ATE247107T1 - Angiotensin-ii-antagonisten - Google Patents
Angiotensin-ii-antagonistenInfo
- Publication number
- ATE247107T1 ATE247107T1 AT93304266T AT93304266T ATE247107T1 AT E247107 T1 ATE247107 T1 AT E247107T1 AT 93304266 T AT93304266 T AT 93304266T AT 93304266 T AT93304266 T AT 93304266T AT E247107 T1 ATE247107 T1 AT E247107T1
- Authority
- AT
- Austria
- Prior art keywords
- angiotensin
- antagonists
- mammals
- receptors
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89285492A | 1992-06-03 | 1992-06-03 | |
| US08/049,916 US5612360A (en) | 1992-06-03 | 1993-04-20 | Angiotensin II antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE247107T1 true ATE247107T1 (de) | 2003-08-15 |
Family
ID=26727699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93304266T ATE247107T1 (de) | 1992-06-03 | 1993-06-02 | Angiotensin-ii-antagonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US5612360A (de) |
| EP (1) | EP0574174B1 (de) |
| JP (1) | JPH0680666A (de) |
| KR (1) | KR940005617A (de) |
| CN (1) | CN1101908A (de) |
| AT (1) | ATE247107T1 (de) |
| AU (1) | AU661396B2 (de) |
| CA (1) | CA2097460A1 (de) |
| CZ (1) | CZ104593A3 (de) |
| DE (1) | DE69333138T2 (de) |
| DK (1) | DK0574174T3 (de) |
| ES (1) | ES2204898T3 (de) |
| FI (1) | FI932518A7 (de) |
| HU (1) | HUT64330A (de) |
| IL (1) | IL105878A0 (de) |
| MX (1) | MX9303263A (de) |
| NO (1) | NO932004L (de) |
| NZ (1) | NZ247770A (de) |
| PL (1) | PL299177A1 (de) |
| PT (1) | PT574174E (de) |
| TW (1) | TW252109B (de) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| EP0757811B1 (de) * | 1994-04-29 | 2001-11-14 | Infineon Technologies AG | Verfahren zur fuzzifizierung von an eingängen eines fuzzy-prozessors anliegenden eingangssignalen unter verwendung von eingangszugehörigkeitsfunktionen |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| JP3709565B2 (ja) * | 1995-01-25 | 2005-10-26 | 三菱化学株式会社 | カラーフィルター用重合組成物 |
| GB9518552D0 (en) * | 1995-09-11 | 1995-11-08 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| SI0912558T1 (en) * | 1996-06-25 | 2003-10-31 | Pfizer Inc. | Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors |
| US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU6031898A (en) * | 1997-01-22 | 1998-08-07 | Eli Lilly And Company | Anti-viral compounds |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| PL337888A1 (en) | 1997-07-03 | 2000-09-11 | Du Pont Pharm Co | Imidazoprimidines and imidazopyridines for use in treating neurological disorders |
| FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| DK1035133T3 (da) | 1999-02-17 | 2005-05-02 | Pfizer Prod Inc | Fusionsproteiner, der omfatter bærere, som kan inducere et dobbelt immunrespons |
| US7378108B1 (en) | 1999-02-19 | 2008-05-27 | Takeda Pharmaceutical Company Limited | Percutaneous absorption preparation of compound having angiotensin II antagonistic activity |
| IL146403A0 (en) * | 1999-06-22 | 2002-07-25 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
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| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
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| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
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| SE0402762D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Indazole sulphonamide derivatives |
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| SI2225230T1 (sl) | 2007-12-07 | 2017-03-31 | Vertex Pharmaceuticals Incorporated | Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline |
| EP2639224B1 (de) | 2007-12-07 | 2016-08-24 | Vertex Pharmaceuticals Incorporated | Verfahren zur Herstellung von Cycloalkylcarboxamidopyridinbenzoesäuren |
