ATE249464T1 - Thienopyrimidinderivate, ihre herstellung und verwendung - Google Patents

Thienopyrimidinderivate, ihre herstellung und verwendung

Info

Publication number
ATE249464T1
ATE249464T1 AT96901958T AT96901958T ATE249464T1 AT E249464 T1 ATE249464 T1 AT E249464T1 AT 96901958 T AT96901958 T AT 96901958T AT 96901958 T AT96901958 T AT 96901958T AT E249464 T1 ATE249464 T1 AT E249464T1
Authority
AT
Austria
Prior art keywords
agent
cancer
animals
female
useful
Prior art date
Application number
AT96901958T
Other languages
English (en)
Inventor
Shuichi Furuya
Nobuo Choh
Koichi Kato
Shuji Hinuma
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1995/000728 external-priority patent/WO1995028405A1/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE249464T1 publication Critical patent/ATE249464T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96901958T 1995-02-08 1996-02-07 Thienopyrimidinderivate, ihre herstellung und verwendung ATE249464T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2071795 1995-02-08
JP4015195 1995-02-28
PCT/JP1995/000728 WO1995028405A1 (en) 1994-04-19 1995-04-14 Bicyclic thiophene derivatives and use as gonadotropin releasing hormone antagonists
JP27163895 1995-10-19
PCT/JP1996/000263 WO1996024597A1 (en) 1995-02-08 1996-02-07 Thienopyrimidine derivatives, their production and use

Publications (1)

Publication Number Publication Date
ATE249464T1 true ATE249464T1 (de) 2003-09-15

Family

ID=27283146

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96901958T ATE249464T1 (de) 1995-02-08 1996-02-07 Thienopyrimidinderivate, ihre herstellung und verwendung

Country Status (10)

Country Link
EP (1) EP0808317B1 (de)
JP (1) JP3789538B2 (de)
KR (1) KR19980702086A (de)
CN (1) CN1064045C (de)
AT (1) ATE249464T1 (de)
AU (1) AU4632796A (de)
CA (1) CA2211969A1 (de)
DE (1) DE69629914T2 (de)
UY (1) UY23948A1 (de)
WO (1) WO1996024597A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2407997A (en) * 1996-04-30 1997-11-19 Takeda Chemical Industries Ltd. Combined use of gnrh agonist and antagonist
US6413724B1 (en) 1996-10-28 2002-07-02 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
AU6908398A (en) * 1996-10-28 1998-05-22 Versicor Inc Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
RU2233284C2 (ru) * 1999-03-24 2004-07-27 Такеда Кемикал Индастриз, Лтд. Тиенопиримидиновые производные, способ их получения, фармацевтическая композиция и способ антагонизации гонадотропин-рилизинг гормона
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
JP4652520B2 (ja) * 1999-03-24 2011-03-16 武田薬品工業株式会社 チエノピリミジン化合物、その製造法および用途
US6608197B2 (en) * 2000-01-25 2003-08-19 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6849738B2 (en) 2000-02-29 2005-02-01 Takeda Chemical Industries, Ltd. Processes for the production of thienopyrimidine derivatives
US20030134863A1 (en) * 2000-04-13 2003-07-17 Shuichi Furuya Preventives/remedies for alzheimer's disease
WO2002047722A1 (en) * 2000-12-15 2002-06-20 Takeda Chemical Industries, Ltd. Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
EP1479684A4 (de) 2002-01-30 2006-01-04 Takeda Pharmaceutical Thienopyrimidine, verfahren zu deren herstellung und deren verwendung
WO2003086464A1 (en) * 2002-04-12 2003-10-23 Takeda Pharmaceutical Company Limited. Preventives/remedies for hotflash
CN101153042A (zh) 2003-01-29 2008-04-02 武田药品工业株式会社 噻吩并嘧啶化合物及其用途
JP2008094846A (ja) * 2003-01-29 2008-04-24 Takeda Chem Ind Ltd チエノピリミジン化合物およびその用途
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
JPWO2006083005A1 (ja) * 2005-02-03 2008-06-26 武田薬品工業株式会社 縮合ピリミジン誘導体およびその用途
KR20080041662A (ko) * 2005-07-22 2008-05-13 다케다 야쿠힌 고교 가부시키가이샤 조기 배란 예방제
JP5352449B2 (ja) 2007-04-18 2013-11-27 キッセイ薬品工業株式会社 縮合へテロ環誘導体、それを含有する医薬組成物及びその医薬用途
CA2682400A1 (en) 2007-04-18 2008-11-06 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
WO2009038057A1 (ja) * 2007-09-18 2009-03-26 Kissei Pharmaceutical Co., Ltd. 含窒素縮合環誘導体、それを含有する医薬組成物およびその医薬用途
EP2095818A1 (de) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen
US20110172249A1 (en) 2008-09-03 2011-07-14 Takeda Pharmaceutical Company Limted Method for improving absorbability of preparation, and preparation having improved absorbability
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
WO2021018105A1 (en) * 2019-07-29 2021-02-04 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidinedione compounds and uses thereof
CN111574534B (zh) * 2020-05-25 2021-06-04 东莞市东阳光新药研发有限公司 苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途
CN116438181B (zh) * 2020-09-29 2025-01-17 广东东阳光药业股份有限公司 磺酰胺基取代的杂芳基嘧啶二酮类化合物及其用途
WO2022067566A1 (zh) * 2020-09-29 2022-04-07 广东东阳光药业有限公司 含有饱和含氧杂环基的嘧啶二酮类化合物及其用途
KR102649886B1 (ko) * 2021-07-21 2024-03-22 충남대학교산학협력단 신규한 피리미딘-4-온 화합물 및 이를 포함하는 항암제 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2006505A1 (de) * 1970-02-13 1971-08-26 Merck Patent Gmbh, 6100 Darmstadt Isoflavanoid ather und Verfahren zu ihrer Herstellung
CA2036618C (en) * 1990-02-22 2002-10-29 Akira Morimoto Fused thiophene derivatives, their production and use
TW276256B (de) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
JP3789538B2 (ja) 2006-06-28
CN1173868A (zh) 1998-02-18
AU4632796A (en) 1996-08-27
UY23948A1 (es) 2001-10-25
KR19980702086A (ko) 1998-07-15
EP0808317B1 (de) 2003-09-10
WO1996024597A1 (en) 1996-08-15
CA2211969A1 (en) 1996-08-15
EP0808317A1 (de) 1997-11-26
JPH09169768A (ja) 1997-06-30
DE69629914D1 (de) 2003-10-16
DE69629914T2 (de) 2004-07-15
CN1064045C (zh) 2001-04-04

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties