DK1254134T3 - Derivater af 1,3-dihydro-2H-indol-2-on og deres anvendelse som ligander for argininvasopressinreceptorerne V1B eller V1B og V1A - Google Patents

Derivater af 1,3-dihydro-2H-indol-2-on og deres anvendelse som ligander for argininvasopressinreceptorerne V1B eller V1B og V1A

Info

Publication number: DK1254134T3
Authority: DK; Denmark
Prior art keywords: indol; dihydro; ligands; derivatives; arginine vasopressin
Prior art date: 2000-01-25

Application number

DK01907687T

Other languages

English (en)

Inventor

Bruno Schoentjes

Gal Claudine Serradeil-Le

Jean Wagnon

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-24

Publication date

2003-11-03

2001-01-24 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-11-03 Application granted granted Critical

2003-11-03 Publication of DK1254134T3 publication Critical patent/DK1254134T3/da

Links

102000004136 Vasopressin Receptors Human genes 0.000 title 1
108090000643 Vasopressin Receptors Proteins 0.000 title 1
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
101800001144 Arg-vasopressin Proteins 0.000 abstract 1
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)

DK01907687T 2000-01-25 2001-01-24 Derivater af 1,3-dihydro-2H-indol-2-on og deres anvendelse som ligander for argininvasopressinreceptorerne V1B eller V1B og V1A DK1254134T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0000958A FR2804115B1 (fr)	2000-01-25	2000-01-25	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000228 WO2001055134A2 (fr)	2000-01-25	2001-01-24	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands pour les recepteurs v1b ou v1b et v1a de l'arginine-vasopressine

Publications (1)

Publication Number	Publication Date
DK1254134T3 true DK1254134T3 (da)	2003-11-03

Family

ID=8846308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01907687T DK1254134T3 (da)	2000-01-25	2001-01-24	Derivater af 1,3-dihydro-2H-indol-2-on og deres anvendelse som ligander for argininvasopressinreceptorerne V1B eller V1B og V1A

Country Status (13)

Country	Link
US (1)	US6624164B2 (da)
EP (1)	EP1254134B1 (da)
JP (1)	JP4861591B2 (da)
AT (1)	ATE245644T1 (da)
AU (1)	AU2001235596A1 (da)
DE (1)	DE60100506T2 (da)
DK (1)	DK1254134T3 (da)
ES (1)	ES2203596T3 (da)
FR (1)	FR2804115B1 (da)
HU (1)	HU225157B1 (da)
PT (1)	PT1254134E (da)
TR (1)	TR200301723T4 (da)
WO (1)	WO2001055134A2 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
US7528124B2 (en)	2003-08-28	2009-05-05	Taisho Pharmaceutical Co., Ltd.	1,3-dihydro-2H-indol-2-one derivative
US20050070718A1 (en)	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en)	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
US20080227802A1 (en) *	2004-12-27	2008-09-18	Kyoto University	Agent For Suppressing Development of Tolerance to Narcotic Analgesics
US8030499B2 (en)	2005-01-28	2011-10-04	Taisho Pharmaceutical Co., Ltd.	1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle
DE102005014936A1 (de)	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
CA2602194A1 (en)	2005-03-24	2006-09-28	Abbott Gmbh & Co. Kg	Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
DE102005014904A1 (de) *	2005-03-26	2007-02-01	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
WO2007063123A1 (de)	2005-12-02	2007-06-07	Abbott Gmbh & Co. Kg	Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
CN101528712B (zh) *	2006-08-26	2013-10-30	Abbvie德国有限责任两合公司	取代的苯并咪唑酮衍生物、包含它们的药物以及其用途
DE102006040915A1 (de) *	2006-08-26	2008-03-20	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
US20080167286A1 (en) *	2006-12-12	2008-07-10	Abbott Laboratories	Pharmaceutical compositions and their methods of use
US8486979B2 (en)	2006-12-12	2013-07-16	Abbvie Inc.	1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es)	2006-12-30	2008-07-31	Abbott Gmbh & Amp	Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
CN102026995B (zh)	2007-12-07	2014-10-29	Abbvie德国有限责任两合公司	5，6-二取代的羟吲哚衍生物和其用途
EP2231643B1 (de)	2007-12-07	2012-10-31	Abbott GmbH & Co. KG	Amidomethyl-substitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen
CN101952276B (zh)	2007-12-07	2014-10-22	Abbvie德国有限责任两合公司	5-卤素取代的羟吲哚衍生物和其用于治疗加压素依赖性疾病的用途
US8703774B2 (en)	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
RU2487872C2 (ru) *	2007-12-27	2013-07-20	Эбботт Гмбх Унд Ко.Кг	Замещенные производные оксиндола и их применение для лечения заболеваний, зависимых от вазопрессина
FR2927625B1 (fr) *	2008-02-19	2010-03-12	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr)	2008-04-21	2010-05-14	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
WO2010138600A2 (en)	2009-05-29	2010-12-02	Abbott Laboratories	Pharmaceutical compositions for the treatment of pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5940149B2 (ja) *	1977-11-09	1984-09-28	大塚製薬株式会社	オキシインド−ル誘導体
JPS55129284A (en) *	1979-03-27	1980-10-06	Shionogi & Co Ltd	3-(1-imipazolyl)indolin-2-one
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US5338755A (en) *	1990-07-31	1994-08-16	Elf Sanofi	N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2714378B1 (fr) *	1993-12-24	1996-03-15	Sanofi Sa	Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
FR2757157B1 (fr)	1996-12-13	1999-12-31	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

