ATE247118T1 - Imidazo(1,2-a)(pyrrolo, thieno oder furano)(3,2- d)azepinderivate, zubereitungen und ihre verwendung - Google Patents

Imidazo(1,2-a)(pyrrolo, thieno oder furano)(3,2- d)azepinderivate, zubereitungen und ihre verwendung

Info

Publication number: ATE247118T1
Authority: AT; Austria
Prior art keywords: 4alkyl; substituted; hydroxycarbonyl; represents hydrogen; 4alkyloxy
Prior art date: 1991-06-13

Application number

AT92911643T

Other languages

English (en)

Inventor

Frans Eduard Janssens

Gaston Stanislas Marcell Diels

Joseph Elisabeth Leenaerts

Ludwig Paul Cooymans

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-13

Filing date

1992-06-09

Publication date

2003-08-15

1992-06-09 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE247118T1 publication Critical patent/ATE247118T1/de

Links

150000001538 azepines Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
-1 hydroxycarbanyl Chemical group 0.000 abstract 2
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Detergent Compositions (AREA)
Paper (AREA)

AT92911643T 1991-06-13 1992-06-09 Imidazo(1,2-a)(pyrrolo, thieno oder furano)(3,2- d)azepinderivate, zubereitungen und ihre verwendung ATE247118T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71448791A	1991-06-13	1991-06-13
PCT/EP1992/001331 WO1992022553A1 (en)	1991-06-13	1992-06-09	IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE

Publications (1)

Publication Number	Publication Date
ATE247118T1 true ATE247118T1 (de)	2003-08-15

Family

ID=24870247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92911643T ATE247118T1 (de)	1991-06-13	1992-06-09	Imidazo(1,2-a)(pyrrolo, thieno oder furano)(3,2- d)azepinderivate, zubereitungen und ihre verwendung

Country Status (26)

Country	Link
US (1)	US5461050A (de)
EP (2)	EP0588859B1 (de)
JP (1)	JP3182421B2 (de)
KR (1)	KR100247504B1 (de)
CN (1)	CN1033587C (de)
AT (1)	ATE247118T1 (de)
AU (1)	AU652841B2 (de)
CA (1)	CA2102889C (de)
DE (1)	DE69233161T2 (de)
ES (1)	ES2204892T3 (de)
FI (1)	FI104077B (de)
HR (1)	HRP920156A2 (de)
HU (1)	HU221013B1 (de)
IE (1)	IE921919A1 (de)
IL (1)	IL101851A (de)
MA (1)	MA22554A1 (de)
MX (1)	MX9202860A (de)
NO (2)	NO300689B1 (de)
NZ (1)	NZ242775A (de)
PL (1)	PL170376B1 (de)
SI (1)	SI9200104A (de)
TN (1)	TNSN92049A1 (de)
TW (1)	TW218382B (de)
WO (1)	WO1992022553A1 (de)
ZA (1)	ZA924327B (de)
ZM (1)	ZM2892A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
GR1001385B (el) *	1992-10-12	1993-10-29	Janssen Pharmaceutica Nv	Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
CA2150805C (en) *	1992-12-04	2006-08-15	Frans Eduard Janssens	Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
NZ258553A (en) *	1992-12-04	1996-06-25	Janssen Pharmaceutica Nv	Azepine derivatives; compounds, process for preparation and pharmaceutical compositions containing such compounds
EP0708776B1 (de) *	1993-07-13	2001-01-03	Janssen Pharmaceutica N.V.	Antiallergische imidazoazepine
TW382017B (en) *	1995-12-27	2000-02-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en)	1996-03-19	2003-04-11	Janssen Pharmaceutica Nv	Fused imidazole derivatives as multidrug resistance modulators
JP3882224B2 (ja) *	1996-05-31	2007-02-14	旭硝子株式会社	パロキセチンの製造方法
AU1146099A (en) *	1997-09-18	1999-04-05	Janssen Pharmaceutica N.V.	Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
BR9916371A (pt) *	1998-12-19	2001-09-18	Janssen Pharmaceutica Nv	Composto de espiro anti-histamìnico
TWI225488B (en) *	1999-12-21	2004-12-21	Janssen Pharmaceutica Nv	Derivatives of homopiperidinyl substituted benzimidazole analogues
WO2002100862A2 (en)	2001-06-12	2002-12-19	Janssen Pharmaceutica N.V.	Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
WO2005009387A2 (en) *	2003-07-23	2005-02-03	X-Ceptor Therapeutics Inc.	Azepine derivatives as pharmaceutical agents
NZ556628A (en)	2005-03-08	2009-09-25	Janssen Pharmaceutica Nv	Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
TWI498115B (zh) *	2007-12-27	2015-09-01	Daiichi Sankyo Co Ltd	咪唑羰基化合物
CN103570731B (zh) *	2012-07-30	2016-05-18	中国科学院广州生物医药与健康研究院	嘧啶并三环或嘧啶并四环类化合物及其药用组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4148903A (en) *	1977-07-28	1979-04-10	Merck & Co., Inc.	Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them

