ATE249473T1 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat - Google Patents

2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat

Info

Publication number: ATE249473T1
Authority: AT; Austria
Prior art keywords: purin; tetrahydrofuran; diol derivative; diol; derivative
Prior art date: 1998-06-23

Application number

AT99929288T

Other languages

English (en)

Inventor

David George Allen

Chuen Chan

Caroline Mary Cook

Richard Peter Charles Cousins

Brian Cox

Hazel Joan Dyke

Frank Ellis

Joanna V Geden

Heather Hobbs

Suzanne Elaine Kelling

Alison Judith Redgrave

Stephen Swanson

Caroline Whitworth

David Bays

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-23

Filing date

1999-06-23

Publication date

2003-09-15

1999-06-23 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249473T1 publication Critical patent/ATE249473T1/de

Links

YQUJSBYIKMQCIT-UHFFFAOYSA-N 2-purin-9-yloxolane-3,4-diol Chemical class OC1C(O)COC1N1C2=NC=NC=C2N=C1 YQUJSBYIKMQCIT-UHFFFAOYSA-N 0.000 title abstract 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99929288T 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat ATE249473T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9813535.3A GB9813535D0 (en)	1998-06-23	1998-06-23	Chemical compounds
PCT/EP1999/004270 WO1999067266A1 (en)	1998-06-23	1999-06-23	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

Publications (1)

Publication Number	Publication Date
ATE249473T1 true ATE249473T1 (de)	2003-09-15

Family

ID=10834237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99929288T ATE249473T1 (de)	1998-06-23	1999-06-23	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat

Country Status (8)

Country	Link
US (1)	US6534486B1 (de)
EP (1)	EP1090021B1 (de)
JP (1)	JP2002518513A (de)
AT (1)	ATE249473T1 (de)
AU (1)	AU4613899A (de)
DE (1)	DE69911206D1 (de)
GB (1)	GB9813535D0 (de)
WO (1)	WO1999067266A1 (de)

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ME01072B (de) *	2004-05-26	2012-10-20	Inotek Pharmaceuticals Corp	Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür
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EP2532677A1 (de)	2005-10-21	2012-12-12	Novartis AG	Menschliche Antikörper gegen IL13 und therapeutische Verwendungen
BRPI0619261A2 (pt) *	2005-11-30	2011-09-27	Inotek Pharmaceuticals Corp	derivados de purina e métodos de uso desses
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607954D0 (en)	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607950D0 (en)	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
HRP20120494T1 (hr)	2006-04-21	2012-08-31	Novartis Ag	Derivati purina za uporabu kao agonista adenozin a2a receptora
EP1889846A1 (de)	2006-07-13	2008-02-20	Novartis AG	Purinderivate als A2a Agonisten
EP1903044A1 (de)	2006-09-14	2008-03-26	Novartis AG	Adenosinderivate als Agonisten des A2A-Rezeptors
JP2010504933A (ja)	2006-09-29	2010-02-18	ノバルティスアーゲー	Ｐｉ３ｋ脂質キナーゼ阻害剤としてのピラゾロピリミジン
BRPI0718266A2 (pt)	2006-10-30	2014-01-07	Novartis Ag	Compostos heterocíclicos como agentes anti-inflamatórios.
FR2924430B1 (fr) *	2007-11-30	2010-03-19	Univ Bordeaux 2	Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation
JP5584138B2 (ja)	2008-01-11	2014-09-03	ノバルティスアーゲー	キナーゼ阻害剤としてのピリミジン類
ES2396023T3 (es)	2009-01-29	2013-02-18	Novartis Ag	Bencimidazoles sustituidos para el tratamiento de astrocitomas
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt)	2009-08-12	2016-05-17	Novartis Ag	compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
UA111579C2 (uk)	2009-08-17	2016-05-25	Інтеллікіне Ллк	ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
IN2012DN01453A (de)	2009-08-20	2015-06-05	Novartis Ag
JP2013516495A (ja)	2010-01-11	2013-05-13	イノテックファーマシューティカルズコーポレイション	眼圧を低下させる組合せ、キット、および方法
JP2013523739A (ja)	2010-03-26	2013-06-17	イノテックファーマシューティカルズコーポレイション	Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
UY33597A (es)	2010-09-09	2012-04-30	Irm Llc	Compuestos y composiciones como inhibidores de la trk
WO2012107500A1 (en)	2011-02-10	2012-08-16	Novartis Ag	[1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en)	2011-02-23	2012-08-30	Intellikine, Llc	Heterocyclic compounds and uses thereof
BR112013021638A2 (pt)	2011-02-25	2016-08-02	Irm Llc	"compostos inibidores de trk, seu uso e composições que os compreendem"
UY34329A (es)	2011-09-15	2013-04-30	Novartis Ag	Compuestos de triazolopiridina
US9174994B2 (en)	2011-11-23	2015-11-03	Intellikine, Llc	Enhanced treatment regimens using mTor inhibitors
SMT201700377T1 (it)	2012-01-26	2017-09-07	Inotek Pharmaceuticals Corp	Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione
MX371119B (es)	2012-04-03	2020-01-17	Novartis Ag	Productos de combinacion con los inhibidores de cinasa de tirosina y su uso.
HK1219421A1 (zh)	2013-03-15	2017-04-07	因特利凯有限责任公司	激酶抑制剂的组合及其用途
NZ630759A (en)	2013-03-15	2017-07-28	Inotek Pharmaceuticals Corp	Ophthalmic formulations comprising an a1 agonist
TW201605450A (zh)	2013-12-03	2016-02-16	諾華公司	Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
WO2016011658A1 (en)	2014-07-25	2016-01-28	Novartis Ag	Combination therapy
US10195208B2 (en)	2014-07-31	2019-02-05	Novartis Ag	Combination therapy
TW202140550A (zh)	2020-01-29	2021-11-01	瑞士商諾華公司	使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

