ATE248922T1 - Hormonanaloge mit mehreren ctp-erweiterungen - Google Patents

Hormonanaloge mit mehreren ctp-erweiterungen

Info

Publication number
ATE248922T1
ATE248922T1 AT92921759T AT92921759T ATE248922T1 AT E248922 T1 ATE248922 T1 AT E248922T1 AT 92921759 T AT92921759 T AT 92921759T AT 92921759 T AT92921759 T AT 92921759T AT E248922 T1 ATE248922 T1 AT E248922T1
Authority
AT
Austria
Prior art keywords
amino acid
ctp units
partial
complete
hormone analogues
Prior art date
Application number
AT92921759T
Other languages
English (en)
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE248922T1 publication Critical patent/ATE248922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92921759T 1991-10-04 1992-10-02 Hormonanaloge mit mehreren ctp-erweiterungen ATE248922T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/771,262 US6225449B1 (en) 1991-10-04 1991-10-04 Hormone analogs with multiple CTP extensions
PCT/US1992/008424 WO1993006844A1 (en) 1991-10-04 1992-10-02 Hormone analogs with multiple ctp extensions

Publications (1)

Publication Number Publication Date
ATE248922T1 true ATE248922T1 (de) 2003-09-15

Family

ID=25091246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921759T ATE248922T1 (de) 1991-10-04 1992-10-02 Hormonanaloge mit mehreren ctp-erweiterungen

Country Status (11)

Country Link
US (2) US6225449B1 (de)
EP (1) EP0607297B1 (de)
JP (2) JP4081137B2 (de)
KR (1) KR100281811B1 (de)
AT (1) ATE248922T1 (de)
CA (1) CA2120358A1 (de)
DE (1) DE69233188T2 (de)
ES (1) ES2204893T3 (de)
FI (1) FI941500L (de)
NO (1) NO941186L (de)
WO (1) WO1993006844A1 (de)

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US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
DE122010000006I2 (de) 1989-02-21 2012-06-21 Univ Washington Modifizierte formen von fortpflanzungshormonen.
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
FR2710845B1 (fr) * 1993-10-08 1996-03-29 Lafon Labor Composition destinée à l'immunothérapie d'un cancer sécrétant l'hCG ou des fragments d'hCG.
CA2160800C (en) * 1993-04-20 2010-06-01 Irving Boime Ctp modified gonadotropic proteins
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US5657411A (en) * 1995-12-15 1997-08-12 Honeywell Inc. Negative trimming of fiber optic winding
AU706504B2 (en) * 1996-02-20 1999-06-17 Merck Serono Sa Hybrid proteins which form heterodimers
US6844161B2 (en) 1997-09-04 2005-01-18 Gryphon Therapeutics, Inc. Modular protein libraries and methods of preparation
PE20010288A1 (es) * 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
US20030036181A1 (en) * 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
KR101229995B1 (ko) * 2000-12-11 2013-02-06 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
EP1342730B1 (de) * 2000-12-11 2006-03-15 Cheil Jedang Corporation Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
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US7173113B2 (en) * 2002-01-31 2007-02-06 The Trustees Of Columbia University In The City Of New York Long-acting hormone and growth factor compositions and uses thereof
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
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US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
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CN104302408B (zh) 2012-02-27 2016-12-14 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
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CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
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Also Published As

Publication number Publication date
WO1993006844A1 (en) 1993-04-15
EP0607297A1 (de) 1994-07-27
CA2120358A1 (en) 1993-04-15
JP4081137B2 (ja) 2008-04-23
DE69233188T2 (de) 2004-05-27
FI941500A0 (fi) 1994-03-30
ES2204893T3 (es) 2004-05-01
AU667489B2 (en) 1996-03-28
AU2864892A (en) 1993-05-03
FI941500A7 (fi) 1994-05-23
EP0607297B1 (de) 2003-09-03
NO941186D0 (no) 1994-03-30
NO941186L (no) 1994-03-30
US5759818A (en) 1998-06-02
DE69233188D1 (de) 2003-10-09
EP0607297A4 (en) 1995-10-25
KR100281811B1 (ko) 2001-02-15
FI941500L (fi) 1994-05-23
JPH07502166A (ja) 1995-03-09
JP2008073057A (ja) 2008-04-03
US6225449B1 (en) 2001-05-01

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