ATE250066T1 - Verfahren zur reduktion von oxiranyl-epothilonen zu olefinischen epothilonen - Google Patents
Verfahren zur reduktion von oxiranyl-epothilonen zu olefinischen epothilonenInfo
- Publication number
- ATE250066T1 ATE250066T1 AT98959652T AT98959652T ATE250066T1 AT E250066 T1 ATE250066 T1 AT E250066T1 AT 98959652 T AT98959652 T AT 98959652T AT 98959652 T AT98959652 T AT 98959652T AT E250066 T1 ATE250066 T1 AT E250066T1
- Authority
- AT
- Austria
- Prior art keywords
- epothilones
- oxiranyl
- olefinic
- reducing
- reduction
- Prior art date
Links
- 229930013356 epothilone Natural products 0.000 title abstract 4
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical compound C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title abstract 3
- -1 oxiranyl epothilones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6754997P | 1997-12-04 | 1997-12-04 | |
| US8256398P | 1998-04-21 | 1998-04-21 | |
| PCT/US1998/025464 WO1999028324A1 (en) | 1997-12-04 | 1998-12-01 | A process for the reduction of oxiranyl epothilones to olefinic epothilones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250066T1 true ATE250066T1 (de) | 2003-10-15 |
Family
ID=26748002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98959652T ATE250066T1 (de) | 1997-12-04 | 1998-12-01 | Verfahren zur reduktion von oxiranyl-epothilonen zu olefinischen epothilonen |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1042327B1 (de) |
| JP (1) | JP4434484B2 (de) |
| KR (1) | KR100574454B1 (de) |
| AT (1) | ATE250066T1 (de) |
| AU (1) | AU738576B2 (de) |
| CA (1) | CA2311929A1 (de) |
| DE (1) | DE69818304T2 (de) |
| ES (1) | ES2207015T3 (de) |
| HU (1) | HUP0100582A3 (de) |
| IL (1) | IL135590A (de) |
| TW (1) | TWI221469B (de) |
| WO (1) | WO1999028324A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6320045B1 (en) * | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
| IL138113A0 (en) * | 1998-02-25 | 2001-10-31 | Sloan Kettering Inst Cancer | Synthesis of epothilones, intermediates thereto and analogues thereof |
| PT1169038E (pt) | 1999-04-15 | 2012-10-26 | Bristol Myers Squibb Co | Inibidores cíclicos da proteína tirosina cinase |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| HK1049787B (en) | 1999-10-01 | 2014-07-25 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP1340498A1 (de) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Verwendung von Epothilonen zur Behandlung von mit proliferativen Prozessen assoziierten Gehirnerkrankungen |
| US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| CN101389334A (zh) * | 2002-05-20 | 2009-03-18 | 高山生物科学股份有限公司 | 埃坡霉素d的给药方法 |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| AU2003302084A1 (en) | 2002-11-15 | 2004-06-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
| EP1559447A1 (de) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verwendung von Epothilonen zur Behandlung von neuronalen Konnektivitätsdefekten wie zum Beispiel Schizophrenie und Autismus |
| US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| CN104116736A (zh) * | 2008-04-24 | 2014-10-29 | 百时美施贵宝公司 | 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途 |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| CA2824521C (en) | 2011-01-20 | 2016-06-28 | Board Of Regents, The University Of Texas System | Mri markers, delivery and extraction systems, and related methods |
| EP3228325A1 (de) | 2011-06-10 | 2017-10-11 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
| CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
| CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
| WO2014075391A1 (zh) | 2012-11-17 | 2014-05-22 | 北京市丰硕维康技术开发有限责任公司 | 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物 |
| AU2013359506B2 (en) | 2012-12-10 | 2018-05-24 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2931316B1 (de) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxylpolymer-heilmittelproteinkonjugate |
| MA38656A1 (fr) | 2013-06-11 | 2018-05-31 | Bayer Pharma AG | Combinaisons pour le traitement du cancer comprenant un inhibiteur de la kinase mps-1 et un inhibiteur de la mitose |
| CA2926586C (en) | 2013-10-11 | 2020-04-07 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| CN103936748A (zh) * | 2014-05-08 | 2014-07-23 | 成都摩尔生物医药有限公司 | 一种埃博霉素b内酰胺衍生物的制备方法 |
| US11617799B2 (en) | 2016-06-27 | 2023-04-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| CA3066754A1 (en) | 2017-06-22 | 2018-12-27 | Mersana Therapeutics, Inc. | Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates |
| US20210299286A1 (en) | 2018-05-04 | 2021-09-30 | Tagworks Pharmaceuticals B.V. | Tetrazines for high click conjugation yield in vivo and high click release yield |
| ES2975330T3 (es) | 2018-05-04 | 2024-07-04 | Tagworks Pharmaceuticals B V | Compuestos que comprenden un enlazador para aumentar la estabilidad del trans-cicloocteno |
| KR20210084546A (ko) | 2018-10-29 | 2021-07-07 | 메르사나 테라퓨틱스, 인코포레이티드 | 펩티드 함유 링커를 갖는 시스테인 조작된 항체-약물 접합체 |
| IL289093B2 (en) | 2019-06-17 | 2025-02-01 | Tagworks Pharmaceuticals B V | Compounds for a fast and efficient "click release" reaction |
| IL289094A (en) | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Tetrazines for increasing the speed and yield of the "click release" reaction |
| CN118339280A (zh) | 2021-09-06 | 2024-07-12 | 维拉克萨生物技术有限责任公司 | 用于真核生物中遗传密码子扩展的新型氨酰tRNA合成酶变体 |
| KR20240105469A (ko) | 2021-11-25 | 2024-07-05 | 베락사 바이오테크 게엠베하 | 유전자 코드 확장을 이용하는 부위-특이적 접합에 의해 제조되는 개선된 항체-페이로드 접합체 (apc) |
| DK4186529T3 (da) | 2021-11-25 | 2025-08-25 | Veraxa Biotech Gmbh | Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse |
| WO2023104941A1 (en) | 2021-12-08 | 2023-06-15 | European Molecular Biology Laboratory | Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates |
| DK4314031T3 (da) | 2022-02-15 | 2024-06-17 | Tagworks Pharmaceuticals B V | Maskeret il12-protein |
| CA3261603A1 (en) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | ANTIBODY-DRUG CONJUGATES |
| WO2024080872A1 (en) | 2022-10-12 | 2024-04-18 | Tagworks Pharmaceuticals B.V. | Strained bicyclononenes |
| WO2024153789A1 (en) | 2023-01-20 | 2024-07-25 | Basf Se | Stabilized biopolymer composition, their manufacture and use |
| KR20250169530A (ko) | 2023-03-10 | 2025-12-03 | 태그웍스 파마슈티컬스 비.브이. | 개선된 t-링커를 갖는 트랜스-사이클로옥텐 |
| CN121646574A (zh) | 2023-07-27 | 2026-03-10 | 维拉克萨生物技术有限责任公司 | 亲水性反式环辛烯(hyTCO)化合物、含有该化合物的构建体和缀合物 |
| WO2025056807A1 (en) | 2023-09-15 | 2025-03-20 | Basf Se | Stabilized biopolymer composition, their manufacture and use |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025174248A1 (en) | 2024-02-16 | 2025-08-21 | Tagworks Pharmaceuticals B.V. | Trans-cyclooctenes with "or gate" release |
| WO2026043376A1 (en) | 2024-08-22 | 2026-02-26 | Tagworks Pharmaceuticals B.V. | Trans-cyclooctene formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4138042C2 (de) * | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| EP1440973A3 (de) * | 1995-11-17 | 2004-10-20 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilonderivate, Herstellung und Mittel |
-
1998
- 1998-12-01 IL IL13559098A patent/IL135590A/xx not_active IP Right Cessation
- 1998-12-01 DE DE69818304T patent/DE69818304T2/de not_active Expired - Lifetime
- 1998-12-01 JP JP2000523216A patent/JP4434484B2/ja not_active Expired - Fee Related
- 1998-12-01 HU HU0100582A patent/HUP0100582A3/hu unknown
- 1998-12-01 AT AT98959652T patent/ATE250066T1/de active
- 1998-12-01 AU AU15408/99A patent/AU738576B2/en not_active Ceased
- 1998-12-01 WO PCT/US1998/025464 patent/WO1999028324A1/en not_active Ceased
- 1998-12-01 KR KR1020007005086A patent/KR100574454B1/ko not_active Expired - Fee Related
- 1998-12-01 EP EP98959652A patent/EP1042327B1/de not_active Expired - Lifetime
- 1998-12-01 CA CA002311929A patent/CA2311929A1/en not_active Abandoned
- 1998-12-01 TW TW087119880A patent/TWI221469B/zh not_active IP Right Cessation
- 1998-12-01 ES ES98959652T patent/ES2207015T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001525324A (ja) | 2001-12-11 |
| HUP0100582A2 (hu) | 2001-09-28 |
| DE69818304T2 (de) | 2004-07-01 |
| ES2207015T3 (es) | 2004-05-16 |
| HUP0100582A3 (en) | 2003-03-28 |
| KR100574454B1 (ko) | 2006-04-27 |
| EP1042327A4 (de) | 2002-07-17 |
| JP4434484B2 (ja) | 2010-03-17 |
| KR20010031976A (ko) | 2001-04-16 |
| IL135590A (en) | 2003-09-17 |
| AU1540899A (en) | 1999-06-16 |
| EP1042327A1 (de) | 2000-10-11 |
| WO1999028324A1 (en) | 1999-06-10 |
| EP1042327B1 (de) | 2003-09-17 |
| IL135590A0 (en) | 2001-05-20 |
| HK1028401A1 (en) | 2001-02-16 |
| AU738576B2 (en) | 2001-09-20 |
| TWI221469B (en) | 2004-10-01 |
| CA2311929A1 (en) | 1999-06-10 |
| DE69818304D1 (de) | 2003-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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