2000
- 2000-01-25 FR FR0000958A patent/FR2804115B1/fr not_active Expired - Fee Related
2001
- 2001-01-24 AT AT01907687T patent/ATE245644T1/de active
- 2001-01-24 PT PT01907687T patent/PT1254134E/pt unknown
- 2001-01-24 US US10/182,638 patent/US6624164B2/en not_active Expired - Fee Related
- 2001-01-24 AU AU2001235596A patent/AU2001235596A1/en not_active Abandoned
- 2001-01-24 JP JP2001560993A patent/JP4861591B2/ja not_active Expired - Fee Related
- 2001-01-24 WO PCT/FR2001/000228 patent/WO2001055134A2/fr not_active Ceased
- 2001-01-24 ES ES01907687T patent/ES2203596T3/es not_active Expired - Lifetime
- 2001-01-24 TR TR2003/01723T patent/TR200301723T4/xx unknown
- 2001-01-24 DK DK01907687T patent/DK1254134T3/da active
- 2001-01-24 HU HU0204157A patent/HU225157B1/hu not_active IP Right Cessation
- 2001-01-24 EP EP01907687A patent/EP1254134B1/fr not_active Expired - Lifetime
- 2001-01-24 DE DE60100506T patent/DE60100506T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2003523354A (ja)	2003-08-05
US6624164B2 (en)	2003-09-23
ATE245644T1 (de)	2003-08-15
AU2001235596A1 (en)	2001-08-07
HUP0204157A3 (en)	2005-04-28
TR200301723T4 (tr)	2004-02-23
JP4861591B2 (ja)	2012-01-25
WO2001055134A3 (fr)	2002-03-14
FR2804115A1 (fr)	2001-07-27
PT1254134E (pt)	2003-11-28
ES2203596T3 (es)	2004-04-16
FR2804115B1 (fr)	2002-03-08
DE60100506D1 (de)	2003-08-28
HU225157B1 (en)	2006-07-28
DE60100506T2 (de)	2004-05-13
WO2001055134A2 (fr)	2001-08-02
HUP0204157A2 (hu)	2003-04-28
EP1254134B1 (fr)	2003-07-23
EP1254134A2 (fr)	2002-11-06
US20030139413A1 (en)	2003-07-24

Publication	Publication Date	Title
NO20023510D0 (no)	2002-07-23	Nye 1,3-dihydro-2H-indol-2-on-derivater og deres anvendelse som ligander for V1B og V1A
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TR200202288T2 (tr)	2003-01-21	Yeni indolin-2-on türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar
MXPA03004549A (es)	2004-03-26	Derivados de 3-arilindola y su uso como agonistas del receptor cb2.
NO20005535D0 (no)	2000-11-02	Pyrazol-derivater som P-38 MAP kinase-inhibitorer
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
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MXPA04000507A (es)	2004-07-23	Derivados de 1-fenilsulfonil-1,3-dihidro-2h-indol-2-ona, su preparacion y uso terapeutico.
TR200402067T4 (tr)	2004-09-21	1,3-Dihidro-2H-İndol-2-One türevleri ve bunların arjinin-vasopresin alıcılarının V1B veya V1B ve V1A ligandları olarak kullanımları
ECSP045104A (es)	2004-06-28	Ligandos de los receptores de los cannabinoides
NO20026094D0 (no)	2002-12-18	Fusjonerte azepinderivater og deres anvendelse som antidiuretiske midler
AR029942A1 (es)	2003-07-23	Compuestos derivados de 1,3-dihidro-2h-indol-2-ona, su utilizacion, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden, medicamentos constituidos por dichos compuestos y compuestos intermediarios
HRP20050213A2 (en)	2006-12-31	2,4-substituted indoles and their use as 5-ht6 modulators
WO2003097597A3 (fr)	2004-04-01	Derives d'indole et leur utilisation en tant que ligands des recepteurs cb2
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
SE9904128D0 (sv)	1999-11-15	Novel compounds
ATE282608T1 (de)	2004-12-15	Chinoxalindionen
CY1105798T1 (el)	2011-02-02	Στepοειδη, η παρασκευη τους, φαρμακευτικες συνθεσεις απο αυτα και χρησεις των ενωσεων
YU82302A (sh)	2005-11-28	Derivati 2-aminokarbonil-9h-purina