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| CA2722811C (en) * | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
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| NZ591115A (en) * | 2008-09-26 | 2012-10-26 | Boehringer Ingelheim Int | Azaindazole compounds as ccr1 receptor antagonists |
| EP2352374B1 (de) * | 2008-10-29 | 2014-09-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| PH12012500775A1 (en) | 2009-10-21 | 2012-11-26 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
| US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
| WO2011071730A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| HRP20211752T1 (hr) | 2010-04-07 | 2022-02-18 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
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-
1993
- 1993-04-20 US US08/049,916 patent/US5612360A/en not_active Expired - Fee Related
- 1993-06-01 CZ CZ931045A patent/CZ104593A3/cs unknown
- 1993-06-01 TW TW082104360A patent/TW252109B/zh active
- 1993-06-01 IL IL105878A patent/IL105878A0/xx unknown
- 1993-06-01 CA CA002097460A patent/CA2097460A1/en not_active Abandoned
- 1993-06-01 MX MX9303263A patent/MX9303263A/es unknown
- 1993-06-01 HU HU9301602A patent/HUT64330A/hu unknown
- 1993-06-02 DE DE69333138T patent/DE69333138T2/de not_active Expired - Fee Related
- 1993-06-02 PT PT93304266T patent/PT574174E/pt unknown
- 1993-06-02 FI FI932518A patent/FI932518A7/fi not_active Application Discontinuation
- 1993-06-02 ES ES93304266T patent/ES2204898T3/es not_active Expired - Lifetime
- 1993-06-02 AU AU39986/93A patent/AU661396B2/en not_active Ceased
- 1993-06-02 AT AT93304266T patent/ATE247107T1/de not_active IP Right Cessation
- 1993-06-02 NZ NZ247770A patent/NZ247770A/en unknown
- 1993-06-02 KR KR1019930009916A patent/KR940005617A/ko not_active Withdrawn
- 1993-06-02 EP EP93304266A patent/EP0574174B1/de not_active Expired - Lifetime
- 1993-06-02 NO NO932004A patent/NO932004L/no unknown
- 1993-06-02 DK DK93304266T patent/DK0574174T3/da active
- 1993-06-03 PL PL29917793A patent/PL299177A1/xx unknown
- 1993-06-03 JP JP5133314A patent/JPH0680666A/ja active Pending
- 1993-06-03 CN CN93108420A patent/CN1101908A/zh active Pending
-
1995
- 1995-05-30 US US08/453,532 patent/US5556981A/en not_active Expired - Fee Related
- 1995-05-30 US US08/453,591 patent/US5693633A/en not_active Expired - Fee Related
- 1995-05-31 US US08/455,239 patent/US5569768A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR940005617A (ko) | 1994-03-21 |
| TW252109B (de) | 1995-07-21 |
| CA2097460A1 (en) | 1993-12-04 |
| US5569768A (en) | 1996-10-29 |
| EP0574174A2 (de) | 1993-12-15 |
| HUT64330A (en) | 1993-12-28 |
| DK0574174T3 (da) | 2003-12-08 |
| ES2204898T3 (es) | 2004-05-01 |
| JPH0680666A (ja) | 1994-03-22 |
| EP0574174B1 (de) | 2003-08-13 |
| DE69333138D1 (de) | 2003-09-18 |
| NO932004L (no) | 1993-12-06 |
| MX9303263A (es) | 1993-12-01 |
| FI932518A0 (fi) | 1993-06-02 |
| HU9301602D0 (en) | 1993-09-28 |
| AU3998693A (en) | 1993-12-09 |
| US5556981A (en) | 1996-09-17 |
| DE69333138T2 (de) | 2004-06-09 |
| AU661396B2 (en) | 1995-07-20 |
| US5693633A (en) | 1997-12-02 |
| CZ104593A3 (en) | 1994-01-19 |
| IL105878A0 (en) | 1993-10-20 |
| FI932518L (fi) | 1993-12-04 |
| US5612360A (en) | 1997-03-18 |
| FI932518A7 (fi) | 1993-12-04 |
| NO932004D0 (no) | 1993-06-02 |
| NZ247770A (en) | 1995-10-26 |
| PL299177A1 (en) | 1994-02-07 |
| EP0574174A3 (en) | 1994-07-06 |
| CN1101908A (zh) | 1995-04-26 |
| PT574174E (pt) | 2003-12-31 |
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