ATE248176T1 - Natriumsalz von 3-(4-cinnamyl-1-piperazinyl)- iminomethyl-rifamycin sv und verfahren zu seiner herstellung - Google Patents

Natriumsalz von 3-(4-cinnamyl-1-piperazinyl)- iminomethyl-rifamycin sv und verfahren zu seiner herstellung

Info

Publication number: ATE248176T1
Authority: AT; Austria
Prior art keywords: sodium salt; rifamycin; cinnamyl; piperazinyl; iminomethyl
Prior art date: 1998-11-04

Application number

AT99953444T

Other languages

English (en)

Inventor

Roumiana Gueorgu Konstantinova

Kiril Asenov Nonov

Velitchka Ilieva Dimova

Anka Veltcheva Evstatieva

Original Assignee

Roumiana Gueorgu Konstantinova

Kiril Asenov Nonov

Velitchka Ilieva Dimova

Anka Veltcheva Evstatieva

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-04

Filing date

1999-11-03

Publication date

2003-09-15

1999-11-03 Application filed by Roumiana Gueorgu Konstantinova, Kiril Asenov Nonov, Velitchka Ilieva Dimova, Anka Veltcheva Evstatieva filed Critical Roumiana Gueorgu Konstantinova

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248176T1 publication Critical patent/ATE248176T1/de

Links

229940109171 rifamycin sv Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
159000000000 sodium salts Chemical class 0.000 abstract 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
HJYYPODYNSCCOU-ZDHWWVNNSA-N Rifamycin SV Natural products COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C)cc(O)c4c3C2=O HJYYPODYNSCCOU-ZDHWWVNNSA-N 0.000 abstract 3
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
238000004821 distillation Methods 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 abstract 1
229960001225 rifampicin Drugs 0.000 abstract 1
HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
235000010378 sodium ascorbate Nutrition 0.000 abstract 1
229960005055 sodium ascorbate Drugs 0.000 abstract 1
PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 abstract 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT99953444T 1998-11-04 1999-11-03 Natriumsalz von 3-(4-cinnamyl-1-piperazinyl)- iminomethyl-rifamycin sv und verfahren zu seiner herstellung ATE248176T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
BG102897A BG64021B1 (bg)	1998-11-04	1998-11-04	Натриева сол на 3-(4-цинамил-1-пиперазинил)-иминометил рифамицин и метод за получаването й
PCT/BG1999/000022 WO2000025721A2 (en)	1998-11-04	1999-11-03	Sodium salt of 3-(4-cinnamyl-1-piperazinyl)imino-methyl rifamycin sv and process of preparation

Publications (1)

Publication Number	Publication Date
ATE248176T1 true ATE248176T1 (de)	2003-09-15

Family

ID=3927599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99953444T ATE248176T1 (de)	1998-11-04	1999-11-03	Natriumsalz von 3-(4-cinnamyl-1-piperazinyl)- iminomethyl-rifamycin sv und verfahren zu seiner herstellung

Country Status (12)

Country	Link
US (1)	US6476036B1 (de)
EP (1)	EP1124831B1 (de)
AT (1)	ATE248176T1 (de)
AU (1)	AU1020400A (de)
BG (1)	BG64021B1 (de)
BR (1)	BR9915035A (de)
DE (1)	DE69910810T2 (de)
DK (1)	DK1124831T3 (de)
ES (1)	ES2207296T3 (de)
PT (1)	PT1124831E (de)
RU (1)	RU2001114830A (de)
WO (1)	WO2000025721A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100383143C (zh) *	2004-04-29	2008-04-23	薛荔	一锅烩合成利福平的方法
WO2009137380A1 (en) *	2008-05-05	2009-11-12	Janssen Pharmaceutica Nv	3-hydrazone piperazinyl rifamycin derivatives useful as antimicrobial agents
HUE054955T2 (hu) *	2012-08-13	2021-10-28	Adipharm Ead	3-Formilrifamicin S 3-(4-cinnamil-L-piperazinil)-amino származékait tartalmazó gyógyszerészeti készítmények

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR64108B (en) *	1977-04-15	1980-01-24	Dso Pharmachim	Method for the preparation of azomethine-derivatives of rifamycin s.v
SE458505B (sv) *	1979-07-10	1989-04-10	Lepetit Spa	Anvaendningen av rifamycin sv och salter daerav foer framstaellning av en beredning foer behandling av reumatoid artrit samt vissa av salterna och deras framstaellning
MC1819A1 (fr) *	1985-10-18	1988-03-18	Ciba Geigy Ag	Composes 4-benzyl-piperazinyl substitues
IT1202424B (it) *	1987-01-26	1989-02-09	Prodotti Antibiotici Spa	Sali di un derivato rifamicinico
EP0284552A1 (de) *	1987-03-06	1988-09-28	Ciba-Geigy Ag	4-Benzyl-piperazinyl-Hydrazone
US5095108A (en) *	1990-08-28	1992-03-10	Technologichen Kombinat Za Promishlena Microbiologia	Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production

1998
- 1998-11-04 BG BG102897A patent/BG64021B1/bg unknown
1999
- 1999-11-03 BR BR9915035-2A patent/BR9915035A/pt not_active Application Discontinuation
- 1999-11-03 EP EP99953444A patent/EP1124831B1/de not_active Expired - Lifetime
- 1999-11-03 RU RU2001114830/04A patent/RU2001114830A/ru not_active Application Discontinuation
- 1999-11-03 WO PCT/BG1999/000022 patent/WO2000025721A2/en not_active Ceased
- 1999-11-03 AU AU10204/00A patent/AU1020400A/en not_active Abandoned
- 1999-11-03 PT PT99953444T patent/PT1124831E/pt unknown
- 1999-11-03 US US09/831,012 patent/US6476036B1/en not_active Expired - Fee Related
- 1999-11-03 ES ES99953444T patent/ES2207296T3/es not_active Expired - Lifetime
- 1999-11-03 AT AT99953444T patent/ATE248176T1/de not_active IP Right Cessation
- 1999-11-03 DK DK99953444T patent/DK1124831T3/da active
- 1999-11-03 DE DE69910810T patent/DE69910810T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK1124831T3 (da)	2003-12-22
BG102897A (en)	2000-06-30
EP1124831B1 (de)	2003-08-27
BR9915035A (pt)	2001-10-16
BG64021B1 (bg)	2003-10-31
RU2001114830A (ru)	2003-07-10
DE69910810T2 (de)	2004-08-19
PT1124831E (pt)	2004-01-30
WO2000025721A2 (en)	2000-05-11
DE69910810D1 (de)	2003-10-02
ES2207296T3 (es)	2004-05-16
EP1124831A2 (de)	2001-08-22
US6476036B1 (en)	2002-11-05
AU1020400A (en)	2000-05-22
WO2000025721A3 (en)	2000-11-16

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