ATE249473T1 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat - Google Patents

2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat

Info

Publication number: ATE249473T1
Authority: AT; Austria
Prior art keywords: purin; tetrahydrofuran; diol derivative; diol; derivative
Prior art date: 1998-06-23

Application number

AT99929288T

Other languages

English (en)

Inventor

David George Allen

Chuen Chan

Caroline Mary Cook

Richard Peter Charles Cousins

Brian Cox

Hazel Joan Dyke

Frank Ellis

Joanna V Geden

Heather Hobbs

Suzanne Elaine Kelling

Alison Judith Redgrave

Stephen Swanson

Caroline Whitworth

David Bays

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-23

Filing date

1999-06-23

Publication date

2003-09-15

1999-06-23 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249473T1 publication Critical patent/ATE249473T1/de

Links

YQUJSBYIKMQCIT-UHFFFAOYSA-N 2-purin-9-yloxolane-3,4-diol Chemical class OC1C(O)COC1N1C2=NC=NC=C2N=C1 YQUJSBYIKMQCIT-UHFFFAOYSA-N 0.000 title abstract 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99929288T 1998-06-23 1999-06-23 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat ATE249473T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9813535.3A GB9813535D0 (en)	1998-06-23	1998-06-23	Chemical compounds
PCT/EP1999/004270 WO1999067266A1 (en)	1998-06-23	1999-06-23	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives

Publications (1)

Publication Number	Publication Date
ATE249473T1 true ATE249473T1 (de)	2003-09-15

Family

ID=10834237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99929288T ATE249473T1 (de)	1998-06-23	1999-06-23	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat

Country Status (8)

Country	Link
US (1)	US6534486B1 (de)
EP (1)	EP1090021B1 (de)
JP (1)	JP2002518513A (de)
AT (1)	ATE249473T1 (de)
AU (1)	AU4613899A (de)
DE (1)	DE69911206D1 (de)
GB (1)	GB9813535D0 (de)
WO (1)	WO1999067266A1 (de)

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AU2005267706B2 (en)	2004-08-02	2011-12-08	University Of Virginia Patent Foundation	2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
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MX2007003271A (es) *	2004-09-20	2007-06-05	Inotek Pharmaceuticals Corp	Derivados de purina y metodos de uso de los mismos.
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WO2007045477A2 (en)	2005-10-21	2007-04-26	Novartis Ag	Human antibodies against il-13 and therapeutic uses
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GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607954D0 (en)	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
PT2322525E (pt)	2006-04-21	2013-12-26	Novartis Ag	Derivados de purina para utilização como agonistas do recetor de adenosina a2a
EP1889846A1 (de)	2006-07-13	2008-02-20	Novartis AG	Purinderivate als A2a Agonisten
EP1903044A1 (de)	2006-09-14	2008-03-26	Novartis AG	Adenosinderivate als Agonisten des A2A-Rezeptors
WO2008037477A1 (en)	2006-09-29	2008-04-03	Novartis Ag	Pyrazolopyrimidines as p13k lipid kinase inhibitors
JP2010508315A (ja)	2006-10-30	2010-03-18	ノバルティスアーゲー	抗炎症剤としてのヘテロ環式化合物
FR2924430B1 (fr) *	2007-11-30	2010-03-19	Univ Bordeaux 2	Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation
AU2009203693B2 (en)	2008-01-11	2012-06-07	Novartis Ag	Pyrimidines as kinase inhibitors
PL2391366T3 (pl)	2009-01-29	2013-04-30	Novartis Ag	Podstawione benzimidazole do leczenia gwiaździaków
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru)	2009-08-12	2012-09-28	Новартис Аг	Гетероциклические гидразоны и их применение для лечения рака и воспаления
NZ598220A (en)	2009-08-17	2014-02-28	Intellikine Llc	Heterocyclic compounds and uses thereof
CA2771432A1 (en)	2009-08-20	2011-02-24	Novartis Ag	Heterocyclic oxime compounds
SG182285A1 (en)	2010-01-11	2012-08-30	Inotek Pharmaceuticals Corp	Combination, kit and method of reducing intraocular pressure
EA201290958A1 (ru)	2010-03-26	2013-04-30	Инотек Фармасьютикалз Корпорейшн	Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
UY33597A (es)	2010-09-09	2012-04-30	Irm Llc	Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
EP2673277A1 (de)	2011-02-10	2013-12-18	Novartis AG	[1, 2, 4] triazolo [4, 3]pyridazinverbindungen als inhibitoren dec-met-tyrosinkinase
WO2012116237A2 (en)	2011-02-23	2012-08-30	Intellikine, Llc	Heterocyclic compounds and uses thereof
MA34969B1 (fr)	2011-02-25	2014-03-01	Irm Llc	Composes et compositions en tant qu inibiteurs de trk
CA2848809A1 (en)	2011-09-15	2013-03-21	Novartis Ag	6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
JP6130391B2 (ja)	2011-11-23	2017-05-17	インテリカイン，エルエルシー	Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
BR112014018413A8 (pt)	2012-01-26	2017-07-11	Inotek Pharmaceuticals Corp	Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
AU2013243097A1 (en)	2012-04-03	2014-10-09	Novartis Ag	Combination products with tyrosine kinase inhibitors and their use
CA2903114A1 (en)	2013-03-15	2014-09-25	Inotek Pharmaceuticals Corporation	Ophthalmic formulations
EP2968340A4 (de)	2013-03-15	2016-08-10	Intellikine Llc	Kombination von kinaseinhibitoren und verwendungen davon
TW201605450A (zh)	2013-12-03	2016-02-16	諾華公司	Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
WO2016011658A1 (en)	2014-07-25	2016-01-28	Novartis Ag	Combination therapy
CA2954862A1 (en)	2014-07-31	2016-02-04	Novartis Ag	Combination therapy
TW202140550A (zh)	2020-01-29	2021-11-01	瑞士商諾華公司	使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

