ATE249475T1 - Oligonukleotid-analoge - Google Patents

Oligonukleotid-analoge

Info

Publication number: ATE249475T1
Authority: AT; Austria
Prior art keywords: attached; group; unsubstituted; cycloalkyl; alkenyl
Prior art date: 1996-03-05

Application number

AT97905245T

Other languages

English (en)

Inventor

Anthony David Baxter

Stephen Paul Collingwood

Mark Edward Douglas

Roger John Taylor

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-05

Filing date

1997-02-24

Publication date

2003-09-15

1997-02-24 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249475T1 publication Critical patent/ATE249475T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000003833 nucleoside derivatives Chemical group 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97905245T 1996-03-05 1997-02-24 Oligonukleotid-analoge ATE249475T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9604669.3A GB9604669D0 (en)	1996-03-05	1996-03-05	Chemical compounds
PCT/GB1997/000499 WO1997032887A1 (en)	1996-03-05	1997-02-24	Oligonucleotide analogues

Publications (1)

Publication Number	Publication Date
ATE249475T1 true ATE249475T1 (de)	2003-09-15

Family

ID=10789879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97905245T ATE249475T1 (de)	1996-03-05	1997-02-24	Oligonukleotid-analoge

Country Status (12)

Country	Link
US (1)	US6562960B1 (de)
EP (1)	EP0885237B1 (de)
JP (1)	JP2000506849A (de)
CN (1)	CN1212701A (de)
AT (1)	ATE249475T1 (de)
AU (1)	AU1886797A (de)
BR (1)	BR9707918A (de)
CA (1)	CA2247480A1 (de)
DE (1)	DE69724768T2 (de)
GB (1)	GB9604669D0 (de)
WO (1)	WO1997032887A1 (de)
ZA (1)	ZA971849B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6639061B1 (en) *	1999-07-07	2003-10-28	Isis Pharmaceuticals, Inc.	C3′-methylene hydrogen phosphonate oligomers and related compounds
US6414135B1 (en)	1999-07-07	2002-07-02	Isis Pharmaceuticals, Inc.	C3′-methylene hydrogen phosphonate monomers and related compounds
WO2003052134A2 (en) *	2001-12-18	2003-06-26	Human Genetic Signatures Pty Ltd	Oligonucleotides comprising intercalator pseudonucleotide(s) for detection of nucleic acids and mutants hereof
FR2858976B1 (fr) *	2003-08-22	2006-02-10	Isochem Sa	Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane
WO2009023855A2 (en) *	2007-08-15	2009-02-19	Isis Pharmaceuticals, Inc.	Tetrahydropyran nucleic acid analogs
SG171914A1 (en)	2008-12-02	2011-07-28	Chiralgen Ltd	Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (de)	2009-07-06	2013-05-29	Ontorii Inc	Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
DK2620428T3 (da)	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
US9605019B2 (en)	2011-07-19	2017-03-28	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
JP6246121B2 (ja)	2012-07-13	2017-12-13	株式会社新日本科学	キラル核酸アジュバント
DK2872485T3 (da)	2012-07-13	2021-03-08	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
CN112007045B (zh)	2012-07-13	2026-01-06	波涛生命科学有限公司	手性控制
WO2015108048A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095461A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäure-adjuvans mit immunitätsinduktionswirkung und immunitätsinduktionsaktivator
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko)	2014-01-16	2022-07-22	웨이브 라이프 사이언시스 리미티드	키랄 디자인

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4469863A (en) *	1980-11-12	1984-09-04	Ts O Paul O P	Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4507433A (en) *	1983-10-07	1985-03-26	The Johns Hopkins University	Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates
US4806463A (en)	1986-05-23	1989-02-21	Worcester Foundation For Experimental Biology	Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (de)	1986-10-28	1990-09-19	The Johns Hopkins University	Alkyl- oder Arylphosphonat-Oligonukleosid, das sich mit Nukleinesäuren vernetzen kann oder das Nukleinsäure spalten kann
GB8721442D0 (en)	1987-09-11	1987-10-21	Ciba Geigy Ag	Process
EP0402402B1 (de)	1988-02-26	1995-12-27	Worcester Foundation For Biomedical Research, Inc.	Hemmung von htlv-iii durch exogene oligonukleotide
DK0942000T3 (da)	1989-10-24	2004-11-01	Isis Pharmaceuticals Inc	2'-modificerede oligonukleotider
US5610289A (en) *	1990-07-27	1997-03-11	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogues
US5378825A (en)	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
US6033909A (en) *	1992-01-22	2000-03-07	Hoechst Aktiengesellschaft	Oligonucleotide analogs, their preparation and use
US5681747A (en)	1992-03-16	1997-10-28	Isis Pharmaceuticals, Inc.	Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
US5625050A (en) *	1994-03-31	1997-04-29	Amgen Inc.	Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5563255A (en) *	1994-05-31	1996-10-08	Isis Pharmaceuticals, Inc.	Antisense oligonucleotide modulation of raf gene expression
GB9417746D0 (en)	1994-09-03	1994-10-19	Ciba Geigy Ag	Chemical compounds

