ATE248224T1 - Die bestimmung von mutationen durch spaltung mit resolvase - Google Patents

Die bestimmung von mutationen durch spaltung mit resolvase

Info

Publication number
ATE248224T1
ATE248224T1 AT95918266T AT95918266T ATE248224T1 AT E248224 T1 ATE248224 T1 AT E248224T1 AT 95918266 T AT95918266 T AT 95918266T AT 95918266 T AT95918266 T AT 95918266T AT E248224 T1 ATE248224 T1 AT E248224T1
Authority
AT
Austria
Prior art keywords
resolvase
mutations
heteroduplex
clivation
determination
Prior art date
Application number
AT95918266T
Other languages
English (en)
Inventor
Richard G H Cotton
Rima Youil
Borries W Kemper
Original Assignee
Avitech Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avitech Diagnostics Inc filed Critical Avitech Diagnostics Inc
Application granted granted Critical
Publication of ATE248224T1 publication Critical patent/ATE248224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Dental Preparations (AREA)
AT95918266T 1994-04-25 1995-04-21 Die bestimmung von mutationen durch spaltung mit resolvase ATE248224T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23253094A 1994-04-25 1994-04-25
PCT/US1995/004852 WO1995029251A1 (en) 1994-04-25 1995-04-21 Detection of mutation by resolvase cleavage

Publications (1)

Publication Number Publication Date
ATE248224T1 true ATE248224T1 (de) 2003-09-15

Family

ID=22873505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918266T ATE248224T1 (de) 1994-04-25 1995-04-21 Die bestimmung von mutationen durch spaltung mit resolvase

Country Status (8)