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1998
- 1998-06-23 GB GBGB9813535.3A patent/GB9813535D0/en not_active Ceased
1999
- 1999-06-23 US US09/720,193 patent/US6534486B1/en not_active Expired - Fee Related
- 1999-06-23 JP JP2000555917A patent/JP2002518513A/ja active Pending
- 1999-06-23 AU AU46138/99A patent/AU4613899A/en not_active Abandoned
- 1999-06-23 AT AT99929288T patent/ATE249473T1/de not_active IP Right Cessation
- 1999-06-23 WO PCT/EP1999/004270 patent/WO1999067266A1/en not_active Ceased
- 1999-06-23 EP EP99929288A patent/EP1090021B1/de not_active Expired - Lifetime
- 1999-06-23 DE DE69911206T patent/DE69911206D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2002518513A (ja)	2002-06-25
GB9813535D0 (en)	1998-08-19
EP1090021A1 (de)	2001-04-11
WO1999067266A1 (en)	1999-12-29
DE69911206D1 (de)	2003-10-16
AU4613899A (en)	2000-01-10
EP1090021B1 (de)	2003-09-10
US6534486B1 (en)	2003-03-18

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE249473T1 (de)	2003-09-15	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivat
DE69903708D1 (de)	2002-12-05	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate
IS5779A (is)	2000-12-19	2-(púrín-9-ýl)-tetrahýdrófúran-3,4-díól afleiður
DK1056759T3 (da)	2003-01-06	2-(Purin-9-yl)-tetrahydrofuran-3,4-diol-derivater
IS5774A (is)	2000-12-15	2-(púrín-9-ýl)-tetrahýdrófúran-3,4-díól afleiður
DE69719816D1 (de)	2003-04-17	N6-heterocyclisch substituierte Adenosin-Derivate
IT1316986B1 (it)	2003-05-26	Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
BR0007864A (pt)	2001-11-06	Composto, e, uso de um composto
RU94017654A (ru)	1996-06-20	Распорный дюбель
FI892753A7 (fi)	1989-12-14	Hoejdregleringsanordning foer armstoed pao stolar, saerskilt rullstolar.
IT1291288B1 (it)	1999-01-07	Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
IT1289250B1 (it)	1998-09-29	Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
DE58905963D1 (de)	1993-11-25	Werkzeug, insbesondere ausbohrwerkzeug od. dgl.
EP1446132A4 (de)	2006-02-15	Antidiabetische 2-substituierte-5'-o- (1-boranotriphosphat) adenosin-derivate
FI951500L (fi)	1995-03-29	2-substituoituja adenosiineja, joilla on A-2-reseptoriaffiniteetti
ZA991154B (en)	2000-08-14	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives.
SI1056759T1 (en)	2003-04-30	2-(purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives
FI881182A0 (fi)	1988-03-14	Nytt, automatiskt, pao minne baserande flygriktnings-, uppfoeljnings- och styrningssystem.
ES1025558Y (es)	1995-01-16	Estructura perfeccionada, para muebles de laboratorio.
BR0001883A (pt)	2001-11-27	Borda de telhado para veìculos
DK1115687T3 (da)	2004-09-20	5,6-Dihydronaphthalenylderivater med retinoid-lignende aktivitet
ES1037229Y (es)	1998-06-01	Plantilla perfeccionada aplicable para el deslizamiento selectivo de ratones de ordenadores.
ATE104675T1 (de)	1994-05-15	Therapeutische nucleoside.