ATE245644T1 - 1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a - Google Patents

1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a

Info

Publication number: ATE245644T1
Authority: AT; Austria
Prior art keywords: arginine; indol; dihydro; ligands; derivatives
Prior art date: 2000-01-25

Application number

AT01907687T

Other languages

English (en)

Inventor

Bruno Schoentjes

Gal Claudine Serradeil-Le

Jean Wagnon

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-24

Publication date

2003-08-15

2001-01-24 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245644T1 publication Critical patent/ATE245644T1/de

Links

101800001144 Arg-vasopressin Proteins 0.000 title abstract 2
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 title abstract 2
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/12—Antihypertensives

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Pregnancy & Childbirth (AREA)
Emergency Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)

AT01907687T 2000-01-25 2001-01-24 1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a ATE245644T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0000958A FR2804115B1 (fr)	2000-01-25	2000-01-25	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000228 WO2001055134A2 (fr)	2000-01-25	2001-01-24	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands pour les recepteurs v1b ou v1b et v1a de l'arginine-vasopressine

Publications (1)

Publication Number	Publication Date
ATE245644T1 true ATE245644T1 (de)	2003-08-15

Family

ID=8846308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01907687T ATE245644T1 (de)	2000-01-25	2001-01-24	1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a

Country Status (13)

Country	Link
US (1)	US6624164B2 (de)
EP (1)	EP1254134B1 (de)
JP (1)	JP4861591B2 (de)
AT (1)	ATE245644T1 (de)
AU (1)	AU2001235596A1 (de)
DE (1)	DE60100506T2 (de)
DK (1)	DK1254134T3 (de)
ES (1)	ES2203596T3 (de)
FR (1)	FR2804115B1 (de)
HU (1)	HU225157B1 (de)
PT (1)	PT1254134E (de)
TR (1)	TR200301723T4 (de)
WO (1)	WO2001055134A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
JP4618127B2 (ja) *	2003-08-28	2011-01-26	大正製薬株式会社	１，３−ジヒドロ−２ｈ−インドール−２−オン誘導体
US20050070718A1 (en)	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en)	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
WO2006070742A1 (ja) *	2004-12-27	2006-07-06	Kyoto University	麻薬性鎮痛剤の耐性形成抑制剤
US8030499B2 (en)	2005-01-28	2011-10-04	Taisho Pharmaceutical Co., Ltd.	1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle
DE102005014936A1 (de)	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
DE102005014904A1 (de) *	2005-03-26	2007-02-01	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
CA2602194A1 (en) *	2005-03-24	2006-09-28	Abbott Gmbh & Co. Kg	Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
EP1957480A1 (de)	2005-12-02	2008-08-20	Abbott GmbH & Co. KG	Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
DE102006040915A1 (de) *	2006-08-26	2008-03-20	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
US8119676B2 (en) *	2006-08-26	2012-02-21	Abbott GmbH & Co. HG	Substituted benzimidazolone derivatives, medicaments comprising them and their use
US8486979B2 (en) *	2006-12-12	2013-07-16	Abbvie Inc.	1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) *	2006-12-12	2008-07-10	Abbott Laboratories	Pharmaceutical compositions and their methods of use
UY30846A1 (es) *	2006-12-30	2008-07-31	Abbott Gmbh & Amp	Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US8703774B2 (en) *	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
US8703775B2 (en)	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
CA2707671C (en)	2007-12-07	2016-02-02	Abbott Gmbh & Co. Kg	5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases
CA2707669C (en)	2007-12-07	2016-07-05	Wilfried Braje	5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
SG188781A1 (en)	2007-12-27	2013-04-30	Abbott Gmbh & Co Kg	Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
FR2927625B1 (fr) *	2008-02-19	2010-03-12	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr)	2008-04-21	2010-05-14	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
EP2435080A2 (de)	2009-05-29	2012-04-04	Abbott Laboratories	Pharmazeutische zusammensetzungen zur schmerzbehandlung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5940149B2 (ja) *	1977-11-09	1984-09-28	大塚製薬株式会社	オキシインド−ル誘導体
JPS55129284A (en) *	1979-03-27	1980-10-06	Shionogi & Co Ltd	3-(1-imipazolyl)indolin-2-one
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US5338755A (en) *	1990-07-31	1994-08-16	Elf Sanofi	N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2714378B1 (fr)	1993-12-24	1996-03-15	Sanofi Sa	Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
FR2757157B1 (fr)	1996-12-13	1999-12-31	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

2000
- 2000-01-25 FR FR0000958A patent/FR2804115B1/fr not_active Expired - Fee Related
2001
- 2001-01-24 TR TR2003/01723T patent/TR200301723T4/xx unknown
- 2001-01-24 WO PCT/FR2001/000228 patent/WO2001055134A2/fr not_active Ceased
- 2001-01-24 ES ES01907687T patent/ES2203596T3/es not_active Expired - Lifetime
- 2001-01-24 HU HU0204157A patent/HU225157B1/hu not_active IP Right Cessation
- 2001-01-24 US US10/182,638 patent/US6624164B2/en not_active Expired - Fee Related
- 2001-01-24 AU AU2001235596A patent/AU2001235596A1/en not_active Abandoned
- 2001-01-24 JP JP2001560993A patent/JP4861591B2/ja not_active Expired - Fee Related
- 2001-01-24 EP EP01907687A patent/EP1254134B1/de not_active Expired - Lifetime
- 2001-01-24 AT AT01907687T patent/ATE245644T1/de active
- 2001-01-24 DK DK01907687T patent/DK1254134T3/da active
- 2001-01-24 PT PT01907687T patent/PT1254134E/pt unknown
- 2001-01-24 DE DE60100506T patent/DE60100506T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60100506D1 (de)	2003-08-28
HU225157B1 (en)	2006-07-28
PT1254134E (pt)	2003-11-28
AU2001235596A1 (en)	2001-08-07
HUP0204157A2 (hu)	2003-04-28
JP2003523354A (ja)	2003-08-05
WO2001055134A2 (fr)	2001-08-02
TR200301723T4 (tr)	2004-02-23
EP1254134B1 (de)	2003-07-23
WO2001055134A3 (fr)	2002-03-14
FR2804115A1 (fr)	2001-07-27
DK1254134T3 (da)	2003-11-03
FR2804115B1 (fr)	2002-03-08
JP4861591B2 (ja)	2012-01-25
DE60100506T2 (de)	2004-05-13
HUP0204157A3 (en)	2005-04-28
US20030139413A1 (en)	2003-07-24
EP1254134A2 (de)	2002-11-06
US6624164B2 (en)	2003-09-23
ES2203596T3 (es)	2004-04-16

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Publication	Publication Date	Title
ATE245644T1 (de)	2003-08-15	1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a
IS2313B (is)	2007-11-15	1,3-díhýdró-2H-indól-2-ón afleiður og notkun þeirra sem bindlar fyrir V1b eða V1b og V1a arginín-þvagtemprandi viðtaka
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