ATE254626T1 - Antibiotische caprazamycine und verfahren zu deren herstellung - Google Patents

Antibiotische caprazamycine und verfahren zu deren herstellung

Info

Publication number
ATE254626T1
ATE254626T1 AT00951962T AT00951962T ATE254626T1 AT E254626 T1 ATE254626 T1 AT E254626T1 AT 00951962 T AT00951962 T AT 00951962T AT 00951962 T AT00951962 T AT 00951962T AT E254626 T1 ATE254626 T1 AT E254626T1
Authority
AT
Austria
Prior art keywords
caprazamycins
production
antibiotic
bacteria
antibiotic caprazamycins
Prior art date
Application number
AT00951962T
Other languages
English (en)
Inventor
Tomio Takeuchi
Masayuki Igarashi
Hiroshi Naganawa
Masa Hamada
Original Assignee
Zaidan Hojin Biseibutsu
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zaidan Hojin Biseibutsu, Meiji Seika Kaisha filed Critical Zaidan Hojin Biseibutsu
Application granted granted Critical
Publication of ATE254626T1 publication Critical patent/ATE254626T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT00951962T 1999-08-12 2000-08-11 Antibiotische caprazamycine und verfahren zu deren herstellung ATE254626T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22886699 1999-08-12
PCT/JP2000/005415 WO2001012643A1 (en) 1999-08-12 2000-08-11 Antibiotic caprazamycins and process for producing the same

Publications (1)

Publication Number Publication Date
ATE254626T1 true ATE254626T1 (de) 2003-12-15

Family

ID=16883115

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00951962T ATE254626T1 (de) 1999-08-12 2000-08-11 Antibiotische caprazamycine und verfahren zu deren herstellung

Country Status (10)

Country Link
US (1) US6780616B1 (de)
EP (1) EP1211259B1 (de)
JP (1) JP4521145B2 (de)
KR (1) KR100659680B1 (de)
AT (1) ATE254626T1 (de)
AU (1) AU6475600A (de)
CA (1) CA2388050C (de)
DE (1) DE60006690T2 (de)
ES (1) ES2209942T3 (de)
WO (1) WO2001012643A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4759756B2 (ja) * 2001-07-05 2011-08-31 公益財団法人微生物化学研究会 抗生物質カプラザマイシンｄ、ｇ、ｄ１、ｇ１とその製造法
AU2003284577A1 (en) * 2002-11-20 2004-06-15 Sankyo Company, Limited Novel antibiotic muraminomicin
WO2004057011A1 (ja) * 2002-12-20 2004-07-08 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 抗生物質カプラザマイシンｄ、ｇ、ｄ１およびｇ１とその製造法
ES2556135T3 (es) 2003-01-31 2016-01-13 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivados de caprazeno-1'''-amida
JP5339840B2 (ja) * 2008-10-02 2013-11-13 公益財団法人微生物化学研究会 抗ｘｄｒ−ｔｂ薬、抗ｍｄｒ−ｔｂ薬、及び併用抗結核薬
JP2012102019A (ja) * 2009-03-03 2012-05-31 Hokkaido Univ ヌクレオシド系抗生物質誘導体
DE102009014432A1 (de) 2009-03-26 2010-09-30 Eberhard-Karls-Universität Tübingen Ein neues Caprazamycin Biosynthesegencluster
US8754054B2 (en) * 2010-07-09 2014-06-17 Albany Molecular Research, Inc. Antibacterial compounds, methods of making them, and uses thereof
JP5922936B2 (ja) * 2012-01-25 2016-05-24 公益財団法人微生物化学研究会 新規微生物及びカプラゾールの製造方法
WO2014196512A1 (ja) 2013-06-04 2014-12-11 公益財団法人微生物化学研究会 併用抗抗酸菌薬、抗抗酸菌薬のスクリーニング方法、及びＷｅｃＡ乃至そのオルソログの活性阻害剤
WO2018226949A1 (en) 2017-06-08 2018-12-13 Pai Life Sciences Inc. Cpzen compositions and uses
MX2020000265A (es) 2017-07-07 2020-07-22 Epicentrx Inc Composiciones para la administración parenteral de agentes terapéuticos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6098995A (ja) * 1983-11-04 1985-06-01 Microbial Chem Res Found 光学活性３−（３，４−ジヒドロキシフエニル）セリン，およびその誘導体の製造法
JPH02306992A (ja) * 1989-05-20 1990-12-20 Rikagaku Kenkyusho 抗生物質ｒｋ―１０６１ｇ及びｒｋ―１０６１ｈ並びにその製造法
US6455694B1 (en) * 1996-04-26 2002-09-24 Daiichi Pharmaceutical Co., Ltd. Antibiotics RK-1061 and process for preparing the same

Also Published As

Publication number Publication date
AU6475600A (en) 2001-03-13
WO2001012643A1 (en) 2001-02-22
CA2388050C (en) 2008-03-18
US6780616B1 (en) 2004-08-24
EP1211259B1 (de) 2003-11-19
ES2209942T3 (es) 2004-07-01
DE60006690D1 (de) 2003-12-24
KR100659680B1 (ko) 2006-12-21
EP1211259A1 (de) 2002-06-05
DE60006690T2 (de) 2004-09-23
KR20020092899A (ko) 2002-12-12
EP1211259A4 (de) 2002-09-04
CA2388050A1 (en) 2001-02-22
JP4521145B2 (ja) 2010-08-11

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