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1998
- 1998-06-23 GB GBGB9813535.3A patent/GB9813535D0/en not_active Ceased
1999
- 1999-06-23 DE DE69911206T patent/DE69911206D1/de not_active Expired - Lifetime
- 1999-06-23 EP EP99929288A patent/EP1090021B1/de not_active Expired - Lifetime
- 1999-06-23 JP JP2000555917A patent/JP2002518513A/ja active Pending
- 1999-06-23 WO PCT/EP1999/004270 patent/WO1999067266A1/en not_active Ceased
- 1999-06-23 US US09/720,193 patent/US6534486B1/en not_active Expired - Fee Related
- 1999-06-23 AU AU46138/99A patent/AU4613899A/en not_active Abandoned
- 1999-06-23 AT AT99929288T patent/ATE249473T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB9813535D0 (en)	1998-08-19
JP2002518513A (ja)	2002-06-25
WO1999067266A1 (en)	1999-12-29
EP1090021B1 (de)	2003-09-10
US6534486B1 (en)	2003-03-18
DE69911206D1 (de)	2003-10-16
AU4613899A (en)	2000-01-10
EP1090021A1 (de)	2001-04-11

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69911206D1 (de)	2003-10-16	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate
DE69903708D1 (de)	2002-12-05	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate
IS5779A (is)	2000-12-19	2-(púrín-9-ýl)-tetrahýdrófúran-3,4-díól afleiður
DK1056759T3 (da)	2003-01-06	2-(Purin-9-yl)-tetrahydrofuran-3,4-diol-derivater
NO20006521D0 (no)	2000-12-20	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivater
ES2086313T3 (es)	1996-07-01	Nuevos derivados de xantina con efecto antagonista de adenosina.
ATE202361T1 (de)	2001-07-15	N6-heterocyclisch-substituierte adenosin-derivate
BR0007864A (pt)	2001-11-06	Composto, e, uso de um composto
MX9303709A (es)	1994-05-31	Nucleosidos de purina substituidos e intermediarios de los mismos, que tienen actividad anti-viral y anti-cancerigena y composicion farmaceutica que los contiene.
FI922014L (fi)	1992-05-05	Nukleosidderivat.
BR0010882A (pt)	2002-06-11	Agonistas receptores de adenosina a1 oralmente ativos e processo para uso de tal composição
IT1289250B1 (it)	1998-09-29	Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
DE69017305D1 (de)	1995-04-06	Hitzebeständiger, leichter Werkstoff auf Titan-Aluminiumbasis.
FI951500L (fi)	1995-03-29	2-substituoituja adenosiineja, joilla on A-2-reseptoriaffiniteetti
ZA991154B (en)	2000-08-14	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives.
HK1033761A (en)	2001-09-21	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
HK1033760A (en)	2001-09-21	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
SI1056759T1 (en)	2003-04-30	2-(purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives
ITMI940683A0 (it)	1994-04-13	Derivati di benzo (b) decalin-5,10-dioni-2,3,4-alfa,10-alfa-deidro ad attivita' antitumorale
FI881182A0 (fi)	1988-03-14	Nytt, automatiskt, pao minne baserande flygriktnings-, uppfoeljnings- och styrningssystem.
IT8920319A0 (it)	1989-04-28	Nuovi derivati ad azione antivirale e antibatterica, procedimento per la loro preparazione e loro composizioni farmaceutiche.
SE9801716D0 (sv)	1998-05-13	Lätt headset med flera funktioner
BR0001883A (pt)	2001-11-27	Borda de telhado para veìculos