ATE248156T1 - Verwendung von 7-acyltaxolen zur behandlung von multidrugresistenten zellen - Google Patents

Verwendung von 7-acyltaxolen zur behandlung von multidrugresistenten zellen

Info

Publication number
ATE248156T1
ATE248156T1 AT99916599T AT99916599T ATE248156T1 AT E248156 T1 ATE248156 T1 AT E248156T1 AT 99916599 T AT99916599 T AT 99916599T AT 99916599 T AT99916599 T AT 99916599T AT E248156 T1 ATE248156 T1 AT E248156T1
Authority
AT
Austria
Prior art keywords
acyltaxols
resistant cells
treat multidrug
multidrug
treat
Prior art date
Application number
AT99916599T
Other languages
English (en)
Inventor
Christopher K Murray
Qun Y Zheng
Sagar R Shakya
Original Assignee
Hauser Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hauser Inc filed Critical Hauser Inc
Application granted granted Critical
Publication of ATE248156T1 publication Critical patent/ATE248156T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99916599T 1998-04-10 1999-04-09 Verwendung von 7-acyltaxolen zur behandlung von multidrugresistenten zellen ATE248156T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/058,036 US6136988A (en) 1998-04-10 1998-04-10 7-hexanoyltaxol and methods for preparing the same
PCT/US1999/007880 WO1999052887A1 (en) 1998-04-10 1999-04-09 7-hexanoyltaxol and methods for preparing the same

Publications (1)

Publication Number Publication Date
ATE248156T1 true ATE248156T1 (de) 2003-09-15

Family

ID=22014264

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99916599T ATE248156T1 (de) 1998-04-10 1999-04-09 Verwendung von 7-acyltaxolen zur behandlung von multidrugresistenten zellen

Country Status (8)

Country Link
US (3) US6136988A (de)
EP (1) EP1070057B1 (de)
JP (1) JP2002511457A (de)
AT (1) ATE248156T1 (de)
AU (1) AU757211B2 (de)
CA (1) CA2327791A1 (de)
DE (1) DE69910755T2 (de)
WO (1) WO1999052887A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
DE60004630T2 (de) * 1999-01-12 2004-06-17 Quanam Medical Corp., Santa Clara Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
CN1377282A (zh) * 1999-03-09 2002-10-30 普罗塔盖公司 脂肪酸－抗癌缀合物及其应用
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
ATE342260T1 (de) * 1999-05-28 2006-11-15 Bristol Myers Squibb Co Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
PL350328A1 (en) * 2000-02-02 2002-12-02 Univ Florida State Res Found C7 heterosubstituted acetate taxanes as antitumor agents
US6624317B1 (en) * 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US20070113575A1 (en) * 2003-12-05 2007-05-24 Ritchie Engineering Company, Inc. Valve manifold assembly
GT200500041A (es) 2004-03-05 2005-10-24 Taxanos con sustituyente lactiloxilo en el c7
US7449196B2 (en) * 2004-07-09 2008-11-11 Robert Sabin Anti tumor compositions and methods of use
US20080081051A1 (en) * 2006-09-28 2008-04-03 Robert Sabin Method of manufacturing anti-tumor and anti-viral compositions
CN101735179B (zh) * 2008-11-19 2012-09-12 上海百灵医药科技有限公司 一种多烯紫杉醇的制备方法，其中间体及制备方法
CN103242267B (zh) * 2012-02-03 2015-03-18 福建南方制药股份有限公司 卡巴他赛及其中间体的制备方法及卡巴他赛中间体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4039319A1 (de) 1990-12-10 1992-06-11 Sicowa Verfahrenstech Verfahren zum herstellen von gipsbaustoffen
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5352806A (en) * 1992-04-17 1994-10-04 Abbott Laboratories Taxol derivatives
WO1994005282A1 (en) * 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5580899A (en) 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same

Also Published As

Publication number Publication date
US20030083367A1 (en) 2003-05-01
JP2002511457A (ja) 2002-04-16
US6469050B1 (en) 2002-10-22
DE69910755T2 (de) 2004-07-01
EP1070057B1 (de) 2003-08-27
CA2327791A1 (en) 1999-10-21
AU3488899A (en) 1999-11-01
AU757211B2 (en) 2003-02-06
DE69910755D1 (de) 2003-10-02
WO1999052887A1 (en) 1999-10-21
EP1070057A4 (de) 2001-09-05
US6753345B2 (en) 2004-06-22
EP1070057A1 (de) 2001-01-24
US6136988A (en) 2000-10-24

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