ATE246192T1 - Ethyliden-derivate tricyclyscher carbapenems - Google Patents

Ethyliden-derivate tricyclyscher carbapenems

Info

Publication number
ATE246192T1
ATE246192T1 AT97947251T AT97947251T ATE246192T1 AT E246192 T1 ATE246192 T1 AT E246192T1 AT 97947251 T AT97947251 T AT 97947251T AT 97947251 T AT97947251 T AT 97947251T AT E246192 T1 ATE246192 T1 AT E246192T1
Authority
AT
Austria
Prior art keywords
formula
carbapenems
derivatives
disclosed
novel
Prior art date
Application number
AT97947251T
Other languages
English (en)
Inventor
Anton Copar
Tomaz Solmajer
Borut Anzic
Tadeja Kuzman
Tomaz Mesar
Darko Kocjan
Original Assignee
Lek Farmacevtska Druzba Dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Farmacevtska Druzba Dd filed Critical Lek Farmacevtska Druzba Dd
Application granted granted Critical
Publication of ATE246192T1 publication Critical patent/ATE246192T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT97947251T 1996-12-18 1997-12-18 Ethyliden-derivate tricyclyscher carbapenems ATE246192T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9600371A SI9600371B (sl) 1996-12-18 1996-12-18 Etilidenski derivati tricikličnih karbapenemov
PCT/SI1997/000035 WO1998027094A1 (en) 1996-12-18 1997-12-18 Ethylidene derivatives of tricyclic carbapenems

Publications (1)

Publication Number Publication Date
ATE246192T1 true ATE246192T1 (de) 2003-08-15

Family

ID=20431974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947251T ATE246192T1 (de) 1996-12-18 1997-12-18 Ethyliden-derivate tricyclyscher carbapenems

Country Status (8)

Country Link
US (1) US6489318B1 (de)
EP (1) EP0946558B1 (de)
JP (1) JP4252628B2 (de)
AT (1) ATE246192T1 (de)
AU (1) AU5237598A (de)
DE (1) DE69723864T2 (de)
SI (1) SI9600371B (de)
WO (1) WO1998027094A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2350907B (en) * 1999-06-09 2002-02-13 Keith Andrew Burton Computer system
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
EP1560584B1 (de) 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab-i-inhibitoren
EP1575951B1 (de) 2002-12-06 2014-06-25 Debiopharm International SA Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
DK1828167T3 (da) 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
WO2006064788A1 (ja) * 2004-12-13 2006-06-22 Apt Co., Ltd. 口腔内洗浄液
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
EP1958630A1 (de) * 2007-02-13 2008-08-20 LEK Pharmaceuticals d.d. Antibakterielle Kombination eines tricyclische Carbapenems und einem Antibiotikum
EP2125802A4 (de) 2007-02-16 2014-08-20 Debiopharm Int Sa Salze, prodrugs und polymorphe von fab-i-inhibitoren
EP2085084A1 (de) 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Verwendung eines Hemmers von Beta-Lactamasen und dessen Kombination mit Beta-Lactam-Antibiotika
EP2135871A1 (de) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. Neuartige Trinemantibiotika und Hemmer von Beta-Lactamasen
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
US11021514B2 (en) 2016-06-01 2021-06-01 Athira Pharma, Inc. Compounds
TN2021000159A1 (en) 2019-02-14 2023-04-04 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
SG11202113174SA (en) 2019-06-14 2021-12-30 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm
US11345681B1 (en) 2020-06-05 2022-05-31 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005349A1 (de) * 1978-05-06 1979-11-14 Beecham Group Plc Alkylcarbapeneme, ihre Herstellung, pharmazeutische Zubereitungen und Zwischenprodukte
US4235922A (en) * 1979-06-15 1980-11-25 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid
AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds
GB9104832D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104769D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
EP0507313A1 (de) * 1991-04-05 1992-10-07 Takeda Chemical Industries, Ltd. Polycyclische Carbapenem-Verbindungen, ihre Herstellung und Verwendung
JPH06166688A (ja) * 1992-10-02 1994-06-14 Takeda Chem Ind Ltd カルバペネム化合物、その製造法および抗菌組成物
GB9323137D0 (en) * 1993-11-10 1994-01-05 Glaxo Spa Chemical compounds
GB9403729D0 (en) * 1994-02-26 1994-04-13 Glaxo Spa Amine derivatives

Also Published As

Publication number Publication date
EP0946558B1 (de) 2003-07-30
SI9600371B (sl) 2005-04-30
WO1998027094A1 (en) 1998-06-25
AU5237598A (en) 1998-07-15
DE69723864T2 (de) 2004-04-22
US6489318B1 (en) 2002-12-03
EP0946558A1 (de) 1999-10-06
DE69723864D1 (en) 2003-09-04
JP4252628B2 (ja) 2009-04-08
SI9600371A (sl) 1998-06-30
JP2001506258A (ja) 2001-05-15

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