ATE246192T1 - Ethyliden-derivate tricyclyscher carbapenems - Google Patents

Ethyliden-derivate tricyclyscher carbapenems

Info

Publication number: ATE246192T1
Authority: AT; Austria
Prior art keywords: formula; carbapenems; derivatives; disclosed; novel
Prior art date: 1996-12-18

Application number

AT97947251T

Other languages

English (en)

Inventor

Anton Copar

Tomaz Solmajer

Borut Anzic

Tadeja Kuzman

Tomaz Mesar

Darko Kocjan

Original Assignee

Lek Farmacevtska Druzba Dd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-18

Filing date

1997-12-18

Publication date

2003-08-15

1997-12-18 Application filed by Lek Farmacevtska Druzba Dd filed Critical Lek Farmacevtska Druzba Dd

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE246192T1 publication Critical patent/ATE246192T1/de

Links

229940041011 carbapenems Drugs 0.000 title abstract 5
125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 abstract 4
208000035143 Bacterial infection Diseases 0.000 abstract 1
108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000002132 β-lactam antibiotic Substances 0.000 abstract 1
229940124586 β-lactam antibiotics Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

AT97947251T 1996-12-18 1997-12-18 Ethyliden-derivate tricyclyscher carbapenems ATE246192T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9600371A SI9600371B (sl)	1996-12-18	1996-12-18	Etilidenski derivati tricikličnih karbapenemov
PCT/SI1997/000035 WO1998027094A1 (en)	1996-12-18	1997-12-18	Ethylidene derivatives of tricyclic carbapenems

Publications (1)

Publication Number	Publication Date
ATE246192T1 true ATE246192T1 (de)	2003-08-15

Family

ID=20431974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97947251T ATE246192T1 (de)	1996-12-18	1997-12-18	Ethyliden-derivate tricyclyscher carbapenems

Country Status (8)

Country	Link
US (1)	US6489318B1 (de)
EP (1)	EP0946558B1 (de)
JP (1)	JP4252628B2 (de)
AT (1)	ATE246192T1 (de)
AU (1)	AU5237598A (de)
DE (1)	DE69723864T2 (de)
SI (1)	SI9600371B (de)
WO (1)	WO1998027094A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2350907B (en) *	1999-06-09	2002-02-13	Keith Andrew Burton	Computer system
ES2231275T3 (es)	1999-10-08	2005-05-16	Affinium Pharmaceuticals, Inc.	Inhibidores de fab i.
JP4387804B2 (ja)	2001-04-06	2009-12-24	アフィニアム・ファーマシューティカルズ・インコーポレイテッド	ＦａｂＩ阻害剤
PT1575951E (pt)	2002-12-06	2014-09-15	Debiopharm Int Sa	Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
EP1608377B1 (de) *	2003-03-17	2008-10-01	Affinium Pharmaceuticals, Inc.	Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
US8450307B2 (en)	2004-06-04	2013-05-28	Affinium Pharmaceuticals, Inc.	Therapeutic agents, and methods of making and using the same
US20090155316A1 (en) *	2004-12-13	2009-06-18	Apt Co., Ltd.	Oral Wash
EP2054422B1 (de)	2006-07-20	2017-06-14	Debiopharm International SA	Acrylamidderivate als fab-i-inhibitoren
EP1958630A1 (de) *	2007-02-13	2008-08-20	LEK Pharmaceuticals d.d.	Antibakterielle Kombination eines tricyclische Carbapenems und einem Antibiotikum
WO2008098374A1 (en)	2007-02-16	2008-08-21	Affinium Pharmaceuticals, Inc.	Salts, prodrugs and polymorphs of fab i inhibitors
EP2085084A1 (de)	2008-01-29	2009-08-05	LEK Pharmaceuticals D.D.	Verwendung eines Hemmers von Beta-Lactamasen und dessen Kombination mit Beta-Lactam-Antibiotika
EP2135871A1 (de) *	2008-06-18	2009-12-23	LEK Pharmaceuticals D.D.	Neuartige Trinemantibiotika und Hemmer von Beta-Lactamasen
EP2861608B8 (de)	2012-06-19	2019-06-19	Debiopharm International SA	Prodrug-derivate von (e)-n-methyl-n-((3-methylbenzofuran-2-yl) methyl)-3- (7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamid
DK3419628T3 (da)	2016-02-26	2021-01-11	Debiopharm Int Sa	Medikament til behandling af diabetiske fodinfektioner
SI3464336T1 (sl)	2016-06-01	2022-06-30	Athira Pharma, Inc.	Spojine
ES2944535T3 (es)	2019-02-14	2023-06-22	Debiopharm Int Sa	Formulación de afabicina, método para preparar la misma
UA129222C2 (uk)	2019-06-14	2025-02-12	Дебіофарм Інтернешнл С.А.	Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою
CN116057045B (zh)	2020-06-05	2026-06-09	金耐特生物制药公司	成纤维细胞生长因子受体激酶抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0005349A1 (de) *	1978-05-06	1979-11-14	Beecham Group Plc	Alkylcarbapeneme, ihre Herstellung, pharmazeutische Zubereitungen und Zwischenprodukte
US4235922A (en) *	1979-06-15	1980-11-25	Merck & Co., Inc.	3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid
AU636913B2 (en) *	1989-10-11	1993-05-13	Takeda Chemical Industries Ltd.	Tricyclic carbapenem compounds
GB9104832D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
GB9104769D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
CA2065079C (en) *	1991-04-05	2003-03-18	Michiyuki Sendai	Polycyclic carbapenem compounds, their production and use
JPH06166688A (ja) *	1992-10-02	1994-06-14	Takeda Chem Ind Ltd	カルバペネム化合物、その製造法および抗菌組成物
GB9323137D0 (en) *	1993-11-10	1994-01-05	Glaxo Spa	Chemical compounds
GB9403729D0 (en) *	1994-02-26	1994-04-13	Glaxo Spa	Amine derivatives

1996
- 1996-12-18 SI SI9600371A patent/SI9600371B/sl not_active IP Right Cessation
1997
- 1997-12-18 EP EP97947251A patent/EP0946558B1/de not_active Expired - Lifetime
- 1997-12-18 JP JP52763998A patent/JP4252628B2/ja not_active Expired - Fee Related
- 1997-12-18 US US09/319,660 patent/US6489318B1/en not_active Expired - Fee Related
- 1997-12-18 AU AU52375/98A patent/AU5237598A/en not_active Abandoned
- 1997-12-18 DE DE69723864T patent/DE69723864T2/de not_active Expired - Lifetime
- 1997-12-18 AT AT97947251T patent/ATE246192T1/de active
- 1997-12-18 WO PCT/SI1997/000035 patent/WO1998027094A1/en not_active Ceased

Also Published As

Publication number	Publication date
JP2001506258A (ja)	2001-05-15
EP0946558A1 (de)	1999-10-06
JP4252628B2 (ja)	2009-04-08
US6489318B1 (en)	2002-12-03
SI9600371A (sl)	1998-06-30
WO1998027094A1 (en)	1998-06-25
DE69723864D1 (en)	2003-09-04
DE69723864T2 (de)	2004-04-22
SI9600371B (sl)	2005-04-30
EP0946558B1 (de)	2003-07-30
AU5237598A (en)	1998-07-15

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2004-03-15

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