1992
- 1992-05-13 IL IL10185192A patent/IL101851A/en not_active IP Right Cessation
- 1992-05-15 NZ NZ242775A patent/NZ242775A/en unknown
- 1992-05-16 CN CN92104830A patent/CN1033587C/zh not_active Expired - Fee Related
- 1992-05-21 TW TW081103953A patent/TW218382B/zh active
- 1992-06-09 AT AT92911643T patent/ATE247118T1/de not_active IP Right Cessation
- 1992-06-09 EP EP92911643A patent/EP0588859B1/de not_active Expired - Lifetime
- 1992-06-09 DE DE69233161T patent/DE69233161T2/de not_active Expired - Fee Related
- 1992-06-09 CA CA002102889A patent/CA2102889C/en not_active Expired - Fee Related
- 1992-06-09 JP JP51073492A patent/JP3182421B2/ja not_active Expired - Fee Related
- 1992-06-09 HU HU9303554A patent/HU221013B1/hu not_active IP Right Cessation
- 1992-06-09 KR KR1019930703789A patent/KR100247504B1/ko not_active Expired - Fee Related
- 1992-06-09 US US08/150,121 patent/US5461050A/en not_active Expired - Lifetime
- 1992-06-09 AU AU19011/92A patent/AU652841B2/en not_active Ceased
- 1992-06-09 WO PCT/EP1992/001331 patent/WO1992022553A1/en not_active Ceased
- 1992-06-09 PL PL92301819A patent/PL170376B1/pl unknown
- 1992-06-09 EP EP92201665A patent/EP0518434A1/de active Pending
- 1992-06-09 ES ES92911643T patent/ES2204892T3/es not_active Expired - Lifetime
- 1992-06-10 HR HR920156A patent/HRP920156A2/hr not_active Application Discontinuation
- 1992-06-11 MA MA22844A patent/MA22554A1/fr unknown
- 1992-06-12 SI SI19929200104A patent/SI9200104A/sl not_active IP Right Cessation
- 1992-06-12 MX MX9202860A patent/MX9202860A/es not_active IP Right Cessation
- 1992-06-12 ZA ZA924327A patent/ZA924327B/xx unknown
- 1992-06-12 ZM ZM2892A patent/ZM2892A1/xx unknown
- 1992-06-15 TN TNTNSN92049A patent/TNSN92049A1/fr unknown
- 1992-07-01 IE IE191992A patent/IE921919A1/en not_active Application Discontinuation
1993
- 1993-12-09 NO NO934493A patent/NO300689B1/no not_active IP Right Cessation
- 1993-12-09 NO NO934493D patent/NO934493D0/no unknown
- 1993-12-10 FI FI935557A patent/FI104077B/fi active

Also Published As

Publication number	Publication date
EP0588859A1 (de)	1994-03-30
MA22554A1 (fr)	1992-12-31
NO300689B1 (no)	1997-07-07
FI935557A0 (fi)	1993-12-10
DE69233161T2 (de)	2004-05-27
IE921919A1 (en)	1992-12-16
HU221013B1 (hu)	2002-07-29
FI104077B1 (fi)	1999-11-15
FI935557A7 (fi)	1993-12-10
AU1901192A (en)	1993-01-12
TNSN92049A1 (fr)	1993-06-08
EP0518434A1 (de)	1992-12-16
DE69233161D1 (de)	2003-09-18
HU9303554D0 (en)	1994-04-28
HRP920156A2 (en)	1995-12-31
FI104077B (fi)	1999-11-15
MX9202860A (es)	1992-12-01
AU652841B2 (en)	1994-09-08
US5461050A (en)	1995-10-24
SI9200104A (en)	1992-12-31
TW218382B (de)	1994-01-01
ZA924327B (en)	1993-12-13
PL170376B1 (pl)	1996-12-31
CN1068116A (zh)	1993-01-20
JPH06507890A (ja)	1994-09-08
NO934493D0 (no)	1993-12-09
ZM2892A1 (en)	1994-05-25
EP0588859B1 (de)	2003-08-13
CA2102889A1 (en)	1992-12-14
JP3182421B2 (ja)	2001-07-03
KR100247504B1 (ko)	2000-05-01
NO934493L (no)	1994-01-04
CN1033587C (zh)	1996-12-18
IL101851A (en)	1996-05-14
ES2204892T3 (es)	2004-05-01
CA2102889C (en)	2002-11-26
NZ242775A (en)	1995-03-28
IL101851A0 (en)	1992-12-30
WO1992022553A1 (en)	1992-12-23
HUT70428A (en)	1995-10-30

Legal Events

Date	Code	Title	Description
2004-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
HU9303553D0 (en)	1994-04-28	Imidazo[2,1-b][3]benzazepine derivatives, compositions and methods of use
DE69233161D1 (de)	2003-09-18	Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung
PL300066A1 (en)	1994-02-21	Novel 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxy-tyetracyclines, methods of obtaining them and pharmaceutical composition
AU2174288A (en)	1989-03-09	Lactam derivatives
NZ232283A (en)	1991-08-27	Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
CA2150805A1 (en)	1994-06-23	Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
IL87604A0 (en)	1989-01-31	Pyrrolo(1,2-a)imidazole and pyrrolo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
NO174670C (no)	1994-06-15	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1H-pyrido(4,3-b)indol-1-on-derivater
IE880318L (en)	1988-08-06	Tricyclic triazolopyrimidines
YU61292A (sh)	1994-09-09	Imidazo(1,2,-a)(3)(pirolo, tieno ili furano)(3,2-a)azepinski derivati i preparati