Country Link
US (2) US5698400A (de)
EP (1) EP0760002B1 (de)
JP (1) JPH09512428A (de)
AT (1) ATE248224T1 (de)
AU (1) AU693198B2 (de)
CA (1) CA2188660C (de)
DE (1) DE69531612D1 (de)
WO (1) WO1995029251A1 (de)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) * 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
AU693198B2 (en) * 1994-04-25 1998-06-25 Avitech Diagnostics, Inc. Detection of mutation by resolvase cleavage
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
CA2220467A1 (en) * 1995-05-11 1996-11-14 Arild Lagerkvist Detection of mismatches by resolvase cleavage on a solid support
US5824471A (en) * 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US7122364B1 (en) * 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
EP0964929B1 (de) * 1996-06-05 2004-10-20 Fox Chase Cancer Center Fehlpaarungen erkennende endonukleasen und deren verwendung zur erkennung von mutationen in ziel-polynukleotidsträngen
US5869245A (en) * 1996-06-05 1999-02-09 Fox Chase Cancer Center Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands
CA2273204C (en) 1996-11-29 2008-10-14 Third Wave Technologies, Inc. Fen-1 endonucleases, mixtures and cleavage methods
WO1998046793A1 (en) * 1997-04-16 1998-10-22 Trevigen, Inc. Detection and mapping of point mutations using partial digestion
US6027898A (en) * 1997-08-18 2000-02-22 Transgenomic, Inc. Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals
EP1023463A4 (de) * 1997-10-09 2003-01-02 Transgenomic Inc Modifizierter dns-doppelstrang zur verbesserter strang-trennung durch passende ionische polynukleotidchromatographie
EP1030933A4 (de) 1997-10-14 2003-01-02 Transgenomic Inc Untersuchung von genickter dna mit hilfe von passender ionischer polynukleotidchromatographie
CA2308314A1 (en) * 1997-10-30 1999-05-14 Transgenomic, Inc. Method for high resolution liquid chromatographic separation of polynucleotides
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US6297010B1 (en) 1998-01-30 2001-10-02 Genzyme Corporation Method for detecting and identifying mutations
EP1053352B1 (de) * 1998-02-04 2002-09-18 Variagenics, Inc. Techniken zu detektion von fehlpaarungen
US6183958B1 (en) 1998-05-06 2001-02-06 Variagenics, Inc. Probes for variance detection
US6485648B1 (en) 1998-05-18 2002-11-26 Transgenomic, Inc. MIPC column cleaning system and process
US20070161010A1 (en) * 1998-08-04 2007-07-12 Gjerde Douglas T Methods and compositions for mutation analysis
US20030175723A1 (en) * 1998-08-04 2003-09-18 Gjerde Douglas T. Methods and compositions for mutation analysis
US7225079B2 (en) * 1998-08-04 2007-05-29 Transgenomic, Inc. System and method for automated matched ion polynucleotide chromatography
US6150105A (en) 1998-08-20 2000-11-21 Genetic Assays, Inc. Methods of screening nucleic acids for nucleotide variations
GB9826247D0 (en) * 1998-11-30 1999-01-20 Nycomed Pharma As Method
US6673908B1 (en) * 1999-02-22 2004-01-06 Nuvelo, Inc. Tumor necrosis factor receptor 2
US6221635B1 (en) * 1999-05-06 2001-04-24 The Wistar Institute Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
SE9902741D0 (sv) * 1999-07-19 1999-07-19 Boerries Kemper Method for the enrichment of heteroduplexes and its use in mutation detection
US6420112B2 (en) * 1999-07-21 2002-07-16 The Regents Of The University Of California DNA attachment to support structures
US6524794B1 (en) 1999-10-29 2003-02-25 Decode Genetics Ehf. Identical-by-descent fragment enrichment
AU2001227913A1 (en) * 2000-01-13 2001-07-24 Immunivest Corporation Ferrofluid based arrays
US6699980B1 (en) 2000-02-28 2004-03-02 Fox Chase Cancer Center Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof
US6391557B1 (en) 2000-02-22 2002-05-21 Fox Chase Cancer Center Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof
RU2175015C1 (ru) * 2000-03-01 2001-10-20 Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ определения точечных нуклеотидных замен в днк микобактерий, способ диагностики устойчивости микобактерий к рифампицину, биочип для осуществления этих способов
CN1191374C (zh) * 2000-03-11 2005-03-02 弗雷什基因公司 核酸间差异的检测方法
US6653079B2 (en) 2000-03-13 2003-11-25 Freshgene, Inc. Methods for detection of differences in nucleic acids
US6656686B2 (en) * 2000-03-21 2003-12-02 Ovidiu Platica Method of simultaneous detection of base changes (SDBC) in expressed genes
WO2001075167A1 (en) * 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
WO2002070755A2 (en) * 2000-11-15 2002-09-12 Third Wave Technologies, Inc. Fen endonucleases
ATE446382T1 (de) * 2001-02-07 2009-11-15 Krzysztof Kucharczyk MULTITEMPERATURE ßSINGLE STRAND CONFORMATION POLYMORPHISMß (MSSCP)
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
US20040053236A1 (en) * 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002097123A2 (en) * 2001-05-25 2002-12-05 Xenon Genetics, Inc. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US8182986B1 (en) * 2001-07-12 2012-05-22 Discoverx Assays for nucleic acid modifying enzymes
WO2003031580A2 (en) * 2001-10-05 2003-04-17 Transgenomic, Inc. Methods and compositions for mutation analysis by liquid chromatography
JP2005525787A (ja) * 2001-10-24 2005-09-02 シンギュレックス・インコーポレイテッド プローブとの相互作用による遺伝子ハプロタイプの検出方法
WO2003064679A2 (en) * 2002-01-30 2003-08-07 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
US6821733B2 (en) * 2002-02-07 2004-11-23 Panomics, Inc. Methods and compositions for detecting differences between nucleic acids
US6878530B2 (en) 2002-02-07 2005-04-12 Panomics, Inc. Methods for detecting polymorphisms in nucleic acids
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
US20040002156A1 (en) * 2002-06-26 2004-01-01 Stratagene Selective cloning of homoduplex nucleic acids
EP1546392A4 (de) * 2002-08-02 2006-05-24 Stratatech Corp Spezies-spezifischer dna-nachweis
US7141371B2 (en) * 2002-09-06 2006-11-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for detecting and localizing DNA mutations by microarray
AU2003298672A1 (en) * 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
US8206904B2 (en) * 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7316903B2 (en) * 2003-03-28 2008-01-08 United States Of America As Represented By The Department Of Health And Human Services Detection of nucleic acid sequence variations using phase Mu transposase
US7833714B1 (en) * 2003-04-11 2010-11-16 Affymetrix, Inc. Combinatorial affinity selection
US6998963B2 (en) * 2003-07-24 2006-02-14 Hunt Technologies, Inc. Endpoint receiver system
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
JP4339062B2 (ja) * 2003-09-30 2009-10-07 富士フイルム株式会社 ミスマッチ領域検出方法
AU2003301503A1 (en) * 2003-12-16 2005-07-14 Centre National De La Recherche Scientifique Methods and compositions for assaying mutations in nucleic acids
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US20080199480A1 (en) * 2004-07-22 2008-08-21 Sequenom, Inc. Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
JP2008520245A (ja) * 2004-11-23 2008-06-19 ワン，シャオ・ビン 切断−増幅法による核酸多様性の検出
US20060160102A1 (en) 2005-01-18 2006-07-20 Hossein Fakhrai-Rad Identification of rare alleles by enzymatic enrichment of mismatched heteroduplexes
WO2006122215A2 (en) * 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
EP3617321B1 (de) 2006-05-31 2024-10-23 Sequenom, Inc. Kit zur nukleinsäureextraktion und -verstärkung aus einer probe
KR101105564B1 (ko) 2006-06-01 2012-01-17 써드 웨이브 테크놀로지스, 아이앤씨. 핵산의 검출
CA2654165A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
AU2008213634B2 (en) * 2007-02-08 2013-09-05 Sequenom, Inc. Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
EP2243834A1 (de) 2007-03-05 2010-10-27 Cancer Care Ontario Abschätzung des Kolorektalkarzinomrisikos
US8652780B2 (en) 2007-03-26 2014-02-18 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CA2687218A1 (en) * 2007-05-14 2008-11-27 Insight Genetics, Inc. Methods of screening nucleic acids for single nucleotide variations
GB0713183D0 (en) * 2007-07-06 2007-08-15 King S College London Method
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
CA2697411C (en) * 2007-09-07 2015-04-14 Third Wave Technologies, Inc. Methods and applications for target quantification
EP2271772B1 (de) 2008-03-11 2014-07-16 Sequenom, Inc. Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
WO2009117327A2 (en) * 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
EP3514244B1 (de) 2009-04-03 2021-07-07 Sequenom, Inc. Verfahren für die herstellung von nukleinsäuren
US20110091931A1 (en) * 2009-04-24 2011-04-21 Colby Pharmaceutical Company Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
EP2494077A4 (de) 2009-10-27 2013-08-21 Caris Mpi Inc Molekulare profilierung für personalisierte medizin
US8394589B2 (en) 2009-12-21 2013-03-12 Northwestern University Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
CA2826696C (en) 2011-02-02 2019-12-03 Mayo Foundation For Medical Education And Research Digital sequence analysis of dna methylation
AU2012249531B2 (en) 2011-04-29 2017-06-29 Sequenom, Inc. Quantification of a minority nucleic acid species
CN104450680A (zh) 2011-05-12 2015-03-25 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
EP2820129A1 (de) 2012-03-02 2015-01-07 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
US11060145B2 (en) 2013-03-13 2021-07-13 Sequenom, Inc. Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
AU2014321355B2 (en) 2013-09-20 2019-10-10 The Regents Of The University Of Michigan Compositions and methods for the analysis of radiosensitivity
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016094839A2 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
CA3183545C (en) 2014-12-12 2026-01-13 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
WO2017125893A1 (en) * 2016-01-22 2017-07-27 Vyome Biosciences Pvt. Ltd. Method of detecting and treating p. acnes and kit thereof
CN109563546B (zh) 2016-05-05 2022-09-09 精密科学发展有限责任公司 通过分析甲基化dna来检测肺肿瘤
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
EP3978624B1 (de) 2016-07-19 2025-03-26 Exact Sciences Corporation Methylierte kontroll-dna
EP3507298B1 (de) 2016-09-02 2023-08-30 Mayo Foundation for Medical Education and Research Erkennung eines leberzellkarzinoms
CN110736695A (zh) 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
JP7356349B2 (ja) 2017-02-28 2023-10-04 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 前立腺癌検出
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
US11408030B2 (en) 2018-09-10 2022-08-09 Andy Madrid Test for detecting Alzheimer's disease
EP3888021B1 (de) 2018-11-30 2024-02-21 Caris MPI, Inc. Molekulare profilierung der nächsten generation
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
EP3947718A4 (de) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
EP4031683A4 (de) 2019-09-16 2024-01-17 Exact Sciences Corporation Struktur- und temperaturabhängige flap-endonukleasesubstrate
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
CA3163319A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
CN115605138A (zh) 2020-04-17 2023-01-13 精密科学公司（Us） 可摄取取样装置
AU2021329899A1 (en) 2020-08-19 2023-03-09 Exact Sciences Corporation Detecting non-hodgkin lymphoma
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
WO2023011660A1 (en) 2021-08-06 2023-02-09 Sansure Biotech Inc. Compositions for liquefying a viscous biological sample, combination products, liquefying agents, and kits thereof, and methods and application thereof
WO2026055641A1 (en) 2024-09-06 2026-03-12 Exact Sciences Corporation Methods and compositions for preparing biomolecule analytes from complex samples

