ATE247101T1 - Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden - Google Patents

Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden

Info

Publication number
ATE247101T1
ATE247101T1 AT97307376T AT97307376T ATE247101T1 AT E247101 T1 ATE247101 T1 AT E247101T1 AT 97307376 T AT97307376 T AT 97307376T AT 97307376 T AT97307376 T AT 97307376T AT E247101 T1 ATE247101 T1 AT E247101T1
Authority
AT
Austria
Prior art keywords
methods
preparations
processes
intermediate products
benzothiophene derivatives
Prior art date
Application number
AT97307376T
Other languages
English (en)
Inventor
Kenneth Lee Hauser
Alan David Palkowitz
Kenneth Jeff Thrasher
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE247101T1 publication Critical patent/ATE247101T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT97307376T 1996-09-24 1997-09-22 Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden ATE247101T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2655796P 1996-09-24 1996-09-24

Publications (1)

Publication Number Publication Date
ATE247101T1 true ATE247101T1 (de) 2003-08-15

Family

ID=27609008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97307376T ATE247101T1 (de) 1996-09-24 1997-09-22 Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden

Country Status (7)

Country Link
US (2) US5843963A (de)
EP (1) EP0831089B1 (de)
JP (1) JP3256168B2 (de)
AT (1) ATE247101T1 (de)
CA (1) CA2214919A1 (de)
DE (1) DE69724062T2 (de)
ES (1) ES2205131T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0997460B1 (de) * 1998-10-28 2002-12-11 Eli Lilly And Company Benzothiophenderivate als antithrombotische Mitteln und Zwischenprodukte
JP2004531559A (ja) * 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
US7056931B2 (en) * 2001-05-22 2006-06-06 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
US7135531B2 (en) * 2004-01-28 2006-11-14 Basf Catalysts Llc Spherical catalyst for olefin polymerization
US6962889B2 (en) * 2004-01-28 2005-11-08 Engelhard Corporation Spherical catalyst for olefin polymerization
US20080200458A1 (en) * 2007-01-18 2008-08-21 Joseph Barbosa Methods and compositions for the treatment of body composition disorders
US20080194557A1 (en) * 2007-01-18 2008-08-14 Joseph Barbosa Methods and compositions for the treatment of pain, inflammation and cancer
US7638585B2 (en) 2008-05-13 2009-12-29 Basf Catalysts, Llc Catalyst flow
US8003559B2 (en) * 2008-05-13 2011-08-23 Basf Corporation Internal donor for olefin polymerization catalysts
CN101606848A (zh) * 2008-06-20 2009-12-23 Ge医疗系统环球技术有限公司 数据输入方法和超声成像装置
US8003558B2 (en) * 2008-07-29 2011-08-23 Basf Corporation Internal donor for olefin polymerization catalysts

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138163A (en) * 1965-05-21 1968-12-27 Bristol Myers Co Benzothiophene derivatives having anti-fertility properties
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
FR2375228A1 (fr) * 1976-12-23 1978-07-21 Parcor Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
AU2543388A (en) * 1987-09-30 1989-04-18 University Of Tennessee Research Corporation, The Certain 3-substituted 2-alkyl benzothiophene derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US6399634B1 (en) * 1994-09-20 2002-06-04 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds

Also Published As

Publication number Publication date
EP0831089B1 (de) 2003-08-13
DE69724062D1 (de) 2003-09-18
ES2205131T3 (es) 2004-05-01
JP3256168B2 (ja) 2002-02-12
US6075151A (en) 2000-06-13
CA2214919A1 (en) 1998-03-24
EP0831089A1 (de) 1998-03-25
JPH10130262A (ja) 1998-05-19
US5843963A (en) 1998-12-01
DE69724062T2 (de) 2004-06-17

Similar Documents

Publication Publication Date Title
GB9722520D0 (en) Compounds
ZA200109995B (en) Nematicidal Trifluorobutenes.
EP0911321A3 (de) Verbindungen zur Behandlung von Osteoporose
ATE247101T1 (de) Benzothiophenderivate, zwischenprodukte, verfahren, zubereitungen und methoden
ATE278684T1 (de) Benzo(b)thiophen-verbindungen, zwischenprodukte, verfahren und zusammensetzungen
ATE277026T1 (de) Naphthylverbindungen, zusammensetzungen und verfahren
TW276172B (de)
ZA9810215B (en) 2-Aryl-3-Aroylbenzo[b]thiophenes useful for the treatment of estrogen deprivation syndrome.
ATE245637T1 (de) Benzothiophenverbindungen, zubereitungen und verfahren
DE69724548D1 (de) Substituierte 2,3-Aryl-Benzothiophene und ihre östrogene Aktivität
ATE244233T1 (de) Benzo(b)indeno(2,1-d)thiophenverbindungen, zwischenprodukte, verfahren, zusammensetzungen und methoden
NO990450D0 (no) Behandling av sinnslidelser
ATE244230T1 (de) Dihydrobenzofluorenverbindungen, zwischenprodukte,zusammensetzungen und methode
ATE259361T1 (de) Benzothiophenverbindungen, zwischenprodukte, zusammensetzungen und methode
NO943765L (no) Aryloksybenzen-herbicidmidler
DK0832883T3 (da) Tetrahydrobenzo(a)fluorenforbindelser og fremgangsmåder til anvendelse
DE69711528D1 (de) Naphthofluorenverbindungen, Zwischenverbindungen, Zusammensetzungen und Verfahren
ATE246183T1 (de) Dihydrobenzo(b)indeno(2,1-d)thiophen-derivate, zwischenprodukte, verfahren, zubereitungen und methoden
ZA968383B (en) Composition for treatment of osteoporosis.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties