-13
EP1224212A1 (de)	2002-07-24
AU5258500A (en)	2001-04-30
AU784578B2 (en)	2006-05-04
DE60003837D1 (de)	2003-08-14
RU2155063C1 (ru)	2000-08-27
CA2388357A1 (en)	2001-04-26
EP1224212B1 (de)	2003-07-09
JP4668497B2 (ja)	2011-04-13
WO2001029067A1 (en)	2001-04-26
JP2003532630A (ja)	2003-11-05
IL149243A0 (en)	2002-11-10

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2004-09-15

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Publication	Publication Date	Title
DE60003837D1 (de)	2003-08-14	Tetrapeptid, das die funktionelle aktivität von neuronen stimuliert, dieses enthaltendes pharmakologisches mittel und seine verwendung
ATE321068T1 (de)	2006-04-15	Alterungsschutztetrapeptid, dieses enthaltende pharmazeutische zusammensetzungen und seine verwendung
DE69909794D1 (de)	2003-08-28	Verwendung eines dipeptids für wiederherstellungsprozesse
NO20043871L (no)	2004-09-15	Legemiddelformuleringer med kontrollert frigjoring som inneholder et baererpeptid
TR200101633T2 (tr)	2002-06-21	Farmasötik bileşim
IT1187828B (it)	1987-12-23	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
KR970025615A (ko)	1997-06-24	암 전이 억제제
IL194500A0 (en)	2011-08-01	Peptide substance enhancing capillaries resistance, pharmaceutical composition on its base and method of its application
US6174541B1 (en)	2001-01-16	Skin aging and wound treatment using cell migration agents
DE60112725D1 (de)	2005-09-22	Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors
CA2425445A1 (en)	2002-04-18	Tetrapeptide stimulating functional activity of hepatocytes, pharmacological substance on its basis and the method of its application
MY132437A (en)	2007-10-31	New applications of lysozyme dimer
ATE513845T1 (de)	2011-07-15	Peptidsubstanz mit immunogeroprotektiver wirkung, darauf basierende pharmazeutische zusammensetzung und verfahren zu ihrer anwendung
ATE90874T1 (de)	1993-07-15	Verwendung von phytinsaeure als antidot gegen alkoholvergiftung.
ES2042818T3 (es)	1993-12-16	Agente terapeutico para la trombocitopenia.
NO20051958L (no)	2001-10-10	Forbindelser
TR200201503T2 (tr)	2002-10-21	Heterosiklik türevler.
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RU2001112719A (ru)	2003-03-10	Способ лечения стенокардии и алекситимии у больных пожилого возраста
SE9903609D0 (sv)	1999-10-06	Novel compounds I