1996
- 1996-03-05 GB GBGB9604669.3A patent/GB9604669D0/en active Pending
1997
- 1997-02-24 WO PCT/GB1997/000499 patent/WO1997032887A1/en not_active Ceased
- 1997-02-24 JP JP9531546A patent/JP2000506849A/ja active Pending
- 1997-02-24 BR BR9707918A patent/BR9707918A/pt not_active IP Right Cessation
- 1997-02-24 DE DE69724768T patent/DE69724768T2/de not_active Expired - Lifetime
- 1997-02-24 AT AT97905245T patent/ATE249475T1/de not_active IP Right Cessation
- 1997-02-24 EP EP97905245A patent/EP0885237B1/de not_active Expired - Lifetime
- 1997-02-24 US US09/142,212 patent/US6562960B1/en not_active Expired - Fee Related
- 1997-02-24 AU AU18867/97A patent/AU1886797A/en not_active Abandoned
- 1997-02-24 CA CA002247480A patent/CA2247480A1/en not_active Abandoned
- 1997-02-24 CN CN97192761A patent/CN1212701A/zh active Pending
- 1997-03-04 ZA ZA9701849A patent/ZA971849B/xx unknown

Also Published As

Publication number	Publication date
GB9604669D0 (en)	1996-05-01
CN1212701A (zh)	1999-03-31
BR9707918A (pt)	1999-07-27
DE69724768T2 (de)	2004-08-05
US6562960B1 (en)	2003-05-13
ZA971849B (en)	1997-09-05
EP0885237A1 (de)	1998-12-23
EP0885237B1 (de)	2003-09-10
AU1886797A (en)	1997-09-22
DE69724768D1 (de)	2003-10-16
CA2247480A1 (en)	1997-09-12
WO1997032887A1 (en)	1997-09-12
JP2000506849A (ja)	2000-06-06

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BR9707918A (pt)	1999-07-27	Análogos de oligonucleotídeos
CO4560475A1 (es)	1998-02-10	Un producto de carbon modificado
ES2036551T3 (es)	1996-07-16	Compuestos heterociclicos.
DK0802188T3 (da)	2001-03-05	Heteroforbundne phenylglycinolamider som antiatherosklerotiske lægemidler
ATE231918T1 (de)	2003-02-15	Verfahren zur fermentativen herstellung von l- cystein oder l-cystein-derivaten
ES2066991T3 (es)	1995-03-16	Agentes hipoglucemiantes de oxazolidinadiona.
EA199800768A1 (ru)	1999-02-25	Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
DE69611773D1 (de)	2001-03-22	13-Substituierte Milbemycin 5-Oxim Derivate, ihre Herstellung und Verwendung gegen Insekten und andere Schädlinge
ES2164164T3 (es)	2002-02-16	Derivados de aminotetrazol utiles como inhibidores de oxido nitrico sintasa.
TW258735B (de)	1995-10-01
ATE132139T1 (de)	1996-01-15	Diaminoethylen-verbindungen
AU2148595A (en)	1995-10-30	4,6-di-t-butyl-2,3-dihydrobenzothiophene derivative
ATE189203T1 (de)	2000-02-15	Trizyklische derivate, ihre herstellung, ihre verwendung zur herstellung von optisch aktivem oder racemischem colchizin, thiocolchizin, dessen analoge oder derivate, und intermediate
ES2059595T3 (es)	1994-11-16	Beta-carbonil-carboxiamidas de 1,3-tiazolidinas.
ATE328055T1 (de)	2006-06-15	Substituierte lineare thioureaverbindungen als schmiermittelzusatzstoff
PT906295E (pt)	2002-04-29	Dibenzo-oxazepina e derivados de dioxepina e a respectiva utilizacao como agentes anti-tumores
DE69830653D1 (en)	2005-07-28	Chelatisierungsmitteln
ATE210675T1 (de)	2001-12-15	Zwischenprodukten für oligonukleotid-synthese
PT695296E (pt)	2002-08-30	Derivados de acidos 3-ariloxi-carboxilicos e processo para a sua preparacao
AU4195893A (en)	1994-01-20	Alkylenediamine derivatives
ATE155785T1 (de)	1997-08-15	Mitomycinderivate
DE69711506D1 (de)	2002-05-08	Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
ES529415A0 (es)	1984-10-01	Procedimiento para la preparacion de derivados de piridin-pirimidinona
IL94898A (en)	1994-07-31	Preparation of s-2,2,r1. r2-1,3-dioxolane-4- methanols
DE3664467D1 (de)	1989-08-24	Pineapple ketone l'alkoxyalkyl derivatives