ATE250129T1 - Modifizierte peptidsynthetasen, und deren verwendung in der nicht-ribosomalen herstellung von peptiden - Google Patents

Modifizierte peptidsynthetasen, und deren verwendung in der nicht-ribosomalen herstellung von peptiden

Info

Publication number
ATE250129T1
ATE250129T1 AT96109937T AT96109937T ATE250129T1 AT E250129 T1 ATE250129 T1 AT E250129T1 AT 96109937 T AT96109937 T AT 96109937T AT 96109937 T AT96109937 T AT 96109937T AT E250129 T1 ATE250129 T1 AT E250129T1
Authority
AT
Austria
Prior art keywords
peptides
modified peptide
peptide synthetases
ribosomal
production
Prior art date
Application number
AT96109937T
Other languages
English (en)
Inventor
Guido Grandi
Ferra Francesca De
Francesco Rodrigues
Original Assignee
Enitecnologie Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enitecnologie Spa filed Critical Enitecnologie Spa
Application granted granted Critical
Publication of ATE250129T1 publication Critical patent/ATE250129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96109937T 1995-08-09 1996-06-20 Modifizierte peptidsynthetasen, und deren verwendung in der nicht-ribosomalen herstellung von peptiden ATE250129T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001764A IT1277466B1 (it) 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Publications (1)

Publication Number Publication Date
ATE250129T1 true ATE250129T1 (de) 2003-10-15

Family

ID=11372167

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96109937T ATE250129T1 (de) 1995-08-09 1996-06-20 Modifizierte peptidsynthetasen, und deren verwendung in der nicht-ribosomalen herstellung von peptiden

Country Status (5)

Country Link
US (1) US5795738A (de)
EP (1) EP0789078B1 (de)
AT (1) ATE250129T1 (de)
DE (1) DE69630010D1 (de)
IT (1) IT1277466B1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
DE19909146A1 (de) * 1999-03-03 2000-09-28 Mohamed A Marahiel Verfahren zur gezielten biologischen Synthese von Peptiden
EP1096011A1 (de) * 1999-05-10 2001-05-02 Holland Sweetener Company V.o.F. Mikrobiologisches Verfahren zur Herstellung von Alpha-L-Aspartyl-L-Phenylalanin
DE19928313A1 (de) * 1999-06-16 2000-12-21 Ullrich Keller Verfahren zur Veränderung von Peptidsynthefasen in der Weise, daß sie ihre Substrataminosäuren N-methylieren können
FR2796465B1 (fr) * 1999-07-16 2001-11-23 Suisse Electronique Microtech Systeme capteur biochimique a sensibilite accrue par amplification moleculaire du signal
US20050027113A1 (en) * 2001-08-06 2005-02-03 Miao Vivian Pak Woon Compositions and methods relating to the daptomycin biosynthetic gene cluster
WO2004058960A1 (ja) 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
US20080051326A1 (en) * 2004-11-12 2008-02-28 Alexander Dylan C Antiinfective Lipopeptides
JP4881854B2 (ja) * 2005-03-18 2012-02-22 協和発酵バイオ株式会社 ジペプチドの製造法
EP1924699A4 (de) * 2005-08-26 2009-11-11 Aureogen Biosciences Aureobasidin-a-synthetase
US20090197303A1 (en) * 2005-12-27 2009-08-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
WO2008131014A1 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Lipopeptides and lipopeptide synthetases
US7981685B2 (en) * 2007-04-16 2011-07-19 Modular Genetics, Inc. Generation of acyl amino acids
JPWO2009028253A1 (ja) * 2007-08-31 2010-11-25 協和発酵バイオ株式会社 ペプチドの製造法
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
CA3316609A1 (en) 2013-03-15 2026-08-05 Modular Genetics, Inc. Generation of acyl amino acids
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US12123004B2 (en) 2018-07-18 2024-10-22 Modular Genetics, Inc. Generation of acyl amino acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540074A1 (de) * 1991-10-09 1993-05-05 ENIRICERCHE S.p.A. Klonierung und Sequenzierung der chromosomalen DNS-Region aus Bacillus subtilis, die den für den Multienzym-Komplex Surfactin-Synthetase kodierenden SRFA Operon enthält
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi

Also Published As

Publication number Publication date
DE69630010D1 (de) 2003-10-23
EP0789078A2 (de) 1997-08-13
EP0789078B1 (de) 2003-09-17
ITMI951764A1 (it) 1997-02-09
ITMI951764A0 (it) 1995-08-09
EP0789078A3 (de) 1999-10-27
US5795738A (en) 1998-08-18
IT1277466B1 (it) 1997-11-10

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