ATE247468T1 - Kombinationstherapie von topoisomerase ii toxinen und bis-dioxypiperazinderivaten - Google Patents

Kombinationstherapie von topoisomerase ii toxinen und bis-dioxypiperazinderivaten

Info

Publication number
ATE247468T1
ATE247468T1 AT97900205T AT97900205T ATE247468T1 AT E247468 T1 ATE247468 T1 AT E247468T1 AT 97900205 T AT97900205 T AT 97900205T AT 97900205 T AT97900205 T AT 97900205T AT E247468 T1 ATE247468 T1 AT E247468T1
Authority
AT
Austria
Prior art keywords
topoisomerase
dioxypiperazine
bis
mammal
toxins
Prior art date
Application number
AT97900205T
Other languages
English (en)
Inventor
Peter Buhl Lensen
Maxwell Sehested
Original Assignee
Topotarget Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topotarget Aps filed Critical Topotarget Aps
Application granted granted Critical
Publication of ATE247468T1 publication Critical patent/ATE247468T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97900205T 1996-01-11 1997-01-10 Kombinationstherapie von topoisomerase ii toxinen und bis-dioxypiperazinderivaten ATE247468T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK2296 1996-01-11
US60310596A 1996-02-20 1996-02-20
PCT/DK1997/000013 WO1997025044A1 (en) 1996-01-11 1997-01-10 Topoisomerase ii poison and bis-dioxypiperazine derivative combination therapy

Publications (1)

Publication Number Publication Date
ATE247468T1 true ATE247468T1 (de) 2003-09-15

Family

ID=26063143

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97900205T ATE247468T1 (de) 1996-01-11 1997-01-10 Kombinationstherapie von topoisomerase ii toxinen und bis-dioxypiperazinderivaten

Country Status (8)

Country Link
EP (1) EP0874630B1 (de)
AT (1) ATE247468T1 (de)
AU (1) AU1367797A (de)
CA (1) CA2242406C (de)
DE (1) DE69724228T2 (de)
ES (1) ES2205164T3 (de)
PT (1) PT874630E (de)
WO (1) WO1997025044A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1459752A3 (de) 1999-03-12 2007-07-18 TopoTarget A/S Bisdioxopiperazine zur Behandlung von unerwünschter Extravasation von Anthrazyklinen
GB0404675D0 (en) 2004-03-02 2004-04-07 Topotarget As Cancer treatment
CN118766918B (zh) * 2024-07-26 2025-04-04 中国科学院微生物研究所 m-AMSA或其衍生物在制备预防和/或治疗非洲猪瘟病毒感染的药物中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8403912D0 (sv) * 1984-07-30 1984-07-30 Pharmacia Ab Lekemedelssats eller -komposition
US5242901A (en) * 1988-01-27 1993-09-07 New York University Reduction of anthracycline induced cardiotoxicity
PT93772A (pt) * 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
GB9024861D0 (en) * 1990-11-15 1991-01-02 Hellmann Kurt Bis-dioxopiperazines for treating liver tumors
GB9115596D0 (en) * 1991-07-12 1991-09-04 Creighton Andrew M Pharmaceutical compositions
US5587382A (en) * 1994-03-28 1996-12-24 Boehringer Mannheim Italia, Spa 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity

Also Published As

Publication number Publication date
EP0874630A1 (de) 1998-11-04
DE69724228D1 (de) 2003-09-25
CA2242406A1 (en) 1997-07-17
EP0874630B1 (de) 2003-08-20
DE69724228T2 (de) 2004-06-09
AU1367797A (en) 1997-08-01
ES2205164T3 (es) 2004-05-01
PT874630E (pt) 2004-01-30
WO1997025044A1 (en) 1997-07-17
CA2242406C (en) 2009-09-08

Similar Documents

Publication Publication Date Title
EP0333606A3 (en) Preparation of t-cell and t-cell membrane for use in prevention and treatment of autoimmune diseases
MX9703621A (es) Nuevos derivados aminoacidos con actividad mejorada para la resistencia a drogas multiples.
DE69333775D1 (de) Synthetische katalytische freie radikalfänger, verwendbar als antioxidantien zur prävention und therapie von krankheiten
ATE307608T1 (de) Kombination von doctaxel und rhumab her2 zür krebsbehandlung
CA2184242A1 (en) Drug Targeting System, Method for Preparing Same and Its Use
EA199900553A1 (ru) Чрескожная терапевтическая система
CA2111836A1 (en) Spin-trapping pharmaceutical compositions and methods for use thereof
BR9714677A (pt) "enantiÈmeros 3-piridila e seu uso como analgésicos"
GR3032523T3 (en) Therapeutic preparation for the transdermal administration of active substances
ES2173111T3 (es) Uso de fenserina para la preparacion de medicamentos para el tratamiento de desordenes cognoscitivos.
DE69817602D1 (de) Arzneistoffverabreichungssystem mit zweistufigem targeting
DE69426334D1 (de) Parenterales Busulfan zur Behandlung von malignen Krankheiten
ATE173627T1 (de) Medizinische zusammensetzung
UA32457C2 (uk) Лікарський засіб (варіанти) і спосіб медикаментозного впливу на організм
NO994165L (no) Anvendelse av deskarboetoksyloratadin for fremstilling av et medikament for behandling av urininkontinens, reisesyke og svimmelhet
DE69633396D1 (de) Activin stimulator enthaltende pharmazeutische zusammensetzung
AU6553790A (en) Pharmazeutische praparate
NO973197D0 (no) Kombinert terapeutisk behandling av hyperproliferative sykdommer
AU3401093A (en) Therapeutic agent for threatened abortion
ATE247468T1 (de) Kombinationstherapie von topoisomerase ii toxinen und bis-dioxypiperazinderivaten
RU93039070A (ru) Способ лечения больных местно-распространенными формами рака
PT862454E (pt) Novas utilizacoes de ctla-8 de mamifero e reagentes relacionados
RU94024337A (ru) Антиметастатическое средство
BR0016720A (pt) Uso de trimebutina para tratamento de dores
Kovach et al. Phase I study of hycanthone

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0874630

Country of ref document: EP

EEFA Change of the company name