ATE245645T1 - Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten - Google Patents

Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten

Info

Publication number
ATE245645T1
ATE245645T1 AT00976907T AT00976907T ATE245645T1 AT E245645 T1 ATE245645 T1 AT E245645T1 AT 00976907 T AT00976907 T AT 00976907T AT 00976907 T AT00976907 T AT 00976907T AT E245645 T1 ATE245645 T1 AT E245645T1
Authority
AT
Austria
Prior art keywords
alpha
intermediate products
integrin antagonists
imidazolinone
producing
Prior art date
Application number
AT00976907T
Other languages
English (en)
Inventor
Mark S Jensen
Michael Palucki
Nelo R Rivera
Kenneth M Wells
Yi Xiao
Yaling Wang
Chunhua Yang
Nobuyoshi Yasuda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE245645T1 publication Critical patent/ATE245645T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
AT00976907T 1999-11-08 2000-11-03 Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten ATE245645T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16397999P 1999-11-08 1999-11-08
PCT/US2000/030361 WO2001034602A2 (en) 1999-11-08 2000-11-03 Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists

Publications (1)

Publication Number Publication Date
ATE245645T1 true ATE245645T1 (de) 2003-08-15

Family

ID=22592461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976907T ATE245645T1 (de) 1999-11-08 2000-11-03 Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten

Country Status (20)

Country Link
EP (1) EP1230240B1 (de)
JP (1) JP2003513974A (de)
KR (1) KR20020048427A (de)
CN (1) CN1414966A (de)
AR (1) AR029407A1 (de)
AT (1) ATE245645T1 (de)
AU (1) AU777919B2 (de)
BR (1) BR0015384A (de)
CA (1) CA2389999A1 (de)
CZ (1) CZ20021508A3 (de)
DE (1) DE60004087T2 (de)
EA (1) EA200200548A1 (de)
ES (1) ES2202191T3 (de)
HU (1) HUP0203246A3 (de)
IL (1) IL149313A0 (de)
MX (1) MXPA02004547A (de)
PL (1) PL355011A1 (de)
SK (1) SK8012002A3 (de)
WO (1) WO2001034602A2 (de)
YU (1) YU32502A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004508400A (ja) * 2000-09-13 2004-03-18 メルク　エンド　カムパニー　インコーポレーテッド アルファνインテグリン受容体アンタゴニスト
WO2002022615A1 (en) 2000-09-14 2002-03-21 Merck & Co., Inc. Alpha v integrin receptor antagonists
US6706885B2 (en) 2001-06-06 2004-03-16 Merck & Co., Inc. Process for preparing integrin antagonist intermediates
US6509347B2 (en) 2001-06-11 2003-01-21 Merck & Co., Inc. Crystalline forms of an integrin receptor antagonist
US6646130B2 (en) 2001-07-19 2003-11-11 Merck & Co., Inc. Process to chiral integrin antagonist beta-amino acid intermediate
AR038189A1 (es) * 2002-01-29 2005-01-05 Merck & Co Inc Proceso para la preparacion de intermediarios de antagonistas de integrina
EP1551401A4 (de) * 2002-09-20 2006-03-22 Merck & Co Inc Mannitol-formulierung f r einen integrin-rezeptor-antagonisten
PT2593452T (pt) 2010-07-14 2017-04-24 Novartis Ag Compostos heterocíclicos agonistas do receptor ip
UY34572A (es) 2012-01-13 2013-09-02 Novartis Ag Compuestos heterocíclicos agonistas del receptor ip
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
SI3050878T1 (sl) 2013-09-24 2022-01-31 Fujifilm Corporation Nova dušik-vsebujoča spojina ali njena sol ali kovinski kompleks le-te
TN2016000115A1 (en) * 2013-10-25 2017-07-05 Novartis Ag Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors.
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
JP6585167B2 (ja) * 2014-10-03 2019-10-02 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604681D0 (en) * 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
US10118929B2 (en) 2016-04-27 2018-11-06 Scifluor Life Sciences, Inc. Nonanoic and decanoic acid derivatives and uses thereof
HRP20210228T1 (hr) * 2016-11-08 2021-03-19 Bristol-Myers Squibb Company Amidi pirola kao inhibitori alfa v integrina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA003095B1 (ru) * 1997-12-17 2002-12-26 Мерк Энд Ко., Инк. Антагонисты рецепторов интегринов

Also Published As

Publication number Publication date
BR0015384A (pt) 2002-10-08
WO2001034602A2 (en) 2001-05-17
AU1461401A (en) 2001-06-06
YU32502A (sh) 2004-12-31
EP1230240B1 (de) 2003-07-23
DE60004087D1 (de) 2003-08-28
SK8012002A3 (en) 2002-10-08
HUP0203246A2 (hu) 2003-01-28
CZ20021508A3 (cs) 2002-10-16
AU777919B2 (en) 2004-11-04
EA200200548A1 (ru) 2002-10-31
ES2202191T3 (es) 2004-04-01
CA2389999A1 (en) 2001-05-17
KR20020048427A (ko) 2002-06-22
DE60004087T2 (de) 2004-04-15
JP2003513974A (ja) 2003-04-15
EP1230240A2 (de) 2002-08-14
CN1414966A (zh) 2003-04-30
WO2001034602A3 (en) 2002-01-17
IL149313A0 (en) 2002-11-10
PL355011A1 (en) 2004-03-22
AR029407A1 (es) 2003-06-25
MXPA02004547A (es) 2002-09-02
HUP0203246A3 (en) 2003-12-29

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