ATE246492T1 - Mittel, die fein verteilte, kristalline budenosid-partikel enthalten - Google Patents

Mittel, die fein verteilte, kristalline budenosid-partikel enthalten

Info

Publication number
ATE246492T1
ATE246492T1 AT98924697T AT98924697T ATE246492T1 AT E246492 T1 ATE246492 T1 AT E246492T1 AT 98924697 T AT98924697 T AT 98924697T AT 98924697 T AT98924697 T AT 98924697T AT E246492 T1 ATE246492 T1 AT E246492T1
Authority
AT
Austria
Prior art keywords
budenoside
particles
agents containing
finely distributed
containing finely
Prior art date
Application number
AT98924697T
Other languages
English (en)
Inventor
Mikael Bisrat
Saeed Moshashaee
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE246492T1 publication Critical patent/ATE246492T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98924697T 1997-05-23 1998-05-15 Mittel, die fein verteilte, kristalline budenosid-partikel enthalten ATE246492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701956A SE9701956D0 (sv) 1997-05-23 1997-05-23 New composition of matter
PCT/SE1998/000908 WO1998052544A1 (en) 1997-05-23 1998-05-15 Composition comprising finely divided, crystalline particles of budesonide

Publications (1)

Publication Number Publication Date
ATE246492T1 true ATE246492T1 (de) 2003-08-15

Family

ID=20407079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924697T ATE246492T1 (de) 1997-05-23 1998-05-15 Mittel, die fein verteilte, kristalline budenosid-partikel enthalten

Country Status (28)

Country Link
US (2) US6346523B1 (de)
EP (1) EP1005328B1 (de)
JP (1) JP2001525850A (de)
KR (1) KR100514971B1 (de)
CN (1) CN1146406C (de)
AR (1) AR015820A1 (de)
AT (1) ATE246492T1 (de)
AU (1) AU734763B2 (de)
BR (1) BR9808812A (de)
CA (1) CA2290538C (de)
DE (1) DE69816997T2 (de)
DK (1) DK1005328T3 (de)
EE (1) EE03850B1 (de)
ES (1) ES2205496T3 (de)
HU (1) HUP0002212A3 (de)
ID (1) ID24332A (de)
IL (1) IL133098A (de)
IS (1) IS5254A (de)
NO (1) NO995540D0 (de)
NZ (1) NZ500852A (de)
PL (1) PL336902A1 (de)
PT (1) PT1005328E (de)
SE (1) SE9701956D0 (de)
SK (1) SK158799A3 (de)
TR (1) TR199902880T2 (de)
TW (1) TW518236B (de)
WO (1) WO1998052544A1 (de)
ZA (1) ZA984127B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4990696A (en) * 1995-02-24 1996-09-11 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
MXPA02008331A (es) * 2000-03-03 2003-01-28 Boehringer Ingelheim Pharma Procesamiento de material mediante expansion-contraccion repetidas de solvente.
EP1354581A4 (de) * 2000-12-26 2007-07-04 Takeda Pharmaceutical Poröse substanz und verfahren zu ihrer herstellung
GB0106403D0 (en) * 2001-03-15 2001-05-02 Pharmaceutical Profiles Labelling of dry powder formulations for inhalation
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
WO2003013683A1 (en) * 2001-08-08 2003-02-20 Brown University Research Foundation Methods for micronization of hydrophobic drugs
CA2462338C (en) * 2001-10-10 2011-04-19 Boehringer Ingelheim Pharmaceuticals, Inc. Powder processing with pressurized gaseous fluids
US20030129242A1 (en) * 2002-01-04 2003-07-10 Bosch H. William Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7842232B2 (en) 2003-05-22 2010-11-30 Elan Pharma International, Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020196A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
ATE446581T1 (de) * 2004-03-12 2009-11-15 Trinity College Dublin Magnetoresistives medium
CN101312713A (zh) * 2005-03-18 2008-11-26 纳米材料科技有限公司 可吸入的药物
AU2006272438B2 (en) 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
EP1782839A1 (de) 2005-11-03 2007-05-09 Genetic S.p.A. Verfahren zur Sterilisation von Glucocorticosteroiden mit überkritischem CO2
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070178051A1 (en) * 2006-01-27 2007-08-02 Elan Pharma International, Ltd. Sterilized nanoparticulate glucocorticosteroid formulations
CA2642577A1 (en) * 2006-02-15 2007-08-23 Tika Lakemedel Ab Methods of manufacturing corticosteroid solutions
PL2425820T3 (pl) 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
AU2011305566A1 (en) * 2010-09-22 2013-05-02 Map Pharmaceuticals, Inc. Aerosol composition for administering drugs
CN102975731B (zh) * 2012-04-24 2015-08-12 南车南京浦镇车辆有限公司 轨道车辆司机室骨架与车体的安装结构
WO2021219230A1 (en) 2020-04-30 2021-11-04 Paolo Fiorina Antiviral treatment
KR102567655B1 (ko) 2020-11-13 2023-08-17 주식회사 비츠로이엠 진공커패시터 및 진공커패시터 제조 방법
KR102739398B1 (ko) 2021-11-17 2024-12-06 주식회사 비츠로이엠 가변형 진공 커패시터
KR102739399B1 (ko) 2021-11-17 2024-12-06 주식회사 비츠로이엠 가변형 진공 커패시터의 나선형 전극 위치 결정구조

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1282405C (en) 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
DE68907062T2 (de) 1988-10-05 1993-10-07 Upjohn Co Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel.
GB9001635D0 (en) 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
JP3282731B2 (ja) 1990-06-15 2002-05-20 メルク エンド カムパニー インコーポレーテッド 結晶の構造および大きさを改良する結晶化方法
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5874063A (en) * 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
CA2123909C (en) * 1991-12-18 2002-10-01 Christer Carl Gustav Carling New combination of formoterol and budesonide
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SE9501384D0 (sv) 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles

Also Published As

Publication number Publication date
NO995540L (no) 1999-11-12
KR100514971B1 (ko) 2005-09-15
DK1005328T3 (da) 2003-11-17
CA2290538C (en) 2007-01-02
CN1146406C (zh) 2004-04-21
NO995540D0 (no) 1999-11-12
ZA984127B (en) 1998-11-23
SE9701956D0 (sv) 1997-05-23
TW518236B (en) 2003-01-21
AU734763B2 (en) 2001-06-21
ES2205496T3 (es) 2004-05-01
EP1005328A1 (de) 2000-06-07
CN1257424A (zh) 2000-06-21
SK158799A3 (en) 2000-05-16
US6346523B1 (en) 2002-02-12
KR20010012821A (ko) 2001-02-26
ID24332A (id) 2000-07-13
US20020037257A1 (en) 2002-03-28
HUP0002212A2 (hu) 2000-12-28
EP1005328B1 (de) 2003-08-06
PT1005328E (pt) 2003-11-28
DE69816997T2 (de) 2004-07-22
PL336902A1 (en) 2000-07-17
DE69816997D1 (de) 2003-09-11
US6468994B2 (en) 2002-10-22
JP2001525850A (ja) 2001-12-11
IL133098A0 (en) 2001-03-19
EE03850B1 (et) 2002-10-15
BR9808812A (pt) 2000-07-18
CA2290538A1 (en) 1998-11-26
EE9900533A (et) 2000-06-15
AU7680098A (en) 1998-12-11
NZ500852A (en) 2001-07-27
HUP0002212A3 (en) 2001-04-28
IL133098A (en) 2005-03-20
IS5254A (is) 1999-11-18
WO1998052544A1 (en) 1998-11-26
TR199902880T2 (xx) 2000-02-21
AR015820A1 (es) 2001-05-30

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