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8802508D0 (en) * 1988-02-04 1988-03-02 Medical Res Council Detection of mutations in nucleic acids
US5217863A (en) * 1988-02-04 1993-06-08 Medical Research Council Detection of mutations in nucleic acids
AU3539089A (en) * 1988-04-08 1989-11-03 Salk Institute For Biological Studies, The Ligase-based amplification method
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5556750A (en) * 1989-05-12 1996-09-17 Duke University Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
DE69218776T2 (de) * 1991-07-19 1997-11-27 Upstate Biotech Inc Verfahren zum nachweis von mutationen
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
FR2709761B1 (fr) * 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
AU693198B2 (en) * 1994-04-25 1998-06-25 Avitech Diagnostics, Inc. Detection of mutation by resolvase cleavage
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support

Also Published As

Publication number Publication date
EP0760002A4 (de) 1999-09-08
US5958692A (en) 1999-09-28
AU2425395A (en) 1995-11-16
CA2188660A1 (en) 1995-11-02
WO1995029251A1 (en) 1995-11-02
EP0760002B1 (de) 2003-08-27
US5698400A (en) 1997-12-16
JPH09512428A (ja) 1997-12-16
CA2188660C (en) 2005-01-18
AU693198B2 (en) 1998-06-25
DE69531612D1 (de) 2003-10-02
EP0760002A1 (de) 1997-03-05

Similar Documents

Publication Publication Date Title
ATE248224T1 (de) Die bestimmung von mutationen durch spaltung mit resolvase
FI843529A7 (fi) Organismien ja virusten havaitsemis-, identifiointi- ja kvantitatisoin timenetelmä.
ATE190357T1 (de) Schnelles verfahren fur die dns sequenzierung und diagnostische anwendungen
ES8609472A1 (es) Una sonda de deteccion de acidos nucleicos
DE69731418D1 (de) Such- und Wiederauffindungssystem für Dokumente mit Suchverfahren von teilweise passenden, benutzergezeichneten Anmerkungen
DE69938867D1 (de) Verfahren und verwendung von anordungen von proteinfixierungsmitteln
DE69103775D1 (de) Vorrichtung zur Unterscheidung von stabilen und instabilen ventriculären tachycardien.
ATE412002T1 (de) Gruppen zum einfangen von nukleinsäuren
DE3677677D1 (de) Mehrstufenverfahren zur umsetzung von olefinen in schwereren kohlenwasserstoffen.
DE3677248D1 (de) Bimodale silikonemulsionen, verfahren zur herstellung von silikonemulsionen und die so erhaltenen emulsionen.
DE69708848D1 (de) Mischung von erdalkalialkylarylsulfonaten, ihre verwendung als schmierölzusatz und herstellungsmethode
DE3575307D1 (de) Konzentrierte, waessrige dispersionen von vinylidenfluorid-polymeren und verfahren zu deren herstellung.
DE68912114D1 (de) Verfahren zur Trennung von 1,1-Dichlor-1-fluorethan und 1,1,1,3,3-Pentafluorbutan.
DE3682149D1 (de) Verfahren zur quantitativen bestimmung von 1,5-anhydroglucitol.
DE3882078D1 (de) Amperometrische methode zur titration von nadh (1,4-dihydronicotinamid-adenine-dinucleotide) in loesung.
NL195097C (nl) Kwantificering van nucleinezuur moleculen en de daarbij gebruikte reagens set.
DE3774897D1 (de) Behandelte sojabohnen mit reduziertem phosphor- und kaliumgehalt, verfahren zur zubereitung derselben und damit erhaltene sojabohnen-nahrungsmittel.
WO2000034652A8 (en) Methods of identifying point mutations in a genome
DE69107448D1 (de) Integriertes Verfahren mit zwei Reaktionszonen zur Isomerisierung von C4, C5 und C6 Kohlenwasserstoffen.
DE3670642D1 (de) Polymere von substituierten 1,3-butadienverbindungen und verfahren zu deren herstellung.
DE58904726D1 (de) Verwendung von n-phenyl-substituierten oxazindionen als herbizide sowie n-phenyl-substituierte oxazindione und mehrere verfahren zu deren herstellung.
DE68919387D1 (de) DNS- und RNS-Proben, Methoden und Testsätze zum Nachweis von Salmonella.
WO2001075149A3 (de) Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor
WO2003055978A3 (en) Gene recombination and hybrid protein development
DE68908550D1 (de) Verfahren zur herstellung von korrosions-, waerme- und verschleissbestaendigen werkstuecken und so hergestellte werkstuecke.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties