DK1063228T5 - Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Info

Publication number
DK1063228T5
DK1063228T5 DK99907879T DK99907879T DK1063228T5 DK 1063228 T5 DK1063228 T5 DK 1063228T5 DK 99907879 T DK99907879 T DK 99907879T DK 99907879 T DK99907879 T DK 99907879T DK 1063228 T5 DK1063228 T5 DK 1063228T5
Authority
DK
Denmark
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Application number
DK99907879T
Other languages
English (en)
Other versions
DK1063228T3 (da
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DK1063228T3 publication Critical patent/DK1063228T3/da
Application granted granted Critical
Publication of DK1063228T5 publication Critical patent/DK1063228T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silicon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK99907879T 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf DK1063228T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (en) 1998-03-09 1999-03-08 Cycloalkene derivatives, process for producing the same, and use

Publications (2)

Publication Number Publication Date
DK1063228T3 DK1063228T3 (da) 2005-04-25
DK1063228T5 true DK1063228T5 (da) 2009-06-15

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99907879T DK1063228T5 (da) 1998-03-09 1999-03-08 Cycloalkenderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf

Country Status (19)

Country Link
US (1) US6495604B1 (da)
EP (2) EP1524263A1 (da)
JP (2) JP3665712B2 (da)
KR (4) KR100492098B1 (da)
CN (1) CN100432049C (da)
AT (1) ATE287393T1 (da)
AU (1) AU747521B2 (da)
BR (1) BR9908610A (da)
CA (1) CA2320467C (da)
DE (1) DE69923300T2 (da)
DK (1) DK1063228T5 (da)
ES (1) ES2232114T3 (da)
HU (1) HU230061B1 (da)
ID (1) ID25649A (da)
NO (1) NO326426B1 (da)
NZ (1) NZ505874A (da)
PT (1) PT1063228E (da)
RU (1) RU2214398C2 (da)
WO (1) WO1999046242A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69923300T2 (de) 1998-03-09 2006-01-05 Takeda Pharmaceutical Co. Ltd. Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
KR100778256B1 (ko) * 1999-08-06 2007-11-27 다케다 야쿠힌 고교 가부시키가이샤 치환 방향환 화합물, 그의 제조법 및 용도
AU1553001A (en) * 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
CA2400804C (en) * 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives
AU2001278705A1 (en) 2000-08-10 2002-02-25 Takeda Chemical Industries Ltd. Pharmaceutical composition
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
US6982344B2 (en) 2000-10-18 2006-01-03 Takeda Pharmaceutical Company Limited Process for preparation of optically active sulfonamides and intermediates for their synthesis
US20040063685A1 (en) * 2000-12-08 2004-04-01 Juji Ilzawa Combination Drugs
US7579325B2 (en) 2001-03-21 2009-08-25 Eisai R & D Management Co., Ltd. Drugs containing reduced of vitamin B2
JP5137289B2 (ja) * 2001-08-03 2013-02-06 武田薬品工業株式会社 安定な乳化組成物
EP1495756A4 (en) * 2002-04-08 2009-10-28 Takeda Pharmaceutical THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION
EP1692116B1 (en) * 2003-12-03 2011-03-09 Boehringer Ingelheim Pharmaceuticals Inc. 1,2,3-triazole amide derivatives as inhibitors of cytokine production
MY147790A (en) 2005-04-28 2013-01-31 Takeda Pharmaceutical Stable emulsion composition
BRPI0615932A2 (pt) * 2005-09-14 2011-05-31 Daiichi Sankyo Co Ltd composto, composição farmacêutica ,e, uso de uma composição farmacêutica
JP4962982B2 (ja) 2006-03-30 2012-06-27 国立大学法人広島大学 スクリーニング方法
US20090062355A1 (en) 2006-04-20 2009-03-05 Takeda Pharmaceutical Company Limited Pharmaceutical Product
EP2018855A1 (en) 2006-05-15 2009-01-28 Takeda Pharmaceutical Company Limited Pharmaceutical agent
WO2008004673A1 (fr) 2006-07-07 2008-01-10 Takeda Pharmaceutical Company Limited Dérives de cycloalkène, procédé de production des dérivés et utilisation de ceux-ci
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
NZ601635A (en) 2010-01-27 2013-06-28 Takeda Pharmaceutical Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent
WO2012039447A1 (ja) 2010-09-24 2012-03-29 第一三共株式会社 置換シクロアルケン誘導体の結晶
WO2014008273A2 (en) * 2012-07-03 2014-01-09 Jay Pravda Methods for treating, diagnosing and/or monitoring progression of oxo associated states
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
UY36675A (es) 2015-05-08 2016-12-30 Takeda Pharmaceuticals Co Compuestos cíclicos que tienen una acción inhibidora de la señalización del receptor de tipo toll 4 (tlr4)
CN109923101B (zh) 2016-09-09 2021-03-09 武田药品工业株式会社 环状化合物
US20200247761A1 (en) * 2017-02-24 2020-08-06 Taiwanj Pharmaceuticals Co., Ltd Sulfonamide or amide compounds, compositions and methods for the prophylaxis and/or treatment of autoimmune, inflammation or infection related disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007552A1 (fr) 1990-11-06 1992-05-14 Nippon Shinyaku Co., Ltd. Preparation lyophilisee et sa production
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
HUT74735A (en) 1994-02-25 1997-02-28 Takeda Chemical Industries Ltd Injectable emulsion composition containing antifungal triazole derivatives and process for producing it
US6124351A (en) * 1994-08-18 2000-09-26 Chugai Seiyaku Kabushiki Kaisha Amino acid derivatives having a nitric oxide synthase inhibiting action
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
DE69923300T2 (de) 1998-03-09 2006-01-05 Takeda Pharmaceutical Co. Ltd. Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
CA2400804C (en) 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives

Also Published As

Publication number Publication date
US6495604B1 (en) 2002-12-17
AU747521C (en) 1999-09-27
PT1063228E (pt) 2005-05-31
DE69923300D1 (de) 2005-02-24
JP4342453B2 (ja) 2009-10-14
AU747521B2 (en) 2002-05-16
HK1031723A1 (en) 2001-06-22
DK1063228T3 (da) 2005-04-25
CN1291184A (zh) 2001-04-11
JP2000178246A (ja) 2000-06-27
NO326426B1 (no) 2008-12-01
HU230061B1 (hu) 2015-06-29
HUP0101192A2 (hu) 2001-08-28
CN100432049C (zh) 2008-11-12
KR20010034555A (ko) 2001-04-25
KR100577044B1 (ko) 2006-05-08
DE69923300T2 (de) 2006-01-05
EP1063228A4 (en) 2001-08-08
JP2005232168A (ja) 2005-09-02
NO20004485L (no) 2000-09-08
HUP0101192A3 (en) 2003-09-29
ID25649A (id) 2000-10-19
CA2320467A1 (en) 1999-09-16
KR20060017921A (ko) 2006-02-27
KR100492098B1 (ko) 2005-06-01
AU2746499A (en) 1999-09-27
WO1999046242A1 (en) 1999-09-16
KR20050071719A (ko) 2005-07-07
PL342826A1 (en) 2001-07-02
JP3665712B2 (ja) 2005-06-29
KR100779889B1 (ko) 2007-11-28
ATE287393T1 (de) 2005-02-15
NZ505874A (en) 2003-09-26
EP1524263A1 (en) 2005-04-20
RU2214398C2 (ru) 2003-10-20
NO20004485D0 (no) 2000-09-08
KR20050026075A (ko) 2005-03-14
ES2232114T3 (es) 2005-05-16
CA2320467C (en) 2010-05-04
EP1063228B1 (en) 2005-01-19
EP1063228A1 (en) 2000-12-27
BR9908610A (pt) 2000-12-05

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